No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
6220 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2569 |
4. Check minimum number of eventsNone |
2569 |
5. Include endpointsNone |
2569 |
6. Filter based on genotype QC (FinnGen only) |
2569 |
Control definitions (FinnGen only)
- Control exclude
- AUTOIMMUNE
- Control conditions
- not E4_THYTOXGOITDIF
Extra metadata
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Autoimmune hyperthyroidism
based on the number of shared cases.
Similar with more cases:
- Thyrotoxicosis with diffuse goitre
- Thyrotoxicosis, other and/or unspecified
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Developmental endpoint to exclude non autoimmune-cases from E4_HYTHY_AI_STRICT
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 14824 | 11965 | 2766 |
| Only index persons | 14358 | 11690 | 2668 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.29 | 0.34 | 0.08 |
| Only index persons | 0.37 | 0.43 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 50.67 | 50.39 | 52.43 |
| Only index persons | 50.46 | 50.13 | 51.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2569 | 2134 | 435 |
| Unadjusted period prevalence (%) | 0.64 | 0.73 | 0.19 |
| Median age at first event (years) | 50.53 | 49.43 | 55.93 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2279
- Matched controls
- 22789
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
216.6
323.0
349
19
104
Kela drug reimbursment
Thyroid insufficiency
40.8
323.0
671
231
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
323.0
587
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
4503599627370496.0
323.0
2263
5
H03BB01
ATC
carbimazole; oral
993.6
323.0
2006
171
H03AA01
ATC
levothyroxine sodium; systemic
92.3
323.0
1708
715
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
43.5
323.0
409
114
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
31.2
323.0
446
176
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
1169.8
323.0
2018
152
BAA60
NOMESCO Finland
Total thyroidectomy
34.8
323.0
601
232
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
106.2
287.8
312
34
C07AA05
ATC
propranolol; systemic
5.9
286.8
1023
2757
H062, E050
ICD-10 Finland
NA
+∞
187.1
177
*
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
974.9
186.2
180
*
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
30.3
169.5
230
84
E03
ICD-10 Finland
Other hypothyroidism
22.0
141.7
211
105
T86
ICPC
Hypothyroidism/myxoedema
26.5
135.1
190
78
C07AB07
ATC
bisoprolol; oral
3.0
132.7
1182
5980
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.2
132.5
955
4173
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.9
124.7
1193
6239
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
40.7
123.6
156
41
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
33.4
122.7
162
52
E03.89
ICD-10 Finland
Other specified hypothyroidism
33.9
122.3
161
51
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
19.1
119.9
187
106
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
156.8
113.3
119
8
T85
ICPC
Hyperthyroidism/thyrotoxicosis
68.3
106.9
123
19
EP1AE
NOMESCO Finland
Neck ultrasound examination
6.4
100.8
285
499
H02AB06
ATC
prednisolone; systemic
2.5
90.6
1125
6411
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
66.7
83.2
96
15
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
8.1
81.2
191
254
H05.2
ICD-10 Finland
Exophthalmic conditions
80.8
69.5
78
10
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
88.6
69.4
77
9
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
73.2
68.6
78
11
E05.89
ICD-10 Finland
Other thyrotoxicosis
78.7
67.5
76
10
