lactose intolerance: Inability to fully digest and absorb lactose due to limited or no lactase activity in the small intestine. Congenital intolerance is inherited following an autosomal recessive pattern but is rare. It is more often due to a gradual decline of lactase production in adulthood following the ingestion of fewer lactose-containing foods or secondary to an intestinal mucosal brush-border injury. Prevalence is highest among Asians, Native Americans and Africans. Clinical signs include abdominal cramping, bloating, flatulence and diarrhea following the dietary intake of lactose.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1086 |
4. Check minimum number of eventsNone |
1086 |
5. Include endpointsNone |
1086 |
6. Filter based on genotype QC (FinnGen only) |
1086 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Lactose intolerance, other/unspecified
based on the number of shared cases.
Similar with more cases:
- Lactose intolerance
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10993 | 6393 | 4499 |
| Only index persons | 8968 | 5282 | 3686 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.18 | 0.13 |
| Only index persons | 0.17 | 0.19 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 34.08 | 43.09 | 20.61 |
| Only index persons | 30.81 | 38.17 | 20.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1086 | 742 | 344 |
| Unadjusted period prevalence (%) | 0.22 | 0.25 | 0.15 |
| Median age at first event (years) | 40.76 | 40.05 | 42.28 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 973
- Matched controls
- 9729
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E73.9
ICD-10 Finland
Lactose intolerance, unspecified
1589.9
323.0
485
6
2713A
ICD-9 Finland
Disorders of carbohydrate transport and metabolism, Intestinal disaccharidase deficiencies and disaccharide malabsorption[MALABSORPTIO LACTOSI]
+∞
304.6
276
*
E73.8
ICD-10 Finland
Other lactose intolerance
1587.1
258.3
240
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.2
61.9
491
2353
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.5
61.3
382
1526
UJF32
NOMESCO Finland
Coloscopy
3.5
56.5
336
1281
A06AC01
ATC
ispaghula (psylla seeds); oral
3.3
50.1
324
1292
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
5.8
47.8
145
284
A02BC05
ATC
esomeprazole; systemic
2.3
33.3
437
2511
A02BA02
ATC
ranitidine; systemic
2.9
31.8
229
939
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
4.5
31.0
118
292
A02BC01
ATC
omeprazole; systemic
2.4
29.3
312
1590
A02BC03
ATC
lansoprazole; oral
2.4
28.7
308
1574
A02BC02
ATC
pantoprazole; systemic
2.1
28.3
615
4323
K90.0
ICD-10 Finland
Coeliac disease
6.4
27.6
75
126
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.4
25.6
266
1324
K30
ICD-10 Finland
Functional dyspepsia
3.2
25.1
144
499
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
24.8
318
1744
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.7
24.8
198
851
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
3.5
24.3
122
384
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
24.0
241
1173
K59.1
ICD-10 Finland
Functional diarrhoea
4.6
23.6
84
194
P01AB01
ATC
metronidazole; oral, rectal
2.0
22.9
410
2573
J01MA02
ATC
ciprofloxacin; systemic
2.1
22.8
368
2215
E73
ICD-10 Finland
Lactose intolerance
33.1
22.5
29
9
N03AX16
ATC
pregabalin; oral
2.3
22.1
234
1163
A03CA02
ATC
clidinium and psycholeptics; oral
4.1
22.0
90
238
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.4
21.5
202
943
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
3.1
21.1
123
429
R01AD09
ATC
mometasone; nasal
1.9
21.1
457
3054
R06.0
ICD-10 Finland
Dyspnoea
