≡ Risteys
FG R12 + FR

Documentation Changelog GitHub Contact & Feedback
info icon

Type 1 diabetes, wide definition, subgroup 2

DOID EFO Endpoint Browser

T1D_WIDE2

type I diabetes mellitus: A chronic condition characterized by minimal or absent production of insulin by the pancreas.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

  • not PANCREATITIS
  • and not INSULIN_INTER_AND_LONG
  • and KELA_DIAB_INSUL
  • and INSULIN_SHORTFAST
1180

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

724

6. Filter based on genotype QC (FinnGen only)

724

Control definitions (FinnGen only)

Control exclude
DIABETES_FG
Control conditions
not PANCREATITIS
and not INSULIN_INTER_AND_LONG
and not KELA_DIAB_INSUL
and not INSULIN_SHORTFAST

Extra metadata

First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8193 3476 4409
Only index persons 2249 991 1258
Unadjusted period prevalence (%)
Whole population 0.12 0.10 0.12
Only index persons 0.04 0.04 0.05
Median age at first event (years)
Whole population 53.87 58.28 50.15
Only index persons 48.96 53.50 45.38

-FinnGen-

Key figures

All Female Male
Number of individuals 724 322 402
Unadjusted period prevalence (%) 0.15 0.11 0.18
Median age at first event (years) 55.80 56.23 55.46