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
635.2
63.1
62
*
H53.2
ICD-10 Finland
Diplopia
7.6
59.4
145
203
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
26.5
58.9
82
32
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
94.1
58.2
64
7
H03BA02
ATC
propylthiouracil; oral
299.3
57.5
58
*
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
54.4
52
*
K90.0
ICD-10 Finland
Coeliac disease
20.2
53.0
80
41
H02AB07
ATC
prednisone; oral
2.9
52.1
349
1322
H50.2
ICD-10 Finland
Vertical strabismus
17.8
50.0
79
46
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.2
48.7
286
988
A10AA01
ATC
NA
79.1
48.1
54
7
H04AA01
ATC
glucagon; nasal, parenteral
57.3
47.7
56
10
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
245.0
47.2
48
*
CAC30
NOMESCO Finland
Decompression of orbit to sinuses
+∞
47.0
45
*
T89
ICPC
Diabetes insulin dependent
16.3
46.7
76
48
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
23.0
46.3
67
30
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.6
46.0
394
1719
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
22.2
45.9
67
31
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
60.2
45.5
53
9
E05.5
ICD-10 Finland
Thyroid crisis or storm
+∞
44.9
43
*
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
14.7
43.6
74
52
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
42.8
849
5372
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
4.5
41.2
153
358
K51.5
ICD-10 Finland
Left sided colitis
+∞
40.7
39
*
H04.10
ICD-10 Finland
Dry eye syndrome
2.9
40.6
277
1052
XCK00
NOMESCO Finland
Perimetry
3.5
40.4
202
616
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
39.8
459
2316
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
+∞
39.7
38
*
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
36.5
39.2
50
14
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
7.6
38.8
93
127
ZX120
NOMESCO Finland
Intravenous
3.1
38.7
234
817
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
+∞
37.6
36
*
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
14.8
36.8
62
43
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.6
35.4
128
292
E06.3
ICD-10 Finland
Autoimmune thyroiditis
59.6
35.2
41
7
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
4.5
34.5
127
295
ZXA10
NOMESCO Finland
Bilateral
2.1
34.1
433
2262
A11CC03
ATC
alfacalcidol; systemic
8.4
34.0
76
93
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
33.8
812
5374
A10AA02
ATC
NA
15.1
33.6
56
38
CA1AD
NOMESCO Finland
Orbita CT
56.6
33.3
39
7
E10
ICD-10 Finland
Type 1 diabetes mellitus
49.5
32.6
39
8
CAC44
NOMESCO Finland
Combined decompression of orbit
+∞
32.4
31
*
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
22.9
31.4
45
20
107
Kela drug reimbursment
Pernicious anaemia
+∞
31.3
30
*
P01BA02
ATC
hydroxychloroquine; oral
4.1
31.1
125
316
XCD10
NOMESCO Finland
Electrophysiological examination of eye
5.8
29.5
86
154
A02BC02
ATC
pantoprazole; systemic
1.7
29.3
1378
10933
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
6.9
29.3
74
110
G35
ICD-10 Finland
Multiple sclerosis
146.8
27.7
29
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
27.4
584
3666
CBK00
NOMESCO Finland
Myotomy or resection of tarsal muscle or levator muscle of eyelid for correction of retraction
+∞
27.1
26
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
38.3
27.1
34
9
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
32.3
26.9
35
11
H50.6
ICD-10 Finland
Mechanical strabismus
274.1
26.8
27
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
26.4
507
3067
C07AB02
ATC
metoprolol; systemic
2.0
26.4
403
2245
A07EC02
ATC
mesalazine; oral, rectal
6.0
26.4
74
127
A07EC01
ATC
sulfasalazine; oral, rectal
4.1
26.3
105
264
A10AE05
ATC
insulin detemir; parenteral
4.5
25.9
94
216
XCK10
NOMESCO Finland
Photography of fundus of eye
2.6
25.8
197
792
2AB04
NOMESCO Finland
NA
94.5
25.7
28
*
H50.8
ICD-10 Finland
Other specified strabismus
50.6
25.3
30
6
CAC20
NOMESCO Finland
Lateral decompression of orbit
+∞
25.0
24
*
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
19.8
24.8
37
19
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
10.2
24.8
49
49
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.0
24.7
344
1848
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
24.4
536
3378
H3600, E103
ICD-10 Finland
NA
+∞
24.0
23
*
A10AE04
ATC
insulin glargine; parenteral
3.1
23.8
136
456
L04AA13
ATC
leflunomide; oral
17.1
23.6
37
22
CEC00
NOMESCO Finland
Recession of extraocular muscle
17.1
23.6
37
22
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
+∞
22.9
22
*
109
Kela drug reimbursment
Multiple sclerosis
+∞
22.9
22
*
Z3231
NOMESCO Finland
Registered nurse
1.7
22.8
561
3647
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
52.5
22.1
26
5
H02.5
ICD-10 Finland
Other disorders affecting eyelid function
35.4
22.1
28
8
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
22.0
830
6050
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
+∞
21.9
21
*
157
Kela drug reimbursment
Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)
+∞
21.9
21
*
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
222.0
21.6
22
*
C03CA01
ATC
furosemide; systemic
1.8
21.4
425
2577
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
34.1
21.1
27
8
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
+∞
20.9
20
*
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
+∞
20.9
20
*
106
Kela drug reimbursment
Hypoparathyroidism
19.6
20.8
31
16
L04AX01
ATC
azathioprine; systemic
7.9
20.3
46
59
C01BD01
ATC
amiodarone; systemic
4.8
20.1
68
146
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.3
19.9
103
323
L40.0
ICD-10 Finland
Psoriasis vulgaris
9.3
19.8
41
45
R00.0
ICD-10 Finland
Tachycardia, unspecified
3.1
19.6
109
360
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
105.9
19.6
21
*
WF099
NOMESCO Finland
Other radiotherapy
12.2
19.6
35
29
H50.0
ICD-10 Finland
Convergent concomitant strabismus
9.0
18.6
39
44
H02AB09
ATC
hydrocortisone; systemic
5.4
18.5
55
103
B03BA03
ATC
hydroxocobalamin; parenteral
3.6
18.4
83
234
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
3.0
18.4
106
359
N02BE01
ATC
paracetamol; systemic, rectal
1.6
18.1
1863
16741
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
18.1
413
2606
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.0
18.1
104
352
K51.8
ICD-10 Finland
Other ulcerative colitis
52.9
18.0
21
*
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.6
17.9
139
565
E83.51
ICD-10 Finland
Hypocalcemia
16.7
17.8
28
17
TFP20
NOMESCO Finland
Cardiodefibrillation
2.7
17.8
128
498
H3601, E103
ICD-10 Finland
NA
+∞
17.7
17
*
H3603, E103
ICD-10 Finland
NA
+∞
17.7
17
*
2420A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic diffuse goitre
+∞
17.7
17
*
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
8.7
17.4
37
43
R00.2
ICD-10 Finland
Palpitations
2.2
17.3
180
851
R53
ICD-10 Finland
Malaise and fatigue
1.7
16.9
405
2583
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
63.8
16.7
19
*
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
6.6
16.4
42
65
SPAT1249
SPAT
Treatment-related counselling outside office
1.5
16.2
803
6118
ZXE00
NOMESCO Finland
One hour or less
1.5
16.1
825
6319
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
2.9
16.0
99
353
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.7
16.0
344
2126
N05CF01
ATC
zopiclone; oral
1.5
15.8
608
4371
WX110
NOMESCO Finland
Local anesthesy
1.4
15.5
1476
12746
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
161.0
15.5
16
*
A10AE06
ATC
insulin degludec; parenteral
5.8
15.4
43
75
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
12.4
15.3
27
22
B01AA03
ATC
warfarin; systemic
1.8
15.3
287
1696
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
45.3
15.1
18
*
R06.0
ICD-10 Finland
Dyspnoea
1.6
14.9
436
2930
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
31.9
14.8
19
6
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
21.2
14.6
21
10
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.4
14.6
123
525
L88
ICPC
Rheumatoid/seropositive arthritis
4.7
14.6
49
106
E05.3
ICD-10 Finland
Thyrotoxicosis from ectopic thyroid tissue
+∞
14.6
14
*
G73.0*E05.9
ICD-10 Finland
Myasthenic syndromes in thyrotoxicosis [hyperthyroidism]
+∞
14.6
14
*
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
14.4
272
1611
UJF30
NOMESCO Finland
Ileoscopy through colon
2.1
14.3
165
813
J01DB01
ATC
cefalexin; oral
1.5
14.3
1746
15688
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.5
14.2
583
4239
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.1
14.1
160
784
A02BC05
ATC
esomeprazole; systemic
1.4
14.0
805
6271
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
53.7
13.8
16
*
CEW99
NOMESCO Finland
Other operation on extraocular muscle
20.2
13.8
20
10
177
Kela drug reimbursment
Insulin glargine 300 U / ml
7.6
13.6
31
41
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.4
13.6
116
498
CEC90
NOMESCO Finland
Total transposition of extraocular muscle or muscles
75.6
13.6
15
*
CA1BM
NOMESCO Finland
Eye and orbita MRI examination with 3 Tesla magnet
75.6
13.6
15
*
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
14.8
13.6
22
15
K50.8
ICD-10 Finland
Other Crohn disease
+∞
13.6
13
*
M06.8
ICD-10 Finland
Other specified rheumatoid arthritis
+∞
13.6
13
*
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
+∞
13.6
13
*
M01CB01
ATC
sodium aurothiomalate; parenteral
34.2
13.5
17
5
E05.4
ICD-10 Finland
Thyrotoxicosis factitia
34.2
13.5
17
5
K50.0
ICD-10 Finland
Crohn disease of small intestine
140.8
13.5
14
*
BAA25
NOMESCO Finland
Bilateral partial excision of thyroid gland
25.9
13.4
18
7
H02AB04
ATC
methylprednisolone; systemic
1.7
13.1
267
1619
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
13.1
725
5588
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.8
13.0
238
1395
ZXE20
NOMESCO Finland
More than three and less than five hours
1.8
12.9
244
1442
C07AA07
ATC
sotalol; systemic
3.2
12.9
68
219
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.7
12.7
269
1648
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.0
12.7
74
255
207
Kela drug reimbursment
Chronic arrhythmias
1.8
12.7
212
1204
WX402
NOMESCO Finland
General anaesthesia
1.6
12.7
347
2286
N02AX02
ATC
tramadol; systemic, rectal
1.4
12.6
762
5958
K50.1
ICD-10 Finland
Crohn disease of large intestine
70.2
12.6
14
*
CA1BD
NOMESCO Finland
Extensive orbita CT
70.2
12.6
14
*
K50.9
ICD-10 Finland
Crohn disease, unspecified
70.2
12.6
14
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
+∞
12.5
12
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
130.7
12.4
13
*
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.7
12.4
283
1772
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.9
12.2
190
1052
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
6.4
12.1
31
49
K04
ICPC
Palpitations/awareness of heart
2.3
12.0
114
517
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
6.6
12.0
30
46
TCC40
NOMESCO Finland
Closure of lacrimal canaliculus with plug
21.4
12.0
17
8
A07EA02
ATC
hydrocortisone; rectal
7.3
12.0
28
39
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
11.9
1144
9670
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
30.2
11.6
15
5
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
6.9
11.6
28
41
164
Kela drug reimbursment
Fingolimod
+∞
11.5
11
*
353
Kela drug reimbursment
Cladribine and fingolimod
+∞
11.5
11
*
A11CC02
ATC
dihydrotachysterol; oral
13.7
11.4
19
14
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
120.6
11.4
12
*
B01AB05
ATC
enoxaparin; parenteral
1.4
11.2
541
4037
A02BC01
ATC
omeprazole; systemic
1.5
11.2
494
3624
XF404
NOMESCO Finland
Ambulatory ECG
1.9
10.9
160
869
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.5
10.9
468
3410
Z3229
NOMESCO Finland
Other healthcare associate professional
2.0
10.8
140
726
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.5
10.8
474
3466
TFP34
NOMESCO Finland
Electrophysiological investigation
2.9
10.7
64
226
R07.4
ICD-10 Finland
Chest pain, unspecified
1.5
10.7
448
3246
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
10.7
320
2149
SPAT1262
SPAT
Handing over of treatment supplies
1.6
10.5
265
1702
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
10.4
329
2237
C01AA05
ATC
digoxin; systemic
2.3
10.4
95
423
E50.0
ICD-10 Finland
Vitamin A deficiency with conjunctival xerosis
110.5
10.4
11
*
M14.5*E05.9
ICD-10 Finland
Arthropathy in thyrotoxicosis [hyperthyroidism]
110.5
10.4
11
*
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
110.5
10.4
11
*
L03AX13
ATC
glatiramer acetate; parenteral
+∞
10.4
10
*
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
+∞
10.4
10
*
L04AA27
ATC
fingolimod; oral
+∞
10.4
10
*
A12AA04
ATC
calcium carbonate; oral
5.9
10.4
28
48
B81
ICPC
Anaemia vit B12/folate deficiency
3.4
10.2
48
144
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
1.7
10.1
199
1193
L01BB02
ATC
mercaptopurine; oral
14.6
10.0
16
11
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
3.8
10.0
41
110
Z2221
NOMESCO Finland
Medical doctor
1.4
10.0
568
4358
E06.4
ICD-10 Finland
Drug-induced thyroiditis
40.2
10.0
12
*
E89.1
ICD-10 Finland
Postprocedural hypoinsulinaemia
40.2
10.0
12
*
K51.2
ICD-10 Finland
Ulcerative (chronic) proctitis
40.2
10.0
12
*
L13.0
ICD-10 Finland
Dermatitis herpetiformis
40.2
10.0
12
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.0
10.0
127
656
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
26.1
9.8
13
5
UJF32
NOMESCO Finland
Coloscopy
1.5
9.8
397
2852
R01AD08
ATC
fluticasone; nasal
1.4
9.6
577
4469
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.6
9.5
264
1740
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.6
9.5
274
1822
R63.4
ICD-10 Finland
Abnormal weight loss
2.8
9.4
60
221
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
+∞
9.4
9
*
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.7
9.4
190
1150
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
9.3
201
1239
WX002
NOMESCO Finland
Sedation and analgesia
1.5
9.3
330
2304
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.4
9.2
565
4384
I47.1
ICD-10 Finland
Supraventricular tachycardia
2.3
9.2
84
374
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.6
9.2
222
1411
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
1.9
9.1
134
729
SGA01
NOMESCO Finland
Tooth opening as first aid
1.5
9.1
319
2220
H01.0
ICD-10 Finland
Blepharitis
2.0
9.0
110
560
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
4.7
9.0
29
62
J01AA02
ATC
doxycycline; systemic
1.3
9.0
1615
14703
A07EA06
ATC
budesonide; oral, local oral
3.7
9.0
37
100
N86
ICPC
Multiple sclerosis
18.7
8.9
13
7
R50.9
ICD-10 Finland
Fever, unspecified
1.6
8.9
227
1461
TFP46
NOMESCO Finland
Ablation treatment of atrial fibrillation
3.7
8.9
37
101
BBA70
NOMESCO Finland
Implantation or transplantation of parathyroid gland
24.1
8.9
12
5
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
5.8
8.9
24
42
XCH00
NOMESCO Finland
Eye pressure measurement
2.4
8.9
71
298
CE2W4
NOMESCO Finland
Eye movement mapping
12.6
8.9
15
12
N06AX21
ATC
duloxetine; oral
1.7
8.9
200
1249
A04
ICPC
Weakness/tiredness general
1.6
8.9
234
1521
Z3226
NOMESCO Finland
Physiotherapist
1.5
8.8
326
2295
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
1.8
8.8
143
810
H57.1
ICD-10 Finland
Ocular pain
2.5
8.7
67
276
R03AC02
ATC
salbutamol; inhalant
1.3
8.7
1057
9081
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.5
8.7
285
1952
E06.1
ICD-10 Finland
Subacute thyroiditis
4.9
8.7
27
56
M03BC51
ATC
orphenadrine, combinations; systemic
1.4
8.7
571
4476
C08CA01
ATC
amlodipine; oral
1.4
8.7
524
4052
1XC02
NOMESCO Finland
NA
6.6
8.6
21
32
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.1
8.6
93
451
WX892
NOMESCO Finland
Monitored bed care
2.0
8.6
110
569
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.6
8.6
236
1552
I50.9
ICD-10 Finland
Heart failure, unspecified
1.8
8.6
143
814
M54.5
ICD-10 Finland
Low back pain
1.3
8.6
636
5081
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.7
8.6
184
1132
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
3.1
8.5
45
148
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
9.0
8.5
17
19
ZXD05
NOMESCO Finland
Urgent procedure
1.4
8.5
586
4627
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.5
8.4
347
2500
L04AA31
ATC
teriflunomide; oral
+∞
8.3
8
*
2504B
ICD-9 Finland
Diabetes mellitus, Diabetes with renal manifestations[DIABETES MELLITUS CUM COMPLICATIONE OCULI ,TYYPPI I]
+∞
8.3
8
*
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
8.3
8
*
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
+∞
8.3
8
*
M14.5*E03.9
ICD-10 Finland
Arthropathy in hypothyroidism (E00-E03+)
+∞
8.3
8
*
G70.0
ICD-10 Finland
Myasthenia gravis
+∞
8.3
8
*
L03AB07
ATC
interferon beta-1a; parenteral
+∞
8.3
8
*
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.7
8.3
164
986
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.8
8.3
148
864
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
8.2
880
7413
SPAT1263
SPAT
Sampling
1.3
8.2
804
6686
M25.5
ICD-10 Finland
Pain in joint
1.4
8.1
543
4258
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.6
8.1
208
1341
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.3
8.1
910
7712
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.5
8.0
323
2310
A10AB06
ATC
insulin glulisine; parenteral
8.9
8.0
16
18
L40.5
ICD-10 Finland
Arthropathic psoriasis
22.1
8.0
11
5
R02
ICPC
Shortness of breath/dyspnoea
1.6
8.0
201
1293
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
8.0
1477
13362
F29
ICPC
Eye symptom/complaint other
1.7
8.0
148
872
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
2.7
7.9
51
192
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.3
7.8
749
6203
K80
ICPC
Cardiac arrhythmia NOS
1.8
7.7
132
757
C01BC04
ATC
flecainide; systemic
2.3
7.7
66
287
A10AA03
ATC
NA
15.1
7.7
12
8
J45.9
ICD-10 Finland
Asthma, unspecified
1.5
7.7
313
2245
L04AB04
ATC
adalimumab; parenteral
7.4
7.7
17
23
K29.4
ICD-10 Finland
Chronic atrophic gastritis
3.8
7.6
30
79
CKC12
NOMESCO Finland
Photocoagulation of retina
2.3
7.6
66
290
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.3
7.6
665
5430
L28
ICPC
Limited function/disability (L)
1.5
7.6
226
1514
XF600
NOMESCO Finland
Bloodpressure measurement
1.9
7.5
102
541
103
Kela drug reimbursment
Diabetes, insulin-treated
1.4
7.5
337
2465
N05BA04
ATC
oxazepam; oral
1.4
7.4
468
3634
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
80.3
7.4
8
*
CBK99
NOMESCO Finland
Other operation for retraction of eyelid
80.3
7.4
8
*
J01MA02
ATC
ciprofloxacin; systemic
1.3
7.4
647
5276
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
1.8
7.4
122
695
AA1AD
NOMESCO Finland
CT of head and brain
1.4
7.4
354
2620
N03AX16
ATC
pregabalin; oral
1.4
7.4
396
2989
J01FF01
ATC
clindamycin; systemic
1.4
7.3
463
3592
E50.9
ICD-10 Finland
Vitamin A deficiency, unspecified
+∞
7.3
7
*
L04AA24
ATC
abatacept; parenteral
+∞
7.3
7
*
71238
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita
+∞
7.3
7
*
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
+∞
7.3
7
*
108
Kela drug reimbursment
Myasthenia gravis
+∞
7.3
7
*
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
10.9
7.3
13
12
A02BC03
ATC
lansoprazole; oral
1.3
7.3
496
3895
N02AJ06
ATC
codeine and paracetamol; systemic
1.3
7.3
689
5682
H05.0
ICD-10 Finland
Acute inflammation of orbit
15.8
7.2
11
7
W84
ICPC
Pregnancy high risk
2.2
7.2
71
333
R4110
NOMESCO Finland
Physiotherapy
1.4
7.2
463
3603
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.3
7.2
574
4616
J01FA06
ATC
roxithromycin; oral
1.3
7.2
788
6625
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.7
7.2
141
849
K51
ICD-10 Finland
Ulcerative colitis
30.1
7.1
9
*
M01CB03
ATC
auranofin; oral
20.1
7.1
10
5
CS494
NOMESCO Finland
Other visual field testing
2.8
7.1
42
150
L40.3
ICD-10 Finland
Pustulosis palmaris et plantaris
5.0
7.1
21
42
D64.9
ICD-10 Finland
Anaemia, unspecified
1.8
7.1
125
729
WX140
NOMESCO Finland
Parabulbar anesthesy
2.2
7.1
65
295
R51.80
ICD-10 Finland
Headache
1.5
7.0
282
2014
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.5
7.0
221
1502
A60
ICPC
General and Unspecified, Result test/procedure
2.1
7.0
77
380
R05
ICPC
Cough
1.4
6.9
405
3098
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.3
6.9
500
3962
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.4
6.9
294
2128
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.7
6.9
130
772
N02AA05
ATC
oxycodone; systemic
1.6
6.9
195
1290
S01GX01
ATC
cromoglicic acid; ophthalmic
1.4
6.9
413
3176
TFC25
NOMESCO Finland
Transseptal catheterisation of left atrium or ventricle
3.7
6.9
28
77
SPAT1097
SPAT
Recording of ECG
1.5
6.8
231
1592
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
3.4
6.8
31
93
ZXA00
NOMESCO Finland
Right side
1.4
6.8
444
3459
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
2.3
6.8
60
266
R94.6
ICD-10 Finland
Abnormal results of thyroid function studies
6.1
6.8
17
28
D69.0
ICD-10 Finland
Allergic purpura
40.2
6.8
8
*
E20.8
ICD-10 Finland
Other hypoparathyroidism
40.2
6.8
8
*
R03BA02
ATC
budesonide; inhalant
1.4
6.7
323
2391
R21
ICPC
Throat symptom/complaint
1.4
6.7
394
3019
J01FA10
ATC
azithromycin; systemic
1.3
6.7
1207
10764
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
4.1
6.7
24
59
E11.1
ICD-10 Finland
Type 2 diabetes mellitus, with ketoacidosis
22.6
6.7
9
*
N07AA02
ATC
pyridostigmine; systemic
22.6
6.7
9
*
R06AE07
ATC
cetirizine; oral
1.3
6.7
895
7703
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
2.0
6.7
85
443
I95.2
ICD-10 Finland
Hypotension due to drugs
7.8
6.6
14
18
E06.9
ICD-10 Finland
Thyroiditis, unspecified
5.9
6.6
17
29
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
5.5
6.6
18
33
J01MA12
ATC
levofloxacin; systemic
1.4
6.6
276
1992
L15
ICPC
Knee symptom/complaint
1.4
6.6
358
2706
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.1
6.5
73
360
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.5
