Paracetamol of NSAID medication

RX_PARACETAMOL_NSAID

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Medicine purchases: ATC N02BE01|N02BE51|M01A|M01B

1 out of 7 registries used, show all original rules.

442635

4. Check minimum number of events

Min. number of events 3
442635

5. Include endpoints

None

442635

6. Filter based on genotype QC (FinnGen only)

442635

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4047479 2165498 1856583
Only index persons 3785975 2043748 1742227
Unadjusted period prevalence (%)
Whole population 57.15 62.03 51.87
Only index persons 71.16 75.13 66.51
Median age at first event (years)
Whole population 40.07 40.98 38.98
Only index persons 38.64 39.56 37.57

-FinnGen-

Key figures

All Female Male
Number of individuals 442635 259059 183576
Unadjusted period prevalence (%) 85.24 88.30 80.93
Median age at first event (years) 40.32 37.45 44.37

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
3625
9270
2.28
316.20
2.4
2.2
—
—
—
0
0
6505
20982
1.99
313.52
4.8
4.4
6.6
6.7
mmol/l
3.44
6028
18567
12040
48102
2.29
307.65
14.8
10.1
77.6
77.0
umol/l
1.32
12034
48059
6682
21339
2.04
307.65
8.7
9.6
4.1
4.0
e9/l
1.79
5847
18271
11467
43659
2.35
307.65
15.0
10.7
4.0
3.9
mmol/l
11.85
11093
41684
11435
43502
2.34
307.65
14.9
10.6
139.6
139.7
mmol/l
2.16
11083
41662
7928
26307
2.09
307.65
4.1
3.3
—
—
—
0
0
4026
10447
2.28
307.65
3.5
2.8
56.3
84.1
ng/l
1.01
2534
6706
12153
48740
2.32
307.65
12.4
8.4
—
—
—
0
0
8369
26899
2.27
307.65
7.0
6.2
79.0
80.9
u/l
1.99
7850
25056
1801
2685
3.70
307.65
1.2
1.1
9.1
10.5
u/ml
0.31
701
934
5606
16079
2.20
307.65
5.9
5.7
11.3
12.7
umol/l
11.57
5288
15121
5374
15509
2.16
307.65
4.2
3.7
—
—
—
0
0
7612
24461
2.15
307.65
4.2
3.2
1801.0
921.2
e6/l
0.51
119
353
8268
25242
2.44
307.65
3.9
2.9
10.9
10.5
mm/h
1.51
7644
23010
11759
42603
2.77
307.65
13.5
8.7
24.1
25.1
mg/l
2.14
9329
29232
1894
3027
3.46
307.65
1.2
1.1
31.3
37.7
iu/ml
0.30
554
814
6045
19254
1.97
297.26
6.3
6.6
0.2
0.2
e9/l
0.39
5358
16716
2709
6220
2.46
296.58
2.6
2.7
5740.2
6986.9
umol/l
0.57
2367
5531
10280
39433
1.98
292.85
4.3
3.7
2.0
2.4
mu/l
1.62
9485
36111
12042
49143
2.16
286.41
9.5
6.8
27.4
26.4
u/l
2.88
11614
46924
5834
18593
1.95
282.49
6.1
6.1
0.0
0.0
e9/l
0.41
5088
15863
5813
18521
1.95
281.41
6.0
6.0
0.6
0.6
e9/l
0.76
5060
15791
6030
19474
1.93
280.46
6.1
6.0
1.9
1.9
e9/l
0.04
5367
16955
7262
25027
1.89
277.62
3.4
3.0
—
—
—
0
0
2504
5736
2.44
273.44
1.9
2.2
1.1
1.6
mg/l
6.73
1827
