Risteys · O15_LABOUR_ABNORM

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule only females	293373
2. Check conditions None	293373
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — O62 Hospital discharge: ICD-9 — 661 Cause of death: ICD-10 — O62 Cause of death: ICD-9 — 661 2 out of 7 registries used, show all original rules.	4529
4. Check minimum number of events None	4529
5. Include endpoints None	4529
6. Filter based on genotype QC (FinnGen only)	4529

	All	Female	Male
Number of individuals
Whole population	33684	33684	-
Only index persons	33242	33242	-
Unadjusted period prevalence (%)
Whole population	0.96	0.96	-
Only index persons	1.22	1.22	-
Median age at first event (years)
Whole population	-	29.80	-
Only index persons	-	29.79	-

	All	Female	Male
Number of individuals	4529	4529	-
Unadjusted period prevalence (%)	1.54	1.54	-
Median age at first event (years)	29.96	29.96	-

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
4131: Matched controls
41309

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

O68.0

ICD-10 Finland

Labour and delivery complicated by fetal heart rate anomaly

+∞

323.0

307

O82.10

ICD-10 Finland

Delivery by emergency caesarean section

16.9

323.0

744

531

O63.1

ICD-10 Finland

Prolonged second stage (of labour)

+∞

323.0

369

6610B

ICD-9 Finland

Abnormality of forces of labour, Primary uterine inertia

+∞

323.0

637

MCA10

NOMESCO Finland

Lower uterine segment caesarean section

8.0

323.0

1147

1887

O62.1

ICD-10 Finland

Secondary uterine inertia

+∞

323.0

892

MAE00

NOMESCO Finland

Outlet vacuum delivery

67.6

323.0

768

139

O81.4

ICD-10 Finland

Vacuum extractor delivery

70.6

323.0

941

172

6611B

ICD-9 Finland

Abnormality of forces of labour, Secondary uterine inertia

+∞

323.0

1265

O62.0

ICD-10 Finland

Primary inadequate contractions

+∞

323.0

590

8801

FHL

Suction cup delivery

31.3

323.0

707

271

8811

FHL

Cesarean section

12.6

323.0

881

870

O34.2

ICD-10 Finland

Maternal care due to uterine scar from previous surgery

11.0

323.0

709

762

O62.2

ICD-10 Finland

Other uterine inertia

2023.4

323.0

352

O63.0

ICD-10 Finland

Prolonged first stage (of labour)

+∞

305.0

289

O64.0

ICD-10 Finland

Obstructed labour due to incomplete rotation of fetal head

+∞

247.4

235

O62.3

ICD-10 Finland

Precipitate labour

+∞

206.0

196

O72.1

ICD-10 Finland

Other immediate postpartum haemorrhage

1632.4

158.3

153

6622B

ICD-9 Finland

Long labour, Prolonged second stage

+∞

154.1

147

O72.0

ICD-10 Finland

Third-stage haemorrhage

+∞

149.9

143

O75.0

ICD-10 Finland

Maternal distress during labour and delivery

+∞

146.7

140

Z36.3

ICD-10 Finland

Antenatal screening for malformations using ultrasound and other physical methods

