Risteys · M13_DISCINFECTION

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M46.3 Cause of death: ICD-10 — M46.3 2 out of 7 registries used, show all original rules.	434
4. Check minimum number of events None	434
5. Include endpoints None	434
6. Filter based on genotype QC (FinnGen only)	434

	All	Female	Male
Number of individuals
Whole population	2789	1003	1779
Only index persons	2627	945	1682
Unadjusted period prevalence (%)
Whole population	0.04	0.03	0.05
Only index persons	0.05	0.03	0.06
Median age at first event (years)
Whole population	64.58	68.10	62.60
Only index persons	64.18	67.66	62.22

	All	Female	Male
Number of individuals	434	135	299
Unadjusted period prevalence (%)	0.11	0.05	0.13
Median age at first event (years)	66.68	68.96	65.64

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
383: Matched controls
3828

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M46.3

ICD-10 Finland

Infection of intervertebral disc (pyogenic)

+∞

323.0

382

M46.4

ICD-10 Finland

Discitis, unspecified

+∞

121.5

110

NA3CG

NOMESCO Finland

Lumbar spine extensive MRI examination with high intensity magnet

262.5

114.5

112

A41.0

ICD-10 Finland

Sepsis due to Staphylococcus aureus

64.2

99.5

114

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

30.3

83.1

113

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

103.2

82.2

M54.5

ICD-10 Finland

Low back pain

9.7

82.0

206

408

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

50.0

69.2

N03AX16

ATC

pregabalin; oral

8.7

62.8

157

282

M48.0

ICD-10 Finland

Spinal stenosis

48.7

62.3

N02AA05

ATC

oxycodone; systemic

8.2

58.1

150

278

N02AX02

ATC

tramadol; systemic, rectal

5.8

56.1

245

899

A49.9

ICD-10 Finland

Bacterial infection, unspecified

8.1

54.4

139

250

NA3DG

NOMESCO Finland

Lumbar spine very extensive MRI examination with high intensity magnet

583.1

52.8

TPH30

NOMESCO Finland

Insertion of central venous catheter through periferal vein

30.6

46.4

J04AB02

ATC

rifampicin; systemic

48.8

42.5

M54.4

ICD-10 Finland

Lumbago with sciatica

10.3

42.1

108

N03AX12

ATC

gabapentin; oral

8.7

41.4

141

M54.9

ICD-10 Finland

Dorsalgia, unspecified

12.1

41.1

G06.1

ICD-10 Finland

Intraspinal abscess and granuloma

441.6

40.9

J01FF01

ATC

clindamycin; systemic

4.7

40.5

184

631

L03

ICPC

Low back symptom/complaint

5.6

39.4

134

333

ZXD05

NOMESCO Finland

Urgent procedure

4.4

38.8

198

750

ABC36

NOMESCO Finland

Decompression of lumbar nerve roots

144.2

37.5

GD1AA

NOMESCO Finland

Thorax X-ray examination

4.1

36.8

249

1201