4275
5662
18045
1.93
271.27
3.4
2.7
0.0
0.0
estimate
0.21
1113
3151
5720
18316
1.92
269.97
3.4
2.8
0.0
0.0
estimate
0.06
1105
3166
3425
9126
2.15
264.51
2.6
2.3
55.8
61.8
u/l
4.74
3191
8406
5649
18155
1.91
261.62
4.6
3.9
0.0
0.0
estimate
0.27
1140
3267
4186
12189
2.01
255.51
8.8
9.3
1.2
1.3
inr
6.15
1283
3598
5565
17924
1.89
254.17
6.4
6.3
8.5
8.5
%
0.00
5234
16787
5768
18829
1.88
252.55
6.2
6.0
28.6
29.2
%
3.60
5412
17595
5534
17833
1.89
251.77
6.1
6.1
2.8
2.8
%
0.35
5179
16633
3019
7782
2.19
251.08
4.3
3.9
—
—
—
0
0
9534
36562
1.85
250.39
5.1
4.4
39.1
38.7
mmol/mol
3.38
8871
33886
8593
31910
1.83
249.55
3.7
3.3
14.6
14.7
pmol/l
0.16
7821
28513
5665
18506
1.87
245.72
6.0
5.9
56.8
56.4
%
1.79
5335
17362
12968
55546
2.26
244.57
19.4
12.9
250.6
249.2
e9/l
1.47
12641
53084
2738
6842
2.24
244.30
2.3
2.2
—
—
—
0
0
12989
55709
2.26
243.06
19.4
12.9
6.8
6.6
e9/l
15.23
12642
53049
10354
40966
1.87
242.53
3.9
3.4
5.8
5.8
mmol/l
4.34
9450
37480
5352
17218
1.88
242.43
6.2
6.2
0.6
0.7
%
0.57
5021
16063
12975
55675
2.25
240.90
19.3
12.8
30.1
30.0
pg
13.10
12777
54370
5134
16328
1.89
240.29
6.7
6.7
1.2
1.2
mmol/l
0.30
4318
13779
12977
55702
2.25
240.27
19.3
12.9
4.6
4.6
e12/l
15.62
12627
53064
12975
55691
2.24
240.23
19.3
12.8
90.2
89.7
fl
25.50
12778
54381
4656
14341
1.92
239.54
6.2
6.4
1.2
1.2
mmol/l
0.17
4232
12977
12981
55752
2.24
239.19
19.5
13.0
136.4
137.3
g/l
8.77
12775
54477
3085
8202
2.12
236.15
2.1
2.0
240.8
284.7
u/l
0.83
2908
7693
4487
13802
1.91
229.85
4.9
5.1
35.9
36.0
g/l
0.25
4161
12741
4102
12237
1.95
229.69
3.6
3.4
121.2
106.4
e6/l
0.25
2873
8101
7789
28836
1.75
214.39
3.1
2.6
44.8
38.9
u/l
7.21
7348
27112
4455
14100
1.84
204.41
3.5
2.8
—
—
—
0
0
3453
10098
1.94
200.32
3.1
3.0
2.3
2.4
mmol/l
0.82
3048
8780
5469
18538
1.76
199.42
2.8
2.7
111.1
104.2
ug/l
0.71
5076
17331
4149
12969
1.84
196.46
2.1
1.8
—
—
—
0
0
3452
10198
1.91
193.47
3.2
3.0
95.1
112.2
e6/l
0.27
2670
7560
10674
43982
1.76
190.41
4.2
3.7
2.7
2.8
mmol/l
11.77
9847
40779
2698
7395
2.02
185.74
3.1
3.2
1732.8
1779.0
ng/l
0.14
2266
6361
10526
43366
1.74
184.20
3.8
3.4
4.6
4.7
mmol/l
17.21
9803
40507
3904
12193
1.83
183.04
6.2
6.2
—
—
—
0
0
10443
42967
1.73
182.77
3.8
3.4
1.4
1.5
mmol/l
31.50
9668
40041
1637
3665
2.40
182.47
2.0
1.8
—
—
—
0
0
10046
41057
1.70
176.69
3.5
3.1
1.3
1.2
mmol/l
24.66
9284
38176
3066
8944
1.91
176.07
3.1
2.9
—
—
—
0
0
1883
4582
2.22
173.87
1.5
1.3
—
—
—
0
0
11037
46392
1.74
173.65
13.9
10.2
40.4
39.8
%
8.13
8465
35429
3116