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
694
Matched controls
6941
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
16384.0
323.0
538
*
2500A
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE,TYYPPI II]
+∞
323.0
301
*
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
6837.3
323.0
623
9
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
233.2
323.0
386
37
A10AA01
ATC
NA
+∞
323.0
362
*
103
Kela drug reimbursment
Diabetes, insulin-treated
+∞
323.0
694
*
A10AA02
ATC
NA
+∞
323.0
480
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2238.0
304.7
273
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
4005.3
303.1
270
*
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
+∞
298.0
264
*
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3771.4
290.7
260
*
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
3124.6
254.3
230
*
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
2964.8
244.7
222
*
215
Kela drug reimbursment
Diabetes, non-insulin-treated
+∞
235.1
212
*
A10BB01
ATC
glibenclamide; oral
1487.3
227.3
209
*
A10BA02
ATC
metformin; oral
83.1
215.3
237
43
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
+∞
196.4
179
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
+∞
180.3
165
*
H04AA01
ATC
glucagon; nasal, parenteral
+∞
151.8
140
*
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
+∞
121.5
113
*
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
+∞
115.9
108
*
A10AA03
ATC
NA
+∞
114.8
107
*
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
+∞
113.7
106
*
A10AD05
ATC
insulin aspart; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
620.6
110.0
106
*
T89
ICPC
Diabetes insulin dependent
613.7
108.9
105
*
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
+∞
96.1
90
*
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
117.6
86.3
92
9
A10AE05
ATC
insulin detemir; parenteral
+∞
84.1
79
*
A98
ICPC
Health maint/preventive medicine
0.2
82.3
210
4718
A10AE04
ATC
insulin glargine; parenteral
409.4
75.3
74
*
A10BX01
ATC
guar gum; systemic
23.1
75.2
110
56
A10BB12
ATC
glimepiride; oral
209.7
73.7
75
*
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
+∞
71.1
67
*
H36.00
ICD-10 Finland
Diabetic background retinopathy
+∞
68.9
65
*
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
+∞
65.7
62
*
E10
ICD-10 Finland
Type 1 diabetes mellitus
+∞
65.7
62
*
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
+∞
63.5
60
*
H3601, E113
ICD-10 Finland
NA
+∞
62.4
59
*
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
+∞
62.4
59
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
+∞
60.3
57
*
H3603, E113
ICD-10 Finland
NA
+∞
60.3
57
*
C09AA02
ATC
enalapril; systemic
4.3
58.8
277
926
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
311.3
57.1
57
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
5.7
56.9
186
420
2507A
ICD-9 Finland
Diabetes mellitus, Diabetes with peripheral circulatory disorders[DIABETES MELLITUS CUM COMPLICAT ALIA ,TYYPPI II]
+∞
53.8
51
*
C02EA02
ATC
NA
8.3
53.5
126
180
H3600, E113
ICD-10 Finland
NA
+∞
52.8
50
*
205
Kela drug reimbursment
Chronic hypertension
3.6
51.0
333
1430
XCK10
NOMESCO Finland
Photography of fundus of eye
6.6
50.2
140
255
E14.9
ICD-10 Finland
Unspecified diabetes mellitus, without complications
268.8
49.7
50
*
H3600, E103
ICD-10 Finland
NA
+∞
49.6
47
*
H36.01
ICD-10 Finland
Diabetic maculopathy
+∞
49.6
47
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
16.0
48.4
80
56
CKC10
NOMESCO Finland
Local photocoagulation of retina
25.0
48.1
68
30
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
+∞
47.4
45
*
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
+∞
47.4
45
*
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
+∞
46.4
44
*
C03CA01
ATC
furosemide; systemic
3.2
46.2
387
1956
H3603, E103
ICD-10 Finland
NA
+∞
44.2
42
*
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
+∞
44.2
42
*
4019X
ICD-9 Finland
Essential hypertension, Unspecified
8.4
44.0
102
140
T90
ICPC
Diabetes non-insulin dependent
10.0
43.4
90
102
201
Kela drug reimbursment
Chronic cardiac insufficiency
5.3
41.4
138
309
2505A
ICD-9 Finland
Diabetes mellitus, Diabetes with ophthalmic manifestations[NEUROPATHIA DIABETICA,TYYPPI II]
+∞
41.0
39
*
2500X
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,NUD]
+∞
41.0
39
*
NGQ20
NOMESCO Finland
Amputation of lower leg
80.2
40.4
45
6
A10BB07
ATC
glipizide; oral
217.4
40.3
41
*
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
+∞
40.0
38
*
NHQ40
NOMESCO Finland
Amputation of toe
18.3
39.7
62
37
A12AA04
ATC
calcium carbonate; oral
19.2
39.1
60
34
2507B
ICD-9 Finland
Diabetes mellitus, Diabetes with peripheral circulatory disorders[DIABETES MELLITUS CUM COMPLICAT ALIA ,TYYPPI I]
+∞
38.9
37
*
CKC15
NOMESCO Finland
Panretinal photocoagulation
45.6
38.6
47
11
E11.6
ICD-10 Finland
Type 2 diabetes mellitus, with other specified complications
+∞
37.8
36
*
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
387.0
37.4
37
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
11.7
37.0
70
66
25002
ICD-8 Finland
Diabetes mellitus, Retinopathia diabetica
+∞
35.7
34
*
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
+∞
35.7
34
*
A11CC03
ATC
alfacalcidol; systemic
11.8
33.2
62
57
J01DA01
ATC
[U] cefalexin; systemic
2.7
32.9
472
3059
N02BE01
ATC
paracetamol; systemic, rectal
0.4
32.7
276
4407
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
75.6
32.2
36
5
C09AA01
ATC
captopril; oral
9.0
31.0
67
81
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
+∞
30.4
29
*
25008
ICD-8 Finland
Diabetes mellitus, Complicatio alia definita
+∞
30.4
29
*
C01DA14
ATC
isosorbide mononitrate; oral
2.9
30.3
241
1089
B03XA01
ATC
erythropoietin; parenteral
18.1
29.7
46
27
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
+∞
29.4
28
*
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
2.6
29.2
293
1513
2501B
ICD-9 Finland
Diabetes mellitus, Diabetes with ketoacidosis[DIABETES MELLITUS CUM KETOACIDOSI ,TYYPPI I]
+∞
28.3
27
*
M01AH05
ATC
etoricoxib; oral
0.3
27.0
79
2045
H43.1
ICD-10 Finland
Vitreous haemorrhage
