lymphatic system disease: a disease in lymphatic system
Other noninfective disorders of lymphatic vessels and lymph nodes
DOID EFO Endpoint Browser PheWeb
I9_LYMPHOTH
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1318 |
4. Check minimum number of eventsNone |
1318 |
5. Include endpointsNone |
1318 |
6. Filter based on genotype QC (FinnGen only) |
1318 |
Control definitions (FinnGen only)
- Control exclude
- I9_DISVEINLYMPH
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- I80-I89
- Name in latin
- Aliae morbositates non infectiosae vasorum et nodorum lymphaticorum
Similar endpoints
↥List of similar endpoints to
Other noninfective disorders of lymphatic vessels and lymph nodes
based on the number of shared cases.
Similar with more cases:
- Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9748 | 5979 | 3698 |
| Only index persons | 8497 | 5284 | 3213 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.14 | 0.17 | 0.10 |
| Only index persons | 0.17 | 0.19 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 56.39 | 58.40 | 53.03 |
| Only index persons | 55.00 | 56.91 | 51.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1318 | 888 | 430 |
| Unadjusted period prevalence (%) | 0.27 | 0.30 | 0.19 |
| Median age at first event (years) | 56.84 | 55.61 | 59.36 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1163
- Matched controls
- 11630
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I89.0
ICD-10 Finland
Lymphoedema, not elsewhere classified
1064.5
323.0
689
16
I89.1
ICD-10 Finland
Lymphangitis
1024.7
258.7
244
*
I89.9
ICD-10 Finland
Noninfective disorder of lymphatic vessels and lymph nodes, unspecified
+∞
171.2
160
*
A46
ICD-10 Finland
Erysipelas
8.0
158.4
414
749
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
18.9
135.2
214
137
R60.0
ICD-10 Finland
Localized oedema
7.5
125.8
336
600
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
6.9
96.4
265
475
PJ1AN
NOMESCO Finland
Lymphsystem isotope imaging
249.4
90.9
92
*
I83.9
ICD-10 Finland
Varicose veins of lower extremities without ulcer or inflammation
23.0
83.4
122
59
PHD99
NOMESCO Finland
Resection of other vein
+∞
82.3
78
*
C03CA01
ATC
furosemide; systemic
3.6
79.9
473
1843
J01CE08
ATC
benzathine benzylpenicillin; parenteral
38.4
70.0
89
25
B01AB05
ATC
enoxaparin; parenteral
3.2
66.6
475
2065
PHD76
NOMESCO Finland
Resection of long saphenous vein
641.1
62.4
61
*
45499
ICD-8 Finland
Varicose veins of lower extremities, Other and unspecified, without ulcer
+∞
61.0
58
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
11.7
56.7
108
101
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
6.0
53.1
156
291
4549X
ICD-9 Finland
Varicose veins of lower extremities, Without mention of ulcer or inflammation
+∞
49.3
47
*
I89.8
ICD-10 Finland
Other specified noninfective disorders of lymphatic vessels and lymph nodes
497.8
48.7
48
*
J01DB01
ATC
cefalexin; oral
3.3
48.2
1021
7978
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
48.9
46.4
56
12
H02AB02
ATC
dexamethasone; systemic
3.9
46.1
213
635
A03FA01
ATC
metoclopramide; systemic, rectal
2.8
44.7
351
1539
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
9.1
44.0
95
112
R60.9
ICD-10 Finland
Oedema, unspecified
5.8
41.9
126
240
I97.2
ICD-10 Finland
Postmastectomy lymphoedema syndrome
25.4
41.4
58
24
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
38.8
41.3
52
14
A08
ICPC
Swelling
6.4
41.1
113
192
ZZQ70
NOMESCO Finland
Free microvascular graft of lymph nodes
114.2
41.0
44
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
6.1
40.0
114
203
I80.0
ICD-10 Finland
Phlebitis and thrombophlebitis of superficial vessels of lower extremities
19.7
39.6
60
32
PHM76
NOMESCO Finland
Endovenous obliteration of v.saphena magna
+∞
37.7
36
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
37.2
554
3345
J01FF01
ATC
clindamycin; systemic
2.5
37.1
389
1976
HAE10
NOMESCO Finland