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

5.2

36.1

133

357

A41.9

ICD-10 Finland

Sepsis, unspecified

13.0

34.8

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

8.1

34.1

125

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

61.7

33.9

M46.2

ICD-10 Finland

Osteomyelitis of vertebra

+∞

33.8

TPH04

NOMESCO Finland

Cathetrisation of vein

4.4

33.2

149

483

NA7DG

NOMESCO Finland

Spine and spinal cord very extensive MRI examination with high intensity magnet

54.1

33.2

FM1BE

NOMESCO Finland

Cardiac ultrasound examination through oesophagus

7.0

32.6

154

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

4.6

32.0

131

385

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

6.5

30.2

161

WX408

NOMESCO Finland

General anesthesy, balanced

3.8

28.8

156

585

N10

ICD-10 Finland

Acute tubulo-interstitial nephritis

5.2

28.6

240

R50.9

ICD-10 Finland

Fever, unspecified

4.8

28.0

105

277

A40.8

ICD-10 Finland

Other streptococcal sepsis

41.2

27.6

A02BC02

ATC

pantoprazole; systemic

3.5

27.3

287

1760

N02BE01

ATC

paracetamol; systemic, rectal

5.6

27.2

353

2599

J01MA12

ATC

levofloxacin; systemic

3.9

26.1

130

446

C03CA01

ATC

furosemide; systemic

3.3

25.6

175

770

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

4.6

25.1

272

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

4.2

24.9

110

337

FM1AE

NOMESCO Finland

Standard cardiac ultrasound examination

3.7

24.6

128

453

M46.9

ICD-10 Finland

Inflammatory spondylopathy, unspecified

+∞

22.1

B01AB05

ATC

enoxaparin; parenteral

3.1

22.1

161

722

R4110

NOMESCO Finland

Physiotherapy

3.2

21.7

147

625

JN4BD

NOMESCO Finland

Extensive body CT

4.2

21.6

269

A41.5

ICD-10 Finland

Sepsis due to other Gram-negative organisms

9.8

21.5

NA2BG

NOMESCO Finland

Thoracal spine MRI examination with high intensity magnet

36.1

21.4

NA2CG

NOMESCO Finland

Thoracal spine extensive MRI examination with high intensity magnet

53.3

21.4

J18.9

ICD-10 Finland

Pneumonia, unspecified

3.2

21.3

141

589

NA3AD

NOMESCO Finland

Lumbar spine and sacrum CT examination

30.1

21.3

M47.2

ICD-10 Finland

Other spondylosis with radiculopathy

39.7

21.0

J01DB01

ATC

cefalexin; oral

3.7

21.0

332

2449

TPH07

NOMESCO Finland

Cathetrisation of artery

4.5

20.6

208

B18.2

ICD-10 Finland

Chronic viral hepatitis C

34.7

20.5

A41.1

ICD-10 Finland

Sepsis due to other specified staphylococcus

51.0

20.4

L28

ICPC

Limited function/disability (L)

3.9

20.2

296

7227C

ICD-9 Finland

Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]