9186
1.89
173.08
3.1
3.0
0.4
0.4
e6/l
0.08
2360
6662
4400
14520
1.74
169.43
2.3
2.2
73.2
72.9
nmol/l
0.32
3992
13320
2422
6612
2.01
166.77
2.6
2.6
5.7
5.6
e6/l
0.12
2131
5654
1567
3580
2.34
166.45
1.4
1.3
473.5
556.4
titre
0.80
288
660
2830
8178
1.91
165.89
4.1
4.2
88.9
86.1
%
6.30
2753
7975
4125
13488
1.74
162.67
1.9
1.7
94.5
94.4
pmol/l
0.03
2268
7192
3095
9311
1.85
159.98
3.7
2.9
0.0
0.0
estimate
0.26
1090
3081
550
667
4.27
159.92
1.1
1.0
—
—
—
0
0
1447
3266
2.36
157.38
1.6
1.6
—
—
—
0
0
2986
8935
1.85
156.50
2.2
2.2
2.9
2.8
mg/l
2.19
2551
7610
3203
9819
1.82
155.42
2.9
2.3
—
—
—
0
0
3647
11813
1.73
145.80
4.7
4.2
4.4
4.2
ug/l
0.05
3243
10594
1362
3139
2.30
140.82
1.2
1.2
—
—
—
0
0
3013
9323
1.78
139.87
4.0
4.1
7.4
7.4
ph
0.59
594
1672
9848
41125
1.59
139.61
15.9
11.8
13.5
13.4
%
4.88
9639
39874
2854
8722
1.80
137.73
3.6
3.3
—
—
—
0
0
3263
10439
1.73
134.55
3.0
2.5
—
—
—
0
0
2717
8303
1.79
130.29
4.2
4.3
—
—
—
0
0
1829
4901
2.00
129.90
2.9
2.8
2.4
2.4
mmol/l
0.08
1598
4164
2947
9295
1.74
126.63
1.3
1.4
1.7
2.4
u/ml
1.37
771
2311
2617
7978
1.79
126.04
1.4
1.4
2.2
2.3
g/l
0.13
1637
4802
2903
9163
1.74
124.10
4.2
3.8
21.5
22.3
%
1.69
1317
4471
2281
6691
1.84
124.05
2.7
2.6
573.6
575.5
mosm/kgh2o
0.12
1955
5588
3783
12851
1.64
123.42
3.3
3.1
32.6
32.9
u/l
0.10
3601
12187
5105
18783
1.56
118.90
9.3
8.0
0.0
0.0
e9/l
0.36
4153
15177
2393
7234
1.79
117.64
1.5
1.4
19.8
19.5
nmol/l
0.45
2054
6384
1400
3511
2.11
117.60
1.3
1.2
—
—
—
0
0
2563
7923
1.76
116.88
3.4
2.7
—
—
—
0
0
2851
9121
1.71
115.15
6.6
7.3
—
—
—
0
0
10232
43996
1.53
113.26
16.5
11.4
333.6
333.7
g/l
0.64
10134
43393
1910
5488
1.86
109.62
1.7
1.6
1152.5
1126.0
nmol/l
0.56
1452
4068
1991
5827
1.83
107.79
3.6
3.1
363.7
847.1
ng/l
5.48
1425
4302
2576
8245
1.69
102.48
3.7
2.8
1.0
1.0
kg/l
0.37
371
1487
278
274
5.19
100.57
1.4
1.3
—
—
—
0
0
1628
4610
1.87
96.90
2.4
3.2
116.1
135.5
ug/g
1.33
1286
3699
871
1935
2.35
96.51
3.3
2.9
—
—
—
0
0
251
239
5.36
93.85
1.8
1.4
14200.7
13531.8
e6/l
0.07
190
163
1157
2985
2.03
89.34
1.4
1.4
—
—
—
0
0
2081
6504
1.71
89.01
3.0
2.8
0.8
0.9
ug/l
3.19
1315
4296
1824
5488
1.77
89.00
2.8
2.7
1.0
1.2
e6/l
0.98
1029
3055
1321
3617
1.92
86.36
3.1
3.3
8.3
9.9
umol/l
1.39
1141
3150
1323
3650
1.91
84.52
23.3
25.2
1.3
1.5
inr
4.35
206
382
1085
2816
2.01
82.23
2.0
2.2
381.1
394.7
nmol/l
1.16
1004
2621
1206
3284
1.92
79.86
7.1
5.2
—
—
—
0
0
1759
5407
1.72
79.10
3.0
2.7
2.1
2.4
e6/l
0.87
970
2972
1758
5415
1.72
78.45
2.3
2.6
13.5
13.8
umol/l