2.5

146.4

1625

8542

O70.1

ICD-10 Finland

Second degree perineal laceration during delivery

+∞

142.5

136

65000

ICD-8 Finland

Delivery without mention of complication, Occipital presentation

0.2

131.6

146

6510

MA2AE

NOMESCO Finland

Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus

2.7

117.6

955

4115

ZXD05

NOMESCO Finland

Urgent procedure

2.3

113.8

1361

7201

6620B

ICD-9 Finland

Long labour, Prolonged first stage

+∞

112.0

107

O60

ICD-10 Finland

Preterm labour and delivery

258.9

99.1

101

Z39.2

ICD-10 Finland

Routine postpartum follow-up

2.7

93.6

740

3087

MBA30

NOMESCO Finland

Manual removal of placenta from delivered uterus

37.3

84.9

109

O99.80

ICD-10 Finland

The fear of childbirth

3.9

82.2

361

980

Z34.0

ICD-10 Finland

Supervision of normal first pregnancy

2.4

82.2

791

3657

MA2HE

NOMESCO Finland

Detailed morfological ultrasound examination of fetus

2.2

80.8

962

4933

6612B

ICD-9 Finland

Abnormality of forces of labour, Other and unspecified uterine inertia

+∞

80.5

O24.4

ICD-10 Finland

Diabetes mellitus arising in pregnancy

2.7

78.7

600

2429

SPAT1197

SPAT

Extensive health check-up of expecting family

2.6

76.9

661

2865

O75.6

ICD-10 Finland

Delayed delivery after spontaneous or unspecified rupture of membranes

+∞

76.3

Z34.8

ICD-10 Finland

Supervision of other normal pregnancy

2.2

74.5

955

5036

O61.0

ICD-10 Finland

Failed medical induction of labour

+∞

74.2

TMA00

NOMESCO Finland

Episiotomy

4.8

74.0

259

563

O72.2

ICD-10 Finland

Delayed and secondary postpartum haemorrhage

254.6

73.6

6441A

ICD-9 Finland

Early or threatened labour, Other threatened labour

+∞

71.0

6522B

ICD-9 Finland

Malposition and malpresentation of foetus, Breech presentation without mention of version[PRAESENTATIO CLUNIUM,SYNNYTYKSEN AIKANA]

+∞

68.9

O82.0

ICD-10 Finland

Delivery by elective caesarean section

3.4

68.3

361

1137

6660A

ICD-9 Finland

Postpartum haemorrhage, Third-stage haemorrhage[HAEMORRHAGIA POST PARTUM STADII III]

+∞

67.9

WX306

NOMESCO Finland

Lumbar epidural anesthesy

3.0

65.6

410

1454

6534B

ICD-9 Finland

Disproportion, Foetopelvic disproportion[DISPROPORTIO FOETOPELVICA,SYNNYTYKSEN AIKANA]

+∞

64.7

6500B

ICD-9 Finland

Delivery in a completely normal case[PARTUS SINE COMPLICATIONE]

0.5

63.2

664

11440

W78

ICPC

Pregnancy

2.2

63.1

710

3497

MA2JE

NOMESCO Finland

Ultrasound screening of fetal nuchal translucency

2.7

62.8

476

1906

6542B

ICD-9 Finland

Abnormality of organs and soft tissues of pelvis, Previous Caesarean delivery[CICATRIX UTERI POSTOPERATIVA, SYNNYTYKSEN AIKANA]

12.2

60.6

112

WX307

NOMESCO Finland

Obstetric epidural analgesia

2.8

60.2

432

1670

Z35.8

ICD-10 Finland

Supervision of other high-risk pregnancies

2.3

58.5

585

2713

Z37.0

ICD-10 Finland

Single live birth

2.3

58.5

643

3124

MAE03

NOMESCO Finland

Mid-cavity or high vacuum delivery

65.9

56.4

SPAT1379

SPAT

Health check-up of pregnant person

2.4

56.0

529

2380

SPAT1380

SPAT

Postpartum check-up

2.6

55.2

452

1884

O65.4

ICD-10 Finland

Obstructed labour due to fetopelvic disproportion, unspecified

+∞

54.3

O64.1

ICD-10 Finland

Obstructed labour due to breech presentation

+∞

53.2

6619X

ICD-9 Finland

Abnormality of forces of labour, Unspecified abnormality of labour

+∞

51.1

O62.9

ICD-10 Finland

Abnormality of forces of labour, unspecified

253.1

49.1

MBC30

NOMESCO Finland

Repair of partial rupture of perineum

9.2

48.4

103

114

MAW96

NOMESCO Finland

Other operation in pregnancy or at delivery

18.1

46.7

O68.8

ICD-10 Finland

Labour and delivery complicated by other evidence of fetal stress

+∞

45.9

O41.1

ICD-10 Finland

Infection of amniotic sac and membranes

12.2

43.0

O64.8

ICD-10 Finland

Obstructed labour due to other malposition and malpresentation

+∞

42.8

Z32.1

ICD-10 Finland

Pregnancy confirmed

2.1

42.4

540

2767

O66.5

ICD-10 Finland

Failed application of vacuum extractor and forceps, unspecified

+∞

41.7

6440B

ICD-9 Finland

Early or threatened labour, Threatened premature labour[PARTUS PRAEMATURUS]

+∞

41.7

6528B

ICD-9 Finland

Malposition and malpresentation of foetus, Other specified malposition or malpresentation[MUUT VIRHEASENNOT JA -TARJONNAT, SYNNYTYKSEN AIKANA]

+∞

41.7

6563B

ICD-9 Finland

Other foetal and placental problems affecting management of mother, Foetal distress[ASPHYXIA FOETALIS, SYNNYTYKSEN AIKANA]