Reconstruction of breast using graft or flap
11.2
35.0
67
63
PJW20
NOMESCO Finland
Lymphovenous shunt
+∞
34.5
33
*
S97
ICPC
Chronic ulcer skin
5.4
34.5
108
215
JN4BD
NOMESCO Finland
Extensive body CT
3.5
34.3
178
575
ZZQ00
NOMESCO Finland
Free microvascular graft of skin
28.1
33.9
46
17
PH2DE
NOMESCO Finland
Ultrasound examination of bloodflow in veins of lower extremity with Doppler method
36.2
33.0
42
12
I80.29
ICD-10 Finland
Phlebitis and thrombophlebitis of other deep vessels of lower extremities
23.3
31.5
45
20
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
5.0
31.2
104
222
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
3.8
31.1
142
412
J01MA12
ATC
levofloxacin; systemic
2.6
29.9
255
1137
ZX120
NOMESCO Finland
Intravenous
3.3
29.4
158
522
ZXE20
NOMESCO Finland
More than three and less than five hours
2.8
29.2
217
890
A04AA02
ATC
granisetron; systemic, transdermal
3.9
28.7
124
342
S76
ICPC
Skin infection other
4.6
28.7
104
243
115
Kela drug reimbursment
Breast cancer
3.2
28.4
163
563
R4110
NOMESCO Finland
Physiotherapy
2.2
28.3
359
1946
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.6
28.2
244
1093
M79.6
ICD-10 Finland
Pain in limb
2.1
27.8
455
2755
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
27.6
358
1958
N02BE01
ATC
paracetamol; systemic, rectal
2.5
27.6
1017
8563
128
Kela drug reimbursment
Cancers of female genital organs
8.7
27.5
60
72
WF003
NOMESCO Finland
Adjuvant radiotherapy
5.3
27.4
87
176
C03DA01
ATC
spironolactone; oral
3.2
27.4
157
540
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.1
27.1
162
576
HA1AA
NOMESCO Finland
X-ray mammography
3.3
26.9
146
485
N02AX02
ATC
tramadol; systemic, rectal
2.0
26.7
530
3449
TPH04
NOMESCO Finland
Cathetrisation of vein
2.3
26.5
281
1393
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
26.4
467
2899
PJD64
NOMESCO Finland
Laparoscopic dissection of iliac lymph nodes
9.5
26.2
54
59
B01AA03
ATC
warfarin; systemic
2.6
26.1
224
993
PHM99
NOMESCO Finland
Endovenous obliteration of other vein
266.2
25.8
26
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.7
25.7
191
780
5611
FHL
Vena saphena Magna and / or swarm of nodule and possible local emissions
71.5
24.9
28
*
SPAT1229
SPAT
Assessment of need for aid
3.3
24.5
131
429
N02AA05
ATC
oxycodone; systemic
2.6
24.2
195
833
JN4AD
NOMESCO Finland
Body CT examination
3.5
24.0
119
368
E0000UV
ATC
NA
1.9
24.0
492
3200
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
10.2
23.7
47
48
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.6
23.2
184
778
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.8
23.1
165
656
PJW99
NOMESCO Finland
Other operation on lymphatic system
15.1
23.0
38
26
L03AA13
ATC
pegfilgrastim; parenteral
4.6
23.0
82
188
R50.9
ICD-10 Finland
Fever, unspecified
2.6
23.0
188
809
C54.11
ICD-10 Finland
Adenocarcinoma of the endometrium
6.5
22.9
60
96
QDJ00
NOMESCO Finland
Liposuction in lower extremity
85.2
22.7
25
*
S18
ICPC
Laceration/cut
1.9
22.5
492
3253
L02BA01
ATC
tamoxifen; oral
4.2
22.4
88
222
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
4.9
22.4
75
161
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.9
21.8
424
2680
HAE20
NOMESCO Finland
Reconstruction of areola and mamilla using graft or flap
7.4
21.7
52
73
HAC20
NOMESCO Finland
Total mastectomy
3.9
21.6
92
250
QCJ00
NOMESCO Finland
Liposuction in upper limb
44.2
21.5
26
6
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
3.8
21.1
94
266
I80.1
ICD-10 Finland
Phlebitis and thrombophlebitis of femoral vein
61.2
20.9
24
*
Q82.0
ICD-10 Finland
Hereditary lymphoedema
+∞
20.9
20
*
B01AB10
ATC
tinzaparin; parenteral
3.3
20.7
110
358
R4120
NOMESCO Finland
Occupational therapy
3.4
20.6
105
331
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.2
20.6
234
1185
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.3
20.5
220
1081
J01MA02
ATC
ciprofloxacin; systemic
1.8
20.1
451
2972
45709
ICD-8 Finland
Non-infective disease of lymphatic channels, Unspecified
+∞
19.8
19
*
5612
FHL
Local excisions and / or perforations of relapsing varicose veins
+∞
19.8
19
*
TQW20
NOMESCO Finland
Tatoe
8.9
19.7
42
49
L03.1
ICD-10 Finland
Cellulitis of other parts of limb
5.8
19.5
56
101
A02BC02
ATC
pantoprazole; systemic
1.8
19.4
748
5844
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
19.3
465
3131
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
3.4
19.2
98
309
QD9S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in lower extremities, unspecified
18.6
19.2
29
16
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
6.0
19.1
53
92
Z3226
NOMESCO Finland
Physiotherapist
2.1
18.9
238
1257
L03AA02
ATC
filgrastim; parenteral
5.7
18.8
54
98
I82.88
ICD-10 Finland
Embolism and thrombosis of other specified veins
24.1
18.7
26
11
ZXA00
NOMESCO Finland
Right side
1.9
18.7
322
1924
I50.9
ICD-10 Finland
Heart failure, unspecified
2.5
18.4
155
673
ZXA05
NOMESCO Finland
Left side
2.0
18.4
299
1748
H02AB06
ATC
prednisolone; systemic
1.7
18.3
552
3966
N03AX16
ATC
pregabalin; oral
2.0
18.3
294
1709
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
18.0
343
2119
I80.8
ICD-10 Finland
Phlebitis and thrombophlebitis of other sites
53.4
18.0
21
*
L14
ICPC
Leg/thigh symptom/complaint
3.0
18.0
109
389
E66.01
ICD-10 Finland
Obesity due to excess calories
3.0
18.0
109
389
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
6.8
18.0
45
68
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
3.0
17.8
106
373
4571A
ICD-9 Finland
Non-infective disorders of lymphatic channels, Other lymphoedema
+∞
17.7
17
*
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
5.3
17.7
54
105
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
17.7
262
1473
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
3.2
17.1
92
302
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.4
16.9
151
677
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
4.0
16.6
68
179
Z3231
NOMESCO Finland
Registered nurse
1.8
16.6
324
2011
ZXE00
NOMESCO Finland
One hour or less
1.7
16.4
456
3166
I83.2
ICD-10 Finland
Varicose veins of lower extremities with both ulcer and inflammation
40.7
16.4
20
5
K07
ICPC
Swollen ankles/oedema
3.8
16.3
71
198
D07AC01
ATC
betamethasone; topical
1.8
16.1
398
2659
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.2
16.1
172
840
TPH07
NOMESCO Finland
Cathetrisation of artery
2.5
16.0
132
565
J01CE02
ATC
phenoxymethylpenicillin; oral
1.7
15.9
781
6357
E66.8
ICD-10 Finland
Other obesity
3.3
15.8
83
268
XX3DW
NOMESCO Finland
Time consuming IT work
2.5
15.8
133
575
C50.99
ICD-10 Finland
Breast, unspecified
4.6
15.7
54
121
M04AA01
ATC
allopurinol; systemic
2.3
15.6
150
693
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.8
15.6
101
376
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.8
15.6
338
2160
NK6AN
NOMESCO Finland
Total body bone isotope imaging
4.9
15.6
51
108
A04AA55
ATC
palonosetron, combinations; systemic
4.2
15.6
60
150
I80.9
ICD-10 Finland
Phlebitis and thrombophlebitis of unspecified site
22.4
15.6
22
10
TQW80
NOMESCO Finland
Local dermatologic skincare
4.9
15.4
50
105
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.3
15.3
79
253
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.7
15.2
371
2459
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.7
15.2
108
425
A04AD12
ATC
aprepitant; systemic
5.3
15.1
46
90
A04AA01
ATC
ondansetron; systemic, rectal
2.9
15.0
95
347
R06.0
ICD-10 Finland
Dyspnoea
1.8
14.9
280
1703
WX002
NOMESCO Finland
Sedation and analgesia
1.9
14.8
232
1326
JN3AD
NOMESCO Finland
Abdominal CT examination
2.8
14.7
99
378
R06AE07
ATC
cetirizine; oral
1.7
14.7
508
3717
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
3.7
14.7
64
179
J01DA01
ATC
[U] cefalexin; systemic
1.6
14.7
714
5725
45708
ICD-8 Finland
Non-infective disease of lymphatic channels, Alii definiti
+∞
14.6
14
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
14.5
155
756
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.0
14.4
83
286
D70.82
ICD-10 Finland
Drug-induced neutropenia
5.9
14.4
40
70
XX1XN
NOMESCO Finland
Other isotope examination
9.9
14.2
28
29
B01AB04
ATC
dalteparin; parenteral
3.5
14.2
66
195
LAF11
NOMESCO Finland
Laparoscopic bilateral salpingo-oophorectomy
3.0
14.1
85
300
J01CF05
ATC
flucloxacillin; systemic
3.8
14.1
60
165
I82.9
ICD-10 Finland
Embolism and thrombosis of unspecified vein
20.3
13.8
20
10
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.6
13.7
102
411
D07AB08
ATC
desonide; topical
2.3
13.7
133
620
TQW75
NOMESCO Finland
Skin pressure therapy
+∞
13.6
13
*
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.2
13.5
148
728
J45.9
ICD-10 Finland
Asthma, unspecified
1.9
13.5
210
1192
ZXA10
NOMESCO Finland
Bilateral
1.9
13.4
219
1263
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
13.3
508
3782
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
13.2
255
1561
UJF32
NOMESCO Finland
Coloscopy
1.7
13.1
294
1885
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
13.0
397
2780
ZXD05
NOMESCO Finland
Urgent procedure
1.7
13.0
340
2282
B29
ICPC
Lymph/immune mech sympt/complt other
13.2
12.9
22
17
XX1AT
NOMESCO Finland
Other puncture with ultrasound guidance
8.2
12.9
28
35
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.4
12.8
117
527
WX402
NOMESCO Finland
General anaesthesia
1.9
12.8
196
1105
Z31.5
ICD-10 Finland
Genetic counselling
3.0
12.8
74
257
C50
ICD-10 Finland
Malignant neoplasm of breast
4.5
12.8
45
104
L17
ICPC
Foot/toe symptom/complaint
1.7
12.6
282
1804
8380/3-C54.1
ICD-O-3
Endometrioid adenocarcinoma, NOS, of endometrium
6.0
12.6
34
58
PJD54
NOMESCO Finland
Block dissection of iliac lymph nodes
8.8
12.5
26
30
PHM77
NOMESCO Finland
Endovenous obliteration of v.saphena parva
+∞
12.5
12
*
E66.9
ICD-10 Finland
Obesity, unspecified
3.9
12.4
51
136
L03AA14
ATC
lipegfilgrastim; parenteral
5.1
12.4
38
76
L02BG04
ATC
letrozole; oral
2.6
12.4
94
384
PJD45
NOMESCO Finland
Excision of inguinal lymph nodes
14.5
12.3
20
14
A40.8
ICD-10 Finland
Other streptococcal sepsis
9.8
12.3
24
25
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.6
12.2
90
361
N03AX12
ATC
gabapentin; oral
1.9
12.2
183
1021
A28
ICPC
Limited function/disability NOS
2.0
12.1
166
894
J01CR50
ATC
combinations of penicillins; systemic
27.0
12.1
16
6
C50.81
ICD-10 Finland
Overall malignant tumor of the mammary gland, ductal tumor
4.8
11.9
39
84
WB203
NOMESCO Finland
Simple adjuvant hormone therapy of malignancy
3.8
11.9
50
137
L02BG06
ATC
exemestane; oral
6.1
11.7
31
52
QX3HE
NOMESCO Finland
Ultrsound examination of lesion close to skin
7.8
11.7
26
34
SPAT1255
SPAT
Intravenous administration of medicine
2.6
11.6
85
342
PG1BD
NOMESCO Finland
Extensive CT angiography of tissue graft, e.g. assessment of TRAN graft
65.6
11.6
13
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.4
11.5
96
414
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
6.0
11.5
31
53
4578X
ICD-9 Finland
Non-infective disorders of lymphatic channels, Other non-infective disorders of lymphatic channels
+∞
11.5
11
*
PHD77
NOMESCO Finland
Resection of short saphenous vein
+∞
11.5
11
*
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.6
11.5
451
3343
I50.0
ICD-10 Finland
Congestive heart failure
2.7
11.4
79
307
TPX10
NOMESCO Finland
Implantation of vascular injection port
4.1
11.4
43
107
PJD63
NOMESCO Finland
Laparoscopic dissection of aortic lymph nodes
11.9
11.3
20
17
D07AC13
ATC
mometasone; topical
1.6
11.2
322
2203
K94
ICPC
Phlebitis/thrombophlebitis
9.3
11.0
22
24
ZX080
NOMESCO Finland
Image guided radiotherapy
4.3
11.0
40
96
1CD02
NOMESCO Finland
NA
8.4
10.8
23
28
S29
ICPC
Skin symptom/complaint other
1.8
10.8
188
1102
L03.9
ICD-10 Finland
Cellulitis, unspecified
4.8
10.8
35
75
UKC02
NOMESCO Finland
Cystoscopy
1.9
10.8
158
873
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.2
10.8
56
182
PJD55
NOMESCO Finland
Block dissection of inguinal lymph nodes
28.3
10.7
14
5
SPAT1263
SPAT
Sampling
1.5
10.7
455
3420
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.8
10.7
68
252
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
4.5
10.7
37
85
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
3.1
10.6
58
195
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.3
10.6
96
433
J02AC01
ATC
fluconazole; systemic
1.5
10.6
462
3495
R03AC02
ATC
salbutamol; inhalant
1.5
10.6
577
4586
B04
ICPC
Blood symptom/complaint
11.3
10.6
19
17
Z2221
NOMESCO Finland
Medical doctor
1.6
10.5
310
2127
L28
ICPC
Limited function/disability (L)
1.9
10.5
172
988
WB123
NOMESCO Finland
Demanding adjuvant cytostatic therapy
6.0
10.5
28
48
PHD78
NOMESCO Finland
Resection of communicating veins of lower leg and thigh
+∞
10.4
10
*
78260
ICD-8 Finland
Symptoms referable to cardiovascular and lymphatic system, Oedema and dropsy
+∞
10.4
10
*
A02BC05
ATC
esomeprazole; systemic
1.5
10.4
443
3330
L89
ICD-10 Finland
Decubitus ulcer and pressure area
5.6
10.3
29
53
TQW11
NOMESCO Finland
Vacuum treatment of wound
4.8
10.3
33
70
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.5
10.2
81
340
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
10.0
545
4308
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
10.0
185
1108
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
10.0
452
3433
Z2446
NOMESCO Finland
Social worker
2.4
10.0
83
358
R03AC03
ATC
terbutaline; inhalant
1.8
9.9
167
969
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.7
9.9
217
1370
C07AB07
ATC
bisoprolol; oral
1.5
9.9
484
3741
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.9
9.8
59
212
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
3.3
9.8
48
150
ZXC96
NOMESCO Finland
Robot assisted procedure
4.3
9.7
35
84
WF049
NOMESCO Finland
Radiotherapy of metastasis
3.6
9.7
42
119
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.7
9.7
221
1410
PHT99
NOMESCO Finland
Injection of therapeutic or sclerosing agent into other vein
55.5
9.7
11
*
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.9
9.6
151
855
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
9.6
318
2243
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.4
9.6
78
334
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.9
9.5
137
752
SPAT1301
SPAT
No procedures
1.6
9.5
331
2361
J01FA06
ATC
roxithromycin; oral
1.5
9.5
446
3409
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
9.4
199
1238
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.9
9.4
151
860
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.9
9.4
140
775
I87.0
ICD-10 Finland
Postthrombotic syndrome
+∞
9.4
9
*
0350X
ICD-9 Finland
Erysipelas[ERYSIPELAS ALIA DEFINITA SEU NUD]
9.6
9.3
18
19
HAD30
NOMESCO Finland
Reduction mammoplasty with transposition of areola
2.8
9.2
56
203
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
9.2
178
1080
A41.8
ICD-10 Finland
Other specified sepsis
4.8
9.2
29
61
E000001
ATC
NA
1.7
9.2
221
1432
J01FA10
ATC
azithromycin; systemic
1.5
9.2
621
5105
HA1DG
NOMESCO Finland
Very extensive MRI examination of mammary gland with high intensity magnet
6.8
9.2
22
33
J01FA09
ATC
clarithromycin; systemic
1.5
9.1
340
2460
ZX070
NOMESCO Finland
Intensity modified radiotherapy
4.6
9.1
30
66
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.6
9.1
66
266
PJD42
NOMESCO Finland
Excision of axillary lymph nodes
5.4
9.1
26
49
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
6.0
9.1
24
41
QBJ00
NOMESCO Finland
Liposuction in trunk
9.1
9.0
18
20
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
37.0
9.0
11
*
N02AJ06
ATC
codeine and paracetamol; systemic
1.5
9.0
395
2964
J01CA04
ATC
amoxicillin; systemic
1.5
8.9
882
7823
QC9S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in upper extremities, unspecified
24.2
8.9
12
5
WZC30
NOMESCO Finland
Teaching
1.8
8.9
148
854
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
2.9
8.8
52
185
ZX090
NOMESCO Finland
Other technic of radiotherapy
3.5
8.8
39
113
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
8.7
8.8
18
21
S01
ICPC
Pain/tenderness of skin
2.8
8.8
55
201
I50
ICD-10 Finland
Heart failure
3.6
8.8
38
108
ZXE40
NOMESCO Finland
More than seven and less than nine hours
3.6
8.7
37
104
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.7
8.6
187
1173
C50.82
ICD-10 Finland
Overall malignant tumor of the mammary gland, lobular tumor
5.8
8.6
23
40
N05CF01
ATC
zopiclone; oral
1.5
8.6
349
2567
HAD99
NOMESCO Finland
Other plastic operation on breast
8.3
8.6
18
22
E000006
ATC
NA
2.2
8.5
89
429
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.6
8.5
250
1701
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.7
8.4
208
1354
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
2.1
8.4
101
515
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.9
8.3
128
719
4572A
ICD-9 Finland
Non-infective disorders of lymphatic channels, Lymphangitis
+∞
8.3
8
*
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
+∞
8.3
8
*
4579X
ICD-9 Finland
Non-infective disorders of lymphatic channels, Unspecified non-infective disorder of lymphatic channels
+∞
8.3
8
*
L08.9
ICD-10 Finland
Local infection of skin and subcutaneous tissue, unspecified
3.3
8.3
40
124
TQB05
NOMESCO Finland
Puncture of skin of trunk
6.3
8.3
21
34
A41.9
ICD-10 Finland
Sepsis, unspecified
3.0
8.3
45
152
HAE99
NOMESCO Finland
Other reconstruction of breast
5.6
8.3
23
42
G47.3
ICD-10 Finland
Sleep apnoea
1.6
8.2
212
1395
SPAT1249
SPAT
Treatment-related counselling outside office
1.5
8.2
409
3138
03599
ICD-8 Finland
Erysipelas
14.6
8.2
13
9
HA1AT
NOMESCO Finland
Biopsy of mammary glands with ultrasound guidance
3.7
8.1
34
95
PJA01
NOMESCO Finland
Laparoscopic sentinel node excision
11.8
8.1
14
12
R01AD09
ATC
mometasone; nasal
1.4
8.0
481
3825
PJA10
NOMESCO Finland
Exploration of lymph nodes
5.3
8.0
23
44
D07CC01
ATC
betamethasone and antibiotics; topical
1.8
8.0
143
846
SPAT1153
SPAT
Removal of sutures
1.5
8.0
331
2438
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
3.1
8.0
42
140
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.2
7.9
40
129
C50.90
ICD-10 Finland
Malignant tumor in other or unspecified location in mammary gland without histology
4.0
7.9
30
77
I83
ICD-10 Finland
Varicose veins of lower extremities
5.1
7.7
23
46
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
6.0
7.7
20
34
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
3.1
7.7
39
127
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.5
7.7
298
2163
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.7
7.7
158
978
E66
ICD-10 Finland
Obesity
2.7
7.6
52
201
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
1.9
7.6
105
568
ZZF00
NOMESCO Finland
Graft of adipose tissue
5.2
7.6
22
43
L84
ICD-10 Finland
Corns and callosities
3.0
7.6
43
148
Z71.8
ICD-10 Finland
Other specified counselling
1.6
7.5
244
1698
WB133
NOMESCO Finland
Very demanding adjuvant cytostatic therapy
10.1
7.5
14
14
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
1.8
7.5
135
799
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.1
7.5
80
392
JA1AE
NOMESCO Finland
Ultrasound examination of groin and abdominal wall
4.0
7.5
28
71
L04AD01
ATC
ciclosporin; systemic
4.3
7.4
26
62
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.6
7.4
195
1288
A02BA02
ATC
ranitidine; systemic
1.6
7.4
209
1405
SPAT1211
SPAT
Application of soft bandage
1.9
7.4
98
524
ZZA00
NOMESCO Finland
Split skin graft
3.2
7.4
36
114
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
7.3
407
3173
D07AB02
ATC
hydrocortisone butyrate; topical
1.5
7.3
298
2184
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.9
7.3
105
577
I89
ICD-10 Finland
Other noninfective disorders of lymphatic vessels and lymph nodes
+∞
7.3
7
*
PHB78
NOMESCO Finland
Ligature of perforating veins of lower extremity
+∞
7.3
7
*
4540A
ICD-9 Finland
Varicose veins of lower extremities, With ulcer
+∞
7.3
7
*
PHG76
NOMESCO Finland
Intraluminal laser vein occlusion of long saphenous vein
+∞
7.3
7
*
4511A
ICD-9 Finland
Phlebitis and thrombophlebitis, Of deep vessels of lower extremities
+∞
7.3
7
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
5.0
7.3
22
45
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.2
7.3
36
115
PJD53
NOMESCO Finland
Block dissection of aortic lymph nodes
9.4
7.3
14
15
ZX112
NOMESCO Finland
Subcutaneous
3.9
7.3
28
73
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.1
7.3
84
422
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
2.6
7.2
50
196
J01AA02
ATC
doxycycline; systemic
1.4
7.2
857
7666
LCD30
NOMESCO Finland
Radical hysterectomy
15.9
7.2
11
7
A02BC03
ATC
lansoprazole; oral
1.5
7.2
307
2269
R31
ICD-10 Finland
Unspecified haematuria
2.0
7.2
86
439
NG4AA
NOMESCO Finland
Lower leg X-ray examination
3.2
7.2
36
116
GA4AT
NOMESCO Finland
Cathetrisation of pleural cavity with ultrasound guidance
7.4
7.2
16
22
PJA12
NOMESCO Finland
Sentinel node biopsy
1.9
7.2
100
544
SPAT1215
SPAT
Assessment of need for medical rehabilitation
2.5
7.2
56
235
120
Kela drug reimbursment
Hypogammaglobulinaemia
20.2
7.1
10
5
X76
ICPC
Malignant neoplasm breast female
3.3
7.1
34
106
M54.5
ICD-10 Finland
Low back pain
1.5
7.1
338
2554
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.8
7.1
123
720
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.4
7.1
59
257
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
7.1
216
1482
H02AB07
ATC
prednisone; oral
1.7
7.1
154
968
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.0
7.0
89
466
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
3.0
7.0
38
130
M25.5
ICD-10 Finland
Pain in joint
1.5
7.0
288
2113
SPAT1254
SPAT
Administration of medicine
1.7
7.0
142
872
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
3.4
7.0
31
92
M89.0
ICD-10 Finland
Algoneurodystrophy
5.2
6.9
20
39
9733
FHL
Excision of skin change in operating room or anesthesia
5.2
6.9
20
39
QBB05
NOMESCO Finland
Revision of wound of skin of trunk
5.2
6.9
20
39
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
2.2
6.9
64
294
S21
ICPC
Skin texture symptom/complaint
1.8
6.9
122
719
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.2
6.9
68
318
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
1.7
6.9
130
782
Z80.3
ICD-10 Finland
Family history of malignant neoplasm of breast
3.6
6.9
29
82
R4190
NOMESCO Finland
Nutritional therapy
2.7
6.9
45
173
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.5
6.8
220
1528
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
5.1
6.8
20
40
A79
ICPC
Malignancy NOS
5.1
6.8
20
40
XF600
NOMESCO Finland
Bloodpressure measurement
2.1
6.8
74
365
J01MA14
ATC
moxifloxacin; systemic
1.9
6.7
93
505
R03BA01
ATC
beclometasone; inhalant
1.7
6.7
149
938
WW500
NOMESCO Finland
Blood transfusion
2.6
6.7
47
186
L09
ICPC
Arm symptom/complaint
2.4
6.7
54
233
RF312
NOMESCO Finland
NA
22.7
6.7
9
*
LE090
NOMESCO Finland
Profylactive radiotherapy of vulva and vagina
22.7
6.7
9
*
LCD31
NOMESCO Finland
Radical laparoscopic hysterectomy
22.7
6.7
9
*
JAH00
NOMESCO Finland
Laparotomy
3.1
6.7
34
112
T81.3
ICD-10 Finland
Disruption of operation wound, not elsewhere classified
3.5
6.6
29
85
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
5.5
6.6
18
33
XKD00
NOMESCO Finland
Uroflowmetry
1.8
6.6
122
729
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
2.7
6.6
42
157
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
2.8
6.5
39
142
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.5
6.5
282
2083
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
5.1
6.5
19
38
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
5.7
6.5
17
30
A12BA01
ATC
potassium chloride; oral
2.4
6.4
50
212
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.7
6.4
146
926
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.4
6.4
427
3421
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.9
6.4
92
507
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.1
6.4
71
353
SPAT1260
SPAT
Consultation of another employee
1.6
6.4
184
1242
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
2.5
6.4
46
188
QB9S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in torso, unspecified
6.6
6.3
15
23
R60.1
ICD-10 Finland
Generalized oedema
6.0
6.3
16
27
P01AB01
ATC
metronidazole; oral, rectal
1.4
6.3
423
3395
Z51.5
ICD-10 Finland
Palliative care
2.3
6.3
56
252
QX4YT
NOMESCO Finland
Puncture of superficial collection under ultrasound guidance
18.1
6.3
9
5
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
3.4
6.3
28
84
I81
ICD-10 Finland
Portal vein thrombosis
+∞
6.3
6
*
45400
ICD-8 Finland
Varicose veins of lower extremities, With ulcer
+∞
6.3
6
*
B01AF02
ATC
apixaban; oral
1.9
6.2
83
445
NK6AQ
NOMESCO Finland
Whole body bone SPET with low dose CT
26.8
6.2
8
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.6
6.2
164
1084
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.8
6.2
103
593
HA1CG
NOMESCO Finland
Extensive MRI examination of mammary gland with high intensity magnet
3.6
6.2
26
74
K28
ICPC
Limited function/disability (K)
3.6
6.2
26
74
8520/3-C50.9
ICD-O-3
Lobular carcinoma, NOS, of breast, NOS
3.3
6.2
29
90
N30.9
ICD-10 Finland
Cystitis, unspecified
2.2
6.2
61
289
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.5
6.2
278
2066
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.9
6.2
92
511
R18
ICD-10 Finland
Ascites
4.0
6.2
23
59
TQW99
NOMESCO Finland
Other minor procedure on skin
2.3
6.2
54
243
D70.89
ICD-10 Finland
Neutropenic splenomegaly
5.1
6.2
18
36
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.7
6.2
38
142
XG466
NOMESCO Finland
Sleep oxymetry
2.8
6.2
36
129
R04.0
ICD-10 Finland
Epistaxis
2.0
6.2
72
366
HA3AT
NOMESCO Finland
Pucture of mammary gland cyst with ultrasound examination
5.4
6.2
17
32
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.0
6.1
76
395
T81.8
ICD-10 Finland
Other complications of procedures, not elsewhere classified
3.4
6.1
27
80
R51.80
ICD-10 Finland
Headache
1.6
6.1
157
1030
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.9
6.1
82
440
C53.11
ICD-10 Finland
Squamous cell carcinoma and exocervix
12.6
6.1
10
8
D64.9
ICD-10 Finland
Anaemia, unspecified
1.9
6.1
91
507
K42.9
ICD-10 Finland
Umbilical hernia without obstruction or gangrene
2.4
6.0
49
211
C50.40
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication
2.9
6.0
35
125
QBE20
NOMESCO Finland
Excision and repair of scar or web of skin of trunk
5.2
6.0
17
33
I10
ICD-10 Finland
Essential (primary) hypertension
1.4
6.0
566
4790
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.6
6.0
179
1219
J05AB01
ATC
aciclovir; systemic
1.5
6.0
216
1532
Mortality – FinRegistry
↥Association
Association between endpoint I9_LYMPHOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_LYMPHOTH | 1.951 [1.71, 2.23] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.118 |
During the follow-up period (1.1.1998 — 31.12.2019), 1067 out of 4362 females with I9_LYMPHOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_LYMPHOTH | 2.324 [1.96, 2.76] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 702 out of 2784 males with I9_LYMPHOTH died.
Mortality risk
Mortality risk for people of age
years, who have I9_LYMPHOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.183% | 0.446% |
| 5 | 1.15% | 2.746% |
| 10 | 3.003% | 6.869% |
| 15 | 5.467% | 12.824% |
| 20 | 9.696% | 21.8% |
Relationships between endpoints
↥Index endpoint: I9_LYMPHOTH – Other noninfective disorders of lymphatic vessels and lymph nodes
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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