0.52
1628
5038
1662
5044
1.74
78.08
3.9
4.4
0.8
0.8
mmol/l
0.56
1559
4697
969
2471
2.04
76.82
4.0
3.9
—
—
—
0
0
2134
6961
1.63
76.81
1.6
1.6
23764998.7
34815239.3
pmol/l
0.43
1801
5805
847
2061
2.13
75.64
2.4
2.0
6.8
10.5
ug/l
3.93
737
1792
1060
2810
1.97
75.61
2.3
2.4
79.8
38.3
u/l
0.44
897
2446
187
165
5.77
75.00
1.6
1.3
—
—
—
0
0
1270
3594
1.85
74.77
1.5
1.4
—
—
—
0
0
3656
13584
1.47
73.28
1.6
1.6
—
—
—
0
0
1141
3139
1.90
73.10
1.3
1.5
—
—
—
0
0
3200
11584
1.50
72.85
3.4
3.3
8.2
8.3
mmol/l
0.09
2700
9940
735
1760
2.16
68.15
1.2
1.2
—
—
—
0
0
1605
5029
1.68
66.64
2.3
2.7
2.4
2.4
g/l
0.16
1477
4665
788
1968
2.07
65.74
2.4
2.2
18.1
20.0
au/ml
0.22
56
129
1640
5205
1.66
64.80
2.4
2.7
29.9
30.1
s
0.79
1593
5070
422
795
2.72
64.61
1.2
1.1
—
—
—
0
0
1311
3916
1.75
64.39
7.0
7.5
104.4
104.5
mmol/l
0.06
1278
3832
934
2508
1.93
63.96
2.7
2.7
10.6
11.1
g/l
2.57
853
2325
1483
4624
1.68
62.48
2.4
2.8
23.4
23.8
%
0.34
1281
3941
718
1765
2.10
62.32
1.3
1.2
44.8
57.5
au/ml
0.54
34
70
493
1038
2.44
60.89
1.1
1.0
—
—
—
0
0
702
1738
2.09
59.81
1.4
1.4
—
—
—
0
0
427
845
2.59
59.65
1.2
1.2
1.0
1.1
u/ml
0.04
32
47
1133
3314
1.78
59.53
7.8
8.2
12.4
13.0
kpa
3.29
1079
3137
1132
3317
1.78
59.11
7.8
8.3
5.1
5.0
kpa
0.96
1072
3141
1129
3316
1.77
58.48
7.9
8.2
1.0
0.9
mmol/l
0.44
861
2530
2764
10121
1.46
57.54
4.1
4.2
11.5
9.7
mg/mmol
0.79
1825
6862
1023
2930
1.81
57.49
8.2
8.9
95.6
95.5
%
0.18
984
2809
2607
9439
1.47
57.45
3.4
3.4
282.3
344.1
mg/l
0.35
1763
6207
981
2778
1.83
57.13
7.2
8.4
1.4
1.4
mmol/l
0.00
938
2644
819
2185
1.94
57.00
1.3
1.3
237.6
394.1
u/ml
2.13
755
2022
1054
3056
1.79
56.92
3.6
3.0
—
—
—
0
0
283
463
3.12
54.93
1.1
1.1
—
—
—
0
0
283
463
3.12
54.93
1.1
1.1
—
—
—
0
0
1084
3207
1.76
54.68
2.2
1.9
12.9
12.3
nmol/l
1.36
966
2874
783
2098
1.93
53.78
2.5
3.2
4.2
4.1
e9/l
0.55
635
1661
1168
3574
1.70
52.30
3.9
3.7
31.6
32.7
%
2.57
810
2390
162
181
4.55
51.67
1.4
1.2
—
—
—
0
0
125
107
5.93
51.58
1.7
1.5
58.5
58.4
%
0.01
91
74
738
1982
1.92
50.30
1.8
1.8
1.4
1.3
g/l
0.56
682
1828
796
2201
1.87
49.76
3.8
4.3
5.2
5.1
kpa
0.22
738
2059
111
86
6.54
49.74
1.4
1.3
112536.6
96330.2
e6/l
0.07
78
58
787
2185
1.86
48.57
3.8
4.3
7.4
7.4
ph
1.26
87
241
923
2702
1.77
48.08
8.5
9.2
122.6
121.6
g/l
0.66
888
2588
766
2121
1.86
47.65
2.7
2.3
66.7
66.3
g/l
0.77
694
1972
1199
3797
1.64
47.05
3.0
3.2
1.7
1.6
%
1.98
1075
3401
598
1529
2.01
46.73
2.5
2.0
—
—
—
0
0
1010
3065
1.71
46.42
2.4
2.9
0.2
0.2
g/l
2.41
942
2845
1781
6242
1.50
45.04
1.6
1.7
—
