Type 1 diabetes, strict definition, subgroup 2

T1D_STRICT2

diabetic ketoacidosis: The metabolic condition resulted from uncontrolled diabetes mellitus, in which the shift of acid-base status of the body toward the acid side because of loss of base or retention of acids other than carbonic acid is accompanied by the accumulation of ketone bodies in body tissues and fluids.

Endpoint definition

FinnGen phenotype data

414262 individuals

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Apply sex-specific rule None

414262

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Check conditions

not E4_DM2
and not PANCREATITIS
and not INSULIN_INTER_AND_LONG
and KELA_DIAB_INSUL
and INSULIN_SHORTFAST

149

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Check pre-conditions, main-only, mode, registry filters

Pre-conditions EVENT_AGE<40

0 out of 7 registries used, show all original rules.

0

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Check minimum number of events None

0

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Include endpoints

117

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Remove individuals based on genotype QC

97

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T1D_STRICT2

Control definitions

Control exclude DIABETES_FG
Control conditions not E4_DM2
and not PANCREATITIS
and not INSULIN_INTER_AND_LONG
and not KELA_DIAB_INSUL
and not INSULIN_SHORTFAST

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 97 41 56
Unadjusted prevalence (%) 0.03 0.02 0.03
Mean age at first event (years) 15.93 13.36 17.82

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: T1D_STRICT2 – Type 1 diabetes, strict definition, subgroup 2
GWS hits:

Survival analyses between endpoints

Plot

before Type 1 diabetes, strict definition, subgroup 2
after Type 1 diabetes, strict definition, subgroup 2

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Drugs most likely to be purchased after Type 1 diabetes, strict definition, subgroup 2

Not a core endpoint, no data to show.