+∞

20.0

A46

ICD-10 Finland

Erysipelas

3.7

19.8

100

337

I33.0

ICD-10 Finland

Acute and subacute infective endocarditis

26.3

19.8

GD1PA

NOMESCO Finland

X-ray examination of the lungs in one projection

5.0

19.7

155

ABC56

NOMESCO Finland

Decompression of lumbar spinal canal and nerve roots

+∞

18.9

NA3EA

NOMESCO Finland

Lumbar spine X-ray examination with flexion

+∞

18.9

J01CF02

ATC

cloxacillin; systemic

11.2

18.6

M03BC01

ATC

orphenadrine (citrate); systemic

3.5

18.3

336

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

2.9

18.3

143

653

ZXE02

NOMESCO Finland

Procedure duration 10 to 19 minutes

7.7

18.2

M03BX02

ATC

tizanidine; oral

2.6

18.2

230

1398

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

2.7

18.0

186

1004

TPH20

NOMESCO Finland

Insertion of central venous catheter through subclavian or brachiocephalic vein

8.3

17.9

NAG62

NOMESCO Finland

Posterior fusion of lumbar spine with fixation, 2-3 vertebraea

+∞

17.8

X59

ICD-10 Finland

Exposure to unspecified factor

3.4

17.5

330

M54.3

ICD-10 Finland

Sciatica

15.8

17.4

N02AJ06

ATC

codeine and paracetamol; systemic

2.7

17.1

153

752

JN3AD

NOMESCO Finland

Abdominal CT examination

5.0

17.1

129

NA2AA

NOMESCO Finland

Thoracal spine X-ray examination without contrast

23.2

17.1

KH1AE

NOMESCO Finland

Urinary tract ultrasound examination

5.6

16.9

103

A41.8

ICD-10 Finland

Other specified sepsis

10.2

16.8

ABC16

NOMESCO Finland

Microsurgical excision of lumbar intervertebral disc displacement

177.4

16.6

ZXE10

NOMESCO Finland

More than one and less than three hours

2.6

16.2

170

910

J01CF05

ATC

flucloxacillin; systemic

6.7

16.0

Z3226

NOMESCO Finland

Physiotherapist

3.1

16.0

100

390

NA1DG

NOMESCO Finland

Cervical spine very extensive MRI examination with high intensity magnet

+∞

15.7

ABC26

NOMESCO Finland

Open discectomy of lumbar spine

+∞

15.7

NA1CG

NOMESCO Finland

Cervical spine extensive MRI examination with high intensity magnet

30.0

15.3

AA1AD

NOMESCO Finland

CT of head and brain

2.7

15.3

123

562

TPX10

NOMESCO Finland

Implantation of vascular injection port

7.8

14.9

SPAT1255

SPAT

Intravenous administration of medicine

4.8

14.7

115

M46.5

ICD-10 Finland

Other infective spondylopathies

+∞

14.7

TKC20

NOMESCO Finland

Catheterisation of bladder

4.1

14.6

162

NA1AA

NOMESCO Finland

Cervical spine X-ray examination without contrast

17.9

14.5

ZXE00

NOMESCO Finland

One hour or less

2.4

14.1

171

965

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

2.4

13.9

164

913

M43.1

ICD-10 Finland

Spondylolisthesis

55.5

13.9

J01MA02

ATC

ciprofloxacin; systemic

2.3

13.8

183

1080

138

Kela drug reimbursment

Severe anaemia associated with chronic renal failure

9.3

13.7

ZXA00

NOMESCO Finland

Right side

2.6

13.7

125

606

A06AD11

ATC

lactulose; oral

3.2

13.7

287

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

3.6

13.7

205

H02AB06

ATC

prednisolone; systemic

2.3

13.6

194

1182

A28

ICPC

Limited function/disability NOS

2.9

13.6

367

M54

ICD-10 Finland

Dorsalgia

4.3

13.5

136

ZXD35

NOMESCO Finland

Usual procedure

6.3

13.2

M54.1

ICD-10 Finland

Radiculopathy

29.5

13.1

Z49.1

ICD-10 Finland

Extracorporeal dialysis

12.2

13.0

N17.9

ICD-10 Finland

Acute renal failure, unspecified

5.4

12.9

JN3BD

NOMESCO Finland

Extensive abdominal CT

3.4

12.8

221

123

Kela drug reimbursment

Chronic disorders of vitamin D metabolism

7.8

12.7

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

3.6

12.7

182

ZXE04

NOMESCO Finland

Procedure duration 30 to 39 minutes

4.8

12.6

NA7EA

NOMESCO Finland

Scoliosis X-ray examination

+∞

12.6

72510

ICD-8 Finland

Displacement of intervertebral disk, Lumbalis cum prolapsu disci

+∞

12.6

L17

ICPC

Foot/toe symptom/complaint

2.6

12.5

106

490

N39.0

ICD-10 Finland

Urinary tract infection, site not specified

3.3

12.4

237

M54.2

ICD-10 Finland

Cervicalgia

6.5

12.4

N06AX21

ATC

duloxetine; oral

4.3

12.3

117

J01XX08

ATC

linezolid; systemic

38.9

12.3

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

2.9

12.2

316

N05CF01

ATC

zopiclone; oral

2.3

12.2

139

751

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

2.4

12.2

135

716

ZXE03

NOMESCO Finland

Procedure duration 20 to 29 minutes

4.8

12.1

SPAT1148

SPAT

Treatment of chronic ulcer or burn

2.9

12.1

311

WX402

NOMESCO Finland

General anaesthesia

3.0

12.1

285

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

2.5

12.0

116

576

M25.5

ICD-10 Finland

Pain in joint

2.5

12.0

107

508

F15.1

ICD-10 Finland

Mental and behavioural disorders due to use of other stimulants, including caffeine, harmful use