3.7

41.0

187

521

W92

ICPC

Compl labour/ delivery livebirth

7.0

39.3

144

O36.6

ICD-10 Finland

Maternal care for excessive fetal growth

3.2

38.4

217

712

O62.4

ICD-10 Finland

Hypertonic, incoordinate, and prolonged uterine contractions

63.5

38.1

O47.0

ICD-10 Finland

False labour before 37 completed weeks of gestation

2.1

37.2

488

2528

6661A

ICD-9 Finland

Postpartum haemorrhage, Other immediate postpartum haemorrhage[HAEMORRHAGIA POST PARTUM ATONICA UTERI]

+∞

36.5

O68.2

ICD-10 Finland

Labour and delivery complicated by fetal heart rate anomaly with meconium in amniotic fluid

+∞

36.5

O71.4

ICD-10 Finland

Obstetric high vaginal laceration

+∞

35.5

Z3232

NOMESCO Finland

Midwife

2.0

35.1

496

2644

6613B

ICD-9 Finland

Abnormality of forces of labour, Precipitate labour

+∞

33.4

O68.1

ICD-10 Finland

Labour and delivery complicated by meconium in amniotic fluid

+∞

33.4

MA2DE

NOMESCO Finland

Detailed ultrasound examination of fetus including color doppler method

2.1

32.5

423

2177

6654B

ICD-9 Finland

Other obstetrical trauma, High vaginal laceration

+∞

32.3

Z34

ICD-10 Finland

Supervision of normal pregnancy

2.7

32.3

233

897

O48

ICD-10 Finland

Prolonged pregnancy

2.9

31.4

196

688

O73.1

ICD-10 Finland

Retained portions of placenta and membranes, without haemorrhage

+∞

31.3

O73.0

ICD-10 Finland

Retained placenta without haemorrhage

+∞

31.3

Z35.2

ICD-10 Finland

Supervision of pregnancy with other poor reproductive or obstetric history

4.1

30.6

124

312

SPAT1317

SPAT

Planned health check-up monitoring, health check-up performed based on individual need

2.0

30.4

433

2309

8832

FHL

Manual placenta removal and associated scraping

31.0

30.3

6584B

ICD-9 Finland

Other problems associated with amniotic cavity and membranes, Infection of amniotic cavity[AMNIONITIS, SYNNYTYKSEN AIKANA]

14.9

30.0

SPAT1195

SPAT

Antenatal classes

3.5

29.5

144

425

Z34.9

ICD-10 Finland

Supervision of normal pregnancy, unspecified

1.8

29.0

592

3573

WX600

NOMESCO Finland

Single shot through catheter

4.4

28.9

108

252

SPAT1399

SPAT

Acceptance of acknowledgement of paternity of child born outside of marriage before the birth of the child at the maternity clinic. Paternity Act, Section 16.

2.9

28.6

180

635

O70.0

ICD-10 Finland

First degree perineal laceration during delivery

+∞

28.1

6535B

ICD-9 Finland

Disproportion, Unusually large foetus causing disproportion[EPÄTAVALLISEN ISO SIKIÖ (YLI 4500 G), SYNN AIKANA]

+∞

28.1

O70.2

ICD-10 Finland

Third degree perineal laceration during delivery

+∞

28.1

6671A

ICD-9 Finland

Retained placenta or membranes, without haemorrhage, Retained portions of placenta or membranes, without haemorrhage

+∞

28.1

6660B

ICD-9 Finland

Postpartum haemorrhage, Third-stage haemorrhage[HAEMORRHAGIA POST PARTUM CUM RETENT PLAC TOTALI]

+∞

28.1

MAE20

NOMESCO Finland

Failed vacuum delivery

283.3

27.8

6641B

ICD-9 Finland

Trauma to perineum and vulva during delivery, Second-degree perineal laceration

+∞

27.1

6542A

ICD-9 Finland

Abnormality of organs and soft tissues of pelvis, Previous Caesarean delivery[CICATRIX UTERI POSTOPERATIVA, RASKAUDEN AIKANA]

11.2

26.5

6581A

ICD-9 Finland

Other problems associated with amniotic cavity and membranes, Premature rupture of membranes

7.0

26.4

W85

ICPC

Gestational diabetes

2.8

26.2

175

642

O68.3

ICD-10 Finland

Labour and delivery complicated by biochemical evidence of fetal stress

+∞

26.1

MAC01

NOMESCO Finland

Rupture of aminiotic membrane for induction of labor

4.5

25.8

210

SPAT1196

SPAT

Monitoring of normal pregnancy

2.0

25.8

333

1705

6591A

ICD-9 Finland

Other indications for care or intervention related to labour and delivery and not elsewhere classified, Failed medical or unspecified induction

