No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
442635 |
4. Check minimum number of events
Min. number of events
3
|
442635 |
5. Include endpointsNone |
442635 |
6. Filter based on genotype QC (FinnGen only) |
442635 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF5
Paracetamol of NSAID medication
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4047479 | 2165498 | 1856583 |
| Only index persons | 3785975 | 2043748 | 1742227 |
| Unadjusted period prevalence (%) | |||
| Whole population | 57.15 | 62.03 | 51.87 |
| Only index persons | 71.16 | 75.13 | 66.51 |
| Median age at first event (years) | |||
| Whole population | 40.07 | 40.98 | 38.98 |
| Only index persons | 38.64 | 39.56 | 37.57 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 442635 | 259059 | 183576 |
| Unadjusted period prevalence (%) | 85.24 | 88.30 | 80.93 |
| Median age at first event (years) | 40.32 | 37.45 | 44.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
Mortality – FinRegistry
↥Association
Association between endpoint RX_PARACETAMOL_NSAID and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RX_PARACETAMOL_NSAID | 0.8 [0.75, 0.85] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.755 |
During the follow-up period (1.1.1998 — 31.12.2019), 130281 out of 1353979 females with RX_PARACETAMOL_NSAID died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RX_PARACETAMOL_NSAID | 0.791 [0.74, 0.84] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.03 |
During the follow-up period (1.1.1998 — 31.12.2019), 135553 out of 1250642 males with RX_PARACETAMOL_NSAID died.
Mortality risk
Mortality risk for people of age
years, who have RX_PARACETAMOL_NSAID.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.081% | 0.135% |
| 5 | 0.456% | 0.91% |
| 10 | 1.139% | 2.333% |
| 15 | 2.228% | 4.747% |
| 20 | 4.104% | 8.188% |
Relationships between endpoints
↥Index endpoint: RX_PARACETAMOL_NSAID – Paracetamol of NSAID medication
GWS hits: 33
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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