—
—
0
0
713
1965
1.87
44.96
1.1
1.2
168.5
170.2
titre
0.01
13
97
696
1909
1.88
44.52
1.3
1.4
—
—
—
0
0
3976
16092
1.33
43.86
2.5
2.4
—
—
—
0
0
647
1746
1.91
43.43
5.2
4.9
—
—
—
0
0
641
1735
1.90
42.64
1.5
1.4
—
—
—
0
0
815
2383
1.76
42.53
1.4
1.4
—
—
—
0
0
900
2712
1.71
42.33
4.2
4.0
24.7
38.2
ug/l
0.58
739
2136
54
15
18.19
41.57
2.1
1.8
2.1
2.0
ug/l
—
43
9
389
881
2.26
41.04
1.2
1.1
—
—
—
0
0
588
1568
1.92
40.84
4.0
4.7
—
—
—
0
0
54
16
17.06
40.67
2.0
1.8
3.7
2.3
ug/l
—
46
9
326
684
2.43
40.60
1.9
1.6
211.7
195.1
pmol/l
1.25
310
649
815
2417
1.74
40.50
2.5
2.3
5795.9
8520.2
u/l
1.40
319
1031
693
1971
1.81
39.57
1.2
1.2
—
—
—
0
0
380
877
2.21
38.40
1.5
1.8
1.2
1.1
g/l
2.84
363
833
631
1759
1.84
38.38
9.3
11.3
1.4
1.3
%
0.57
625
1748
400
949
2.15
37.85
2.8
2.8
—
—
—
0
0
527
1391
1.94
37.69
4.0
4.8
24.7
24.5
mmol/l
0.83
499
1316
627
1756
1.83
37.58
9.4
11.4
0.7
0.7
%
1.13
621
1749
1402
4847
1.50
37.45
6.3
7.6
1.1
1.1
mmol/l
2.65
1305
4539
278
562
2.52
37.35
1.2
1.3
8.9
14.1
u/ml
0.42
43
88
276
556
2.53
37.34
1.2
1.3
2.8
19.9
u/ml
1.01
30
53
296
620
2.43
37.02
1.2
1.3
39.5
44.7
u/ml
0.08
15
43
2544
9863
1.36
36.17
1.6
1.6
1.4
1.3
mmol/l
3.89
2159
8532
476
1233
1.98
35.89
1.8
1.4
38.0
43.7
nmol/l
5.37
463
1214
902
2842
1.64
35.84
4.2
4.5
0.9
0.8
%
0.37
276
724
366
860
2.17
35.47
1.5
1.8
0.2
0.2
g/l
2.65
350
819
618
1759
1.80
35.18
7.3
7.0
24.3
24.2
mmol/l
0.24
575
1624
291
626
2.37
34.44
1.4
1.4
303.6
271.4
ug/g
1.42
162
350
264
542
2.48
34.43
1.1
1.1
9.0
11.5
au/ml
0.35
21
35
827
2579
1.65
34.17
4.0
4.3
0.6
0.6
%
0.08
199
531
3247
13164
1.31
33.76
2.1
2.0
—
—
—
0
0
856
2705
1.63
33.59
4.3
4.6
0.1
0.1
%
1.82
256
682
371
902
2.10
33.08
3.9
4.3
1.5
1.6
mmol/l
0.72
363
874
795
2480
1.65
32.79
3.0
3.1
216.7
264.7
ng/l
1.94
707
2269
415
1059
2.00
32.62
4.6
5.2
—
—
—
0
0
390
973
2.05
32.55
2.2
2.8
376.1
846.8
ug/l
1.46
363
905
92
94
4.95
32.36
1.4
1.5
31.4
38.2
%
0.69
65
67
810
2567
1.62
31.40
4.3
4.7
0.1
0.0
%
0.88
214
582
842
2701
1.60
31.09
2.8
2.8
69.2
66.8
e9/l
1.01
639
1990
968
3221
1.55
30.60
8.6
9.5
—
—
—
0
0
422
1113
1.94
30.28
1.7
1.7
—
—
—
0
0
817
2621
1.60
30.14
4.0
3.6
1.2
1.2
mmol/l
0.09
708
2279
1127
3906
1.49
29.49
1.5
1.5
—
—
—
0
0
1002
3391
1.52
29.33
1.2
1.2
—
—
—
0
0
233
490
2.42
29.00
1.2
1.2
25.4
33.6
u/ml
0.26
17
38
465
1292
1.84
28.59
1.7
1.7
—
—
—
0
0
309
748
2.10
27.92
4.0
4.8
3.9
3.9
mmol/l
0.48
283
698
892
2977
1.54
27.79
1.2
1.2
140.0
156.5
iu/ml
0.56
334
1077
1118
3917
1.47
27.69
4.8
4.9
7.4