48.3

12.0

A04.7

ICD-10 Finland

Enterocolitis due to Clostridium difficile

9.4

11.9

ZXE05

NOMESCO Finland

Procedure duration 40 to 49 minutes

5.3

11.9

X58

ICD-10 Finland

Exposure to other specified factors

3.3

11.9

216

WX404

NOMESCO Finland

Intravenous generell anesthesy

2.6

11.8

426

R33

ICD-10 Finland

Retention of urine

3.4

11.7

200

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

2.4

11.7

125

650

WX892

NOMESCO Finland

Monitored bed care

3.8

11.6

150

M79.6

ICD-10 Finland

Pain in limb

2.3

11.6

132

708

NAS20

NOMESCO Finland

Incision and debridement of infection of vertebra, unspecified

+∞

11.5

NE1CG

NOMESCO Finland

Pelvic, hip and femur extensive MRI examination with high intensity magnet

15.7

11.4

Z3231

NOMESCO Finland

Registered nurse

2.3

11.4

127

673

M01AB05

ATC

diclofenac; systemic, rectal

2.1

11.4

244

1729

M50.1

ICD-10 Finland

Cervical disc disorder with radiculopathy

36.2

11.3

L02.4

ICD-10 Finland

Cutaneous abscess, furuncle and carbuncle of limb

7.5

11.2

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

4.1

11.2

117

NK6CT

NOMESCO Finland

Bone biopsy with CT guidance

25.9

11.2

C08CA01

ATC

amlodipine; oral

2.2

11.2

164

985

R52.0

ICD-10 Finland

Acute pain

9.7

11.2

N05BA01

ATC

diazepam; systemic, rectal

3.1

11.1

232

M01AE03

ATC

ketoprofen; systemic, rectal

2.2

11.1

153

893

ZXM10

NOMESCO Finland

Intraoperative use of conventional X-ray imaging

6.2

11.0

NA1BG

NOMESCO Finland

Cervical spine MRI examination with high intensity magnet

11.0

10.9

SPAT1083

SPAT

Initiation and monitoring of IV fluid therapy

5.4

10.9

TK800

NOMESCO Finland

Hemodialysis

7.1

10.9

N18.9

ICD-10 Finland

Chronic kidney disease, unspecified

3.9

10.8

127

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

3.6

10.7

155

A40.1

ICD-10 Finland

Sepsis due to streptococcus, group B

61.7

10.7

WX110

NOMESCO Finland

Local anesthesy

2.1

10.7

253

1844

ZXM00

NOMESCO Finland

Intraoperative use of ultrasonographic imaging

10.5

10.6

N06AA09

ATC

amitriptyline; systemic

3.9

10.6

124

NA3CM

NOMESCO Finland

Lumbar spine extensive MRI examination with 3 Tesla magnet

113.0

10.5

M45

ICD-10 Finland

Ankylosing spondylitis

+∞

10.5

NAW10

NOMESCO Finland

Reoperation for superficial infection in in surgery of spine or neck

+∞

10.5

N05AH04

ATC

quetiapine; oral

2.9

10.4

272

L86

ICPC

Back syndrome with radiating pain

6.6

10.3

L97

ICD-10 Finland

Ulcer of lower limb, not elsewhere classified

5.4

10.2

NB1AE

NOMESCO Finland

Shoulder ultrasound examination

15.1

10.1

R53

ICD-10 Finland

Malaise and fatigue

2.5

10.0

382

M47.82

ICD-10 Finland

Other spondylosis, cervical region

26.8

9.9

M13.9

ICD-10 Finland

Arthritis, unspecified

3.8

9.7

117

ZXE20

NOMESCO Finland

More than three and less than five hours

2.7

9.7

293

A11CC03

ATC

alfacalcidol; systemic

7.5

9.6

ZXA05

NOMESCO Finland

Left side

2.2

9.6

111

592

NB1AA

NOMESCO Finland

Shoulder X-ray examination without contrast

4.5

9.6

FM1DE

NOMESCO Finland

Doppler ultrasound examination of heart

3.1

9.5

186

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

3.6

9.5

130

NA7CG

NOMESCO Finland

Spine and spinal cord extensive MRI examination with high intensity magnet

18.1

9.5

Z72.2

ICD-10 Finland

Drug use

102.4

9.5

M00.0

ICD-10 Finland

Staphylococcal arthritis and polyarthritis

102.4

9.5

S97

ICPC

Chronic ulcer skin

3.9

9.4

104

NE1AA

NOMESCO Finland

Pelvis X-ray examination

4.0

9.4

Z2446

NOMESCO Finland

Social worker

4.2

9.4

9211

FHL

Exploration or removal of diskusprolapse

+∞

9.4

XF400

NOMESCO Finland

ECG with 12 standard connections

2.4

9.4

400

A01

ICPC

Pain general/multiple sites

4.3

9.3

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

2.0

9.2

184

1225