+∞

25.0

6690A

ICD-9 Finland

Other complications of labour and delivery, not elsewhere classified, Maternal distress

+∞

25.0

O62.8

ICD-10 Finland

Other abnormalities of forces of labour

+∞

25.0

O69.1

ICD-10 Finland

Labour and delivery complicated by cord around neck, with compression

+∞

24.0

MBC33

NOMESCO Finland

Repair of complete rupture of perineum

67.8

23.8

MBA04

NOMESCO Finland

Curettage of uterus after delivery

41.7

23.6

MAC10

NOMESCO Finland

Antepartum dilatation of cervical canal

3.7

23.3

102

277

MA1AE

NOMESCO Finland

Ultrasound examination of early pregnancy (before 12. postmenstrual week)

1.7

22.1

503

3120

MAC40

NOMESCO Finland

Pharmacological induction or advancement of labor

4.5

21.9

175

O75.2

ICD-10 Finland

Pyrexia during labour, not elsewhere classified

+∞

21.9

O13

ICD-10 Finland

Gestational [pregnancy-induced] hypertension

2.1

21.5

258

1282

MA2XE

NOMESCO Finland

Other obstetric ultrasound examination

1.9

21.3

340

1882

O82.11

ICD-10 Finland

Childbirth with an emergency caesarean section in an emergency

12.9

21.1

O75.7

ICD-10 Finland

Vaginal delivery following previous caesarean section

+∞

20.8

6660C

ICD-9 Finland

Postpartum haemorrhage, Third-stage haemorrhage[HAEMORRHAGIA POST PARTUM CUM RETENT PLAC PARTIALI]

+∞

20.8

6670A

ICD-9 Finland

Retained placenta or membranes, without haemorrhage, Retained placenta without haemorrhage

+∞

20.8

6522A

ICD-9 Finland

Malposition and malpresentation of foetus, Breech presentation without mention of version[PRAESENTATIO CLUNIUM,RASKAUDEN AIKANA]

+∞

20.8

8802

FHL

Forceps delivery

19.5

20.8

6450B

ICD-9 Finland

Prolonged pregnancy[GRAVIDITAS PROLANGATA CUM PARTU]

3.8

20.6

230

MAC96

NOMESCO Finland

Other induction or advancement of labour

2.8

20.5

135

495

SPAT1200

SPAT

Guidance for breast-feeding and breast care

2.9

20.1

122

423

MA5AE

NOMESCO Finland

Morphology ultrasound screening, weeks 18+0 to 21+6 of gestation

2.5

19.9

157

638

LGA10

NOMESCO Finland

Sterilisation by destruction or division of Fallopian tubes

4.2

19.8

184

6631A

ICD-9 Finland

Umbilical cord complications, Cord around neck, with compression

+∞

19.8

SPAT1373

SPAT

Combined screening in early pregnancy

3.6

19.5

251

O26.82

ICD-10 Finland

Exhaustion and fatigue pregnancy-related

3.3

19.4

100

311

6488A

ICD-9 Finland

Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Abnormal glucose tolerance

2.9

19.3

122

434

O66.4

ICD-10 Finland

Failed trial of labour, unspecified

+∞

18.8

O61.1

ICD-10 Finland

Failed instrumental induction of labour

+∞

18.8

MBC10

NOMESCO Finland

Repair of obstetric laceration of vagina

4.5

18.7

152

O47.9

ICD-10 Finland

False labour, unspecified

3.5

18.1

241

SPAT1246

SPAT

Screening of depression or other psychiatric problem

2.2

18.0

189

884

R3110

NOMESCO Finland

Psychosocial training

3.5

17.7

240

O66.0

ICD-10 Finland

Obstructed labour due to shoulder dystocia

+∞

17.7

O71.3

ICD-10 Finland

Obstetric laceration of cervix

+∞

17.7

MA3AE

NOMESCO Finland

Combined first trimester screening

2.4

17.6

151

640

O99.89

ICD-10 Finland

Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium

2.8

17.4

111

398

ZXD00

NOMESCO Finland

Emergency procedure

3.0

17.3

100

338

SPAT1357

SPAT

Monitoring of problem during pregnancy

2.5

17.1

132

531

W84

ICPC

Pregnancy high risk

2.5

17.1

133

539

Z35.9

ICD-10 Finland

Supervision of high-risk pregnancy, unspecified

2.1

16.7

185

889

O66.2

ICD-10 Finland

Obstructed labour due to unusually large fetus

+∞

16.7

6661X

ICD-9 Finland

Postpartum haemorrhage, Other immediate postpartum haemorrhage[HAEMORRHAGIA POST PARTUM ACUTA ALIA]