2.3
21.0
241
1240
N02AX02
ATC
tramadol; systemic, rectal
2.0
20.4
388
2462
UJD02
NOMESCO Finland
Gastroscopy
4.3
20.1
77
191
R07.4
ICD-10 Finland
Chest pain, unspecified
2.2
19.8
241
1269
H02AB04
ATC
methylprednisolone; systemic
2.5
19.3
164
722
C10AC01
ATC
colestyramine; oral
6.2
19.1
52
88
M79.6
ICD-10 Finland
Pain in limb
1.9
19.0
351
2186
R51.80
ICD-10 Finland
Headache
2.4
18.5
176
821
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
4.7
18.4
63
140
R03AC02
ATC
salbutamol; inhalant
1.8
18.2
518
3737
A03FA02
ATC
cisapride; oral, rectal
3.1
17.8
102
352
J02AC01
ATC
fluconazole; systemic
1.8
17.7
409
2744
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
5.5
17.5
52
99
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
4.4
16.8
61
144
N06AB04
ATC
citalopram; systemic
2.1
16.8
213
1135
R01AD08
ATC
fluticasone; nasal
1.9
16.6
295
1793
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
3.5
16.5
80
244
J01FA10
ATC
azithromycin; systemic
1.8
16.5
582
4438
M03BX02
ATC
tizanidine; oral
1.8
16.2
565
4281
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
15.0
15.4
25
17
M01AB05
ATC
diclofenac; systemic, rectal
1.7
15.4
601
4680
N06AX21
ATC
duloxetine; oral
2.6
15.4
119
496
N05AH04
ATC
quetiapine; oral
2.2
15.3
170
851
A07EC02
ATC
mesalazine; oral, rectal
3.3
15.2
78
249
R06AE07
ATC
cetirizine; oral
1.7
15.2
431
3040
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
15.2
360
2401
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
23.8
15.1
21
9
M54.5
ICD-10 Finland
Low back pain
1.8
15.1
317
2028
K29.3
ICD-10 Finland
Chronic superficial gastritis
4.9
14.8
48
101
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
14.8
350
2330
J45.9
ICD-10 Finland
Asthma, unspecified
2.1
14.6
177
919
R42
ICD-10 Finland
Dizziness and giddiness
2.1
14.6
194
1047
J01DA01
ATC
[U] cefalexin; systemic
1.7
14.6
586
4564
J01AA02
ATC
doxycycline; systemic
1.8
14.6
700
5755
N06AA09
ATC
amitriptyline; systemic
2.7
14.4
106
427
M25.5
ICD-10 Finland
Pain in joint
1.9
14.3
265
1618
5641A
ICD-9 Finland
Functional digestive disorders, not elsewhere classified, Irritable colon
27.6
14.3
19
7
G47.3
ICD-10 Finland
Sleep apnoea
2.1
14.0
180
956
A02BC04
ATC
rabeprazole; oral
2.7
13.9
100
399
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
13.9
133
618
H02AB06
ATC
prednisolone; systemic
1.7
13.7
407
2881
E73.0
ICD-10 Finland
Congenital lactase deficiency
+∞
13.6
13
*
M01AE03
ATC
ketoprofen; systemic, rectal
1.8
13.5
332
2220
D01
ICPC
Abdominal pain/cramps general
2.3
13.4
130
608
A06AD11
ATC
lactulose; oral
2.3
13.4
127
586
J01FF01
ATC
clindamycin; systemic
1.9
13.3
243
1473
UJF30
NOMESCO Finland
Ileoscopy through colon
2.6
13.1
98
397
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.7
13.1
89
344
R53
ICD-10 Finland
Malaise and fatigue
2.0
13.1
199
1129
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
17.0
13.0
20
12
A07EC01
ATC
sulfasalazine; oral, rectal
2.6
13.0
95
383
N03AX12
ATC
gabapentin; oral
2.2
12.6
143
719
N05BA04
ATC
oxazepam; oral
1.8
12.5
232
1411
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.8
12.4
82
312
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.9
12.4
51
137
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
3.1
12.3
70
240
L28
ICPC
Limited function/disability (L)
2.2
12.3
132
645
L17
ICPC
Foot/toe symptom/complaint
1.8
12.2
230
1402
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.2
12.1
124
595
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.2
12.0
135
676
A06AC51
ATC
ispaghula, combinations; systemic
3.3
12.0
59
184
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.1
11.9
146
755