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

3.8

9.2

107

X69

ICD-10 Finland

Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances

7.3

9.2

F10.1

ICD-10 Finland

Mental and behavioural disorders due to use of alcohol, Harmful use

3.5

9.0

130

B01AB10

ATC

tinzaparin; parenteral

3.8

9.0

109

WX002

NOMESCO Finland

Sedation and analgesia

2.3

8.9

471

M54.8

ICD-10 Finland

Other dorsalgia

8.9

C07AB07

ATC

bisoprolol; oral

1.9

8.9

200

1386

M00.9

ICD-10 Finland

Pyogenic arthritis, unspecified

11.1

8.9

WX000

NOMESCO Finland

Monitoring vital functions without anesthesy

5.1

8.9

B03XA02

ATC

darbepoetin alfa; parenteral

7.5

8.8

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

3.6

8.8

116

N03AE01

ATC

clonazepam; systemic

4.9

8.8

F11.22

ICD-10 Finland

Addiction-induced dependence is currently independent but uses substitute intermittent medication

51.2

8.7

M01AH05

ATC

etoricoxib; oral

1.9

8.7

196

1356

I50.9

ICD-10 Finland

Heart failure, unspecified

2.5

8.6

339

ZXE11

NOMESCO Finland

Procedure duration 60 to 89 minutes

4.6

8.6

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

2.0

8.5

130

772

M47.9

ICD-10 Finland

Spondylosis, unspecified

28.2

8.5

P19

ICPC

Drug abuse

20.6

8.5

S18

ICPC

Laceration/cut

1.9

8.5

170

1120

M04AA01

ATC

allopurinol; systemic

2.5

8.5

335

NAG63

NOMESCO Finland

Posterior fusion of lumbar spine with fixation, more than 3 vertebraea

92.0

8.4

M46.0

ICD-10 Finland

Spinal enthesopathy

92.0

8.4

M43.0

ICD-10 Finland

Spondylolysis

92.0

8.4

R60.0

ICD-10 Finland

Localized oedema

2.9

8.4

197

N06AX11

ATC

mirtazapine; oral

2.1

8.4

113

637

ABC60

NOMESCO Finland

Decompression of cervical spinal cord

+∞

8.4

M47.1

ICD-10 Finland

Other spondylosis with myelopathy

+∞

8.4

I15.1

ICD-10 Finland

Hypertension secondary to other renal disorders

9.8

8.4

KC1EE

NOMESCO Finland

Ultrasound measurement of residual urine

2.4

8.2

375

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

3.8

8.2

NE1BG

NOMESCO Finland

Pelvic, hip and femur MRI examination with high intensity magnet

7.1

8.2

J01DA01

ATC

[U] cefalexin; systemic

1.9

8.1

228

1686

J15.9

ICD-10 Finland

Bacterial pneumonia, unspecified

3.0

8.1

164

TQW40

NOMESCO Finland

Remowal of suture of skin

3.5

8.1

113

Z49.0

ICD-10 Finland

Preparatory care for dialysis

12.1

8.1

F19.1

ICD-10 Finland

Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use

34.1

8.1

SPAT1254

SPAT

Administration of medicine

2.6

8.1

274

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

3.9

8.1

T36

ICD-10 Finland

Poisoning by systemic antibiotics

5.6

8.0

FB1BD

NOMESCO Finland

Extensive CT examination of arteria pulmonalis

3.4

7.9

121

UJF32

NOMESCO Finland

Coloscopy

2.1

7.9

107

605

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

2.0

7.9

118

692

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

3.3

7.9

127

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

2.1

7.9

106

595

UKC02

NOMESCO Finland

Cystoscopy

2.2

7.8

430

NG1AE

NOMESCO Finland

Knee joint ultrasound exmination

15.4

7.8

NAU20

NOMESCO Finland

Removal of internal fixation device from spine or neck

45.9

7.7

D50.9

ICD-10 Finland

Iron deficiency anaemia, unspecified

3.4

7.7

113

L03.1

ICD-10 Finland

Cellulitis of other parts of limb

6.4

7.6

190

Kela drug reimbursment

Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide

10.3

7.6

JN4AD

NOMESCO Finland

Body CT examination

2.9

7.6

178

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

2.4

7.5

320

351

Kela drug reimbursment

Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation

2.3

7.5

334

TPH90

NOMESCO Finland

Removal of fixed intravenous catheter

7.9

7.5

F19.29

ICD-10 Finland

Addiction caused by several drugs in combination and by other psychoactive substances UNS

81.6

7.4

N05BA04

ATC

oxazepam; oral

2.1

7.4

491

K04.5

ICD-10 Finland

Chronic apical periodontitis

2.1

7.4

546

Z95.2

ICD-10 Finland

Presence of prosthetic heart valve

5.4

7.4

XF600

NOMESCO Finland

Bloodpressure measurement

3.3

7.3

117

JN3AA

NOMESCO Finland

Abdominal X-ray examination without contrast

4.3

7.3

WX704

NOMESCO Finland

Intubation

3.4

7.3

106

ZXE13

NOMESCO Finland

Procedure duration 90 to 119 minutes

5.6

7.3

DM1AA

NOMESCO Finland

Paranasal sinuses X-ray examination without contrast

5.6

7.3

NF1AA

NOMESCO Finland

Hip X-ray examination

3.0

7.3

152

TQW11

NOMESCO Finland

Vacuum treatment of wound

6.0

7.3

M60.0

ICD-10 Finland

Infective myositis

+∞

7.3

F15.2

ICD-10 Finland

Mental and behavioural disorders due to use of other stimulants, including caffeine, dependence syndrome

+∞

7.3

ABC66

NOMESCO Finland

Decompression of lumbal spinal channel

+∞

7.3

F19.30

ICD-10 Finland

Withdrawal symptoms caused by several drugs in combination and by other psychoactive substances uncomplicated

+∞

7.3

R06.0

ICD-10 Finland

Dyspnoea

2.1

7.3

519

SPAT1212

SPAT

Extensive examination of musculoskeletal system

3.5

7.3

101

I48

ICD-10 Finland

Atrial fibrillation and flutter

2.0

7.2

113

671

NF1AE

NOMESCO Finland

Hip joint ultrasound examination

6.8

7.2

L04AA13

ATC

leflunomide; oral

8.2

7.2

WX872

NOMESCO Finland

Intensive care

3.3

7.1

114

XF603

NOMESCO Finland

Direct intraarterial blood pressure measurement

4.2

7.1

D64.9

ICD-10 Finland

Anaemia, unspecified

2.6

7.1

230

Z76.9

ICD-10 Finland

Person encountering health services in unspecified circumstances

3.7

7.1

K43.9

ICD-10 Finland

Other and unspecified ventral hernia without obstruction or gangrene

4.2

7.0

SPAT1149

SPAT

Suture or treatment of traumatic wound

2.3

7.0

314

M70.6

ICD-10 Finland

Trochanteric bursitis

3.1

7.0

137

N05CD07

ATC

temazepam; oral

2.5

6.9

249

I10

ICD-10 Finland

Essential (primary) hypertension

1.8

6.9

236

1814

B01AA03

ATC

warfarin; systemic

2.0

6.9

562

R52.2

ICD-10 Finland

Other chronic pain

6.9

Z01.6

ICD-10 Finland

Radiological examination, not elsewhere classified

2.9

6.9

153

M01AH01

ATC

celecoxib; oral (coxibs)