10.3
26.7
53
55
2504B
ICD-9 Finland
Diabetes mellitus, Diabetes with renal manifestations[DIABETES MELLITUS CUM COMPLICATIONE OCULI ,TYYPPI I]
+∞
26.2
25
*
E11.1
ICD-10 Finland
Type 2 diabetes mellitus, with ketoacidosis
+∞
26.2
25
*
81
HP
Angiography of the heart and coronary arteries
4.1
26.2
110
304
SPAT1262
SPAT
Handing over of treatment supplies
3.9
25.9
117
345
4148X
ICD-9 Finland
Other forms of chronic ischaemic heart disease, Other specified forms of chronic ischaemic heart disease[MORBUS CORDIS ISCHAEMICUS ALIA,MÄÄRITTELEMÄT]
12.9
25.9
46
38
Z13.1
ICD-10 Finland
Special screening examination for diabetes mellitus
46.2
25.7
31
7
I79.2*E11.5
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic peripheral angiopathy
+∞
25.1
24
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
7.9
25.0
58
79
WX110
NOMESCO Finland
Local anesthesy
0.4
24.9
141
2760
A12BA01
ATC
potassium chloride; oral
4.1
24.9
104
286
I50.1
ICD-10 Finland
Left ventricular failure
4.3
24.4
96
249
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
2.5
24.3
239
1191
137
Kela drug reimbursment
Uraemia requiring dialysis
19.9
24.1
36
19
C01AA05
ATC
digoxin; systemic
3.0
23.6
158
623
C10AB02
ATC
bezafibrate; oral
16.0
23.5
38
25
SPAT1053
SPAT
Memory test
0.1
23.4
7
761
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
25.7
23.2
32
13
B01AC07
ATC
dipyridamole; systemic
3.7
23.2
110
337
H3601, E103
ICD-10 Finland
NA
+∞
23.0
22
*
N083, E112
ICD-10 Finland
NA
+∞
23.0
22
*
4402A
ICD-9 Finland
Atherosclerosis, Of native arteries of the extremities
9.3
22.9
48
55
B01AC06
ATC
acetylsalicylic acid; oral (platelet aggregation inhibitors excl. heparin)
4.2
22.6
92
246
40199
ICD-8 Finland
Essential benign hypertension
7.9
22.6
52
70
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.4
22.2
249
1318
J01FF01
ATC
clindamycin; systemic
2.6
22.1
195
906
SAA01
NOMESCO Finland
Simple examination of mouth
0.4
21.5
140
2639
I25.2
ICD-10 Finland
Old myocardial infarction
3.4
21.2
113
378
NHQ30
NOMESCO Finland
Amputation of foot, transmetatarsal
29.1
21.1
28
10
G63.2*E11.4
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic polyneuropathy
+∞
20.9
20
*
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
+∞
20.9
20
*
A10AD04
ATC
insulin lispro; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
+∞
20.9
20
*
I50.0
ICD-10 Finland
Congestive heart failure
3.1
20.6
128
478
C08DB01
ATC
diltiazem; oral
3.5
19.9
99
314
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.7
19.5
158
693
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
16.4
18.9
30
19
4120X
ICD-9 Finland
Old myocardial infarction[STATUS POST INFARCTUM CORDIS,MÄÄRITTELEMÄT]
6.6
18.9
49
79
2506A
ICD-9 Finland
Diabetes mellitus, Diabetes with neurological manifestations[MICROANGIOPATHIA DIABETICA,TYYPPI II]
+∞
18.8
18
*
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
+∞
18.8
18
*
A10AC30
ATC
combinations; parenteral (insulins and analog. for injection, intermediate-acting)
+∞
18.8
18
*
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
71.9
18.8
21
*
SAA02
NOMESCO Finland
Basic examination of mouth
0.4
18.8
119
2299
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
3.7
18.7
87
261
SPAT1256
SPAT
Intramuscular and subcutaneous injection
0.4
18.6
71
1679
SPAT1008
SPAT
Photography of fundus of the eye or interpretation of photograph
39.6
18.6
23
6
42700
ICD-8 Finland
Symptomatic heart disease, Congestive heart failure
16.7
18.5
29
18
V03AE01
ATC
polystyrene sulfonate; oral
11.5
18.4
34
31
B05DA
ATC
Isotonic solutions
18.2
18.4
28
16
P20
ICPC
Memory disturbance
0.1
18.3
8
658
D03BA52
ATC
collagenase, combinations; topical
15.9
18.1
29
19
E11
ICD-10 Finland
Type 2 diabetes mellitus
8.3
18.0
40
51
C02DE04
ATC
NA
4.5
17.9
66
160
TK800
NOMESCO Finland
Hemodialysis
9.7
17.8
36
39
2504A
ICD-9 Finland
Diabetes mellitus, Diabetes with renal manifestations[DIABETES MELLITUS CUM COMPLICATIONE OCULI ,TYP II]
+∞
17.8
17
*
XCK20
NOMESCO Finland
NA
+∞
17.8
17
*
3620B
ICD-9 Finland
Other retinal disorders, Diabetic retinopathy[RETINOPATHIA DIABETICA PROLIFERATIVA]
+∞
17.8
17
*
N083, E102
ICD-10 Finland
NA
+∞
17.8
17
*
2503B
ICD-9 Finland
Diabetes mellitus, Diabetes with other coma[SOKERITAUDIN AIHEUTTAMA MUNUAISSAIRAUS,TYYPPI I]
+∞
17.8
17
*
NFQ20
NOMESCO Finland
Amputation of femur
12.9
17.8
31
25
D01AC02
ATC
miconazole; topical
3.4
16.9
87
282
R73.9
ICD-10 Finland
Hyperglycaemia, unspecified
15.5
16.8
27
18
25009
ICD-8 Finland
Diabetes mellitus, Unspecified
+∞
16.7
16
*
J01MA01
ATC
ofloxacin; systemic
3.0
16.7
102
373
H36.09
ICD-10 Finland
Diabetic retinopathy (E10-E14+ with common fourth character .3)
92.3
16.6
18
*
J01DA09
ATC
[U] cefadroxil; inhalant, oral
2.3
16.6
191
998
A10BH01
ATC
sitagliptin; oral
173.9
16.6
17
*
I70.9
ICD-10 Finland
Generalized and unspecified atherosclerosis
6.3
16.5
44
74
S18
ICPC
Laceration/cut
0.4
16.3
76
1666
Z49.1
ICD-10 Finland
Extracorporeal dialysis
11.1
16.1
30
28
B05DB
ATC
Hypertonic solutions
19.1
16.1
24
13
SPAT1301
SPAT
No procedures
0.4
15.8
56
1382
2505B
ICD-9 Finland
Diabetes mellitus, Diabetes with ophthalmic manifestations[NEUROPATHIA DIABETICA,TYYPPI I]
+∞
15.7
15
*
2506B
ICD-9 Finland
Diabetes mellitus, Diabetes with neurological manifestations[MICROANGIOPATHIA DIABETICA,TYYPPI I]
+∞
15.7
15
*
B06AA55
ATC
streptokinase, combinations; systemic, topical
46.1
15.1
18
*
Z02.4
ICD-10 Finland
Examination for driving licence
0.3
15.0
25
891
4289X
ICD-9 Finland
Heart failure, unspecified
12.8
15.0
26
21
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
0.3
14.9
37
1074
4130X
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),MÄÄRITTELEMÄT]
4.7
14.9
51
115
SPAT1325
SPAT
Vaccination
0.4
14.9
71
1553
SPAT1216
SPAT
Assessment of functional ability
0.2
14.9
17
745
Z01.2
ICD-10 Finland
Dental examination
0.4
14.7
59
1385
M04AA01
ATC
allopurinol; systemic
2.5
14.7
123
541
27799
ICD-8 Finland
Obesity not specified as of endocrine origin
21.6
14.7
21
10
H28.0*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic cataract
+∞
14.6
14
*
4130B