C05AA08
ATC
fluocortolone; rectal, topical
2.1
11.8
135
680
K59.09
ICD-10 Finland
Constipation, unspecified
3.1
11.6
62
206
L03
ICPC
Low back symptom/complaint
1.8
11.5
232
1444
D06
ICPC
Abdominal pain localized other
2.6
11.5
86
351
A07DA03
ATC
loperamide; oral
3.8
11.5
48
131
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
5.1
11.5
35
70
J01MA12
ATC
levofloxacin; systemic
2.0
11.4
156
844
E87.6
ICD-10 Finland
Hypokalaemia
10.7
11.3
21
20
N06AX11
ATC
mirtazapine; oral
1.7
11.3
276
1822
1310
FHL
Esophagogastroscopy
17.3
11.2
17
10
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.0
11.2
158
866
J01FA06
ATC
roxithromycin; oral
1.6
11.1
355
2527
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.7
11.1
76
294
N05BA01
ATC
diazepam; systemic, rectal
2.1
11.0
127
643
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.1
10.9
135
702
C01DA14
ATC
isosorbide mononitrate; oral
2.3
10.9
107
503
C10AX09
ATC
ezetimibe; oral
3.0
10.9
63
220
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.3
10.9
106
495
L01
ICPC
Neck symptom/complaint
2.0
10.8
136
715
5790A
ICD-9 Finland
Intestinal malabsorption, Coeliac disease
18.0
10.7
16
9
7879X
ICD-9 Finland
Symptoms involving digestive system, Other symptoms involving digestive system
18.0
10.7
16
9
M02AA07
ATC
piroxicam; topical
1.7
10.7
307
2117
J01FA09
ATC
clarithromycin; systemic
1.7
10.6
297
2035
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.9
10.6
157
878
N06AX16
ATC
venlafaxine; oral
2.0
10.5
136
719
M79.7
ICD-10 Finland
Fibromyalgia
3.5
10.4
47
138
E86
ICD-10 Finland
Volume depletion
19.0
10.3
15
8
M79.1
ICD-10 Finland
Myalgia
2.1
10.3
128
667
Z3226
NOMESCO Finland
Physiotherapist
1.9
10.0
167
972
J01DB01
ATC
cefalexin; oral
1.6
9.9
745
6478
M01AE02
ATC
naproxen; oral, rectal
1.5
9.9
528
4224
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
9.9
389
2894
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.5
9.9
79
335
N02BE01
ATC
paracetamol; systemic, rectal
1.7
9.9
764
6692
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
9.8
139
763
UKC02
NOMESCO Finland
Cystoscopy
2.1
9.8
121
630
A01AB09
ATC
miconazole; local oral
2.3
9.8
87
391
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.5
9.6
447
3456
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
9.6
434
3333
R52.9
ICD-10 Finland
Pain, unspecified
2.3
9.5
85
382
H04.10
ICD-10 Finland
Dry eye syndrome
2.2
9.4
94
447
A03FA01
ATC
metoclopramide; systemic, rectal
1.8
9.3
182
1115
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.5
9.3
73
308
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
9.2
470
3700
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.0
9.2
122
651
AN1
HP
Coronary angiography
2.5
9.2
74
314
M02AA10
ATC
ketoprofen; topical
1.9
9.1
139
783
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.6
9.1
259
1767
R07.3
ICD-10 Finland
Other chest pain
2.3
9.1
81
364
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.7
9.1
212
1372
R03AC03
ATC
terbutaline; inhalant
1.9
9.1
129
708
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.6
9.0
64
254
M54.4
ICD-10 Finland
Lumbago with sciatica
1.9
9.0
148
854
V700A
ICD-9 Finland
General medical examination, Routine general medical examination at a health care facility
4.1
9.0
34
86
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.6
9.0
62
244
K50.9
ICD-10 Finland
Crohn disease, unspecified
5.3
9.0
26
50
J45
ICD-10 Finland
Asthma
2.1
9.0
98
484
A02BX02
ATC
sucralfate; oral
3.3
8.9
44
139
N05CF01
ATC
zopiclone; oral
1.6
8.9
261
1796
C07AA05
ATC
propranolol; systemic
1.8
8.9
180
1112
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.3
8.9
86
401
L02
ICPC
Back symptom/complaint
2.2
8.9
95
462
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.2
8.9
88
415
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.7
8.9
233
1558
L13
ICPC
Hip symptom/complaint
1.9
8.9
133
745
N06AB06
ATC
sertraline; oral
2.1
8.9
106
544
R01BA52
ATC
pseudoephedrine, combinations; oral
1.6
8.8
261
1797
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.9
8.8
127
701
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
8.8
364
2721
J01EA01
ATC
trimethoprim; systemic
1.6
8.8
235
1578
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
2.5
8.7
69
292
R10.0
ICD-10 Finland
Acute abdomen
3.7
8.7
37
104
C03CA01
ATC
furosemide; systemic
1.7
8.7
192
1220
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.5
8.7
369
2776
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.8
8.7
54
198
M01AH02
ATC
rofecoxib; oral
2.0
8.6
108
564
H02AB07
ATC
prednisone; oral
1.9
8.5
123
679
5355X
ICD-9 Finland
Gastritis and duodenitis, Unspecified gastritis and gastroduodenitis
27.8
8.5
11
*
1370
FHL
Colonoscopy, whole colon
20.2
8.5
12
6
N03AE01
ATC
clonazepam; systemic
2.7
8.4
57
220
A01AB04
ATC
amphotericin B; local oral
3.0
8.4
48
167
R03AK07
ATC
formoterol and budesonide; inhalant
1.8
8.4
166
1020
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.1
8.4
90
443
M03BC51
ATC
orphenadrine, combinations; systemic
1.6
8.4
247
1696
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.9
8.3
120
663
R03DC03
ATC
montelukast; oral
1.8
8.3
146
863
SPAT1336
SPAT
Request for examination
3.2
8.3
42
136
K50.8
ICD-10 Finland
Other Crohn disease
5.0
8.2
25
51
M01AC06
ATC
meloxicam; systemic, rectal
1.6
8.2
298
2154
P06
ICPC
Sleep disturbance
2.1
8.2
93
467
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.8
8.2
155
938
K50.0
ICD-10 Finland
Crohn disease of small intestine
5.2
8.2
24
47
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.3
8.2
76
347
AA1AD
NOMESCO Finland
CT of head and brain
1.7
8.2
164
1010
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
2.8
8.2
49
178
M54.3
ICD-10 Finland
Sciatica
2.7
8.1
55
212
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.9
8.1
122
684
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.8
8.1
51
189
D07AC13
ATC
mometasone; topical
1.6
8.1
239
1642
5301A
ICD-9 Finland
Diseases of oesophagus, Oesophagitis[OESOPHAGITIS REFLUENS]
11.8
8.1
14
12
M01AH05
ATC
etoricoxib; oral
1.5
8.1
499
4050
XF402
NOMESCO Finland
ECG with work load test
2.2
8.0
76
354
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
2.6
8.0
55
216
F34.1
ICD-10 Finland
Dysthymia
3.3
8.0
39
123
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.1
8.0
91
457
R06AX27
ATC
desloratadine; oral
1.6
8.0
262
1849
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
8.0
227
1546
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
2.0
7.9
103
544
C10AA05
ATC
atorvastatin; oral
1.6
7.9
225
1527
I20.09
ICD-10 Finland
Unstable angina
3.3
7.9
38
119
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
7.9
163
1013
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.0
7.9
45
157
M05BA07
ATC
risedronic acid; oral
3.5
7.9
35
103
C07AB07
ATC
bisoprolol; oral
1.5
7.9
325
2418
M01AH01
ATC
celecoxib; oral (coxibs)
1.8
7.8
147
887
N06AB10
ATC
escitalopram; oral
1.7
7.8
185
1196
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
3.1
7.8
41
137
A07EA06
ATC
budesonide; oral, local oral
3.0
7.7
44
152
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
2.3
7.7
73
336
N05CD07
ATC
temazepam; oral
2.0
7.7
104
561
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.5
7.7
60
253
FN1AT
NOMESCO Finland