2.3

6.9

320

290

Kela drug reimbursment

Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation

2.2

6.9

392

R02

ICPC

Shortness of breath/dyspnoea

2.6

6.8

198

J01MA14

ATC

moxifloxacin; systemic

2.6

6.8

198

EBA15

NOMESCO Finland

Extraction of large number of teeth

4.0

6.8

N30.0

ICD-10 Finland

Acute cystitis

2.6

6.8

202

F10.21

ICD-10 Finland

Alcohol dependence currently abstinent, but staying in restrictive environment

40.8

6.8

IAB10

NOMESCO Finland

Psychiatric consultation concerning substance abuse

40.8

6.8

M46.1

ICD-10 Finland

Sacroiliitis, not elsewhere classified

40.8

6.8

F11.29

ICD-10 Finland

Addiction caused by opiates UNS

40.8

6.8

D07AC01

ATC

betamethasone; topical

1.9

6.7

127

805

G55.1*M51.1

ICD-10 Finland

Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions

23.0

6.7

NA2DG

NOMESCO Finland

Thoracal spine very extensive MRI examination with high intensity magnet

23.0

6.7

Y88.3

ICD-10 Finland

Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

5.7

6.7

ZXE06

NOMESCO Finland

Procedure duration 50 to 59 minutes

3.9

6.6

WW500

NOMESCO Finland

Blood transfusion

4.0

6.6

S29

ICPC

Skin symptom/complaint other

2.2

6.6

325

SPAT1229

SPAT

Assessment of need for aid

3.0

6.6

131

J01CA04

ATC

amoxicillin; systemic

1.8

6.5

280

2293

M10.0

ICD-10 Finland

Idiopathic gout

4.4

6.5

J45.9

ICD-10 Finland

Asthma, unspecified

2.2

6.5

319

F10.25

ICD-10 Finland

Alcohol dependence continuous use

7.6

6.5

H05BA01

ATC

calcitonin (salmon synthetic); nasal, parenteral

7.6

6.5

M53.1

ICD-10 Finland

Cervicobrachial syndrome

3.6

6.5

N02AA03

ATC

hydromorphone; systemic, rectal

71.0

6.4

F11.25

ICD-10 Finland

Relationship caused by opiates continuously used

71.0

6.4

R4120

NOMESCO Finland

Occupational therapy

3.5

6.4

V03AE01

ATC

polystyrene sulfonate; oral

6.7

6.4

SPAT1156

SPAT

Guidance concerning treatment of rash and skin

2.3

6.4

286

NH1AA

NOMESCO Finland

Ankle X-ray examination without contrast

3.6

6.4

Z2221

NOMESCO Finland

Medical doctor

1.9

6.3

108

659

F51.0

ICD-10 Finland

Nonorganic insomnia

2.7

6.3

168

QD9S1

NOMESCO Finland

Photography of skin or subcutaneous tissue in lower extremities, unspecified

18.4

6.3

T81.0

ICD-10 Finland

Haemorrhage and haematoma complicating a procedure, not elsewhere classified

3.1

6.3

108

F19.25

ICD-10 Finland

Addiction caused by several drugs in combination and by other psychoactive substances continuously used

+∞

6.3

72880

ICD-8 Finland

Vertebrogenic pain syndrome, Radicula syndrome of lower limbs

+∞

6.3

NA6CG

NOMESCO Finland

Sacro-iliac joint extensive MRI examination with high intensity magnet

+∞

6.3

NA3DM

NOMESCO Finland

Lumbar spine very extensive MRI examination with 3 Tesla magnet

+∞

6.3

NAG65

NOMESCO Finland

Anterior and posterior fusion of lumbar spine

+∞

6.3

F19.24

ICD-10 Finland

Addiction relationship caused by several drugs in combination and by other psychoactive substances active addiction

27.1

6.2

NA3SA

NOMESCO Finland

Lumbar spine X-ray examination in standing position

27.1

6.2

L30.9

ICD-10 Finland

Dermatitis, unspecified

2.2

6.2

349

Z02.7

ICD-10 Finland

Issue of medical certificate

3.5

6.2

QDB05

NOMESCO Finland

Revision of wound of skin of lower limb

4.8

6.2

L02

ICPC

Back symptom/complaint

3.2

6.2

Z50.1

ICD-10 Finland

Other physical therapy

3.6

6.2

V49.9

ICD-10 Finland

Car occupant [any] injured in unspecified traffic accident

5.1

6.1

WZB00

NOMESCO Finland

Telephone receipt or other advice

1.9

6.1

552

C01DA08

ATC

isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal

1.9

6.1

102

618

QBB05

NOMESCO Finland

Revision of wound of skin of trunk

12.8

6.1

WVA20

NOMESCO Finland

Medicine administration

6.9

6.1

PH1AE

NOMESCO Finland

Ultrasound examination of upper extremity veins

10.3

6.1

QCB05

NOMESCO Finland

Revision of wound of skin of upper limb

10.3

6.1

KAS10

NOMESCO Finland

Allogenic transplantation of kidney from cadaver donor

10.3

6.1

NAME	M13_DISCINFECTION
CONTROL_EXCLUDE	M13_DORSOPATHY
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M463
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M463
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
M13_DISCINFECTION	2.197 [1.72, 2.81]	< 0.001
Birth year	0.991 [0.98, 1.0]	0.048

Parameter	HR [95% CI]	p-value
M13_DISCINFECTION	2.163 [1.73, 2.7]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.004

N-year risk	Females	Males
1	0.152%	0.427%
5	1.139%	2.451%
10	2.617%	5.546%
15	5.3%	10.663%
20	9.26%	18.144%

Infection of intervertebral disc (pyogenic)

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints