diabetic ketoacidosis: The metabolic condition resulted from uncontrolled diabetes mellitus, in which the shift of acid-base status of the body toward the acid side because of loss of base or retention of acids other than carbonic acid is accompanied by the accumulation of ketone bodies in body tissues and fluids.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
149 |
3. Check pre-conditions, main-only, mode, registry filtersPre-conditions: EVENT_AGE<40 Registry filters: 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
109 |
6. Filter based on genotype QC (FinnGen only) |
109 |
Control definitions (FinnGen only)
- Control exclude
- DIABETES_FG
- Control conditions
- not E4_DM2
and not PANCREATITIS
and not INSULIN_INTER_AND_LONG
and not KELA_DIAB_INSUL
and not INSULIN_SHORTFAST
Extra metadata
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Type 1 diabetes, strict definition, subgroup 2
based on the number of shared cases.
Similar with more cases:
- Type 1 diabetes, wide definition, subgroup 2
- Type 1 diabetes, strict definition
- Type 1 diabetes, strict (exclude DM2)
- Type 1 diabetes, definitions combined
- Type 1 diabetes, wide definition
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1340 | 519 | 810 |
| Only index persons | 483 | 167 | 316 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 13.08 | 10.37 | 14.53 |
| Only index persons | 15.15 | 14.82 | 15.32 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 109 | 51 | 58 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | 12.38 | 11.71 | 12.97 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 115
- Matched controls
- 1149
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
103
Kela drug reimbursment
Diabetes, insulin-treated
+∞
166.0
115
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
+∞
139.9
104
*
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2170.1
114.2
92
*
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
+∞
104.8
84
*
215
Kela drug reimbursment
Diabetes, non-insulin-treated
+∞
100.1
81
*
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
+∞
86.8
72
*
A10AA01
ATC
NA
+∞
83.9
70
*
A10AA02
ATC
NA
+∞
81.1
68
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
1649.4
80.7
69
*
H04AA01
ATC
glucagon; nasal, parenteral
+∞
79.7
67
*
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
+∞
68.8
59
*
A10AE05
ATC
insulin detemir; parenteral
+∞
49.6
44
*
T89
ICPC
Diabetes insulin dependent
+∞
48.4
43
*
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
+∞
41.1
37
*
E10
ICD-10 Finland
Type 1 diabetes mellitus
+∞
34.1
31
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
+∞
32.9
30
*
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
+∞
29.4
27
*
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
+∞
29.4
27
*
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
+∞
26.0
24
*
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
+∞
24.9
23
*
SPAT1262
SPAT
Handing over of treatment supplies
18.9
23.6
37
28
A98
ICPC
Health maint/preventive medicine
0.1
20.2
76
1103
XCK10
NOMESCO Finland
Photography of fundus of eye
23.6
16.4
23
12
H3600, E103
ICD-10 Finland
NA
+∞
14.9
14
*
A10AA03
ATC
NA
+∞
14.9
14
*
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
170.8
14.8
15
*
H36.00
ICD-10 Finland
Diabetic background retinopathy
+∞
13.8
13
*
A10AE04
ATC
insulin glargine; parenteral
145.2
12.7
13
*
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
+∞
11.7
11
*
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
+∞
10.6
10
*
2501B
ICD-9 Finland
Diabetes mellitus, Diabetes with ketoacidosis[DIABETES MELLITUS CUM KETOACIDOSI ,TYYPPI I]
+∞
10.6
10
*
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
+∞
10.6
10
*
Z13.1
ICD-10 Finland
Special screening examination for diabetes mellitus
33.1
9.6
12
*
SPAT1008
SPAT
Photography of fundus of the eye or interpretation of photograph
54.2
8.8
10
*
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
+∞
8.4
8
*
TBW99
NOMESCO Finland
Other minor procedure in endocrine surgery
18.9
8.3
12
7
E14.9
ICD-10 Finland
Unspecified diabetes mellitus, without complications
+∞
7.4
7
*
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
+∞
7.4
7