6.5
258
1840
R07.0
ICD-10 Finland
Pain in throat
1.8
6.5
116
675
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.3
6.5
601
4926
L04AB01
ATC
etanercept; parenteral
6.9
6.5
15
22
N03AX12
ATC
gabapentin; oral
1.5
6.5
253
1800
L04AA01
ATC
[U] ciclosporin; systemic
5.3
6.5
18
34
CAB00
NOMESCO Finland
Anterior orbitotomy with excision of lesion
70.0
6.4
7
*
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
70.0
6.4
7
*
S01XA18
ATC
ciclosporin; ophthalmic
7.4
6.4
14
19
A10AD04
ATC
insulin lispro; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
14.3
6.4
10
7
UDQ12
NOMESCO Finland
Flexible laryngoscopy
1.9
6.4
91
496
R60.0
ICD-10 Finland
Localized oedema
1.6
6.4
162
1045
WZC30
NOMESCO Finland
Teaching
1.5
6.3
208
1425
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.6
6.3
174
1146
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
2.8
6.3
37
132
L40.8
ICD-10 Finland
Other psoriasis
11.0
6.3
11
10
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.7
6.3
116
687
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
18.1
6.3
9
5
RD210
NOMESCO Finland
NA
3.1
6.3
31
100
C09AA05
ATC
ramipril; oral
1.4
6.3
319
2383
H3602, E103
ICD-10 Finland
NA
+∞
6.3
6
*
24200
ICD-8 Finland
Thyrotoxicosis with or without goitre, Cum struma diffusa et exophthalmo. Morbus Basedowi
+∞
6.3
6
*
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
+∞
6.3
6
*
E06.5
ICD-10 Finland
Other chronic thyroiditis
+∞
6.3
6
*
2507B
ICD-9 Finland
Diabetes mellitus, Diabetes with peripheral circulatory disorders[DIABETES MELLITUS CUM COMPLICAT ALIA ,TYYPPI I]
+∞
6.3
6
*
G61.0
ICD-10 Finland
Guillain-Barré syndrome
+∞
6.3
6
*
Z96.4
ICD-10 Finland
Presence of endocrine implants
+∞
6.3
6
*
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
2.7
6.2
38
140
K02.1
ICD-10 Finland
Caries of dentine
1.2
6.2
1131
10057
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
26.7
6.2
8
*
M05BA04
ATC
alendronic acid; oral
1.7
6.2
115
679
AN1
HP
Coronary angiography
1.6
6.2
137
854
N07BA03
ATC
varenicline; oral
1.8
6.2
95
530
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
1.9
6.2
79
412
L17
ICPC
Foot/toe symptom/complaint
1.3
6.2
424
3328
SPAT1283
SPAT
Restricted health certificate
1.4
6.2
371
2853
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
4.5
6.2
20
45
R96
ICPC
Asthma
1.6
6.1
149
951
D07AD01
ATC
clobetasol; topical
1.4
6.1
246
1757
N06AX11
ATC
mirtazapine; oral
1.3
6.1
576
4724
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
1.8
6.1
105
607
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.0
6.1
76
393
Mortality – FinRegistry
↥Association
Association between endpoint AUTOIMMUNE_HYPERTHYROIDISM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AUTOIMMUNE_HYPERTHYROIDISM | 1.083 [0.97, 1.21] | 0.162 |
| Birth year | 0.998 [0.99, 1.01] | 0.617 |
During the follow-up period (1.1.1998 — 31.12.2019), 1133 out of 10957 females with AUTOIMMUNE_HYPERTHYROIDISM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AUTOIMMUNE_HYPERTHYROIDISM | 1.223 [1.05, 1.42] | 0.008 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 392 out of 2528 males with AUTOIMMUNE_HYPERTHYROIDISM died.
Mortality risk
Mortality risk for people of age
years, who have AUTOIMMUNE_HYPERTHYROIDISM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.117% | 0.217% |
| 5 | 0.744% | 1.299% |
| 10 | 1.652% | 3.238% |
| 15 | 3.454% | 6.115% |
| 20 | 6.064% | 10.044% |
Relationships between endpoints
↥Index endpoint: AUTOIMMUNE_HYPERTHYROIDISM – Autoimmune hyperthyroidism
GWS hits: 12
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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