+∞

16.7

O30.0

ICD-10 Finland

Twin pregnancy

2.8

16.1

103

371

WX320

NOMESCO Finland

Spinalanesthesy

1.5

16.0

627

4436

MAA40

NOMESCO Finland

Puncture of fetus

6.9

15.9

Z30.2

ICD-10 Finland

Sterilization

1.5

15.8

652

4659

8833

FHL

Correction of II ^ 0 or III ^ 0 perineumrupth or vaginal rupture

10.4

15.7

SPAT1189

SPAT

Other ultrasound examination during pregnancy

2.4

15.7

137

591

O68.9

ICD-10 Finland

Labour and delivery complicated by fetal stress, unspecified

+∞

15.6

63497

ICD-8 Finland

Other complications of pregnancy, Partus prematurus imminens, alibi non classificabilis

+∞

15.6

6524B

ICD-9 Finland

Malposition and malpresentation of foetus, Face or brow presentation[HABITUS DEFLEXIONIS,SYNNYTYKSEN AIKANA]

+∞

15.6

Z36.0

ICD-10 Finland

Antenatal screening for chromosomal anomalies

1.9

15.4

244

1346

Z35.0

ICD-10 Finland

Supervision of pregnancy with history of infertility

2.3

15.4

143

636

O99.3

ICD-10 Finland

Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium

2.9

15.2

333

OAA12

SPAT

3.9

15.1

162

XMA22

NOMESCO Finland

General examination of pregnant woman

1.7

15.0

319

1934

Z36.8

ICD-10 Finland

Other antenatal screening

2.7

14.9

102

386

ZXE00

NOMESCO Finland

One hour or less

1.3

14.8

1420

11728

O65.1

ICD-10 Finland

Obstructed labour due to generally contracted pelvis

+∞

14.6

6534A

ICD-9 Finland

Disproportion, Foetopelvic disproportion[DISPROPORTIO FOETOPELVICA,RASKAUDEN AIKANA]

+∞

14.6

8831

FHL

Uterine exploration and / or scraping or suction emptying (ad 24 hours)

11.9

14.5

6400A

ICD-9 Finland

Haemorrhage in early pregnancy, Threatened abortion

3.2

14.4

237

O86.0

ICD-10 Finland

Infection of obstetric surgical wound

4.9

14.4

MAA00

NOMESCO Finland

Amniocentesis

2.3

14.2

137

620

W29

ICPC

Pregnancy symptom/complaint other

2.5

14.1

107

427

8502

FHL

Evacuation and abrasion

1.8

13.8

259

1510

WX322

NOMESCO Finland

Combined spinal-epidural analgesia in obstetrics

3.1

13.7

252

O75.3

ICD-10 Finland

Other infection during labour

+∞

13.5

O61.8

ICD-10 Finland

Other failed induction of labour

+∞

13.5

O42.1

ICD-10 Finland

Premature rupture of membranes, onset of labour after 24 hours

3.1

13.0

222

6582B

ICD-9 Finland

Other problems associated with amniotic cavity and membranes, Delayed delivery after spontaneous or unspecified rupture of membranes

4.0

12.9

125

MBA03

NOMESCO Finland

Curettage of uterus after delivery or abortion

2.0

12.7

172

897

Z39.1

ICD-10 Finland

Care and examination of lactating mother

2.6

12.6

337

6653B

ICD-9 Finland

Other obstetrical trauma, Laceration of cervix

+∞

12.5

O67.9

ICD-10 Finland

Intrapartum haemorrhage, unspecified

+∞

12.5

O65.5

ICD-10 Finland

Obstructed labour due to abnormality of maternal pelvic organs

+∞

12.5

6531B

ICD-9 Finland

Disproportion, Generally contracted pelvis[PELVIS ANGUSTA,SYNNYTYKSEN AIKANA]

+∞

12.5

Z36.4

ICD-10 Finland

Antenatal screening for fetal growth retardation using ultrasound and other physical methods

