This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Diseases of the musculoskeletal system and connective tissue
M13_MUSCULOSKELETAL
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
306165 |
4. Check minimum number of eventsNone |
306165 |
5. Include endpoints |
306966 |
6. Filter based on genotype QC (FinnGen only) |
306966 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 1
- First used in FinnGen datafreeze
- DF10
Diseases of the musculoskeletal system and connective tissue
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 306966 | 176953 | 130013 |
| Unadjusted period prevalence (%) | 59.05 | 60.32 | 57.32 |
| Median age at first event (years) | 47.42 | 45.84 | 49.58 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 107
- Matched controls
- 789
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M79.6
ICD-10 Finland
Pain in limb
40.1
38.1
52
18
M25.5
ICD-10 Finland
Pain in joint
26.5
15.7
23
8
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
+∞
11.3
12
*
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
22.8
10.6
16
6
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
+∞
8.4
9
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
12.6
8.2
15
10
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
+∞
7.5
8
*
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
+∞
6.5
7
*
L04AB01
ATC
etanercept; parenteral
+∞
6.5
7
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
+∞
6.5
7
*
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
+∞
6.5
7
*
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: M13_MUSCULOSKELETAL – Diseases of the musculoskeletal system and connective tissue
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).