Ankylosing spondylitis

M13_ANKYLOSPON

ankylosing spondylitis: An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 M45
Hospital discharge: ICD-9 7200
Hospital discharge: ICD-8 7124
Cause of death: ICD-10 M45
Cause of death: ICD-9 7200
Cause of death: ICD-8 7124

2405

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

2336

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Check minimum number of events None

2336

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Include endpoints None

2336

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M13_ANKYLOSPON

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M45-M49
Name in latin Spondylarthritis/spondylitis ancylopoetica

Summary Statistics

Key figures

All Female Male
Number of individuals 2252 1048 1204
Unadjusted prevalence (%) 0.73 0.60 0.89
Mean age at first event (years) 42.20 41.90 42.46

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.96 [1.11, 3.47] 2.1e-2 128
15 years 0.01 1.39 [0.86, 2.26] 1.8e-1 59
5 years 0.00 1.31 [0.71, 2.40] 3.8e-1 14
1 year 0.00 5.83 [2.98, 11.40] 2.5e-7 11

Correlations

Index endpoint: M13_ANKYLOSPON – Ankylosing spondylitis
GWS hits: 19

Survival analyses between endpoints

Plot

before Ankylosing spondylitis
after Ankylosing spondylitis

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Drugs most likely to be purchased after Ankylosing spondylitis