diabetic ketoacidosis: The metabolic condition resulted from uncontrolled diabetes mellitus, in which the shift of acid-base status of the body toward the acid side because of loss of base or retention of acids other than carbonic acid is accompanied by the accumulation of ketone bodies in body tissues and fluids.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
149 |
3. Check pre-conditions, main-only, mode, registry filtersPre-conditions: EVENT_AGE<40 Registry filters: 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
109 |
6. Filter based on genotype QC (FinnGen only) |
109 |
Control definitions (FinnGen only)
- Control exclude
- DIABETES_FG
- Control conditions
- not E4_DM2
and not PANCREATITIS
and not INSULIN_INTER_AND_LONG
and not KELA_DIAB_INSUL
and not INSULIN_SHORTFAST
Extra metadata
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Type 1 diabetes, strict definition, subgroup 2
based on the number of shared cases.
Similar with more cases:
- Type 1 diabetes, wide definition, subgroup 2
- Type 1 diabetes, strict definition
- Type 1 diabetes, strict (exclude DM2)
- Type 1 diabetes, definitions combined
- Type 1 diabetes, wide definition
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1340 | 519 | 810 |
| Only index persons | 483 | 167 | 316 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 13.08 | 10.37 | 14.53 |
| Only index persons | 15.15 | 14.82 | 15.32 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 109 | 51 | 58 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | 12.38 | 11.71 | 12.97 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 115
- Matched controls
- 1149
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
103
Kela drug reimbursment
Diabetes, insulin-treated
+∞
166.0
115
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
+∞
139.9
104
*
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2170.1
114.2
92
*
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
+∞
104.8
84
*
215
Kela drug reimbursment
Diabetes, non-insulin-treated
+∞
100.1
81
*
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
+∞
86.8
72
*
A10AA01
ATC
NA
+∞
83.9
70
*
A10AA02
ATC
NA
+∞
81.1
68
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
1649.4
80.7
69
*
H04AA01
ATC
glucagon; nasal, parenteral
+∞
79.7
67
*
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
+∞
68.8
59
*
A10AE05
ATC
insulin detemir; parenteral
+∞
49.6
44
*
T89
ICPC
Diabetes insulin dependent
+∞
48.4
43
*
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
+∞
41.1
37
*
E10
ICD-10 Finland
Type 1 diabetes mellitus
+∞
34.1
31
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
+∞
32.9
30
*
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
+∞
29.4
27
*
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
+∞
29.4
27
*
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
+∞
26.0
24
*
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
+∞
24.9
23
*
SPAT1262
SPAT
Handing over of treatment supplies
18.9
23.6
37
28
A98
ICPC
Health maint/preventive medicine
0.1
20.2
76
1103
XCK10
NOMESCO Finland
Photography of fundus of eye
23.6
16.4
23
12
H3600, E103
ICD-10 Finland
NA
+∞
14.9
14
*
A10AA03
ATC
NA
+∞
14.9
14
*
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
170.8
14.8
15
*
H36.00
ICD-10 Finland
Diabetic background retinopathy
+∞
13.8
13
*
A10AE04
ATC
insulin glargine; parenteral
145.2
12.7
13
*
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
+∞
11.7
11
*
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
+∞
10.6
10
*
2501B
ICD-9 Finland
Diabetes mellitus, Diabetes with ketoacidosis[DIABETES MELLITUS CUM KETOACIDOSI ,TYYPPI I]
+∞
10.6
10
*
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
+∞
10.6
10
*
Z13.1
ICD-10 Finland
Special screening examination for diabetes mellitus
33.1
9.6
12
*
SPAT1008
SPAT