7.4
ph
—
5
13
587
1768
1.70
27.56
2.8
2.7
0.3
0.4
e6/l
0.90
568
1728
407
1097
1.89
27.45
1.9
1.9
2.3
2.1
ug/l
0.09
353
980
736
2358
1.60
27.28
2.8
2.4
—
—
—
0
0
1093
3832
1.47
26.96
4.8
4.9
1.8
1.6
mmol/l
0.52
880
3107
1099
3859
1.47
26.90
4.8
4.9
5.9
5.8
kpa
1.22
1070
3723
2558
10350
1.29
26.07
1.7
1.8
—
—
—
0
0
700
2249
1.60
25.65
4.2
5.6
85.0
94.6
ng/l
1.90
631
2025
432
1217
1.81
25.46
1.4
1.3
—
—
—
0
0
417
1171
1.82
24.83
3.2
4.5
0.3
0.3
g/l
0.15
182
686
938
3258
1.48
24.19
4.2
4.3
4.6
4.7
kpa
1.02
911
3135
288
718
2.04
24.18
1.8
1.8
750.1
680.1
e6/l
0.05
239
579
288
719
2.04
24.10
1.7
1.7
14.3
52.2
e6/l
1.54
230
554
312
808
1.96
23.65
1.8
1.6
462.4
489.4
mg/l
0.47
292
773
955
3353
1.46
23.32
7.6
9.5
9.3
9.4
mmol/l
0.10
909
3209
523
1603
1.67
23.06
10.1
11.2
24.3
24.2
mmol/l
0.43
492
1492
307
802
1.95
22.73
1.3
1.3
—
—
—
0
0
477
1436
1.70
22.47
2.4
2.3
—
—
—
0
0
310
816
1.93
22.47
4.3
4.1
7.4
7.4
ph
0.51
256
680
416
1207
1.76
22.30
2.4
2.7
35.2
52.8
u/ml
1.40
397
1169
209
474
2.24
22.17
1.2
1.2
—
—
—
0
0
441
1305
1.72
22.09
1.7
1.7
—
—
—
0
0
728
2450
1.52
21.81
8.6
9.4
24.7
24.7
mmol/l
0.04
721
2431
425
1251
1.73
21.69
1.2
1.2
—
—
—
0
0
452
1358
1.70
21.47
1.4
1.7
8.4
12.5
u/ml
0.63
16
70
661
2192
1.54
21.16
3.4
3.5
4.6
4.6
pmol/l
0.21
593
1973
1279
4822
1.37
20.89
1.8
1.9
—
—
—
0
0
278
725
1.95
20.72
1.8
1.6
3.7
3.7
mmol/l
0.21
258
689
270
699
1.96
20.55
2.6
1.9
37.9
37.1
g/l
1.03
232
616
125
231
2.74
20.10
1.1
1.1
—
—
—
0
0
274
722
1.93
19.85
2.1
2.0
10.9
11.1
mg/l
0.13
247
678
488
1538
1.62
19.37
3.5
3.5
0.7
0.7
%
0.04
474
1488
36
22
8.26
19.24
1.1
1.2
37.9
39.3
g/l
0.10
21
14
308
861
1.82
18.71
2.5
2.0
10.7
10.9
g/l
0.41
264
725
521
1683
1.58
18.70
11.1
11.0
—
—
—
0
0
261
692
1.92
18.61
1.8
1.8
—
—
—
0
0
957
3507
1.40
18.49
2.3
1.8
—
—
—
0
0
262
698
1.91
18.43
4.6
4.1
5.0
5.0
kpa
0.35
257
680
887
3210
1.42
18.40
2.4
1.8
—
—
—
0
0
56
62
4.56
18.29
1.7
1.5
—
—
—
0
0
953
3499
1.40
18.21
2.3
1.8
—
—
—
0
0
943
3456
1.40
18.21
2.2
1.8
—
—
—
0
0
261
698
1.90
18.16
4.6
4.1
2.4
2.4
mmol/l
0.02
170
435
946
3473
1.40
18.09
2.3
1.8
—
—
—
0
0
469
1492
1.60
17.95
1.9
1.9
1.5
1.3
g/l
2.71
412
1262
261
701
1.89
17.94
4.6
4.1
8.9
8.9
kpa
0.11
256
683
754
2663
1.45
17.84
2.4
1.9
—
—
—
0
0
113
213
2.68
17.60
1.3
1.3
—
—
—
0
0
138
291
2.40
17.28
4.1
3.6
—
—
—
0
0
642
2212
1.48
17.22
5.4
5.7
23.9
23.9
mmol/l
0.04
598
2053
220
566
1.97
17.12
1.1
1.1
—
—
—
0
0
253
697
1.84
16.15
4.0
3.9
56.6
56.6
%
0.01
253
697
382
1188
1.64
16.04
