Diabetic retinopathy, strict definition

DM_RETINOPATHY_STRICT

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

7049

4. Check minimum number of events

None

7049

5. Include endpoints

None

7049

6. Filter based on genotype QC (FinnGen only)

7049

Control definitions (FinnGen only)

Control exclude
DM_MACULOPATHY, DM_RETINOPATHY
Control conditions
DIABETES_FG

Extra metadata

First used in FinnGen datafreeze
DF12

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 7049 3157 3892
Unadjusted period prevalence (%) 1.43 1.08 1.72
Median age at first event (years) 51.85 48.12 54.87

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: DM_RETINOPATHY_STRICT – Diabetic retinopathy, strict definition

GWS hits: 2

This endpoint is excluded (different definition than used in FinnGen).