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),AHTAUTUNUT]
5.3
14.5
44
87
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
0.3
14.4
24
853
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
0.4
14.3
54
1303
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
0.4
14.2
95
1836
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
0.2
14.2
11
616
SPAT1263
SPAT
Sampling
0.4
14.1
90
1770
4100X
ICD-9 Finland
Acute myocardial infarction, Of anterolateral wall[INFARCTUS MYOCARDII ACUTUS DEFINITUS,MÄÄRITTELEMÄT]
4.5
13.9
49
114
SPAT1312
SPAT
General health counselling
0.4
13.8
48
1202
GD1AA
NOMESCO Finland
Thorax X-ray examination
0.5
13.7
107
1968
40299
ICD-8 Finland
Hypertensive heart disease
12.4
13.7
24
20
WVC10
NOMESCO Finland
Subcutaneous infusion of drugs
76.6
13.6
15
*
E10.0
ICD-10 Finland
Type 1 diabetes mellitus, With coma
+∞
13.6
13
*
25004
ICD-8 Finland
Diabetes mellitus, Nephropathia diabetica. Polyneuritis diabetica
+∞
13.6
13
*
2503A
ICD-9 Finland
Diabetes mellitus, Diabetes with other coma[SOKERITAUDIN AIHEUTTAMA MUNUAISSAIRAUS,TYYPPI II]
+∞
13.6
13
*
I79.2*E10.5
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic peripheral angiopathy
+∞
13.6
13
*
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
+∞
13.6
13
*
EB1AA
NOMESCO Finland
Tooth X-ray examination
0.5
13.3
97
1828
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
2.8
13.3
89
346
SPAT1153
SPAT
Removal of sutures
0.4
13.2
48
1180
K02.1
ICD-10 Finland
Caries of dentine
0.5
13.1
107
1944
B04AC02
ATC
NA
19.5
13.0
19
10
11
HP
Coronary artery bypass surgery
4.7
12.9
44
99
K85
ICPC
Elevated blood pressure
0.2
12.9
9
538
KMAK
NOMESCO Finland
NA
0.5
12.7
92
1744
N06AA09
ATC
amitriptyline; systemic
2.9
12.7
81
305
A10BK03
ATC
empagliflozin; oral
71.2
12.6
14
*
5315
FHL
Bypass surgery using a mammary artery
6.2
12.5
33
55
SPAT1310
SPAT
Counselling related to known health issue
0.4
12.5
46
1131
25005
ICD-8 Finland
Diabetes mellitus, Neuropathia diabetica. Polyneuritis diabetica
+∞
12.5
12
*
2507X
ICD-9 Finland
Diabetes mellitus, Diabetes with peripheral circulatory disorders[DIABETES MELLITUS CUM COMPLICATIONE ALIA ,NUD]
+∞
12.5
12
*
M14.6*E11.6
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic neuropathic
+∞
12.5
12
*
H360, E113
ICD-10 Finland
NA
+∞
12.5
12
*
J01MA02
ATC
ciprofloxacin; systemic
1.8
12.5
274
1809
SPAT1222
SPAT
Counselling/guidance promoting independent living
0.2
12.5
19
711
E13.9
ICD-10 Finland
Other specified diabetes mellitus, without complications
132.2
12.5
13
*
C02EA01
ATC
NA
6.4
12.4
32
52
I21.9
ICD-10 Finland
Acute myocardial infarction, unspecified
3.8
12.2
52
145
K86
ICPC
Hypertension uncomplicated
0.1
12.2
*
384
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.9
12.2
223
1380
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
0.4
12.2
50
1172
J01DB01
ATC
cefalexin; oral
0.6
12.1
297
3961
H81
ICPC
Excessive ear wax
0.2
12.1
17
667
N18.8
ICD-10 Finland
Other chronic renal failure
5.2
12.0
37
75
N18.0
ICD-10 Finland
End-stage renal disease
7.8
12.0
27
36
S82
ICPC
Naevus/mole
0.1
12.0
*
354
A12AA12
ATC
[U] calcium acetate anhydrous; systemic
47.5
11.9
14
*
SFA10
NOMESCO Finland
Fillning on one surface of tooth
0.5
11.9
99
1798
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
0.4
11.8
42
1045
A28
ICPC
Limited function/disability NOS
0.3
11.8
28
839
Z49.0
ICD-10 Finland
Preparatory care for dialysis
16.7
11.7
18
11
C03DA01
ATC
spironolactone; oral
2.4
11.7
103
466
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
3.4
11.6
56
173
I50.9
ICD-10 Finland
Heart failure, unspecified
2.0
11.6
168
947
C09BA02
ATC
enalapril and diuretics; systemic
3.0
11.6
70
253
M79.6
ICD-10 Finland
Pain in limb
0.4
11.5
61
1301
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
0.5
11.5
99
1782
N08.3
ICD-10 Finland
Glomerular disorders in diabetes mellitus
+∞
11.5
11
*
E11.01
ICD-10 Finland
Non-insulin dependent diabetes diabetic coma with hyperglycaemia
+∞
11.5
11
*
6480A
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Diabetes mellitus
+∞
11.5
11
*
E14.8
ICD-10 Finland
Unspecified diabetes mellitus, with unspecified complications
121.9
11.5
12
*
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
0.2
11.4
15
611
0093A
ICD-9 Finland
Ill-defined intestinal infections, Diarrhoea of presumed infectious origin
12.1
11.4
20
17
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
4.1
11.4
44
113
H13
ICPC
Plugged feeling ear
0.3
11.4
21
711
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
0.2
11.3
11
538
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
0.1
11.3
*
335
B01AB05
ATC
enoxaparin; parenteral
0.4
11.3
54
1194
280
Kela drug reimbursment
Clopidogrel
5.5
11.2
32
60
M54.5
ICD-10 Finland
Low back pain
0.4
11.1
48
1105
J01DA06
ATC
[U] cefuroxime; systemic
2.3
11.1
104
485
C09AA03
ATC
lisinopril; oral
3.6
11.1
49
142
R23.8
ICD-10 Finland
Other and unspecified skin changes
0.2
11.0
11
528
CKC12
NOMESCO Finland
Photocoagulation of retina
5.4
11.0
32
61
I21.99
ICD-10 Finland
Myocardial infarction (acute) UNS unspecified coronary artery status
3.6
11.0
49
143
N02AX02
ATC
tramadol; systemic, rectal
1.8
10.9
265
1789
C08CA02
ATC
felodipine; oral
2.5
10.9
90
393
4120B
ICD-9 Finland
Old myocardial infarction[STATUS POST INFARCTUM CORDIS,AHTAUTUNUT]
5.5
10.8
31
58
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
2.5
10.8
90
396
XFP96
NOMESCO Finland
Other intraoperative electrophysiological investigation in arhythmia or disturbance of impulse propagation
4.5
10.8
37
85
Z49.2
ICD-10 Finland
Other dialysis
13.2
10.7
18
14
G04AC01
ATC
NA
3.8
10.7
44
120
C03BA08
ATC
metolazone; oral
60.9
10.6
12
*
C07AB02
ATC
metoprolol; systemic
1.9
10.6
193
1185
5314
FHL
Bypass surgery for four or more vessels
6.7
10.6
26
40
C10AB04
ATC
gemfibrozil; oral
10.3
10.6
20
20
SPAT1249
SPAT
Treatment-related counselling outside office
0.5
10.6
78
1480
Z96.4
ICD-10 Finland
Presence of endocrine implants
+∞
10.4
10
*
2500C
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,MODY]
+∞
10.4
10
*
A10BX02
ATC
repaglinide; oral
+∞
10.4
10
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.8
10.4
66
248
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
16.3
10.4
16
10
0088X
ICD-9 Finland
Intestinal infections due to other organisms, Other organism, not elsewhere classified
16.3
10.4
16
10
L15
ICPC
Knee symptom/complaint
0.3
10.3
18
633
TBW99
NOMESCO Finland
Other minor procedure in endocrine surgery
23.8
10.3
14
6
JAB30
NOMESCO Finland
Repair of inguinal hernia using prosthetic material
0.2
10.3
9
467
M01AX05
ATC
glucosamine; oral
0.4
10.1
33
857
G04AB05
ATC
NA
4.1
10.1
38
96
G04AA01
ATC
NA
5.7
10.1
28
51
AA1AD
NOMESCO Finland
CT of head and brain
0.4
10.0
50
1091
B01AF02
ATC
apixaban; oral
0.1
10.0
6
398
L03
ICPC
Low back symptom/complaint
0.3
9.9
26
744
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
2.6
9.8
73
302
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
0.1
9.8
6
392
C02CA01
ATC
prazosin; oral
5.5
9.8
28
53
L28
ICPC
Limited function/disability (L)
0.3
9.7
25
723
C07AG02
ATC
carvedilol; oral
2.9
9.7
60
221
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
4.7
9.7
32
71
5253
FHL
Cardiac lung machine
7.0
9.7
23
34
N02AC04
ATC
dextropropoxyphene; oral
3.0
9.6
55
193
I25.5
ICD-10 Finland
Ischaemic cardiomyopathy
4.7
9.5
31
68
B03XA02
ATC
darbepoetin alfa; parenteral
5.5
9.4
27
51
V03AE02
ATC
sevelamer; oral
30.5
9.4
12
*
G63.2
ICD-10 Finland
Diabetic polyneuropathy
+∞
9.4
9
*
N0830, E112
ICD-10 Finland
NA
+∞
9.4
9
*
H3602, E113
ICD-10 Finland
NA
+∞
9.4
9
*
H28.0*E10.3
ICD-10 Finland
Other specified diabetes mellitus - Diabetic cataract
+∞
9.4
9
*
2508A
ICD-9 Finland
Diabetes mellitus, Diabetes with other specified manifestations[DIABETES MELLITUS CUM COMPLICAT NON DESCR,TYP II]
+∞
9.4
9
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
5.0
9.4
29
60
C07AB08
ATC
celiprolol; oral
3.8
9.4
39
108
7804A
ICD-9 Finland
General symptoms, Dizziness and giddiness
4.9
9.3
29
61
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
0.5
9.3
90
1578
N17
ICPC
Vertigo/dizziness
0.2
9.2
7
398
J01XX05
ATC
methenamine; oral
5.3
9.2
27
53
R05
ICPC
Cough
0.3
9.2
25
702
K78
ICPC
Atrial fibrillation/flutter
0.2
9.1
6
374
B04AC04
ATC
NA
9.2
9.1
18
20
2780A
ICD-9 Finland
Obesity and other hyperalimentation, Obesity
15.8
9.1
14
9
D03AX01
ATC
cadexomer iodine; topical
37.2
9.0
11
*
I20.00
ICD-10 Finland
Unstable angina
3.3
9.0
44
139
315
Kela drug reimbursment
Clopidogrel
6.2
9.0
23
38
B04AB02
ATC
NA
3.9
8.9
36
97
D06AX01
ATC
fusidic acid; topical (antibiotics for topical use)
2.5
8.9
72
308
I21.40
ICD-10 Finland
Acute subendocardial infarction no detected stenosis of the coronary artery
3.7
8.9
38
108
I20.09
ICD-10 Finland
Unstable angina
2.7
8.9
60
235
4111X
ICD-9 Finland
Other acute and subacute forms of ischaemic heart disease, Intermediate coronary syndrome[PITKITTYNYT ANGINA PECTORIS -KOHTAUS,MÄÄRITTELEMÄT]
6.1
8.8
23
39
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
3.6
8.8
38
109
M01AB05
ATC
diclofenac; systemic, rectal
0.6
8.7
208
2881
D03BA02
ATC
collagenase; topical
9.1
8.6
17
19
Z94.0
ICD-10 Finland
Kidney transplant status
9.1
8.6
17
19
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
0.5
8.6
75
1359
L17
ICPC
Foot/toe symptom/complaint
0.4
8.5
33
801
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
27.9
8.5
11
*
D19
ICPC
Teeth/gum symptom/complaint
0.4
8.5
27
712
SPAT1100
SPAT
Long-term monitoring of blood pressure
0.1
8.5
*
313
9571
FHL
Amputation of toe or toes
91.1
8.4
9
*
Z76.0
ICD-10 Finland
Issue of repeat prescription
0.2
8.4
10
432
A10AB06
ATC
insulin glulisine; parenteral
+∞
8.3
8
*
N0830, E102
ICD-10 Finland
NA
+∞
8.3
8
*
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
+∞
8.3
8
*
M14.6*E10.6
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic neuropathic
+∞
8.3
8
*
2508B
ICD-9 Finland
Diabetes mellitus, Diabetes with other specified manifestations[DIABETES MELLITUS CUM COMPLICAT NON DESCR,TYP I]
+∞
8.3
8
*
O24.1
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, non-insulin-dependent
+∞
8.3
8
*
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
8.7
8.3
17
20
N03AF01
ATC
carbamazepine; oral, rectal
3.0
8.3
48
170
3661A
ICD-9 Finland
Cataract, Senile cataract
3.5
8.3
37
109
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
0.1
8.3
*
309
J01CF02
ATC
cloxacillin; systemic
4.3
8.3
29
69
M01AE01
ATC
ibuprofen; systemic, rectal
0.6
8.3
346
4255
C02DE02
ATC
NA
4.2
8.3
30
74
N02AJ06
ATC
codeine and paracetamol; systemic
0.5
8.2
62
1178
A03FA02
ATC
cisapride; oral, rectal
2.4
8.2
70
310
D82
ICPC
Teeth/gum disease
0.5
8.2
51
1032
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
11.9
8.1
14
12
ZPB22
NOMESCO Finland
Autograft of vein
11.9
8.1
14
12
NHS99
NOMESCO Finland
Other operation for infection of tendon, joint or bone of ankle or foot
33.8
8.1
10
*
E87.5
ICD-10 Finland
Hyperkalaemia
5.1
8.1
24
48
J01XE01
ATC
nitrofurantoin; oral
4.1
8.0
30
76
PBL09
NOMESCO Finland
Construction of arteriovenous fistula from brachial artery
22.3
8.0
11
5
EBA00
NOMESCO Finland
Extraction of tooth
0.5
8.0
55
1080
I20.99
ICD-10 Finland
Angina pectoris, unspecified
2.3
7.9
72
331
41399
ICD-8 Finland
Angina pectoris, Without mention of hypertensive disease
4.8
7.9
25
54
SPAT1260
SPAT
Consultation of another employee
0.3
7.9
21
596
S21
ICPC
Skin texture symptom/complaint
0.2
7.9
9
400
4029A
ICD-9 Finland
Hypertensive heart disease, Unspecified[DECOMPENSATIO CORDIS NON INDICATA (WHO II)]
7.1
7.8
18
26
127
Kela drug reimbursment
Transplant complication
7.1
7.8
18
26
N06DX01
ATC
memantine; oral
0.3
7.8
13
468
M17.1
ICD-10 Finland
Other primary gonarthrosis
0.4
7.8
34
785
L57.0
ICD-10 Finland
Actinic keratosis
0.3
7.8
14
485
C02AC05
ATC
moxonidine; oral
3.7
7.8
32
89
A01
ICPC
Pain general/multiple sites
0.1
7.7
*
248
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
3.5
7.7
35
105
I20.89
ICD-10 Finland
Other angina pectoris unspecified coronary artery status
2.9
7.7
46
168
J81
ICD-10 Finland
Pulmonary oedema
8.2
7.6
16
20
C03AA03
ATC
hydrochlorothiazide; oral
2.2
7.6
81
400
4110X
ICD-9 Finland
