No definition available.
Other disorders of electrolyte and fluid balance, not elsewhere classified
EFO MESH Endpoint Browser PheWeb
E4_FLUIDELECTRONAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
315 |
4. Check minimum number of eventsNone |
315 |
5. Include endpointsNone |
315 |
6. Filter based on genotype QC (FinnGen only) |
315 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E87
- Name in latin
- Aliae perturbationes aequilibrii electrolytici et humoralis
Similar endpoints
↥List of similar endpoints to
Other disorders of electrolyte and fluid balance, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Other disorders of fluid, electrolyte and acid-base balance
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4640 | 3017 | 1556 |
| Only index persons | 2688 | 1786 | 902 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.09 | 0.04 |
| Only index persons | 0.06 | 0.07 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 67.70 | 70.72 | 61.89 |
| Only index persons | 65.00 | 66.77 | 61.50 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 315 | 189 | 126 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | 61.26 | 59.22 | 64.33 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 279
- Matched controls
- 2789
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E87.8
ICD-10 Finland
Other disorders of electrolyte and fluid balance, not elsewhere classified
+∞
205.5
171
*
2768A
ICD-9 Finland
Disorders of fluid, electrolyte and acid-base balance, Hypopotassaemia[HYPOKALAEMIA]
+∞
115.9
103
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
140.4
70.8
73
7
E87.6
ICD-10 Finland
Hypokalaemia
75.1
35.0
39
6
A12BA01
ATC
potassium chloride; oral
7.6
21.7
53
83
C03DA01
ATC
spironolactone; oral
5.5
21.7
71
164
E86
ICD-10 Finland
Volume depletion
95.8
16.8
18
*
4019X
ICD-9 Finland
Essential hypertension, Unspecified
8.6
15.6
34
44
205
Kela drug reimbursment
Chronic hypertension
2.9
14.8
125
611
R53
ICD-10 Finland
Malaise and fatigue
3.1
13.9
89
362
C03CA01
ATC
furosemide; systemic
2.7
13.5
128
664
E87.5
ICD-10 Finland
Hyperkalaemia
30.0
13.1
17
6
R11
ICD-10 Finland
Nausea and vomiting
4.5
11.8
43
109
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.6
10.8
97
476
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
3.9
10.6
45
131
E87.0
ICD-10 Finland
Hyperosmolality and hypernatraemia
+∞
10.5
10
*
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
6.2
10.3
27
47
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.1
10.2
62
238
N17.9
ICD-10 Finland
Acute renal failure, unspecified
7.0
10.0
24
37
N05BA01
ATC
diazepam; systemic, rectal
3.2
9.6
54
196
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.7
9.3
73
326
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.9
9.2
60
241
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.1
9.1
54
202
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.8
9.0
64
269
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
7.0
8.8
21
32
G40.9
ICD-10 Finland
Epilepsy, unspecified
6.5
8.8
22
36
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
8.7
94
496
F05.9
ICD-10 Finland
Delirium, unspecified
13.3
8.5
14
11
H02AB09
ATC
hydrocortisone; systemic
13.3
8.5
14
11
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.5
8.4
29
70
3071A
ICD-9 Finland
Special symptoms or syndromes not elsewhere classified, Anorexia nervosa
+∞
8.4
8
*
AA1AD
NOMESCO Finland
CT of head and brain
2.4
8.3
81
406
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
12.2
8.2
14
12
N03AX16
ATC
pregabalin; oral
2.4
8.1
74
359
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.6
8.0
27
64
C02EA02
ATC
NA
4.1
8.0
30
79
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
9.8
7.9
15
16
N06AX11
ATC
mirtazapine; oral
2.2
7.7
94
522
N19
ICD-10 Finland
Unspecified kidney failure
6.1
7.7
20
35
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
9.2
7.6
15
17
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.1
7.5
42
151
E87.2
ICD-10 Finland
Acidosis
+∞
7.3
7
*
E87.3
ICD-10 Finland
Alkalosis
+∞
7.3
7
*
K59.1
ICD-10 Finland
Functional diarrhoea
4.6
7.2
24
56
C07AB07
ATC
bisoprolol; oral
2.0
7.2
142
951
F10.24
ICD-10 Finland
Alcohol depence active use
20.6
7.2
10
5
C08CA01
ATC
amlodipine; oral
2.0
7.0
112
689
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
6.4
6.9
17
28
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
6.8
99
584
I10
ICD-10 Finland
Essential (primary) hypertension
1.9
6.8
170
1239
D64.9
ICD-10 Finland
Anaemia, unspecified
2.9
6.8
40
150
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
17.2
6.8
10
6
F50.9
ICD-10 Finland
Eating disorder, unspecified
17.2
6.8
10
6
N05AH04
ATC
quetiapine; oral
2.7
6.7
48
202
SPAT1211
SPAT
Application of soft bandage
3.1
6.6
35
122
A10BH01
ATC
sitagliptin; oral
3.1
6.6
35
122
A06AD11
ATC
lactulose; oral
2.4
6.6
60
288
N05BA04
ATC
oxazepam; oral
2.2
6.5
79
431
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
6.5
126
831
N03AX14
ATC
levetiracetam; systemic
6.8
6.4
15
23
E87
ICD-10 Finland
Other disorders of fluid, electrolyte and acid-base balance
+∞
6.3
6
*
2768X
ICD-9 Finland
Disorders of fluid, electrolyte and acid-base balance, Hypopotassaemia[NESTE-, ELEKTROLYYTTI- JA HAPPOEMÄSTASAP MUUT HÄIR]
+∞
6.3
6
*
124
Kela drug reimbursment
Inborn metabolic disorders
+∞
6.3
6
*
E83.51
ICD-10 Finland
Hypocalcemia
+∞
6.3
6
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.0
6.2
36
133
R42
ICD-10 Finland
Dizziness and giddiness
2.1
6.2
74
402
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.4
6.1
53
249
N03AG01
ATC
valproic acid; systemic, rectal
4.1
6.0
22
57
Mortality – FinRegistry
↥Association
Association between endpoint E4_FLUIDELECTRONAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_FLUIDELECTRONAS | 2.068 [1.65, 2.59] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.524 |
During the follow-up period (1.1.1998 — 31.12.2019), 438 out of 950 females with E4_FLUIDELECTRONAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_FLUIDELECTRONAS | 5.006 [2.97, 8.43] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 272 out of 534 males with E4_FLUIDELECTRONAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_FLUIDELECTRONAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.155% | 0.87% |
| 5 | 1.318% | 5.3% |
| 10 | 3.19% | 13.38% |
| 15 | 6.384% | 24.389% |
| 20 | 10.98% | 38.141% |
Relationships between endpoints
↥Index endpoint: E4_FLUIDELECTRONAS – Other disorders of electrolyte and fluid balance, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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