Endovascular dilatation of coronary arteries (PTCA)
3.8
7.7
31
84
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.6
7.7
203
1352
R05FB02
ATC
cough suppressants and expectorants
1.5
7.7
307
2263
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.6
7.7
56
227
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.0
7.7
97
509
N05CF02
ATC
zolpidem; oral
1.7
7.6
153
940
S01GX01
ATC
cromoglicic acid; ophthalmic
1.7
7.6
188
1227
C10AA07
ATC
rosuvastatin; oral
1.7
7.6
150
919
R01AD12
ATC
fluticasone furoate; nasal
1.5
7.6
276
1987
XQ800
NOMESCO Finland
Prick test
2.1
7.6
86
430
N06AB03
ATC
fluoxetine; oral
1.9
7.6
114
639
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.7
7.6
156
969
M03BC01
ATC
orphenadrine (citrate); systemic
1.6
7.6
206
1384
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
2.3
7.5
67
301
G44.2
ICD-10 Finland
Tension-type headache
1.8
7.5
128
749
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.0
7.5
96
503
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.8
7.5
122
700
D11
ICPC
Diarrhoea
1.9
7.5
108
597
N05BE01
ATC
buspirone; oral
3.5
7.5
33
97
WX722
NOMESCO Finland
PEEP
3.0
7.4
40
137
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.9
7.3
99
534
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.7
7.3
155
968
M01AX01
ATC
nabumetone; oral
2.8
7.3
44
161
B01AC04
ATC
clopidogrel; oral
2.1
7.3
84
424
M54.2
ICD-10 Finland
Cervicalgia
2.3
7.3
66
301
N39.3
ICD-10 Finland
Stress incontinence
2.3
7.3
65
292
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.6
7.3
232
1620
M54.6
ICD-10 Finland
Pain in thoracic spine
2.3
7.3
63
281
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.6
7.3
50
196
M05BA04
ATC
alendronic acid; oral
2.2
7.2
70
328
I25.2
ICD-10 Finland
Old myocardial infarction
2.9
7.2
41
143
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
1.9
7.2
101
552
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
1.7
7.2
155
975
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.3
7.1
64
288
A10AE04
ATC
insulin glargine; parenteral
2.3
7.1
64
289
G04BD07
ATC
tolterodine; oral
2.7
7.1
46
175
Z01.2
ICD-10 Finland
Dental examination
1.5
7.1
374
2913
K08.80
ICD-10 Finland
Toothache NOS
2.1
7.1
78
386
R03BA05
ATC
fluticasone; inhalant
1.7
7.1
165
1063
R02
ICPC
Shortness of breath/dyspnoea
1.9
7.1
97
528
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.2
7.0
73
352
D64.9
ICD-10 Finland
Anaemia, unspecified
2.2
7.0
71
340
H03AA01
ATC
levothyroxine sodium; systemic
1.6
7.0
192
1289
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.5
7.0
282
2077
R12
ICD-10 Finland
Heartburn
2.2
7.0
69
328
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.8
7.0
128
766
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.7
7.0
133
807
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.6
7.0
49
196
1300
FHL
Esophagogastroduodenoscopy (also includes staining)
5.5
6.9
19
35
F32
ICD-10 Finland
Depressive episode
2.5
6.8
51
210
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
9.4
6.8
13
14
M81.5
ICD-10 Finland
Idiopathic osteoporosis
9.4
6.8
13
14
G04CA01
ATC
alfuzosin; oral
2.2
6.8
67
317
SPAT1212
SPAT
Extensive examination of musculoskeletal system
2.1
6.7
76
383
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.0
6.7
84
440
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
3.0
6.7
36
123
J01AA04
ATC
lymecycline; systemic
1.8
6.7
122
728
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
5.0
6.7
20
41
M01AX17
ATC
nimesulide; oral
1.6
6.7
183
1228
K59.0
ICD-10 Finland
Constipation
2.5
6.6
50
208
7865A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Chest pain
5.9
6.6
17
29
R05
ICPC
Cough
1.6
6.6
198
1359
SPAT1262
SPAT
Handing over of treatment supplies
1.8
6.6
120
717
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.4
6.6
55
239
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.5
6.6
235
1679
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.2
6.6
61
282
E0000UV
ATC
NA
1.4
6.5
344
2664
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.4
6.5
465
3816
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.5
6.5
251
1824
R11
ICD-10 Finland
Nausea and vomiting
2.1
6.5
74
373
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
6.5
470
3870
F61.0
ICD-10 Finland
Mixed personality disorders
4.5
6.5
21
47
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.7
6.5
147
936
26998
ICD-8 Finland
Other nutritional deficiency, Aliae definitae
70.3
6.4
7
*
R19.4
ICD-10 Finland
Change in bowel habit
3.6
6.4
27
77
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
1.9
6.4
97
545
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.6
6.4
190
1299
E83.50
ICD-10 Finland
Hypercalcemia
14.4
6.4
10
7
T78.4
ICD-10 Finland
Allergy, unspecified
2.4
6.4
51
217
R00.2
ICD-10 Finland
Palpitations
2.2
6.4
64
305
R19.8
ICD-10 Finland
Other specified symptoms and signs involving the digestive system and abdomen
4.9
6.4
19
39
A02BA03
ATC
famotidine; systemic
2.8
6.4
38
139
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
4.2
6.3
22
53
A07AA02
ATC
nystatin; oral
2.3
6.3
56
251
00919
ICD-8 Finland
Diarrhoeal disease, Diarrhoea
11.1
6.3
11
10
M50.3
ICD-10 Finland
Other cervical disc degeneration
4.6
6.3
20
44
M51.9
ICD-10 Finland
Intervertebral disc disorder, unspecified
4.6
6.3
20
44
1470
FHL
Rectoscopy
9.3
6.3
12
13
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.0
6.3
81
430
N03AF01
ATC
carbamazepine; oral, rectal
2.5
6.3
45
183
K20
ICD-10 Finland
Oesophagitis
4.8
6.2
19
40
X57
ICD-10 Finland
Unspecified privation
4.0
6.2
23
59
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
6.2
635
5545
R4110
NOMESCO Finland
Physiotherapy
1.5
6.2
204
1429
R52.2
ICD-10 Finland
Other chronic pain
3.0
6.2
33
113
Z71.8
ICD-10 Finland
Other specified counselling
1.5
6.2
208
1466
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
3.4
6.2
27
80
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
6.1
300
2287
D07AB02
ATC
hydrocortisone butyrate; topical
1.5
6.1
226
1626
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.2
6.1
60
284
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.8
6.1
102
594
JAH01
NOMESCO Finland
Laparoscopy
2.4
6.1
47
199
Z3231
NOMESCO Finland
Registered nurse
1.5
6.1
224
1610
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.6
6.1
178
1214
C10AA01
ATC
simvastatin; oral
1.5
6.0
244
1789
Mortality – FinRegistry
↥Association
Association between endpoint E4_LACTONAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_LACTONAS | 1.268 [1.11, 1.45] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.206 |
During the follow-up period (1.1.1998 — 31.12.2019), 473 out of 3734 females with E4_LACTONAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_LACTONAS | 1.319 [1.13, 1.53] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 261 out of 2534 males with E4_LACTONAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_LACTONAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.096% | 0.259% |
| 5 | 0.704% | 1.519% |
| 10 | 1.844% | 3.612% |
| 15 | 3.403% | 6.835% |
| 20 | 6.048% | 11.223% |
Relationships between endpoints
↥Index endpoint: E4_LACTONAS – Lactose intolerance, other/unspecified
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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