Other acute and subacute forms of ischaemic heart disease, Postmyocardial infarction syndrome[EPÄSTABIILI ANGINA PECTORIS,MÄÄRITTELEMÄT]
10.2
7.6
14
14
A02BC02
ATC
pantoprazole; systemic
0.6
7.5
224
2991
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
0.5
7.5
72
1273
4340A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral thrombosis
4.7
7.4
24
53
QXA20
NOMESCO Finland
Skin abrasion, unspecified location
80.9
7.4
8
*
CK2S4
SPAT
NA
80.9
7.4
8
*
M25.5
ICD-10 Finland
Pain in joint
0.4
7.4
40
853
SAA03
NOMESCO Finland
Extended examination of mouth
0.5
7.4
69
1230
Z71.8
ICD-10 Finland
Other specified counselling
0.4
7.3
36
798
SPAT1254
SPAT
Administration of medicine
0.4
7.3
29
701
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
11.0
7.3
13
12
E10.01
ICD-10 Finland
Insulin-dependent diabetes diabetic coma with hyperglycemia
+∞
7.3
7
*
A10BD07
ATC
metformin and sitagliptin; systemic
+∞
7.3
7
*
3620A
ICD-9 Finland
Other retinal disorders, Diabetic retinopathy[RETINOPATHIA DIABETICA NON PROLIFERATIVA]
+∞
7.3
7
*
25007
ICD-8 Finland
Diabetes mellitus, Coma diabeticum
+∞
7.3
7
*
2510B
ICD-9 Finland
Other disorders of pancreatic internal secretion, Hypoglycaemic coma[COMA HYPOGLYCAEMICUM]
+∞
7.3
7
*
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
+∞
7.3
7
*
R05FB02
ATC
cough suppressants and expectorants
1.6
7.3
240
1721
WX320
NOMESCO Finland
Spinalanesthesy
0.4
7.3
40
851
A29
ICPC
General symptom/complaint other
0.3
7.3
12
433
B01AF01
ATC
rivaroxaban; oral
0.2
7.2
9
381
N05CD07
ATC
temazepam; oral
1.8
7.2
125
745
Z01.1
ICD-10 Finland
Examination of ears and hearing
0.4
7.2
23
604
S29
ICPC
Skin symptom/complaint other
0.3
7.2
20
559
3643
FHL
Vitrectomy through pars Plana
30.3
7.2
9
*
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
0.3
7.2
20
561
I21.49
ICD-10 Finland
Acute subendocardial infarction unspecified coronary artery status
2.4
7.2
61
270
SPAT1304
SPAT
Counselling and guidance related to ageing
0.1
7.1
*
278
41300
ICD-8 Finland
Angina pectoris, Cum hypertonia
12.2
7.1
12
10
M01AC06
ATC
meloxicam; systemic, rectal
0.5
7.1
84
1402
R21
ICPC
Throat symptom/complaint
0.4
7.1
22
586
5313
FHL
Bypass surgery for three vessels
10.2
7.1
13
13
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.0
7.0
40
140
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
5.9
6.9
18
31
61
HP
Catheterization and pressure measurement of the left side of the heart
4.0
6.9
26
67
L04AA01
ATC
[U] ciclosporin; systemic
7.6
6.9
15
20
L13
ICPC
Hip symptom/complaint
0.3
6.9
16
488
I20.01
ICD-10 Finland
Unstable angina
3.4
6.8
31
94
M86.9
ICD-10 Finland
Osteomyelitis, unspecified
9.4
6.8
13
14
4140X
ICD-9 Finland
Other forms of chronic ischaemic heart disease, Coronary atherosclerosis[ATHEROSCLEROSIS ARTER CORON CORDIS,MÄÄRITTELEMÄT]
6.2
6.8
17
28
G04BX05
ATC
NA
6.2
6.8
17
28
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
0.3
6.8
13
435
4120C
ICD-9 Finland
Old myocardial infarction[STATUS POST INFARCTUM CORDIS,TROMBI]
40.4
6.8
8
*
QDG00
NOMESCO Finland
Debridement of bedsore of lower limb
40.4
6.8
8
*
I21.3
ICD-10 Finland
Acute transmural myocardial infarction of unspecified site
16.9
6.8
10
6
PFH59
NOMESCO Finland
Bypass from femoral or popliteal artery to distal anterior tibial artery
16.9
6.8
10
6
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
0.5
6.7
82
1360
104
Kela drug reimbursment
Thyroid insufficiency
2.4
6.7
56
247
C08CA05
ATC
nifedipine; systemic
2.3
6.7
61
281
G04BD12
ATC
mirabegron; oral
0.2
6.6
7
326
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
0.3
6.6
17
491
I20.90
ICD-10 Finland
Angina pectoris, unspecified
2.6
6.6
44
173
0092A
ICD-9 Finland
Ill-defined intestinal infections, Infectious diarrhoea
8.8
6.6
13
15
CKD40
NOMESCO Finland
Endophotocoagulation of retina
8.8
6.6
13
15
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
0.4
6.5
31
694
SPAT1149
SPAT
Suture or treatment of traumatic wound
0.3
6.5
15
456
EBA05
NOMESCO Finland
Complicated extraction of tooth
0.3
6.5
18
504
R01AD12
ATC
fluticasone furoate; nasal
0.5
6.5
41
831
3792A
ICD-9 Finland
Other disorders of eye, Disorders of vitreous body
70.4
6.4
7
*
R74
ICPC
Upper respiratory infection acute
0.4
6.4
36
759
WX290
NOMESCO Finland
Other blockade of nerve
0.5
6.3
74
1240
N06DA02
ATC
donepezil; oral
0.3
6.3
10
366
V03AE03
ATC
lanthanum carbonate; oral
18.2
6.3
9
5
E11.09
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - With coma
+∞
6.3
6
*
Z45.1
ICD-10 Finland
Adjustment and management of infusion pump
+∞
6.3
6
*
A10AE06
ATC
insulin degludec; parenteral
+∞
6.3
6
*
N0832, E102
ICD-10 Finland
NA
+∞
6.3
6
*
NHQ48
NOMESCO Finland
Revision of amputation of toe
+∞
6.3
6
*
A10BJ06
ATC
semaglutide; parenteral
+∞
6.3
6
*
2506X
ICD-9 Finland
Diabetes mellitus, Diabetes with neurological manifestations[MICROANGIOPATHIA DIABETICA,NUD]
+∞
6.3
6
*
N08.30
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
+∞
6.3
6
*
A10BH05
ATC
linagliptin; oral
+∞
6.3
6
*
H360, E103
ICD-10 Finland
NA
+∞
6.3
6
*
E16.0
ICD-10 Finland
Drug-induced hypoglycaemia without coma
+∞
6.3
6
*
R02
ICPC
Shortness of breath/dyspnoea
0.3
6.2
12
398
B01AC04
ATC
clopidogrel; oral
1.8
6.2
113
682
4140B
ICD-9 Finland
Other forms of chronic ischaemic heart disease, Coronary atherosclerosis[ATHEROSCLEROSIS ARTER CORON CORDIS,AHTAUTUNUT]
4.7
6.1
19
41
SPAT1097
SPAT
Recording of ECG
0.4
6.1
21
537
I22.99
ICD-10 Finland
Recurrent infarction with unspecified location unspecified coronary artery status
12.7
6.1
10
8
C10AA02
ATC
lovastatin; oral
2.4
6.1
49
212
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
0.4
6.1
29
649
L82
ICD-10 Finland
Seborrhoeic keratosis
0.4
6.1
19
503
SDA01
NOMESCO Finland
Simple parodonthologic therapy
0.4
6.1
35
733
FNA01
NOMESCO Finland
Anastomosis to coronary artery from internal mammary artery, one distal anastamosis
2.6
6.1
43
174
R06AX27
ATC
desloratadine; oral
0.5
6.1
40
800
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
0.5
6.1
67
1145
H02
ICPC
Hearing complaint
0.3
6.1
16
456
PEH57
NOMESCO Finland
Bypass from femoral artery to popliteal artery below knee
5.3
6.0
17
33