2.8

12.4

297

8221

FHL

Sterilization of the laparotomy pathway

2.3

12.4

115

514

W90

ICPC

Uncompl labour/delivery livebirth

1.9

12.4

178

953

O42.9

ICD-10 Finland

Premature rupture of membranes, unspecified

2.1

12.3

137

663

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

1.7

12.2

268

1639

O02.1

ICD-10 Finland

Missed abortion

1.6

12.2

292

1835

O40

ICD-10 Finland

Polyhydramnios

3.2

12.0

202

O80.8

ICD-10 Finland

Other single spontaneous delivery

1.9

12.0

169

900

O26.88

ICD-10 Finland

Other specified pregnancy-related conditions

3.0

11.9

220

O36.8

ICD-10 Finland

Maternal care for other specified fetal problems

2.7

11.7

291

WW500

NOMESCO Finland

Blood transfusion

2.5

11.7

376

MBC00

NOMESCO Finland

Repair of obstetric laceration of cervix uteri

30.1

11.6

O90.2

ICD-10 Finland

Haematoma of obstetric wound

12.6

11.6

MCA00

NOMESCO Finland

Upper uterine segment caesarean section

10.0

11.5

6532B

ICD-9 Finland

Disproportion, Inlet contraction of pelvis[PELVIS ANGUSTA, ANOM APERT SUPER,SYNNYTYKSEN AIKANA]

+∞

11.5

O84.1

ICD-10 Finland

Multiple delivery, all by forceps and vacuum extractor

+∞

11.5

O61.9

ICD-10 Finland

Failed induction of labour, unspecified

+∞

11.5

6533B

ICD-9 Finland

Disproportion, Outlet contraction of pelvis[PELVIS ANGUSTA, ANOM APERT INFER,SYNNYTYKSEN AIKANA]

+∞

11.5

MBA96

NOMESCO Finland

Other removal of retained products of conception after delivery or abortion

2.2

11.2

114

532

WX321

NOMESCO Finland

Acute spinal anesthesia for delivery

1.9

11.0

161

867

OAA11

SPAT

2.5

10.9

359

WX602

NOMESCO Finland

Repeated or continuing anesthesia shots throug a catheter

1.6

10.9

307

2009

O42.0

ICD-10 Finland

Premature rupture of membranes, onset of labour within 24 hours

2.5

10.9

342

Z39.0

ICD-10 Finland

Care and examination immediately after delivery

3.4

10.8

152

O21.9

ICD-10 Finland

Vomiting of pregnancy, unspecified

3.2

10.7

175

O65.3

ICD-10 Finland

Obstructed labour due to pelvic outlet and mid-cavity contraction

+∞

10.4

6608B

ICD-9 Finland

Obstructed labour, Other causes of obstructed labour

5.6

10.1

MCA96

NOMESCO Finland

Other caesarean section

10.0

6700A

ICD-9 Finland

Major puerperal infection

3.3

10.0

146

LGA20

NOMESCO Finland

Sterilisation by constriction of Fallopian tubes

2.7

9.9

237

G03AC03

ATC

levonorgestrel; systemic

1.3

9.9

736

5796

E66.01

ICD-10 Finland

Obesity due to excess calories

1.5

9.8

343

2356

O47.1

ICD-10 Finland

False labour at or after 37 completed weeks of gestation

1.8

9.7

169

970

V220A

ICD-9 Finland

Normal pregnancy, Supervision of normal first pregnancy

2.0

9.7

126

654

O36.9

ICD-10 Finland

Maternal care for fetal problem, unspecified

3.4

9.4

131

SPAT1375

SPAT

Structural ultrasound screening, weeks 18+0-21+6

3.0

9.4

170

O71.1

ICD-10 Finland

Rupture of uterus during labour

+∞

9.4

6525B

ICD-9 Finland

Malposition and malpresentation of foetus, High head at term[KORKEALLE JÄÄNYT TARJOUTUVA SIKIÖN PÄÄ,SYNN AIKANA]

+∞

9.4

O66.8

ICD-10 Finland

Other specified obstructed labour

+∞

9.4

O64.3

ICD-10 Finland

Obstructed labour due to brow presentation

+∞

9.4

6440A

ICD-9 Finland

Early or threatened labour, Threatened premature labour[PARTUS PRAEMATURUS IMMINENS]

2.1

9.4

104

507

6310A

ICD-9 Finland

Other abnormal product of conception[OVUM ABORTIVUM]

2.1

9.3

106

521

MBA00

NOMESCO Finland

Vacuum aspiration from uterus after delivery or abortion

1.9

9.1

130

698

Z35

ICD-10 Finland

Supervision of high-risk pregnancy

3.3

9.1

130

O20.0

ICD-10 Finland

Threatened abortion

1.9

9.1

133

719

Z30.1

ICD-10 Finland

Insertion of (intrauterine) contraceptive device

1.3

9.0

609

4720

6510A

ICD-9 Finland

Multiple gestation, Twin pregnancy[GEMINI, RASKAUDEN AIKANA]

4.7

9.0

Z87.5

ICD-10 Finland

Personal history of complications of pregnancy, childbirth and the puerperium

3.8

9.0

Z32.0

ICD-10 Finland

Pregnancy, not (yet) confirmed

2.0

8.9

109

553

6424A

ICD-9 Finland

Hypertension complicating pregnancy, childbirth and the puerperium, Mild or unspecified pre-eclampsia[PRAE-ECLAMPSIA LEVIS, ENNEN SYNNYTYSTÄ]

2.3

8.9

324

8841

FHL

Uterine emptying and scraping (ad 6 weeks)

6.3

8.8

MWE00

NOMESCO Finland

Reoperation for deep haemorrhage in obstetric surgery

14.0

8.7

Z39

ICD-10 Finland

Postpartum care and examination

3.0

8.7

163

6450A

ICD-9 Finland

Prolonged pregnancy[GRAVIDITAS PROLONGATA ANTE PARTUM]

5.5

8.6

WYA40

NOMESCO Finland

Assessment of oral health and treatment needs for family expecting first child

2.6

8.6

228

8501

FHL

Emptying the uterus with suction

2.2

8.5

395

O26.6

ICD-10 Finland

Liver disorders in pregnancy, childbirth and the puerperium

2.2

8.5

364

112

Kela drug reimbursment

Severe psychotic and other severe mental disorders

0.6

8.4

110

1868

TMW99

NOMESCO Finland

Other minor surgical procedure in obstetrics

3.5

8.4

106

O81.0

ICD-10 Finland

Low forceps delivery

90.2

8.4

6510B

ICD-9 Finland

Multiple gestation, Twin pregnancy[GEMINI, SYNNYTYKSEN AIKANA]

3.6

8.4

101

O70.22

ICD-10 Finland

III degree perineal tear involving one half or more of external anal sphincter thickness torn during childbirth

+∞

8.3

O65.0

ICD-10 Finland

Obstructed labour due to deformed pelvis

+∞

8.3

6642B

ICD-9 Finland

Trauma to perineum and vulva during delivery, Third-degree perineal laceration

+∞

8.3

O66.9

ICD-10 Finland

Obstructed labour, unspecified

+∞

8.3

65300

ICD-8 Finland

Occipital presentation

+∞

8.3

6609C

ICD-9 Finland

Obstructed labour, Unspecified obstructed labour[CERVIX RIGIDA]

10.7

8.3

D25.9

ICD-10 Finland

Leiomyoma of uterus, unspecified

0.7

8.2

258

3640

6748X

ICD-9 Finland

Other and unspecified complications of the puerperium, not elsewhere classified, Other

5.1

8.1

O80.0

ICD-10 Finland

Spontaneous vertex delivery

0.8

8.1

1240

14224

N05AH03

ATC

olanzapine; systemic

0.5

8.0

1467

SPAT1187

SPAT

General ultrasound examination in early pregnancy

3.0

7.8

141

O41.0

ICD-10 Finland

Oligohydramnios

2.1

7.8

401

O32.1

ICD-10 Finland

Maternal care for breech presentation

1.6

7.7

186

1173

LGA00

NOMESCO Finland

Sterilisation by ligature of Fallopian tubes

3.3

7.7

114

G02BA03

ATC

plastic IUD with progestogen

1.3

7.7

862

7144

MBC20

NOMESCO Finland

Repair of obstetric laceration of vulva

6.4

7.7

G03GB02

ATC

clomifene; oral

1.7

7.6

163

997

O46.9

ICD-10 Finland

Antepartum haemorrhage, unspecified

2.1

7.5

406

O24.9

ICD-10 Finland

Diabetes mellitus in pregnancy, unspecified

2.2

7.5

338

J01DA09

ATC

[U] cefadroxil; inhalant, oral

1.2

7.4

1027

8718

J01DA01

ATC

[U] cefalexin; systemic

1.2

7.4

2420

22356

O32.2

ICD-10 Finland

Maternal care for transverse and oblique lie

3.1

7.3

119

SFC01

NOMESCO Finland

Adjuvant procedure of filling therapy

1.2

7.3

919

7717

O64.9

ICD-10 Finland

Obstructed labour due to malposition and malpresentation, unspecified

+∞

7.3

6523B

ICD-9 Finland

Malposition and malpresentation of foetus, Transverse or oblique presentation[SITUS TRANSVERSUS ET OBLIQUUS,SYNNYTYKSEN AIKANA]

+∞

7.3

65400

ICD-8 Finland

Occipital presentation

+∞

7.3

6535A

ICD-9 Finland

Disproportion, Unusually large foetus causing disproportion[EPÄTAVALLISEN ISO SIKIÖ (YLI 4500 G), RASKAUDEN AIK]

+∞

7.3

O64.2

ICD-10 Finland

Obstructed labour due to face presentation

+∞

7.3

6289A

ICD-9 Finland

Infertility, female, Of unspecified origin[STERILITAS ET INFERTILITAS MULIERIS NUD PRIM]

2.3

7.3

271

O02.0

ICD-10 Finland

Blighted ovum and nonhydatidiform mole

1.6

7.2

166

1038

O14.9

ICD-10 Finland

Pre-eclampsia, unspecified

2.5

7.2

203

O20.9

ICD-10 Finland

Haemorrhage in early pregnancy, unspecified

1.8

7.1

113

633

6423A

ICD-9 Finland

Hypertension complicating pregnancy, childbirth and the puerperium, Transient hypertension of pregnancy[HYPERTENSIO GRAVIDARUM, ENNEN SYNNYTYSTÄ]

2.2

7.1

325

O10.0

ICD-10 Finland

Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium

2.0

7.1

409

O33.9

ICD-10 Finland

Maternal care for disproportion, unspecified

4.0

7.1

SPAT1315

SPAT

Periodic health check-up of children and adolescents

1.9

6.9

514

WX810

NOMESCO Finland

Neonatal intesive care

10.9

6.8

J01DB01

ATC

cefalexin; oral

1.2

6.8

3136

29792

6598B

ICD-9 Finland

Other indications for care or intervention related to labour and delivery and not elsewhere classified, Other specified indications for care or intervention related to labour and delivery[INDICATIONES INTERVENTIONUM ALIAE ,SYNNYTYKSEN AIKA]

3.7

6.7

O24.0

ICD-10 Finland

Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent

2.1

6.7

348

6467A

ICD-9 Finland

Other complications of pregnancy, not elsewhere classified, Liver disorders in pregnancy[HEPATOSIS GRAVIDARUM]

2.8

6.6

146

J01FA01

ATC

erythromycin; systemic

1.3

6.5

594

4795

TLC00

NOMESCO Finland

Insertion of intrauterine device

1.3

6.5

406

3107

6424B

ICD-9 Finland

Hypertension complicating pregnancy, childbirth and the puerperium, Mild or unspecified pre-eclampsia[PRAE-ECLAMPSIA LEVIS, SYNNYTYKSEN AIKANA]

3.5

6.4

N05AH02

ATC

clozapine; systemic

0.3

6.4

429

O14.0

ICD-10 Finland

Mild to moderate pre-eclampsia

1.9

6.3

423

6340A

ICD-9 Finland

Spontaneous abortion, Complicated by genital tract and pelvic infection

1.7

6.3

113

658

O99.2

ICD-10 Finland

Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium

2.1

6.3

312

O70.21

ICD-10 Finland

III degree perineal tear involving less than one half of external anal sphincter thickness torn during childbirth

+∞

6.2

6651B

ICD-9 Finland

Other obstetrical trauma, Rupture of uterus during labour

+∞

6.2

O67.8

ICD-10 Finland

Other intrapartum haemorrhage

+∞

6.2

6640B

ICD-9 Finland

Trauma to perineum and vulva during delivery, First-degree perineal laceration

+∞

6.2

O65.2

ICD-10 Finland

Obstructed labour due to pelvic inlet contraction

+∞

6.2

Z30.5

ICD-10 Finland

Surveillance of (intrauterine) contraceptive device

1.4

6.2

351

2645

O03.1

ICD-10 Finland

Spontaneous abortion, Incomplete, complicated by delayed or excessive haemorrhage

2.0

6.2

369

NE1AG

NOMESCO Finland

MRI pelvimetry with high intensity magnet

3.6

6.1

NAME	O15_LABOUR_ABNORM_FORCES
CONTROL_EXCLUDE	O15_COMPLIC_LAB_DELIV
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	O62
HD_ICD_9	661
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	O62
COD_ICD_9	661
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
O15_LABOUR_ABNORM_FORCES	0.477 [0.37, 0.61]	< 0.001
Birth year	0.992 [0.98, 1.0]	0.096

N-year risk	Females	Males
1	0.04%	No data
5	0.248%	No data
10	0.652%	No data
15	1.205%	No data
20	2.177%	No data

Abnormalities of forces of labour

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints