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Varicose veins of other sites

DOID EFO Endpoint Browser PheWeb

I9_VARICVESOTH

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I86
  • Hospital discharge: ICD-9 — 456
  • Hospital discharge: ICD-8 — 456
  • Hospital discharge: excluded ICD-9 — 456[0-1]
  • Hospital discharge: excluded ICD-8 — 4560
  • Cause of death: ICD-10 — I86
  • Cause of death: ICD-9 — 456
  • Cause of death: ICD-8 — 456
  • Cause of death: excluded ICD-9 — 456[0-1]
  • Cause of death: excluded ICD-8 — 4560

2 out of 7 registries used, show all original rules.

2653

4. Check minimum number of events

None

2653

5. Include endpoints

None

2653

6. Filter based on genotype QC (FinnGen only)

2653

Control definitions (FinnGen only)

Control exclude
I9_DISVEINLYMPH

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I80-I89
Name in latin
Venae varicosae aliis locis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 21994 4944 16902
Only index persons 20552 4562 15990
Unadjusted period prevalence (%)
Whole population 0.40 0.14 0.47
Only index persons 0.51 0.17 0.61
Median age at first event (years)
Whole population 32.04 43.79 28.56
Only index persons 31.33 42.99 28.00

-FinnGen-

Key figures

All Female Male
Number of individuals 2653 861 1792
Unadjusted period prevalence (%) 0.63 0.29 0.79
Median age at first event (years) 37.11 42.75 34.41

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2379
Matched controls
23790
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
45610
ICD-8 Finland
Varicose veins of other sites, Of scrotum
+∞
323.0
313
*
I86.1
ICD-10 Finland
Scrotal varices
611.7
323.0
852
22
4565A
ICD-9 Finland
Varicose veins of other sites, Pelvic varices
+∞
265.7
250
*
4564A
ICD-9 Finland
Varicose veins of other sites, Scrotal varices
+∞
257.0
242
*
I86.8
ICD-10 Finland
Varicose veins of other specified sites
364.6
234.6
233
7
I86.2
ICD-10 Finland
Pelvic varices
1030.2
196.7
190
*
7504
FHL
Play the depot
+∞
189.1
179
*
PH5GT
NOMESCO Finland
Endovascular embolisation of spermatic vein with radiological guidance
+∞
163.4
155
*
I83.9
ICD-10 Finland
Varicose veins of lower extremities without ulcer or inflammation
26.7
153.2
215
88
PHD99
NOMESCO Finland
Resection of other vein
1317.4
129.4
125
*
45698
ICD-8 Finland
Varicose veins of other sites, Of other sites
+∞
129.3
123
*
I86.4
ICD-10 Finland
Gastric varices
+∞
107.1
102
*
45499
ICD-8 Finland
Varicose veins of lower extremities, Other and unspecified, without ulcer
+∞
100.7
96
*
KFD50
NOMESCO Finland
Resection or ligature of internal spermatic vein
965.9
95.6
93
*
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
9.7
93.5
198
221
PHD76
NOMESCO Finland
Resection of long saphenous vein
+∞
84.9
81
*
4549X
ICD-9 Finland
Varicose veins of lower extremities, Without mention of ulcer or inflammation
+∞
79.6
76
*
PH5AC
NOMESCO Finland
Flebography of spermatic vein
+∞
73.3
70
*
PHM76
NOMESCO Finland
Endovenous obliteration of v.saphena magna
719.2
71.5
70
*
KF8AE
NOMESCO Finland
Ultrasound examination of scrotum
6.6
57.2
153
244
5611
FHL
Vena saphena Magna and / or swarm of nodule and possible local emissions
550.2
54.8
54
*
PHM99
NOMESCO Finland
Endovenous obliteration of other vein
550.2
54.8
54
*
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
+∞
54.4
52
*
I86.3
ICD-10 Finland
Vulval varices
+∞
53.3
51
*
8306
FHL
Hysterectomy (related to abortion 8516, prolapse correction 8436)
6.2
47.4
132
222
PH2DE
NOMESCO Finland
Ultrasound examination of bloodflow in veins of lower extremity with Doppler method
23.7
40.6
58
25
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
39.6
667
3929
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
+∞
38.6
37
*
UJF32
NOMESCO Finland
Coloscopy
1.9
35.0
593
3475
PH6GT
NOMESCO Finland
Endovascular embolisation of ovarian vein with radiological guidance
+∞
31.3
30
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
29.3
747
4965
I86.0
ICD-10 Finland
Sublingual varices
104.7
28.7
31
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.6
27.2
210
853
KFD56
NOMESCO Finland
Excision of varicocele
+∞
27.1
26
*
5612
FHL
Local excisions and / or perforations of relapsing varicose veins
+∞
27.1
26
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.0
27.0
405
2237
A06AC01
ATC
ispaghula (psylla seeds); oral
1.8
26.4
511
3095
2180A
ICD-9 Finland
Uterine leiomyoma, Submucous leiomyoma of uterus
3.5
26.1
128
383
J01MA02
ATC
ciprofloxacin; systemic
1.6
25.2
830
5874
A02BC05
ATC
esomeprazole; systemic
1.6
24.8
876
6306
A02BC02
ATC
pantoprazole; systemic
1.6
24.5
1373
11074
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
2.9
23.0
142
501
N03AX16
ATC
pregabalin; oral
1.7
22.4
494
3098
R10.2
ICD-10 Finland
Pelvic and perineal pain
4.7
22.4
77
168
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
35.4
22.1
28
8
N02AX02
ATC
tramadol; systemic, rectal
1.6
21.9
897
6643
8113
FHL
Fractional scraping
2.9
21.7
135
480
J01AA02
ATC
doxycycline; systemic
1.6
21.0
1681
14458
G04CA01
ATC
alfuzosin; oral
2.0
20.9
302
1636
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
20.8
571
3807
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
20.0
897
6748
1410
FHL
Laparoscopy
4.2
19.6
76
187
PHT99
NOMESCO Finland
Injection of therapeutic or sclerosing agent into other vein
201.6
19.6
20
*
J01FA10
ATC
azithromycin; systemic
1.5
19.5
1225
9902
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
14.7
19.4
32
22
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
18.9
283
1548
N02BE01
ATC
paracetamol; systemic, rectal
1.6
18.9
1850
16417
I80.0
ICD-10 Finland
Phlebitis and thrombophlebitis of superficial vessels of lower extremities
7.8
18.8
43
56
PHM77
NOMESCO Finland
Endovenous obliteration of v.saphena parva
+∞
18.8
18
*
I81
ICD-10 Finland
Portal vein thrombosis
191.4
18.6
19
*
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.2
18.5
207
1008
A02BC03
ATC
lansoprazole; oral
1.6
18.4
597
4138
I80.29
ICD-10 Finland
Phlebitis and thrombophlebitis of other deep vessels of lower extremities
10.7
18.4
35
33
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.7
18.3
396
2454
M01AX05
ATC
glucosamine; oral
1.8
18.3
373
2270
6262A
ICD-9 Finland
Disorders of menstruation and other abnormal bleeding from female genital tract, Excessive or frequent menstruation[HYPERMENORRHOEA]
4.5
18.2
65
148
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.6
18.2
543
3680
M03BX02
ATC
tizanidine; oral
1.5
18.1
1323
10964
R01AD09
ATC
mometasone; nasal
1.5
17.9
901
6903
N03AX12
ATC
gabapentin; oral
1.8
17.7
325
1912
N45.9
ICD-10 Finland
Orchitis, epididymitis and epididymo-orchitis without abscess
3.5
17.5
82
239
M01AB05
ATC
diclofenac; systemic, rectal
1.5
17.1
1440
12202
R51.80
ICD-10 Finland
Headache
1.9
16.9
278
1575
M54.5
ICD-10 Finland
Low back pain
1.5
16.8
654
4717
Y02
ICPC
Pain in testis/scrotum
6.0
16.8
46
78
4566A
ICD-9 Finland
Varicose veins of other sites, Vulval varices
+∞
16.7
16
*
J01DB01
ATC
cefalexin; oral
1.5
16.2
1797
16009
R52.9
ICD-10 Finland
Pain, unspecified
2.1
16.1
183
896
M01AE03
ATC
ketoprofen; systemic, rectal
1.5
16.0
763
5742
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.2
16.0
176
852
I82.88
ICD-10 Finland
Embolism and thrombosis of other specified veins
21.1
16.0
23
11
N43.4
ICD-10 Finland
Spermatocele
3.7
15.8
69
190
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
15.8
444
2952
SAA02
NOMESCO Finland
Basic examination of mouth
1.4
15.8
1340
11286
4568X
ICD-9 Finland
Varicose veins of other sites, Varices of other sites
+∞
15.6
15
*
7503
FHL
Hydrosel or funicular surgery
9.0
15.4
32
36
UKC02
NOMESCO Finland
Cystoscopy
1.7
15.4
328
2018
Z01.2
ICD-10 Finland
Dental examination
1.5
15.3
820
6312
8308
FHL
Hysterectomy and bilateral adnexal removal
4.9
15.2
49
101
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.9
15.2
220
1189
C05AA08
ATC
fluocortolone; rectal, topical
1.8
15.2
305
1843
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
15.1
533
3743
I83
ICD-10 Finland
Varicose veins of lower extremities
6.6
15.1
38
58
N41.1
ICD-10 Finland
Chronic prostatitis
3.0
15.0
88
303
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
14.0
15.0
25
18
M25.5
ICD-10 Finland
Pain in joint
1.5
15.0
544
3846
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.7
15.0
335
2088
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.3
14.9
74
227
JDA52
NOMESCO Finland
Other endoscopic procedure using diathermy or heat in stomach or pylorus
21.2
14.6
21
10
J01DA01
ATC
[U] cefalexin; systemic
1.4
14.6
1290
10872
PHL76
NOMESCO Finland
Ultrasound guided foam sclerotherapy of long saphenous vein
+∞
14.6
14
*
G04CA02
ATC
tamsulosin; oral
1.6
14.5
475
3277
M01AH05
ATC
etoricoxib; oral
1.4
14.4
1231
10305
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
6.6
14.3
36
55
SPAT1263
SPAT
Sampling
1.4
14.1
838
6550
JAH01
NOMESCO Finland
Laparoscopy
2.8
14.1
88
317
N06AX11
ATC
mirtazapine; oral
1.5
14.0
622
4583
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.6
14.0
365
2375
I80.9
ICD-10 Finland
Phlebitis and thrombophlebitis of unspecified site
30.2
13.9
18
6
J01CA04
ATC
amoxicillin; systemic
1.4
13.7
1727
15429
PHD77
NOMESCO Finland
Resection of short saphenous vein
+∞
13.5
13
*
R01AD12
ATC
fluticasone furoate; nasal
1.5
13.5
567
4127
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
13.4
1486
12942
62400
ICD-8 Finland
Malposition of uterus, Retroversion and retroflexion
8.3
13.0
28
34
6266A
ICD-9 Finland
Disorders of menstruation and other abnormal bleeding from female genital tract, Metrorrhagia
3.2
13.0
68
218
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.7
12.9
298
1869
R01AD08
ATC
fluticasone; nasal
1.5
12.9
560
4099
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
12.9
947
7662
J01FA09
ATC
clarithromycin; systemic
1.5
12.8
625
4686
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.7
12.7
298
1877
SPAT1153
SPAT
Removal of sutures
1.4
12.6
632
4758
6173B
ICD-9 Finland
Endometriosis of pelvic peritoneum[ENDOMETRIOSIS RETROUTERINA]
5.9
12.5
34
58
M01AC06
ATC
meloxicam; systemic, rectal
1.4
12.5
699
5373
M79.6
ICD-10 Finland
Pain in limb
1.4
12.4
647
4907
KFD51
NOMESCO Finland
Percutaneous endoscopic resection or ligature of spermatic vein
130.6
12.4
13
*
I86
ICD-10 Finland
Varicose veins of other sites
130.6
12.4
13
*
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.7
12.4
245
1471
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.3
12.2
115
519
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.4
12.1
972
7959
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.8
12.1
218
1271
L13
ICPC
Hip symptom/complaint
1.7
12.0
270
1682
H02AB06
ATC
prednisolone; systemic
1.4
11.7
900
7304
R42
ICD-10 Finland
Dizziness and giddiness
1.5
11.6
374
2555
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.8
11.5
203
1175
8351
FHL
Removal of pelvic floor brackets
10.1
11.5
22
22
4511A
ICD-9 Finland
Phlebitis and thrombophlebitis, Of deep vessels of lower extremities
+∞
11.5
11
*
6146A
ICD-9 Finland
Inflammatory disease of ovary, Fallopian tube, pelvic cellular tissue and peritoneum, Pelvic peritoneal adhesions, female
5.4
11.3
33
62
JDA32
NOMESCO Finland
Endoscopic injection in stomach or pylorus
11.9
11.3
20
17
I80.8
ICD-10 Finland
Phlebitis and thrombophlebitis of other sites
17.1
11.2
17
10
M02AA07
ATC
piroxicam; topical
1.4
11.2
684
5324
I80.1
ICD-10 Finland
Phlebitis and thrombophlebitis of femoral vein
25.1
11.1
15
6
J02AC01
ATC
fluconazole; systemic
1.4
11.1
623
4773
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.8
11.1
211
1250
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
2.0
11.1
150
790
L03
ICPC
Low back symptom/complaint
1.5
11.0
423
3008
M01AE02
ATC
naproxen; oral, rectal
1.3
11.0
1124
9517
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.3
10.9
1069
8986
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
10.9
818
6592
A02BA02
ATC
ranitidine; systemic
1.5
10.8
365
2521
I82.9
ICD-10 Finland
Embolism and thrombosis of unspecified vein
8.3
10.8
23
28
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.8
10.7
190
1100
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
1.8
10.6
184
1058
A02BC04
ATC
rabeprazole; oral
1.8
10.6
173
974
R03AC02
ATC
salbutamol; inhalant
1.3
10.5
1009
8438
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
2.7
10.5
71
271
M01AX17
ATC
nimesulide; oral
1.5
10.4
456
3327
PHM79
NOMESCO Finland
Endovenous obliteration of v.saphena anterior
+∞
10.4
10
*
PHD78
NOMESCO Finland
Resection of communicating veins of lower leg and thigh
+∞
10.4
10
*
NF1AA
NOMESCO Finland
Hip X-ray examination
1.9
10.4
155
849
R52.2
ICD-10 Finland
Other chronic pain
2.6
10.4
71
273
UJF30
NOMESCO Finland
Ileoscopy through colon
1.7
10.3
197
1172
M03BC01
ATC
orphenadrine (citrate); systemic
1.5
10.3
442
3215
C07AA05
ATC
propranolol; systemic
1.5
10.2
344
2369
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
2.0
10.2
127
649
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
2.0
10.2
135
708
R06AX27
ATC
desloratadine; oral
1.4
10.1
498
3715
K94
ICPC
Phlebitis/thrombophlebitis
5.9
10.1
27
46
N43.3
ICD-10 Finland
Hydrocele, unspecified
3.0
10.1
55
184
8203
FHL
Salpingectomy
11.3
10.0
18
16
K92.1
ICD-10 Finland
Melaena
2.2
10.0
103
486
K92.0
ICD-10 Finland
Haematemesis
3.0
10.0
55
185
B01AB05
ATC
enoxaparin; parenteral
1.4
9.9
503
3773
1412
FHL
Laparoscopy and sterilization
2.2
9.9
102
482
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
9.8
750
6032
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.4
9.8
513
3868
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
4.0
9.7
37
93
M01AH01
ATC
celecoxib; oral (coxibs)
1.5
9.7
325
2236
L17
ICPC
Foot/toe symptom/complaint
1.4
9.6
431
3155
N06AA09
ATC
amitriptyline; systemic
1.7
9.5
180
1064
R05
ICD-10 Finland
Cough
1.5
9.5
332
2304
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.3
9.5
1165
10044
A03FA02
ATC
cisapride; oral, rectal
1.9
9.5
136
732
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.7
9.5
64
242
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.3
9.5
1122
9620
6253A
ICD-9 Finland
Pain and other symptoms associated with female genital organs, Dysmenorrhoea
9.1
9.5
19
21
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.3
9.5
805
6574
R06.0
ICD-10 Finland
Dyspnoea
1.4
9.5
428
3136
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.7
9.5
206
1270
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
9.5
958
8036
N05BA04
ATC
oxazepam; oral
1.4
9.4
434
3191
K29.6
ICD-10 Finland
Other gastritis
4.5
9.4
32
72
PHL99
NOMESCO Finland
Ultrasound guided foam sclerotherapy of other vein
+∞
9.4
9
*
PHB99
NOMESCO Finland
Ligature of other vein
+∞
9.4
9
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.3
9.3
710
5701
J31.0
ICD-10 Finland
Chronic rhinitis
1.9
9.3
142
785
XKD00
NOMESCO Finland
Uroflowmetry
1.5
9.2
313
2158
K03.64
ICD-10 Finland
Dental calculus supragingival
1.4
9.2
511
3886
G44.2
ICD-10 Finland
Tension-type headache
1.6
9.2
222
1409
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
9.1
323
2248
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.4
9.0
448
3339
R20.2
ICD-10 Finland
Paraesthesia of skin
1.9
9.0
122
644
78559
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Colica abdominalis NUD
2.5
9.0
70
290
XQ800
NOMESCO Finland
Prick test
1.9
9.0
132
720
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
1.9
8.9
123
652
J01EA01
ATC
trimethoprim; systemic
1.5
8.9
351
2501
NG2AA
NOMESCO Finland
Patella X-ray examination
2.8
8.9
54
194
M01AB51
ATC
indometacin, combinations; oral, rectal
2.8
8.9
54
195
UJD02
NOMESCO Finland
Gastroscopy
2.1
8.9
95
459
M48.0
ICD-10 Finland
Spinal stenosis
1.6
8.9
208
1311
A02BC01
ATC
omeprazole; systemic
1.4
8.8
485
3684
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
2.0
8.8
103
516
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.4
8.8
439
3277
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
1.5
8.7
270
1822
M01AB55
ATC
diclofenac, combinations; oral
1.9
8.7
122
655
M79.1
ICD-10 Finland
Myalgia
1.6
8.7
222
1428
M54.4
ICD-10 Finland
Lumbago with sciatica
1.5
8.6
286
1963
N06AB04
ATC
citalopram; systemic
1.4
8.6
377
2746
JDA42
NOMESCO Finland
Other endoscopic haemostatic procedure in stomach or pylorus
8.2
8.6
18
22
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
1.8
8.4
149
863
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
1.9
8.4
119
638
N06AX16
ATC
venlafaxine; oral
1.6
8.3
244
1628
5613
FHL
Conjunctival occlusion
+∞
8.3
8
*
45699
ICD-8 Finland
NA
+∞
8.3
8
*
M03BC51
ATC
orphenadrine, combinations; systemic
1.4
8.3
519
4020
L01
ICPC
Neck symptom/complaint
1.6
8.3
229
1505
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.7
8.3
160
951
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
2.0
8.3
106
551
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
1.7
8.3
153
902
K95
ICPC
Varicose veins of leg
7.1
8.2
19
27
A06AD11
ATC
lactulose; oral
1.6
8.2
225
1476
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.3
8.2
996
8515
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
1.8
8.2
133
752
JDA35
NOMESCO Finland
Endoscopic contact coagulation in stomach or pylorus
14.5
8.2
13
9
WX002
NOMESCO Finland
Sedation and analgesia
1.4
8.2
348
2517
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
2.3
8.2
70
306
V252A
ICD-9 Finland
Contraceptive management, Sterilisation
1.9
8.2
117
633
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
3.6
8.1
35
99
N73.6
ICD-10 Finland
Female pelvic peritoneal adhesions
6.0
8.1
21
35
N50.8
ICD-10 Finland
Other specified disorders of male genital organs
4.7
8.1
26
56
SPAT1312
SPAT
General health counselling
1.3
8.1
579
4587
R01BA52
ATC
pseudoephedrine, combinations; oral
1.3
8.1
567
4476
E000001
ATC
NA
1.4
8.0
358
2612
6421
FHL
Appendicectomy
1.9
8.0
112
600
SDA02
NOMESCO Finland
Parodonthologic therapy
1.3
8.0
604
4820
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
2.2
8.0
74
336
Y05
ICPC
Scrotum/testis sympt/compl other
3.6
7.9
34
96
KFD30
NOMESCO Finland
Operation for spermatocele
4.4
7.9
27
62
I84.9
ICD-10 Finland
Unspecified hemorrhoids without complication
2.0
7.9
92
459
R05FA02
ATC
opium derivatives and expectorants; systemic
1.3
7.9
743
6131
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.5
7.8
295
2077
M01AE01
ATC
ibuprofen; systemic, rectal
1.4
7.8
1982
18653
J45.9
ICD-10 Finland
Asthma, unspecified
1.5
7.8
299
2115
N99.4
ICD-10 Finland
Postprocedural pelvic peritoneal adhesions
5.7
7.8
21
37
G03CB01
ATC
dienestrol; oral, vaginal
2.9
7.8
46
163
A03CA02
ATC
clidinium and psycholeptics; oral
1.9
7.8
106
563
G04CB01
ATC
finasteride; oral (testosterone-5-alpha reductase inhibitors)
1.6
7.8
186
1178
JHB30
NOMESCO Finland
Rubber band ligature of haemorrhoids or prolapse of mucosa
1.9
7.8
114
623
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.1
7.8
82
394
N80.0
ICD-10 Finland
Endometriosis of uterus
3.6
7.7
33
93
N06AX21
ATC
duloxetine; oral
1.6
7.7
186
1182
R30.0
ICD-10 Finland
Dysuria
2.3
7.7
69
307
M70.6
ICD-10 Finland
Trochanteric bursitis
1.6
7.7
176
1101
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
2.2
7.7
75
349
K07.60
ICD-10 Finland
Snapping jaw
2.1
7.6
79
377
J01MA01
ATC
ofloxacin; systemic
1.7
7.6
149
894
J01FA06
ATC
roxithromycin; oral
1.3
7.6
759
6301
JCA32
NOMESCO Finland
Endoscopic injection in oesophagus
25.1
7.6
10
*
R53
ICD-10 Finland
Malaise and fatigue
1.4
7.5
334
2434
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.4
7.5
365
2709
Z03.8
ICD-10 Finland
Observation for other suspected diseases and conditions
2.1
7.4
80
389
TPH10
NOMESCO Finland
Sclerotherapy of varicose veins
80.3
7.4
8
*
WYA10
NOMESCO Finland
First aid or other corresponding healthcare contact
1.7
7.4
135
794
7434
FHL
Abdominal urethrocystopexy
5.3
7.4
21
40
I80
ICD-10 Finland
Phlebitis and thrombophlebitis
6.0
7.4
19
32
6170A
ICD-9 Finland
Endometriosis of uterus
4.1
7.4
27
67
P01AB01
ATC
metronidazole; oral, rectal
1.3
7.3
675
5538
J05AB01
ATC
aciclovir; systemic
1.4
7.3
347
2559
Z03
ICD-10 Finland
Medical observation and evaluation for suspected diseases and conditions, ruled out
1.8
7.3
130
756
O22.0
ICD-10 Finland
Varicose veins of lower extremity in pregnancy
+∞
7.3
7
*
N05CF01
ATC
zopiclone; oral
1.3
7.2
574
4607
K30
ICD-10 Finland
Functional dyspepsia
1.6
7.2
185
1192
F45.8
ICD-10 Finland
Other somatoform disorders
1.9
7.2
107
586
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
2.5
7.2
54
222
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
1.7
7.2
129
755
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
1.7
7.1
134
794
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
2.4
7.1
59
253
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.3
7.1
569
4572
WX321
NOMESCO Finland
Acute spinal anesthesia for delivery
3.5
7.1
31
90
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
1.9
7.1
92
481
G03CA04
ATC
estriol; systemic, vaginal
1.9
7.0
94
496
H02AB04
ATC
methylprednisolone; systemic
1.5
6.9
255
1788
6200A
ICD-9 Finland
Noninflammatory disorders of ovary, Fallopian tube and broad ligament, Follicular cyst of ovary
6.3
6.9
17
27
60699
ICD-8 Finland
Sterility, male
13.8
6.9
11
8
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.5
6.9
244
1699
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.6
6.8
156
975
SDA01
NOMESCO Finland
Simple parodonthologic therapy
1.4
6.8
439
3411
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
2.5
6.8
49
197
S18
ICPC
Laceration/cut
1.3
6.8
776
6532
D64.9
ICD-10 Finland
Anaemia, unspecified
1.6
6.8
159
1004
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.5
6.8
215
1462
7170A
ICD-9 Finland
Internal derangement of knee, Old bucket handle tear of medial meniscus
2.7
6.8
42
156
I83.2
ICD-10 Finland
Varicose veins of lower extremities with both ulcer and inflammation
16.7
6.7
10
6
M02AA10
ATC
ketoprofen; topical
1.4
6.7
277
1988
N40
ICD-10 Finland
Hyperplasia of prostate
1.4
6.7
380
2891
Z30.2
ICD-10 Finland
Sterilization
1.6
6.7
161
1023
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.6
6.7
161
1023
R49.08
ICD-10 Finland
Other specified dysphonia
2.9
6.7
37
128
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
1.9
6.7
95
513
A02BA04
ATC
nizatidine; systemic
1.7
6.7
133
802
K76.6
ICD-10 Finland
Portal hypertension
22.6
6.7
9
*
8305
FHL
Supravaginal amputation or resection
3.1
6.6
33
106
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.5
6.6
194
1293
R51
ICD-10 Finland
Headache
2.0
6.6
83
430
M01AH02
ATC
rofecoxib; oral
1.5
6.6
220
1511
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
1.7
6.6
124
735
N80.3
ICD-10 Finland
Endometriosis of pelvic peritoneum
3.4
6.6
29
85
XF402
NOMESCO Finland
ECG with work load test
1.5
6.6
204
1381
H02AB07
ATC
prednisone; oral
1.5
6.6
249
1760
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
2.1
6.6
71
346
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
2.7
6.6
43
164
R22.9
ICD-10 Finland
Localized swelling, mass and lump, unspecified
1.8
6.5
114
662
N50.9
ICD-10 Finland
Disorder of male genital organs, unspecified
5.0
6.5
19
38
K29.7
ICD-10 Finland
Gastritis, unspecified
2.1
6.5
68
327
N41.9
ICD-10 Finland
Inflammatory disease of prostate, unspecified
2.7
6.4
40
149
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
2.1
6.4
64
303
XJH00
NOMESCO Finland
Transanal ultrasonography
1.8
6.4
108
618
5619
FHL
Other measure in this category
70.0
6.4
7
*
M54.2
ICD-10 Finland
Cervicalgia
1.7
6.4
124
745
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.0
6.4
72
358
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
2.1
6.4
65
310
NA1BA
NOMESCO Finland
Cervical spine extensive X-ray examination without contrast
3.8
6.4
25
67
N01
ICPC
Headache
1.6
6.3
148
935
KF8KT
NOMESCO Finland
Sclerotherapy of scrotum
8.2
6.3
13
16
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
1.6
6.3
147
927
61610
ICD-8 Finland
Diseases of parametrium and pelvic peritoneum (female), Pelvic peritoneal adhesions, female
3.7
6.3
25
68
PHB76
NOMESCO Finland
Ligature of long saphenous vein
+∞
6.3
6
*
6206A
ICD-9 Finland
Noninflammatory disorders of ovary, Fallopian tube and broad ligament, Broad ligament laceration syndrome
+∞
6.3
6
*
K02.1
ICD-10 Finland
Caries of dentine
1.2
6.2
1131
10034
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.4
6.2
249
1778
AA1AD
NOMESCO Finland
CT of head and brain
1.3
6.2
406
3156
J34.2
ICD-10 Finland
Deviated nasal septum
1.7
6.2
112
659
L02
ICPC
Back symptom/complaint
1.6
6.2
145
916
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
1.8
6.2
93
515
UJF92
NOMESCO Finland
Capsular endoscopy
2.5
6.2
44
176
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.4
6.2
292
2152
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
1.9
6.1
85
459
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.5
6.1
186
1256
5509B
ICD-9 Finland
Inguinal hernia, without mention of obstruction or gangrene[HERNIA INGUINALIS SINE GANGR/OBSTR,LATERALIS (SCROT]
2.2
6.0
55
250
R00.2
ICD-10 Finland
Palpitations
1.7
6.0
115
687
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
1.9
6.0
86
469

Mortality – FinRegistry

↥

Association

Association between endpoint I9_VARICVESOTH and mortality.

Females

Parameter HR [95% CI] p-value
I9_VARICVESOTH 1.4 [1.19, 1.65] < 0.001
Birth year 1.0 [0.99, 1.01] 0.956

During the follow-up period (1.1.1998 — 31.12.2019), 296 out of 2072 females with I9_VARICVESOTH died.

Males

Parameter HR [95% CI] p-value
I9_VARICVESOTH 1.219 [1.07, 1.39] 0.003
Birth year 0.983 [0.97, 1.0] 0.017

During the follow-up period (1.1.1998 — 31.12.2019), 705 out of 9332 males with I9_VARICVESOTH died.

Mortality risk

Mortality risk for people of age

years, who have I9_VARICVESOTH.

N-year risk Females Males
1 0.167% 0.193%
5 0.965% 1.245%
10 2.371% 3.177%
15 4.701% 5.973%
20 7.766% 10.185%

Relationships between endpoints

↥

Index endpoint: I9_VARICVESOTH – Varicose veins of other sites

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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