No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
768 |
4. Check minimum number of eventsNone |
768 |
5. Include endpointsNone |
768 |
6. Filter based on genotype QC (FinnGen only) |
768 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H34
- Name in latin
- Occlusio arteriae centralis retinae
Similar endpoints
↥List of similar endpoints to
Central retinal artery occlusion
based on the number of shared cases.
Similar with more cases:
- Retinal vascular disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6473 | 2574 | 3815 |
| Only index persons | 5023 | 2088 | 2935 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.07 | 0.11 |
| Only index persons | 0.10 | 0.08 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 72.13 | 75.00 | 70.25 |
| Only index persons | 72.80 | 75.34 | 71.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 768 | 263 | 505 |
| Unadjusted period prevalence (%) | 0.18 | 0.09 | 0.22 |
| Median age at first event (years) | 70.53 | 70.69 | 70.44 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 701
- Matched controls
- 7007
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H34.1
ICD-10 Finland
Central retinal artery occlusion
+∞
323.0
656
*
H34.8
ICD-10 Finland
Other retinal vascular occlusions
+∞
114.8
107
*
CKC12
NOMESCO Finland
Photocoagulation of retina
137.2
109.8
115
10
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
274.0
95.1
95
*
H34.2
ICD-10 Finland
Other retinal artery occlusions
1015.2
93.1
89
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
10.9
73.4
149
169
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
13.1
56.6
103
91
H43.1
ICD-10 Finland
Vitreous haemorrhage
46.9
55.9
68
16
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.6
52.8
148
272
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
65.4
52.3
60
10
AA1AD
NOMESCO Finland
CT of head and brain
3.6
50.1
303
1216
B01AC04
ATC
clopidogrel; oral
3.7
47.6
260
953
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
443.0
42.6
42
*
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
8.2
42.5
100
140
XCK10
NOMESCO Finland
Photography of fundus of eye
5.3
42.1
141
317
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
36.7
37.7
48
14
PAF14
NOMESCO Finland
Thrombendarterectomy of internal carotid artery
13.1
37.5
67
56
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
7.8
37.1
89
128
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
4.3
32.5
133
362
XCD20
NOMESCO Finland
Photoangiography of eye
75.5
32.2
36
5
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
5.6
31.9
98
196
G45.3
ICD-10 Finland
Amaurosis fugax
12.1
31.4
58
52
H53.1
ICD-10 Finland
Subjective visual disturbances
6.3
30.7
85
149
C10AA05
ATC
atorvastatin; oral
2.5
30.7
376
2187
3623A
ICD-9 Finland
Other retinal disorders, Retinal vascular occlusion[OCCLUSIO ARTERIAE CENTRALIS RETINAE]
+∞
30.4
29
*
XCK00
NOMESCO Finland
Perimetry
5.0
30.2
104
237
S01ED51
ATC
timolol, combinations; ophthalmic
4.4
28.7
113
295
H53.9
ICD-10 Finland
Visual disturbance, unspecified
9.5
28.3
59
67
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
269.9
25.9
26
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.3
25.7
149
533
37702
ICD-8 Finland
Other diseases of retina and optic nerve, Embolia, spasmus arteriae centralis retinae
+∞
20.9
20
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.8
20.8
147
597
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.8
20.8
153
638
C10AA01
ATC
simvastatin; oral
2.1
20.4
421
2903
PAN14
NOMESCO Finland
Plastic repair of arteries internal carotid artery
19.5
20.1
30
16
H54.4
ICD-10 Finland
Blindness, monocular
59.3
20.0
23
*
H3600, E113
ICD-10 Finland
NA
+∞
19.9
19
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.8
18.9
136
554
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.1
18.5
302
1858
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.5
18.0
167
788
XCH00
NOMESCO Finland
Eye pressure measurement
5.0
17.9
58
123
CKC10
NOMESCO Finland
Local photocoagulation of retina
68.4
17.8
20
*
H33.3
ICD-10 Finland
Retinal breaks without detachment
+∞
17.8
17
*
H3603, E113
ICD-10 Finland
NA
+∞
17.8
17
*
CKC20
NOMESCO Finland
Cryopexy of undetached retina
+∞
17.8
17
*
I63.0
ICD-10 Finland
Cerebral infarction due to thrombosis of precerebral arteries
8.7
17.7
38
46
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
17.3
358
2399
I10
ICD-10 Finland
Essential (primary) hypertension
2.0
17.2
491
3734
H3603, E103
ICD-10 Finland
NA
+∞
16.7
16
*
C08CA01
ATC
amlodipine; oral
2.0
16.3
322
2105
I35.0
ICD-10 Finland
Aortic (valve) stenosis
3.0
15.9
95
343
H34.9
ICD-10 Finland
Retinal vascular occlusion, unspecified
+∞
15.7
15
*
C03CA01
ATC
furosemide; systemic
2.0
15.7
319
2099
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
27.0
15.7
21
8
S01EC01
ATC
acetazolamide; systemic
6.1
15.5
42
72
WX140
NOMESCO Finland
Parabulbar anesthesy
6.0
15.5
43
76
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
18.2
15.2
23
13
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
2.9
15.2
99
378
I50.9
ICD-10 Finland
Heart failure, unspecified
2.2
14.7
183
981
H34.0
ICD-10 Finland
Transient retinal artery occlusion
+∞
14.6
14
*
H33.0
ICD-10 Finland
Retinal detachment with retinal break
+∞
14.6
14
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.2
14.2
174
928
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
18.0
13.9
21
12
H53.4
ICD-10 Finland
Visual field defects
5.9
13.5
37
65
B01AA03
ATC
warfarin; systemic
1.9
13.3
234
1435
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.8
12.9
293
1966
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
10.8
12.8
24
23
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
3.8
12.7
54
150
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.9
12.7
257
1650
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
6.1
12.7
34
58
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
1.9
12.7
227
1399
CKC15
NOMESCO Finland
Panretinal photocoagulation
71.1
12.6
14
*
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
2.4
12.3
116
542
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
5.4
12.3
36
69
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
2.0
12.1
174
982
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
2.7
11.9
85
342
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
4.8
11.9
39
85
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
15.0
11.8
19
13
PA6AD
NOMESCO Finland
CT of neck arteries
7.5
11.8
27
37
H25.1
ICD-10 Finland
Senile nuclear cataract
1.8
11.8
250
1624
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.5
11.8
98
430
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
23.3
11.6
16
7
B01AC07
ATC
dipyridamole; systemic
2.7
11.6
80
316
205
Kela drug reimbursment
Chronic hypertension
1.8
11.6
280
1894
S01EE01
ATC
latanoprost; ophthalmic
2.9
11.5
71
261
CHF15
NOMESCO Finland
Cryotherapy of ciliary body
+∞
11.5
11
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
3.0
11.4
66
233
C07AB07
ATC
bisoprolol; oral
1.7
11.4
399
3029
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
2.3
11.2
107
501
H26.4
ICD-10 Finland
After-cataract
2.5
11.2
89
379
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.9
11.2
217
1361
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
2.9
11.2
68
247
CS494
NOMESCO Finland
Other visual field testing
5.6
11.0
31
57
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
15.8
10.9
17
11
114
Kela drug reimbursment
Glaucoma
2.4
10.8
95
429
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
60.9
10.6
12
*
H36.00
ICD-10 Finland
Diabetic background retinopathy
60.9
10.6
12
*
AN1
HP
Coronary angiography
2.1
10.4
137
741
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
111.6
10.4
11
*
H35.37
ICD-10 Finland
Macular holes
+∞
10.4
10
*
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
+∞
10.4
10
*
H3601, E113
ICD-10 Finland
NA
+∞
10.4
10
*
H35.6
ICD-10 Finland
Retinal haemorrhage
+∞
10.4
10
*
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
16.3
10.4
16
10
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
4.9
10.4
33
70
CJB10
NOMESCO Finland
Laser discission of secondary cataract
2.6
10.4
78
323
H54.6
ICD-10 Finland
Moderate visual impairment, monocular
33.0
10.4
13
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
10.2
10.1
19
19
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.0
10.0
134
730
PA7BD
NOMESCO Finland
CT angiography of neck and brain
6.1
9.9
26
44
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.9
9.9
159
928
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.8
9.8
185
1141
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.7
9.8
239
1605
H21.1
ICD-10 Finland
Other vascular disorders of iris and ciliary body
55.8
9.7
11
*
C10AX09
ATC
ezetimibe; oral
2.3
9.7
97
466
ZXA05
NOMESCO Finland
Left side
1.8
9.6
197
1247
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
3.0
9.6
55
193
N02BE01
ATC
paracetamol; systemic, rectal
1.8
9.5
569
4919
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
101.3
9.4
10
*
H3600, E103
ICD-10 Finland
NA
+∞
9.4
9
*
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
5.3
9.2
27
53
D64.9
ICD-10 Finland
Anaemia, unspecified
2.1
9.1
106
542
C08CA13
ATC
lercanidipine; oral
2.1
9.1
110
573
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.8
9.1
60
229
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.2
9.1
96
474
PD5BD
NOMESCO Finland
Extensive CT of aorta
4.6
9.1
30
67
A10AA01
ATC
NA
6.6
9.0
22
34
F05
ICPC
Visual disturbance other
4.8
9.0
29
63
I70.9
ICD-10 Finland
Generalized and unspecified atherosclerosis
4.3
9.0
32
77
C09AA05
ATC
ramipril; oral
1.7
9.0
225
1512
PA6AE
NOMESCO Finland
Ulrasound examination of neck vasculature
8.8
8.8
18
21
C01DA14
ATC
isosorbide mononitrate; oral
1.8
8.8
187
1198
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
50.6
8.7
10
*
I63.1
ICD-10 Finland
Cerebral infarction due to embolism of precerebral arteries
5.9
8.7
23
40
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
8.4
8.6
18
22
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
4.1
8.5
32
81
TCG40
NOMESCO Finland
Measurement of higher-grade errors of refraction
27.9
8.5
11
*
H47.2
ICD-10 Finland
Optic atrophy
20.3
8.5
12
6
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.4
8.5
39
118
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
+∞
8.3
8
*
H3601, E103
ICD-10 Finland
NA
+∞
8.3
8
*
H35.8
ICD-10 Finland
Other specified retinal disorders
+∞
8.3
8
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.8
8.2
169
1067
103
Kela drug reimbursment
Diabetes, insulin-treated
1.7
8.2
218
1485
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.9
8.1
124
708
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.7
8.0
202
1354
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
8.0
205
1380
S01ED01
ATC
timolol; ophthalmic
3.0
7.9
43
147
S01EC54
ATC
brinzolamide, combinations; ophthalmic
6.2
7.9
20
33
A02BC02
ATC
pantoprazole; systemic
1.6
7.9
420
3409
R4120
NOMESCO Finland
Occupational therapy
2.8
7.8
50
190
XCD10
NOMESCO Finland
Electrophysiological examination of eye
4.3
7.8
27
64
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
3.3
7.8
38
121
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.3
7.7
68
307
A10AA02
ATC
NA
3.9
7.7
30
79
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.6
7.6
233
1643
AA1
HP
Conventional CABG
3.5
7.5
33
97
I50.0
ICD-10 Finland
Congestive heart failure
2.0
7.5
91
477
PAW37
NOMESCO Finland
Biopsy of temporal artery
7.8
7.4
16
21
ZXD05
NOMESCO Finland
Urgent procedure
1.6
7.4
217
1514
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
8.5
7.3
15
18
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
+∞
7.3
7
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
4.5
7.2
24
55
S01EE03
ATC
bimatoprost; ophthalmic
4.0
7.1
27
70
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
2.6
7.1
49
195
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
7.1
237
1705
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.9
7.0
27
71
C07AB02
ATC
metoprolol; systemic
1.6
6.9
187
1269
C03DA01
ATC
spironolactone; oral
1.9
6.9
100
561
A46
ICD-10 Finland
Erysipelas
1.8
6.8
115
679
I74.3
ICD-10 Finland
Embolism and thrombosis of arteries of lower extremities
5.7
6.8
18
32
I71.4
ICD-10 Finland
Abdominal aortic aneurysm, without mention of rupture
2.9
6.8
39
139
T90
ICPC
Diabetes non-insulin dependent
1.7
6.7
166
1100
FNA01
NOMESCO Finland
Anastomosis to coronary artery from internal mammary artery, one distal anastamosis
2.2
6.6
63
295
FME20
NOMESCO Finland
Transvenous aortic valve replacement via femoral artery
4.7
6.6
21
46
Z71.9
ICD-10 Finland
Counselling, unspecified
2.8
6.6
40
149
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
1.9
6.5
92
510
H43.8
ICD-10 Finland
Other disorders of vitreous body
2.4
6.4
51
218
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
70.4
6.4
7
*
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
8.3
6.3
13
16
M04AA01
ATC
allopurinol; systemic
1.7
6.3
130
816
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.4
6.3
51
222
Z3229
NOMESCO Finland
Other healthcare associate professional
2.2
6.3
63
303
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
18.2
6.3
9
5
H46
ICD-10 Finland
Optic neuritis
18.2
6.3
9
5
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
6.3
182
1254
CK2K4
NOMESCO Finland
Red-free imaging of ocular fundus
+∞
6.3
6
*
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
4.2
6.2
22
54
S01EA03
ATC
apraclonidine; ophthalmic
7.1
6.2
14
20
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
26.9
6.2
8
*
CKD40
NOMESCO Finland
Endophotocoagulation of retina
26.9
6.2
8
*
ZXA00
NOMESCO Finland
Right side
1.6
6.2
187
1301
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
2.3
6.2
55
250
I63.2
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
5.4
6.2
17
32
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
6.2
136
868
280
Kela drug reimbursment
Clopidogrel
3.6
6.2
26
75
I20.09
ICD-10 Finland
Unstable angina
2.1
6.1
64
313
Z2446
NOMESCO Finland
Social worker
2.4
6.1
47
200
F01
ICPC
Eye pain
4.4
6.1
20
46
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
3.9
6.0
23
61
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
3.9
6.0
23
61
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.8
6.0
36
133
Mortality – FinRegistry
↥Association
Association between endpoint H7_CENTRRETARTOCC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CENTRRETARTOCC | 1.489 [1.29, 1.71] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.027 |
During the follow-up period (1.1.1998 — 31.12.2019), 869 out of 1918 females with H7_CENTRRETARTOCC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CENTRRETARTOCC | 1.483 [1.29, 1.7] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 1259 out of 2717 males with H7_CENTRRETARTOCC died.
Mortality risk
Mortality risk for people of age
years, who have H7_CENTRRETARTOCC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.101% | 0.298% |
| 5 | 0.648% | 1.86% |
| 10 | 1.66% | 4.71% |
| 15 | 3.185% | 8.66% |
| 20 | 5.884% | 14.684% |
Relationships between endpoints
↥Index endpoint: H7_CENTRRETARTOCC – Central retinal artery occlusion
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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