Photography of fundus of the eye or interpretation of photograph
54.2
8.8
10
*
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
+∞
8.4
8
*
TBW99
NOMESCO Finland
Other minor procedure in endocrine surgery
18.9
8.3
12
7
E14.9
ICD-10 Finland
Unspecified diabetes mellitus, without complications
+∞
7.4
7
*
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
+∞
7.4
7
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
+∞
7.4
7
*
C02EA02
ATC
NA
42.6
6.8
8
*
C09AA02
ATC
enalapril; systemic
5.9
6.3
17
33
Z97.8
ICD-10 Finland
Presence of other specified devices
+∞
6.3
6
*
2504B
ICD-9 Finland
Diabetes mellitus, Diabetes with renal manifestations[DIABETES MELLITUS CUM COMPLICATIONE OCULI ,TYYPPI I]
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3012516) Albumin [Mass/volume] in Urine
60
58
21.79
60.07
4.0
1.9
mg/l
47.9
86.5
0.25
47
33
(3020682) Albumin/Creatinine [Ratio] in Urine
60
66
19.00
55.09
4.3
2.3
mg/mmol
16.9
282.3
0.46
44
40
(3010813) Leukocytes [#/volume] in Blood
72
1030
0.11
23.69
14.1
16.2
e9/l
6.8
6.7
0.19
67
1008
(3026361) Erythrocytes [#/volume] in Blood
72
1029
0.12
23.33
14.1
16.1
e12/l
4.7
4.7
0.21
67
1005
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
53
910
0.19
17.11
8.4
11.2
mg/l
13.5
21.2
2.43
35
646
(3009542) Hematocrit [Volume Fraction] of Blood
60
922
0.22
13.22
13.0
14.0
%
38.5
40.8
1.26
54
824
(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
24
615
0.22
10.87
5.1
3.5
u/l
27.8
36.6
1.02
24
596
(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting
14
6
26.46
10.54
2.1
1.0
nmol/l
0.1
0.8
—
14
6
(40761511) CBC panel - Blood by Automated count
65
929
0.26
10.49
7.3
8.5
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
51
817
0.29
9.14
4.1
3.9
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
5
275
0.14
7.34
3.8
1.8
—
—
—
0
0
(3020564) Creatinine [Moles/volume] in Serum or Plasma
69
911
0.34
6.45
9.8
11.2
umol/l
71.2
69.2
0.12
69
911
(3013707) Erythrocyte sedimentation rate by Westergren method
33
609
0.34
6.26
5.3
3.8
mm/h
10.2
7.1
1.21
33
583
(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma
14
383
0.27
5.39
10.4
8.3
umol/l
11.7
14.5
0.76
14
367
(3031040) Bacteria [#/volume] in Urine by Automated count
24
480
0.36
4.84
4.6
3.8
—
36.4
—
0
7
(46235355) HIV 1 and 2 tests - Meaningful Use set
8
262
0.25
4.72
2.0
2.1
—
—
—
0
0
(3013650) Neutrophils [#/volume] in Blood by Automated count
30
536
0.39
4.61
8.5
12.1
e9/l
4.0
3.7
0.22
23
458
(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum
46
256
2.38
4.53
3.0
1.3
u/ml
7.5
1.2
—
10
59
(3037467) Urinalysis macro (dipstick) panel - Urine
32
551
0.41
4.42
4.3
4.0
—
—
—
0
0
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
0
107
0.00
4.28
0.0
1.6
—
—
—
0
0
(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma
7
226
0.26
3.95
2.0
2.2
u/l
36.1
56.2
—
7
214
(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum
17
61
3.12
3.90
1.1
1.1
—
—
—
0
0
(3018010) Neutrophils/100 leukocytes in Blood
26
469
0.41
3.80
7.9
8.9
%
48.5
52.7
0.86
26
454
(3002030) Lymphocytes/100 leukocytes in Blood
27
477
0.42
3.71
8.2
9.0
%
33.3
32.7
0.09
27
462
(3003694) ABO and Rh group [Type] in Blood
11
292
0.31
3.68
1.4
1.5
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
7
218
0.27
3.59
2.0
1.6
—
—
—
0
0
(3019198) Lymphocytes [#/volume] in Blood
29
492
0.44
3.53
7.7
8.9
e9/l
2.3
2.2
0.13
21
433
(3000764) Benzodiazepines [Presence] in Urine
0
86
0.00
3.50
0.0
1.9
—
—
—
0
0
(3019069) Monocytes/100 leukocytes in Blood
27
466
0.44
3.39
8.1
9.2
%
9.2
8.5
0.57
27
451
(3006504) Eosinophils/100 leukocytes in Blood
27
462
0.45
3.28
8.1
9.1
%
4.6
3.1
1.22
27
443
(3027008) Opiates [Presence] in Urine
0
85
0.00
3.27
0.0
1.9
—
—
—
0
0
(3028300) Cannabinoids [Presence] in Urine
0
85
0.00
3.27
0.0
1.9
—
—
—
0
0
(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
13
302
0.35
3.26
6.8
4.5
u/l
41.5
32.2
0.36
13
294
(3001604) Monocytes [#/volume] in Blood
29
482
0.46
3.24
7.7
8.9
e9/l
0.6
0.6
0.33
21
413
(3041096) Erythrocytes [Presence] in Urine by Automated
8
217
0.32
3.14
6.4
2.7
—
—
—
0
0
(3013115) Eosinophils [#/volume] in Blood
31
498
0.47
3.10
7.5
9.9
e9/l
0.3
0.2
0.93
23
434
(1761868) Lipid panel - Serum or Plasma
14
307
0.38
3.06
3.5
2.0
—
—
—
0
0
(3022096) Basophils/100 leukocytes in Blood
27
454
0.46
3.05
8.1
9.1
%
0.8
0.7
0.80
27
436
(3006315) Basophils [#/volume] in Blood
30
482
0.48
2.95
7.4
8.9
e9/l
0.0
0.0
0.83
22
413
(3026493) Urate [Moles/volume] in Serum or Plasma
5
165
0.27
2.87
3.6
4.0
umol/l
271.6
2569.7
—
5
158
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
20
369
0.44
2.85
3.3
3.9
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
13
285
0.38
2.80
4.5
3.2
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
71
0.00
2.70
0.0
1.4
—
—
—
0
0
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
52
687
0.54
2.62
7.2
8.0
ml/min/173m2
91.6
95.3
0.46
40
547
(3004716) Salmonella sp identified in Stool by Organism specific culture
0
66
0.00
2.51
0.0
1.2
—
—
—
0
0
(3017732) Neutrophils [#/volume] in Blood
0
67
0.00
2.49
0.0
2.4
—
4.1
—
0
61
(3044889) 12 lead EKG panel
30
462
0.52
2.44
3.4
2.7
—
—
—
0
0
(3018095) Leukocytes [#/volume] in Urine
16
306
0.44
2.42
6.0
4.5
e6/l
4.4
83.9
—
10
220
(3015736) pH of Urine
16
300
0.45
2.28
2.2
3.2
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
21
110
2.13
2.25
1.2
1.2
—
—
—
0
0
(3009261) Glucose [Presence] in Urine by Test strip
24
389
0.51
2.24
3.9
3.4
estimate
0.0
0.0
—
5
75
(40760892) CBC W Ordered Manual Differential panel - Blood
8
186
0.39
2.21
8.4
5.0
—
—
—
0
0
(3021601) Nitrite [Presence] in Urine by Test strip
24
385
0.52
2.14
4.8
4.8
estimate
0.0
0.0
—
6
73
(3001019) Free T4 and TSH panel - Serum or Plasma
0
55
0.00
2.14
0.0
1.8
—
—
—
0
0
(3011288) Drugs identified in Urine by Screen method
0
57
0.00
2.13
0.0
2.0
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
15
281
0.46
2.10
5.0
3.9
—
—
—
0
0
(21494755) Public health laboratory ask at order entry panel
6
159
0.34
2.10
1.2
1.3
—
—
—
0
0
(3035350) Ketones [Presence] in Urine by Test strip
24
383
0.52
2.10
3.7
3.4
estimate
0.0
0.0
—
5
70
(1002224) Polysomnography panel
0
54
0.00
1.91
0.0
1.0
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
14
259
0.47
1.87
2.0
2.7
—
—
—
0
0
(3028707) Methadone [Presence] in Urine by Screen method
0
46
0.00
1.75
0.0
1.6
—
—
—
0
0
(3013139) Helicobacter pylori Ag [Presence] in Stool
0
48
0.00
1.75
0.0
1.1
—
—
—
0
0
(3024561) Albumin [Mass/volume] in Serum or Plasma
16
276
0.51
1.73
5.6
7.4
g/l
35.8
37.5
0.77
16
265
(3021589) Normoblasts [#/volume] in Blood
33
458
0.60
1.64
8.8
11.0
e9/l
0.0
0.0
0.00
23
355
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
12
223
0.48
1.60
1.9
2.1
ng/l
9.6
28.0
—
7
103
(3002582) Erythrocytes [#/volume] in Urine
16
270
0.52
1.60
4.8
3.7
e6/l
7.8
51.2
—
10
213
(42870588) Differential panel, method unspecified - Blood
22
337
0.57
1.58
9.2
10.3
—
—
—
0
0
(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method
0
43
0.00
1.56
0.0
1.7
—
3.4
—
0
30
(3022217) INR in Platelet poor plasma by Coagulation assay
0
44
0.00
1.55
0.0
17.9
—
1.4
—
0
7
(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma
0
44
0.00
1.55
0.0
1.5
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
11
207
0.48
1.52
1.8
1.8
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
11
207
0.48
1.52
2.1
2.7
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
8
161
0.46
1.51
3.5
5.1
—
—
—
0
0
(3030467) Casts [#/volume] in Urine by Automated count
14
242
0.52
1.50
5.4
3.7
e6/l
0.3
0.3
—
8
183
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
19
299
0.56
1.49
2.0
1.8
—
—
—
0
0
(40758558) Short blood count panel - Blood
17
275
0.55
1.47
1.9
8.9
—
—
—
0
0
(3019832) Treponema pallidum Ab [Presence] in Serum
7
147
0.44
1.45
1.4
1.8
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
14
239
0.52
1.44
5.3
3.6
—
—
—
0
0
(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight
0
38
0.00
1.37
0.0
1.3
—
—
—
0
0
(3006418) Campylobacter sp identified in Tissue by Organism specific culture
0
38
0.00
1.37
0.0
1.2
—
—
—
0
0
(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age
0
38
0.00
1.37
0.0
1.3
—
—
—
0
0
(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma
0
38
0.00
1.37
0.0
1.3
—
—
—
0
0
(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma
0
38
0.00
1.37
0.0
1.3
—
—
—
0
0
(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma
0
39
0.00
1.37
0.0
1.9
—
—
—
0
0
(3014765) Yersinia sp identified in Stool by Organism specific culture
0
39
0.00
1.37
0.0
1.2
—
—
—
0
0
(42529406) Shigella sp [Presence] in Stool by Culture
0
41
0.00
1.34
0.0
1.1
—
—
—
0
0
(3047352) Trisomy 18 risk [Likelihood] in Fetus
0
34
0.00
1.18
0.0
1.3
—
—
—
0
0
(3005033) Fetal Nuchal fold Thickness US
0
34
0.00
1.18
0.0
1.3
—
—
—
0
0
(40761535) Cells panel - Urine sediment
0
35
0.00
1.17
0.0
3.8
—
—
—
0
0
(3043238) Trisomy 21 risk [Likelihood] in Fetus
0
36
0.00
1.16
0.0
1.4
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
9
159
0.53
1.09
2.0
1.6
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
10
171
0.54
1.02
5.3
2.3
—
—
—
0
0
(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation
0
30
0.00
0.99
0.0
1.6
—
287.6
—
0
30
(3016543) Leukocytes [#/volume] in Cerebral spinal fluid
0
31
0.00
0.98
0.0
4.0
—
3.2
—
0
21
(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid
0
31
0.00
0.98
0.0
4.1
—
301.3
—
0
23
(3045414) Leukocytes [Presence] in Urine
6
32
1.92
0.83
1.2
1.7
—
—
—
0
0
(3022313) Gas panel - Capillary blood
14
90
1.64
0.83
3.6
9.3
—
—
—
0
0
(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay
0
24
0.00
0.80
0.0
1.5
—
8.2
—
0
10
(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma
0
24
0.00
0.80
0.0
1.4
—
—
—
0
0
(3019230) Fractional oxyhemoglobin in Venous blood
5
23
2.23
0.77
12.4
28.6
%
65.8
68.6
—
5
23
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
6
109
0.52
0.77
1.8
1.5
—
—
—
0
0
(3029937) Albumin [Presence] in Urine by Test strip
12
178
0.63
0.72
4.9
3.9
estimate
0.0
0.0
—
5
72
(3007164) IgA [Mass/volume] in Serum or Plasma
32
254
1.37
0.71
1.9
1.6
g/l
1.5
1.9
0.91
14
149
(3021879) Hepatitis B virus core Ab [Presence] in Serum
5
92
0.52
0.70
2.0
1.6
—
—
—
0
0
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
5
27
1.89
0.69
1.0
2.5
—
—
—
0
0
(3018677) aPTT in Platelet poor plasma by Coagulation assay
8
127
0.60
0.69
5.4
5.7
s
29.0
30.6
—
8
127
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
13
187
0.65
0.68
1.6
1.7
pmol/l
104.1
97.2
—
8
104
(3017044) Thyrotropin receptor Ab [Units/volume] in Serum
0
20
0.00
0.61
0.0
1.8
—
4.8
—
0
6
(3008757) Leukocyte morphology finding [Identifier] in Blood
0
20
0.00
0.61
0.0
5.0
—
—
—
0
0
(3039443) Prostate specific Ag panel - Serum or Plasma
0
22
0.00
0.60
0.0
1.2
—
—
—
0
0
(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum
0
23
0.00
0.59
0.0
1.1
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
14
190
0.70
0.55
2.2
3.6
—
—
—
0
0
(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma
27
328
0.76
0.53
13.2
11.7
mmol/l
1.2
1.2
0.41
27
312
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
15
110
1.42
0.52
11.2
17.8
mmol/l
21.0
25.1
1.73
15
110
(3028167) CD3+CD4+ (T4 helper) cells [#/volume] in Blood
0
15
0.00
0.41
0.0
2.5
—
588.2
—
0
6
(1761482) Bacteria [#/volume] in Urine by Culture
0
15
0.00
0.41
0.0
2.3
—
—
—
0
0
(3036071) Salmonella sp Ab [Titer] in Serum
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
(4268621)
0
16
0.00
0.41
0.0
2.8
—
—
—
0
0
(3023150) Myeloperoxidase Ab [Units/volume] in Serum
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
(3019897) Erythrocyte distribution width [Ratio] by Automated count
0
17
0.00
0.41
0.0
1.4
—
13.2
—
0
17
(3013512) EKG study
11
147
0.72
0.40
1.9
2.5
—
—
—
0
0
(4198724)
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection
0
18
0.00
0.40
0.0
1.9
—
—
—
0
0
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
(4306422)
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection
0
19
0.00
0.39
0.0
3.3
—
—
—
0
0
(3023410) Appearance of Cerebral spinal fluid
0
19
0.00
0.39
0.0
5.9
—
—
—
0
0
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
5
76
0.64
0.37
1.0
1.0
—
—
—
0
0
(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction
5
78
0.62
0.37
3.4
5.4
u/l
213.0
256.5
—
5
78
(3000991) Gas panel - Venous blood
13
105
1.27
0.26
12.8
12.0
—
—
—
0
0
(3022948) Iron [Moles/volume] in Serum or Plasma
8
101
0.78
0.22
6.0
3.0
umol/l
14.8
15.4
—
8
101
(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
(3008037) Lactate [Moles/volume] in Venous blood
0
11
0.00
0.21
0.0
5.3
—
0.9
—
0
11
(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma
0
11
0.00
0.21
0.0
9.3
—
16.9
—
0
11
(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
(3000093) Morphology [Interpretation] in Blood Narrative
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
(3042111) Morphology [Interpretation] in Bone marrow Narrative
0
10
0.00
0.21
0.0
4.0
—
—
—
0
0
(3051611) Lipemic interference index of Serum or Plasma
0
10
0.00
0.21
0.0
2.9
—
—
—
0
0
(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
(3045142) Bone marrow Pathology biopsy report
0
12
0.00
0.21
0.0
2.7
—
—
—
0
0
(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
9
112
0.79
0.21
1.2
2.1
—
—
—
0
0
(3016701) Glucose [Moles/volume] in Serum or Plasma --2 hours post dose glucose
0
13
0.00
0.21
0.0
1.5
—
6.7
—
0
7
(3016018) Differential panel - Cerebral spinal fluid
0
13
0.00
0.21
0.0
6.6
—
—
—
0
0
(40768793) Breast Pathology biopsy report
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
(3025130) Human papilloma virus identified in Specimen
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
(3018405) Lactate [Moles/volume] in Arterial blood
0
14
0.00
0.20
0.0
4.8
—
1.3
—
0
14
(3003458) Phosphate [Moles/volume] in Serum or Plasma
15
129
1.19
0.18
9.9
11.5
mmol/l
1.3
1.3
0.00
15
123
(40768797) Stomach Pathology biopsy report
9
82
1.11
0.15
1.0
1.2
—
—
—
0
0
(3013826) Glucose [Moles/volume] in Serum or Plasma
46
437
1.09
0.13
8.3
7.3
mmol/l
9.3
5.8
5.66
46
405
(3004119) Hemoglobin [Mass/volume] in Venous blood
5
45
1.12
0.10
12.8
19.3
g/l
130.0
130.8
—
5
45
(3007853) Bacteria identified in Skin by Aerobe culture
10
106
0.94
0.01
1.3
1.7
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
5
51
0.98
0.00
2.0
2.8
—
—
—
0
0
(3021788) Differential panel - Synovial fluid
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3005011) Chlamydia sp Ab [Titer] in Serum
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(36304052) Adalimumab Ab [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
0.3
—
0
5
(3026179) Normetanephrine [Moles/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
2.3
—
0.5
—
0
7
(3011363) Streptococcus pneumoniae Ag [Presence] in Urine
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3028433) Virus identified in Specimen by Culture
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3012565) Volume of 24 hour Urine
0
5
0.00
0.00
0.0
1.4
—
1529.0
—
0
5
(3022670) pH of Venous cord blood
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(3001964) Herpes simplex virus Ag [Presence] in Specimen
0
6
0.00
0.00
0.0
4.0
—
—
—
0
0
(4027681)
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3016724) Homocysteine [Moles/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
1.7
—
9.0
—
0
9
(40761995) Spermatozoa Progressive [#/volume] in Semen
0
9
0.00
0.00
0.0
2.3
—
—