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
214
5014
0.19
100.91
32.2
21.9
7.2
6.8
e9/l
1.36
204
4831
214
5012
0.19
100.74
32.1
21.8
4.4
4.4
e12/l
0.03
204
4830
214
5010
0.19
100.56
32.3
21.8
260.0
239.7
e9/l
3.65
206
4842
184
4605
0.19
88.01
24.9
15.3
24.3
27.1
mg/l
0.68
145
3683
195
4686
0.20
87.08
13.6
9.3
24.4
24.7
u/l
0.12
186
4465
133
4110
0.17
85.71
4.9
3.8
8.3
5.6
mmol/l
14.58
114
3633
202
4677
0.21
82.16
21.7
14.0
—
—
—
0
0
209
4651
0.23
76.23
28.3
17.8
138.4
139.6
mmol/l
7.76
204
4487
211
4660
0.23
75.68
28.6
17.9
4.1
4.0
mmol/l
3.10
205
4494
167
4054
0.24
63.25
24.3
16.8
36.7
39.0
%
1.76
118
2795
202
4117
0.29
49.33
6.3
4.2
2.3
2.7
mmol/l
12.93
191
3667
144
3498
0.27
47.55
9.9
6.5
98.3
83.8
u/l
1.35
135
3219
130
3326
0.26
46.58
5.8
3.8
15.8
12.9
mm/h
1.10
124
3006
197
3998
0.30
46.00
5.8
3.8
4.2
4.6
mmol/l
8.28
187
3588
193
3918
0.31
44.16
6.0
4.1
2.1
2.0
mu/l
0.23
179
3482
198
3958
0.31
43.76
5.8
3.7
1.5
1.5
mmol/l
0.66
187
3531
32
16
20.88
41.79
2.8
2.9
44.1
57.3
ug/min
—
15
7
132
3209
0.28
40.95
5.8
4.4
—
—
—
0
0
190
3813
0.32
40.92
5.0
3.4
1.1
1.2
mmol/l
1.07
178
3378
174
657
3.17
35.07
5.0
1.9
356.0
373.1
mg/l
0.02
131
374
25
11
23.50
34.23
1.2
1.0
36.0
—
iu/ml
—
7
0
134
3015
0.32
32.97
4.7
3.9
—
—
—
0
0
205
3760
0.37
32.87
12.7
3.8
55.9
37.0
mmol/mol
49.09
192
3367
174
699
2.96
31.13
6.0
2.3
19.2
39.5
mg/mmol
0.32
128
394
163
3186
0.37
28.05
4.7
3.4
15.0
14.9
pmol/l
0.30
153
2819
46
1742
0.21
26.66
2.7
5.3
3.2
3.9
ug/l
0.26
38
1528
117
2610
0.34
26.05
11.4
8.5
4.4
4.2
e9/l
0.46
100
2255
98
2343
0.33
24.76
6.9
5.7
11.7
13.6
umol/l
0.78
89
2192
172
766
2.63
24.73
4.9
2.4
7.2
7.5
mmol/l
0.43
158
645
50
1690
0.24
23.51
2.5
2.2
—
—
—
0
0
71
1966
0.29
23.51
5.5
3.8
85.6
48.0
ng/l
0.45
58
1404
69
1893
0.30
22.15
2.2
2.0
96.9
93.3
pmol/l
0.17
36
983
93
2065
0.37
18.67
4.9
4.0
—
—
—
0
0
89
2015
0.36
18.64
15.5
10.2
1.3
1.3
inr
0.31
30
533
119
2369
0.40
18.54
15.7
6.5
1.2
1.2
mmol/l
0.54
103
1975
115
2291
0.41
17.72
9.2
6.1
0.2
0.2
e9/l
0.24
97
1988
109
2219
0.40
17.68
4.7
4.0
0.0
0.0
estimate
0.00
22
437
113
2251
0.41
17.30
8.9
5.8
1.8
1.8
e9/l
0.19
95
1966
108
2191
0.40
17.27
6.0
5.2
0.0
0.0
estimate
0.00
28
421
101
2107
0.39
17.25
9.6
5.9
55.6
57.7
%
0.78
95
1970
105
2152
0.40
17.18
9.7
6.1
26.6
26.9
%
0.09
99
1994
154
2713
0.45
17.17
9.8
4.6
9.5
6.2
mmol/l
21.08
144
2539
101
2098
0.40
17.02
8.7
4.3
33.1
34.7
g/l
1.90
96
1906
84
1891
0.37
17.02
5.3
2.7
171.7
142.6
ug/l
0.53
79
1712
110
2201
0.41
16.92
4.7
3.9
0.0
0.0
estimate
0.00
25
429
110
2198
0.41
16.85
8.9
5.8
0.6
0.6
e9/l
0.39
95
1884
111
2197
0.42
16.53
13.3
6.0
1.2
1.2
mmol/l
0.07
103
1947
78
1796
0.37
16.50
5.4
3.8
62.8
156.1
e6/l
1.29
56
1329
114
2213
0.42
16.05
8.7
5.8
0.0
0.0
e9/l
0.87
96
1905
21
999
0.19
16.01
2.0
3.2
0.7
0.9
ug/l
0.52
15
679
63
1573
0.34
15.70
4.3
3.5
—
—
—
0
0
107
2109
0.42
15.52
9.3
6.2
8.4
8.9
%
1.01
101
1970
107
2100
0.42
15.30
9.1
5.9
3.3
2.9
%
0.76
101
1949
103
2041
0.42
15.02
9.5
6.0
0.7
0.6
%
1.09
97
1904
35
1157
0.27
14.77
1.6
1.6
22.8
19.6
nmol/l
0.54
28
971
35
1121
0.28
13.87
2.3
1.8
1467.7
1154.5
nmol/l
0.75
30
823
100
1947
0.44
13.64
15.4
9.9
0.0
0.0
e9/l
0.93
78
1563
37
1117
0.30
13.08
1.2
1.4
—
—
—
0
0
74
1600
0.40
12.97
4.9
3.4
32.6
117.5
e6/l
1.30
56
1249
67
1493
0.39
12.54
2.9
2.5
—
—
—
0
0
66
1448
0.40
11.80
5.1
3.3
0.5
0.5
e6/l
0.04
47
1113
64
1407
0.40
11.45
4.8
3.3
—
—
—
0
0
59
1326
0.40
11.07
2.2
2.1
3.1
3.0
mg/l
0.17
52
1088
74
1515
0.43
11.05
8.4
6.0
—
—
—
0
0
35
994
0.32
10.82
5.9
4.0
141.3
319.1
ng/l
1.18
30
835
60
1322
0.40
10.69
4.0
3.9
—
—
—
0
0
74
1471
0.45
10.10
6.7
4.2
—
—
—
0
0
51
1164
0.40
9.78
8.1
6.5
—
—
—
0
0
37
974
0.35
9.72
1.7
1.6
386.3
14810571.4
pmol/l
0.80
29
790
72
1409
0.46
9.32
11.9
3.5
7.4
7.4
ph
0.75
17
255
26
793
0.30
9.12
22.5
28.1
1.9
1.5
inr
—
5
97
55
1177
0.42
8.95
5.2
3.6
—
—
—
0
0
61
1226
0.45
8.38
4.4
2.4
—
—
—
0
0
48
1049
0.42
8.16
4.8
2.8
441.0
564.7
mosm/kgh2o
5.34
43
883
65
1253
0.47
7.91
5.3
4.3
0.0
0.0
estimate
0.69
26
412
42
942
0.41
7.57
1.5
2.1
1.7
1.3
mg/l
0.26
35
721
53
1078
0.45
7.44
3.5
2.8
6316.4
7211.7
umol/l
0.05
48
920
52
1052
0.46
7.17
3.9
4.0
—
—
—
0
0
51
1031
0.46
7.01
4.3
4.3
1.0
1.0
kg/l
0.33
12
149
16
490
0.31
5.61
3.8
3.1
832.3
308.9
ng/l
1.35
16
450
23
560
0.39
4.99
1.3
1.3
—
—
—
0
0
13
414
0.30
4.93
1.2
1.3
—
—
—
0
0
17
455
0.36
4.56
6.4
4.2
—
—
—
0
0
28
604
0.44
4.53
1.6
1.3
17.5
26.7
iu/ml
1.30
12
184
0
111
0.00
4.41
0.0
1.2
—
—
—
0
0
8
9
8.97
4.29
3.7
1.1
—
—
—
0
0
50
868
0.54
4.24
8.8
4.3
—
—
—
0
0
29
587
0.47
3.96
1.7
1.3
26.8
10.6
u/ml
0.48
12
221
13
360
0.35
3.78
1.8
1.6
—
—
—
0
0
15
378
0.38
3.56
1.5
1.4
—
—
—
0
0
11
305
0.35
3.24
1.2
1.3
—
—
—
0
0
12
318
0.37
3.21
1.2
2.1
17.1
12.9
nmol/l
—
7
275
9
244
0.36
3.10
2.1
2.6
—
—
—
0
0
7
208
0.33
2.97
1.9
2.7
—
—
—
0
0
47
750
0.60
2.92
2.6
2.5
29.8
30.0
s
0.11
47
726
31
553
0.54
2.90
11.2
6.2
0.5
1.4
mmol/l
0.37
21
424
29
522
0.54
2.81
1.3
1.2
—
—
—
0
0
5
163
0.30
2.58
1.0
1.2
—
—
—
0
0
5
7
7.18
2.55
5.6
2.4
—
—
—
0
0
29
500
0.56
2.44
1.8
1.3
813.3
475.5
titre
—
9
107
0
63
0.00
2.43
0.0
2.4
—
—
—
0
0
6
177
0.33
2.42
2.3
2.8
25.0
59.5
u/ml
—
6
171
17
342
0.48
2.35
1.2
1.5
—
—
—
0
0
24
428
0.55
2.28
3.9
3.8
—
—
—
0
0
24
423
0.55
2.20
7.1
2.9
67.8
63.8
e9/l
0.28
19
327
28
472
0.58
2.19
1.6
1.4
—
—
—
0
0
5
150
0.33
2.17
1.0
1.2
—
—
—
0
0
0
56
0.00
2.07
0.0
1.5
—
—
—
0
0
13
270
0.47
2.00
1.5
1.4
—
—
—
0
0
8
187
0.42
1.95
1.4
1.2
—
—
—
0
0
0
54
0.00
1.86
0.0
1.3
—
—
—
0
0
0
54
0.00
1.86
0.0
1.3
—
—
—
0
0
42
613
0.67
1.81
2.3
1.8
—
—
—
0
0
7
166
0.42
1.81
5.4
3.6
—
—
—
0
0
11
233
0.46
1.80
1.3
1.3
—
—
—
0
0
5
138
0.36
1.76
1.2
1.2
—
2.0
—
0
14
24
391
0.60
1.69
7.0
4.3
—
—
—
0
0
15
278
0.53
1.68
14.9
9.0
93.6
93.7
%
0.03
15
278
14
265
0.52
1.67
3.2
2.6
0.2
0.3
e6/l
0.16
14
256
17
301
0.55
1.64
3.3
3.4
—
—
—
0
0
12
237
0.50
1.63
4.4
3.6
—
—
—
0
0
15
275
0.54
1.62
1.5
1.7
—
—
—
0
0
5
14
3.59
1.62
1.6
1.6
—
—
—
0
0
20
335
0.59
1.58
5.5
3.7
—
—
—
0
0
7
26
2.71
1.58
1.1
1.3
—
—
—
0
0
0
43
0.00
1.52
0.0
1.3
—
—
—
0
0
5
125
0.40
1.51
1.0
1.9
—
—
—
0
0
0
39
0.00
1.34
0.0
2.4
—
—
—
0
0
7
147
0.47
1.33
1.0
1.1
—
—
—
0
0
0
41
0.00
1.31
0.0
2.6
—
—
—
0
0
6
135
0.44
1.28
2.0
1.6
—
—
—
0
0
9
171
0.52
1.19
2.4
2.1
164.6
689.1
ug/l
—
9
157
5
20
2.51
1.15
1.8
2.8
1351.0
761.4
u/ml
—
5
20
0
36
0.00
1.14
0.0
3.1
—
—
—
0
0
13
221
0.58
1.14
1.3
1.3
—
49.6
—
0
14
22
329
0.66
1.13
1.5
2.4
—
—
—
0
0
20
304
0.65
1.11
10.2
4.3
0.0
0.0
%
—
6
87
12
207
0.57
1.11
1.7
1.9
0.6
2.9
ug/l
0.88
12
168
49
635
0.76
1.11
2.8
1.8
—
—
—
0
0
64
796
0.79
1.07
1.8
1.4
2.2
2.4
g/l
0.29
30
456
7
34
2.07
1.03
1.3
1.3
—
—
—
0
0
14
226
0.61
1.02
16.4
9.3
—
—
—
0
0
14
84
1.68
0.98
1.8
1.5
—
—
—
0
0
0
29
0.00
0.98
0.0
2.2
—
—
—
0
0
0
29
0.00
0.98
0.0
1.2
—
—
—
0
0
0
30
0.00
0.97
0.0
1.8
—
—
—
0
0
7
36
1.95
0.97
2.6
2.6
—
—
—
0
0
16
101
1.60
0.94
6.5
4.4
—
—
—
0
0
7
127
0.55
0.89
4.1
4.4
—
—
—
0
0
11
180
0.61
0.87
2.1
2.0
—
—
—
0
0
9
150
0.59
0.79
4.6
11.8
—
—
—
0
0
0
25
0.00
0.79
0.0
1.0
—
237.9
—
0
12
0
26
0.00
0.78
0.0
1.3
—
1.4
—
0
21
12
74
1.63
0.78
7.1
3.1
—
—
—
0
0
10
160
0.62
0.74
2.7
4.3
22.1
21.3
s
—
10
154
23
311
0.73
0.74
9.0
4.1
0.5
0.6
%
—
6
82
7
39
1.80
0.72
1.9
1.6
—
—
—
0
0
13
193
0.67
0.70
3.8
4.3
—
—
—
0
0
24
319
0.74
0.70
8.8
4.2
0.1
0.1
%
—
8
97
18
248
0.72
0.66
1.9
1.8
1.2
1.6
g/l
0.72
18
223
6
102
0.58
0.62
1.5
1.5
295.2
317.9
mu/l
—
6
93
40
487
0.81
0.61
2.5
1.6
—
—
—
0
0
20
266
0.74
0.60
8.8
5.4
121.7
124.6
g/l
0.17
20
261
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
27
343
0.78
0.59
7.9
4.1
1.2
0.9
%
0.32
11
110
0
22
0.00
0.59
0.0
1.0
—
165.4
—
0
22
10
149
0.67
0.57
5.2
3.5
4.1
3.9
mmol/l
—
10
141
16
216
0.73
0.54
8.1
5.1
0.6
0.7
%
0.66
16
210
9
61
1.48
0.54
1.7
1.3
—
—
—
0
0
6
39
1.54
0.53
1.5
1.1
—
—
—
0
0
6
98
0.61
0.52
8.7
5.0
14.2
11.3
mmol/l
—
6
87
6
98
0.61
0.52
8.7
5.0
102.7
104.9
mmol/l
—
6
87
9
134
0.67
0.52
7.8
4.8
2.0
1.4
mmol/l
—
9
118
46
539
0.84
0.50
2.6
1.6
—
—
—
0
0
11
77
1.44
0.45
4.5
3.8
65.9
60.9
%
0.52
11
77
22
275
0.79
0.45
4.6
5.8
—
—
—
0
0
34
404
0.83
0.44
2.6
1.5
—
—
—
0
0
14
104
1.35
0.43
7.1
7.8
—
—
—
0
0
8
56
1.43
0.42
2.0
1.3
—
—
—
0
0
6
94
0.64
0.42
3.5
1.6
11.3
11.3
mg/l
—
6
87
0
15
0.00
0.41
0.0
2.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
3.7
—
35.5
—
0
12
0
17
0.00
0.40
0.0
1.3
—
10.3
—
0
8
0
19
0.00
0.39
0.0
1.4
—
0.9
—
0
19
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
13
170
0.76
0.38
6.9
4.1
1.5
1.6
%
0.12
13
157
5
36
1.39
0.38
10.4
18.6
10.6
10.8
%
—
5
36
20
246
0.81
0.37
1.7
1.4
—
—
—
0
0
8
115
0.69
0.37
5.1
3.8
28.1
31.8
mg/l
—
8
80
5
37
1.35
0.37
1.0
2.2
—
—
—
0
0
31
360
0.85
0.33
5.9
5.7
7.4
7.4
ph
—
5
34
13
166
0.78
0.33
6.9
4.2
0.9
1.0
%
0.35
13
153
93
863
1.09
0.30
2.3
1.2
5.7
1.4
u/ml
0.80
26
211
12
93
1.30
0.30
1.3
1.4
233.9
273.4
miu/ml
—
5
43
8
110
0.72
0.29
6.6
2.3
130.1
128.6
g/l
—
8
84
10
76
1.32
0.28
4.7
3.3
4.3
4.5
e9/l
—
10
76
20
235
0.85
0.26
5.4
6.4
24.4
24.9
mmol/l
0.37
20
220
9
72
1.25
0.25
1.6
1.4
29.5
28.9
g/l
—
9
64
0
11
0.00
0.21
0.0
2.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
3.0
—
0
11
0
11
0.00
0.21
0.0
1.1
—
1.6
—
0
6
0
10
0.00
0.21
0.0
7.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
0
10
0.00
0.21
0.0
4.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
160.3
—
0
10
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
129.0
—
0
14
0
14
0.00
0.20
0.0
1.1
—
37.1
—
0
9
6
78
0.77
0.15
4.7
2.3
1.6
1.6
mmol/l
—
6
78
7
90
0.78
0.14
2.1
1.2
—
91.3
—
0
8
8
100
0.80
0.13
8.3
3.4
—
—
—
0
0
87
906
0.95
0.13
2.2
1.6
1.0
1.2
mmol/l
3.95
80
767
10
117
0.85
0.13
2.7
1.2
—
—
—
0
0
6
55
1.09
0.09
1.3
1.3
—
—
—
0
0
5
60
0.83
0.08
7.8
2.1
35.0
32.4
pg
—
5
60
7
64
1.09
0.08
1.4
1.2
—
—
—
0
0
7
65
1.08
0.08
1.9
1.6
—
—
—
0
0
8
76
1.05
0.07
4.1
3.5
38970.5
482.7
u/ml
—
8
71
9
86
1.05
0.07
9.0
8.7
73.7
62.0
%
—
9
86
8
94
0.85
0.06
1.5
3.0
—
—
—
0
0
34
325
1.05
0.06
1.3
1.1
—
—
—
0
0
41
414
0.99
0.00
12.0
8.3
—
—
—
0
0
13
129
1.01
0.00
1.5
1.5
—
—
—
0
0
47
471
1.00
0.00
8.8
5.6
0.8
1.8
mmol/l
0.90
39
372
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
4.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
9.3
—
0.7
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
74.0
—
0
5
0
6
0.00
0.00
0.0
2.7
—
85.5
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
1208.2
—
0
6
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
162.5
—
0
6
5
56
0.89
0.00
1.6
2.2
—
—
—
0
0
6
68
0.88
0.00
1.0
1.1
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint T1D_WIDE2 and mortality.

Females

Parameter HR [95% CI] p-value
T1D_WIDE2 6.681 [5.35, 8.35] < 0.001
Birth year 0.996 [0.99, 1.0] 0.368

During the follow-up period (1.1.1998 — 31.12.2019), 331 out of 651 females with T1D_WIDE2 died.

Males

Parameter HR [95% CI] p-value
T1D_WIDE2 7.376 [6.0, 9.07] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 592 out of 1001 males with T1D_WIDE2 died.

Mortality risk

Mortality risk for people of age

years, who have T1D_WIDE2.

N-year risk Females Males
1 0.619% 1.217%
5 4.152% 8.264%
10 9.596% 19.66%
15 17.983% 34.211%
20 28.735% 51.143%

Relationships between endpoints

↥

Index endpoint: T1D_WIDE2 – Type 1 diabetes, wide definition, subgroup 2

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data