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
+∞
7.4
7
*
C02EA02
ATC
NA
42.6
6.8
8
*
C09AA02
ATC
enalapril; systemic
5.9
6.3
17
33
Z97.8
ICD-10 Finland
Presence of other specified devices
+∞
6.3
6
*
2504B
ICD-9 Finland
Diabetes mellitus, Diabetes with renal manifestations[DIABETES MELLITUS CUM COMPLICATIONE OCULI ,TYYPPI I]
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
60
66
19.00
55.09
4.3
2.3
16.9
282.3
mg/mmol
0.46
44
40
53
910
0.19
17.11
8.4
11.2
13.5
21.2
mg/l
2.43
35
646
24
615
0.22
10.87
5.1
3.5
27.8
36.6
u/l
1.02
24
596
14
6
26.46
10.54
2.1
1.0
0.1
0.8
nmol/l
—
14
6
51
817
0.29
9.14
4.1
3.9
—
—
—
0
0
69
911
0.34
6.45
9.8
11.2
71.2
69.2
umol/l
0.12
69
911
33
609
0.34
6.26
5.3
3.8
10.2
7.1
mm/h
1.21
33
583
14
383
0.27
5.39
10.4
8.3
11.7
14.5
umol/l
0.76
14
367
30
536
0.39
4.61
8.5
12.1
4.0
3.7
e9/l
0.22
23
458
46
256
2.38
4.53
3.0
1.3
7.5
1.2
u/ml
—
10
59
0
107
0.00
4.28
0.0
1.6
—
—
—
0
0
7
226
0.26
3.95
2.0
2.2
36.1
56.2
u/l
—
7
214
13
302
0.35
3.26
6.8
4.5
41.5
32.2
u/l
0.36
13
294
5
165
0.27
2.87
3.6
4.0
271.6
2569.7
umol/l
—
5
158
20
369
0.44
2.85
3.3
3.9
—
—
—
0
0
13
285
0.38
2.80
4.5
3.2
—
—
—
0
0
52
687
0.54
2.62
7.2
8.0
91.6
95.3
ml/min/173m2
0.46
40
547
0
66
0.00
2.51
0.0
1.2
—
—
—
0
0
24
389
0.51
2.24
3.9
3.4
0.0
0.0
estimate
—
5
75
24
385
0.52
2.14
4.8
4.8
0.0
0.0
estimate
—
6
73
15
281
0.46
2.10
5.0
3.9
—
—
—
0
0
24
383
0.52
2.10
3.7
3.4
0.0
0.0
estimate
—
5
70
16
276
0.51
1.73
5.6
7.4
35.8
37.5
g/l
0.77
16
265
12
223
0.48
1.60
1.9
2.1
9.6
28.0
ng/l
—
7
103
0
43
0.00
1.56
0.0
1.7
—
3.4
—
0
30
0
44
0.00
1.55
0.0
1.5
—
—
—
0
0
11
207
0.48
1.52
2.1
2.7
—
—
—
0
0
14
242
0.52
1.50
5.4
3.7
0.3
0.3
e6/l
—
8
183
19
299
0.56
1.49
2.0
1.8
—
—
—
0
0
0
38
0.00
1.37
0.0
1.3
—
—
—
0
0
0
38
0.00
1.37
0.0
1.2
—
—
—
0
0
0
38
0.00
1.37
0.0
1.3
—
—
—
0
0
0
38
0.00
1.37
0.0
1.3
—
—
—
0
0
0
39
0.00
1.37
0.0
1.9
—
—
—
0
0
0
39
0.00
1.37
0.0
1.2
—
—
—
0
0
0
30
0.00
0.99
0.0
1.6
—
287.6
—
0
30
0
24
0.00
0.80
0.0
1.5
—
8.2
—
0
10
0
24
0.00
0.80
0.0
1.4
—
—
—
0
0
6
109
0.52
0.77
1.8
1.5
—
—
—
0
0
12
178
0.63
0.72
4.9
3.9
0.0
0.0
estimate
—
5
72
5
27
1.89
0.69
1.0
2.5
—
—
—
0
0
8
127
0.60
0.69
5.4
5.7
29.0
30.6
s
—
8
127
13
187
0.65
0.68
1.6
1.7
104.1
97.2
pmol/l
—
8
104
27
328
0.76
0.53
13.2
11.7
1.2
1.2
mmol/l
0.41
27
312
15
110
1.42
0.52
11.2
17.8
21.0
25.1
mmol/l
1.73
15
110
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.4
—
13.2
—
0
17
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.9
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
0
19
0.00
0.39
0.0
3.3
—
—
—
0
0
5
76
0.64
0.37
1.0
1.0
—
—
—
0
0
5
78
0.62
0.37
3.4
5.4
213.0
256.5
u/l
—
5
78
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
9.3
—
16.9
—
0
11
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
9
112
0.79
0.21
1.2
2.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
6.7
—
0
7
15
129
1.19
0.18
9.9
11.5
1.3
1.3
mmol/l
0.00
15
123
46
437
1.09
0.13
8.3
7.3
9.3
5.8
mmol/l
5.66
46
405
5
51
0.98
0.00
2.0
2.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
0.3
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
55.5
—
0
8
0
9
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
5.3
—
162.3
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
61.8
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
56
0.89
0.00
5.4
1.5
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
0.00
0.0
1.0
—
124.8
—
0
6
0
5
0.00
0.00
0.0
3.0
—
18.5
—
0
5
0
6
0.00
0.00
0.0
3.2
—
2.5
—
0
6
0
7
0.00
0.00
0.0
2.6
—
119.0
—
0
7
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
0.0
—
0
5
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
8
0.00
0.00
0.0
2.4
—
96.9
—
0
8
0
5
0.00
0.00
0.0
1.2
—
7.1
—
0
5
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
118.8
—
0
5
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
4.3
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
1146.4
—
0
9
0
8
0.00
0.00
0.0
2.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint T1D_STRICT2 and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have T1D_STRICT2.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: T1D_STRICT2 – Type 1 diabetes, strict definition, subgroup 2
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data