—
0
0
(3016845) Adenovirus Ag [Presence] in Specimen by Immunofluorescence
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
1.6
—
55.5
—
0
8
(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection
0
9
0.00
0.00
0.0
2.3
—
—
—
0
0
(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum
0
6
0.00
0.00
0.0
5.3
—
162.3
—
0
6
(3024474) Albumin [Mass/volume] in Cerebral spinal fluid
0
7
0.00
0.00
0.0
1.0
—
182.0
—
0
7
(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0
(3016031) Almond IgE Ab [Units/volume] in Serum
0
8
0.00
0.00
0.0
1.3
—
4.1
—
0
8
(3012447) Hantavirus puumala IgG Ab [Titer] in Serum
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(3009550) Parvovirus B19 IgG Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3005082) Progesterone [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.0
—
31.2
—
0
5
(21491868) Cryoglobulin [Mass/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3002222) Hepatitis E virus IgM Ab [Presence] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3006571) Polymorphonuclear cells/100 leukocytes in Synovial fluid
0
5
0.00
0.00
0.0
1.2
—
61.8
—
0
5
(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay
5
56
0.89
0.00
5.4
1.5
—
—
—
0
0
(3009871) Measles virus Ab [Titer] in Serum
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
(3022411) Androstenedione [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
4.0
—
5.0
—
0
5
(3035320) C reactive protein [Mass/volume] in Body fluid
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3003101) Alpha 1 antitrypsin [Mass/mass] in Stool
0
5
0.00
0.00
0.0
1.8
—
76.6
—
0
5
(3032352) Blasts [#/volume] in Cerebral spinal fluid
0
8
0.00
0.00
0.0
6.8
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
0.00
0.0
1.0
—
124.8
—
0
6
(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay
0
5
0.00
0.00
0.0
3.0
—
18.5
—
0
5
(3023530) 17-Hydroxyprogesterone [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
3.2
—
2.5
—
0
6
(3036035) von Willebrand factor (vWf) Ag actual/normal in Platelet poor plasma by Immunoassay
0
7
0.00
0.00
0.0
2.6
—
119.0
—
0
7
(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3045683) HLA typing for celiac disease panel - Blood or Tissue
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(21494434) Karyotype in Bone marrow
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(3016914) Bacteria identified in Cerebral spinal fluid by Culture
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(43055514) Macroprolactin [Presence] in Serum or Plasma
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3014043) Spermatozoa Nonprogressive/100 spermatozoa in Semen
0
9
0.00
0.00
0.0
4.7
—
—
—
0
0
(3019420) Tryptase [Mass/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
1.9
—
7.4
—
0
8
(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(40761847) Hazelnut recombinant (rCor a) 8 IgE Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
0.0
—
0
5
(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
8
0.00
0.00
0.0
2.4
—
96.9
—
0
8
(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
1.1
—
179.8
—
0
8
(3000081) cloZAPine [Moles/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
26.2
—
1310.0
—
0
8
(3005570) Glucose [Moles/volume] in Urine
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3026820) Hemoglobin [Mass/volume] in Venous cord blood
0
6
0.00
0.00
0.0
1.0
—
162.5
—
0
6
(3018921) Toxoplasma gondii IgA Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3028772) Osteocalcin [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
(3010503) CD19 cells [#/volume] in Blood
0
8
0.00
0.00
0.0
2.6
—
0.2
—
0
8
(3033306) Mononuclear cells/100 leukocytes in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3023419) Bacteria identified in Sputum by Culture
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(42869547) Procollagen type III.N-terminal propeptide [Mass/volume] in Serum
0
5
0.00
0.00
0.0
1.2
—
7.1
—
0
5
(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3009340) Metanephrine [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
(3037756) Immunofixation for Serum or Plasma
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
(3034426) Prothrombin time (PT)
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
(3017115) Methotrexate [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
19.7
—
0.7
—
0
6
(40760109) Toxoplasma gondii IgG Ab avidity [Ratio] in Serum by Immunoassay
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3008832) Norclozapine [Moles/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
18.6
—
851.6
—
0
8
(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.0
—
2.2
—
0
5
(3023659) Complement C1 esterase inhibitor.functional/Complement C1 esterase inhibitor.total in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
118.8
—
0
5
(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
(3053028) Streptococcus sp identified in Specimen by Organism specific culture
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
4.3
—
—
—
0
0
(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
10.0
—
0.7
—
0
6
(3032567) Hepatitis B virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
(3010838) Calcium [Moles/time] in 24 hour Urine
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum
0
9
0.00
0.00
0.0
1.0
—
1146.4
—
0
9
(3013336) Amino acids [Identifier] in Serum or Plasma
0
7
0.00
0.00
0.0
4.1
—
—
—
0
0
(3042299) inFLIXimab [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
9.2
—
9.9
—
0
5
(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection
0
8
0.00
0.00
0.0
2.1
—
—
—
0
0
(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(3051651) Icteric interference index of Serum or Plasma
0
8
0.00
0.00
0.0
2.9
—
—
—
0
0
(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.4
—
6.8
—
0
7
(3005322) IgE [Units/volume] in Serum or Plasma
8
86
0.92
0.00
1.6
1.2
u/ml
68.8
142.4
—
8
79
(3014702) Chromogranin A [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
5.0
—
1.5
—
0
6
(3038515) Glucose [Moles/volume] in Venous blood
0
9
0.00
0.00
0.0
6.0
—
5.4
—
0
9
(42869858) Acute and chronic leukemia fusion transcript panel - Blood or Tissue by Molecular genetics method
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(40768795) Lymph node Pathology biopsy report
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3006922) Hepatitis E virus Ab [Presence] in Serum
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3036603) Volume of Urine
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
(3042733) HLA Ab [Presence] in Serum
0
6
0.00
0.00
0.0
2.5
—
—
—
0
0
(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3044941) Cell count panel - Synovial fluid
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
(3050238) Crystals [Presence] in Synovial fluid by Light microscopy
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
1.4
—
1.0
—
0
9
(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
1.7
—
13.8
—
0
9
(3002621) Streptococcal DNAse B [Units/volume] in Serum
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3008536) Aspergillus sp Ab [Presence] in Serum
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(40768800) Prostate Pathology biopsy report
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(4281824)
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(40768446) Kidney Pathology biopsy report
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint T1D_STRICT2 and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have T1D_STRICT2.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: T1D_STRICT2 – Type 1 diabetes, strict definition, subgroup 2
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data