1.1
1.1
5.9
9.5
u/ml
0.68
54
152
209
544
1.95
15.78
1.4
1.4
117.0
104.7
pmol/l
0.09
203
527
62
86
3.64
15.56
1.1
1.1
—
—
—
0
0
315
942
1.70
15.33
7.0
5.5
1.3
1.3
mmol/l
0.04
270
834
63
90
3.54
15.21
2.6
2.5
—
—
—
0
0
622
2189
1.45
15.02
4.0
3.8
129.6
130.7
g/l
0.53
612
2141
359
1120
1.63
14.92
1.3
1.5
232.0
242.4
u/ml
0.25
201
670
170
420
2.05
14.81
1.4
1.5
—
—
—
0
0
84
148
2.87
14.80
1.3
1.1
—
—
—
0
0
520
1771
1.50
14.80
1.6
1.6
7.6
7.6
u/l
0.03
411
1370
187
481
1.97
14.64
3.7
3.1
1.6
1.5
%
0.03
154
369
420
1372
1.56
14.46
3.3
2.5
—
—
—
0
0
1342
5369
1.28
14.35
1.3
1.2
—
—
—
0
0
313
952
1.67
14.35
3.5
3.2
—
—
—
0
0
210
567
1.88
14.31
1.0
1.1
0.5
0.5
u/ml
0.09
52
160
82
146
2.84
14.21
1.2
1.1
1.4
8.1
nmol/l
1.25
11
31
146
346
2.14
14.15
3.0
2.5
—
—
—
0
0
217
595
1.85
14.12
1.3
1.2
—
—
—
0
0
325
1004
1.64
14.06
1.3
1.4
752.0
1140.9
titre
—
5
32
42
46
4.61
13.95
1.3
1.5
1.6
1.5
%
—
9
6
113
241
2.37
13.92
1.5
1.6
22.3
36.6
iu/ml
—
8
13
177
456
1.97
13.82
1.3
1.4
—
—
—
0
0
213
585
1.85
13.80
1.6
1.5
—
—
—
0
0
214
596
1.82
13.30
1.0
1.1
2.4
3.7
u/ml
1.05
99
259
245
713
1.74
13.19
2.0
1.9
—
—
—
0
0
260
771
1.71
13.11
3.7
2.9
34.2
54.3
mg/l
1.31
207
628
625
2260
1.41
13.07
3.4
2.4
—
—
—
0
0
260
773
1.71
13.00
3.7
2.8
81.1
63.1
mg/l
0.31
206
633
255
755
1.71
12.94
3.7
2.8
1.8
5.1
ratio
0.91
31
64
98
203
2.44
12.86
1.1
1.2
—
—
—
0
0
289
887
1.65
12.86
1.8
2.0
4.9
4.1
iu/l
0.55
105
348
110
241
2.31
12.83
3.2
3.6
55.7
58.2
%
0.43
77
151
286
877
1.66
12.77
3.2
3.6
24.6
24.5
mmol/l
0.07
250
785
133
318
2.12
12.67
3.2
3.0
—
—
—
0
0
198
548
1.83
12.58
1.6
1.8
0.8
0.9
g/l
0.48
147
438
75
137
2.77
12.49
1.1
1.3
59.4
10.5
u/ml
—
7
11
101
219
2.33
12.07
1.0
1.0
—
—
—
0
0
247
740
1.69
12.05
1.1
1.1
4.5
5.0
u/ml
0.18
97
368
310
987
1.59
11.97
1.1
1.1
1.5
1.4
u/ml
0.05
143
561
320
1030
1.58
11.82
1.1
1.1
8.5
8.1
u/ml
0.09
181
656
352
1160
1.54
11.74
1.1
1.1
2.4
3.1
u/ml
0.39
155
630
136
339
2.03
11.69
1.3
1.2
43.7
28.5
u/ml
0.28
11
23
337
1101
1.55
11.68
3.5
3.4
12000.5
1437.0
u/ml
0.69
284
954
96
208
2.33
11.52
1.1
1.1
—
—
—
0
0
251
766
1.66
11.46
3.4
4.0
—
—
—
0
0
66
118
2.83
11.44
1.6
1.5
8.0
7.2
u/l
0.16
56
99
129
318
2.05
11.42
1.4
1.3
—
—
—
0
0
136
344
2.00
11.26
5.7
7.0
10.7
11.5
mg/l
1.00
124
323
515
1849
1.42
11.25
1.3
1.3
224.1
241.4
miu/ml
0.47
244
869
192
546
1.78
11.24
1.6
1.8
—
—
—
0
0
215
633
1.72
11.19
2.3
2.6
16.4
16.7
%
0.34
115
354
94
205
2.32
11.14
2.1
1.9
—
—
—
0
0
564
2065
1.39
11.03
1.5
1.5
18.2
19.2
iu/l
0.32
452
1657
497
1780
1.42
11.02
3.6
3.5
25.1
25.1
mmol/l
0.21
482
1730
128
320
2.02
10.95
1.4
1.3
0.4
0.4
g/l
0.89
89
231
252
780
1.64
10.93
3.1
3.0
32.5
33.5
umol/l
0.29
208
666
88
188
2.37
10.91
1.7
1.2
73.6
74.3
umol/l
—
7
22
128
321
2.02
10.86
1.4
1.3
6.5
7.5
g/l
2.35
89
234
128
321
2.02
10.86
1.4
1.3
2.8
3.2
g/l
1.92
89
235
318
1044
1.55
10.83
1.3
1.4
74.5
103.7
titre
0.87
31
107
177
499
1.80
10.68
1.3
1.3
—
—
—
0
0
177
501
1.79
10.55
1.7
1.6
—
—
—
0
0
118
291
2.05
10.48
1.3
1.1
—
—
nmol/l
—
0
0
406
1414
1.46
10.46
5.8
4.4
1.6
1.7
%
0.34
377
1332
306
1005
1.54
10.42
1.1
1.1
2.4
3.6
u/ml
0.71
79
299
120
299
2.03
10.38
1.1
1.1
41.8
54.3
mg/l
0.81
95
257
92
206
2.26
10.32
1.3
1.4
—
—
—
0
0
228
699
1.65
10.29
4.7
4.8
—
—
—
0
0
627
2363
1.35
10.28
1.6
1.7
293.3
373.7
mu/l
3.01
558
2105
49
78
3.17
10.27
1.3
1.4
—
—
—
0
0
71
141
2.54
10.22
1.5
1.3
281.4
758.9
titre
—
7
9
400
1396
1.46
10.21
5.9
4.5
0.9
0.9
%
0.48
372
1316
131
341
1.94
10.08
1.3
1.2
0.5
2.4
nmol/l
0.80
123
332
123
313
1.99
10.07
1.3
1.2
—
—
—
0
0
435
1550
1.43
9.96
3.0
3.0
21.3
21.6
s
0.57
390
1392
195
579
1.71
9.91
3.9
2.9
—
—
—
0
0
55
97
2.86
9.82
2.9
2.7
10.1
10.1
mg/l
0.00
47
83
114
285
2.02
9.80
1.1
1.1
251.3
290.4
mg/l
0.55
95
250
361
1245
1.47
9.80
3.6
4.5
8.8
9.1
kpa
1.89
332
1176
93
216
2.18
9.62
1.1
1.1
9.8
6.5
iu/ml
0.60
26
53
97
230
2.13
9.55
1.2
1.2
—
—
—
0
0
67
134
2.53
9.55
1.4
1.2
66.0
47.0
titre
—
10
10
130
346
1.90
9.42
1.3
1.2
0.4
0.2
nmol/l
—
7
24
214
662
1.64
9.38
8.4
6.5
11.5
11.3
mmol/l
0.24
190
598
214
663
1.63
9.32
8.4
6.5
105.5
105.3
mmol/l
0.17
190
599
220
693
1.61
9.00
1.1
1.1
6.0
7.0
u/ml
0.29
95
365
204
634
1.63
8.81
2.7
3.1
—
—
—
0
0
146
413
1.79
8.81
1.5
1.5
—
—
—
0
0
146
413
1.79
8.81
1.5
1.5
—
—
—
0
0
66
137
2.43
8.77
3.8
2.8
177.2
175.6
umol/l
0.01
40
57
146
414
1.78
8.74
1.5
1.5
—
—
—
0
0
146
414
1.78
8.74
1.5
1.5
—
—
—
0
0
54
102
2.67
8.60
1.5
1.1
—
—
—
0
0
159
466
1.73
8.53
1.1
1.1
1.5
1.5
g/l
0.13
143
435
24
25
4.84
8.47
1.4
1.1
28.1
40.0
%
0.67
19
19
43
72
3.01
8.40
2.3
2.1
233.7
122.4
au/ml
—
7
14
64
134
2.41
8.38
2.9
1.8
—
—
—
0
0
190
588
1.64
8.37
1.2
1.2
—
—
—
0
0
1973
8678
1.17
8.11
1.8
1.7
—
—
—
0
0
129
362
1.80
8.03
2.5
2.2
—
—
—
0
0
267
908
1.49
7.86
3.7
2.4
27.4
30.8
mg/l
0.67
180
581
64
139
2.32
7.79
1.2
1.1
4.4
8.4
iu/ml
—
7
9
81
196
2.09
7.68
1.8
1.7
3.4
3.9
mg/l
0.56
76
188
173
536
1.63
7.63
3.4
4.6
—
—
—
0
0
58
122
2.40
7.56
1.1
1.0
—
—
—
0
0
198
636
1.58
7.55
1.7
2.0
1210.0
3013.3
titre
—
8
33
87
218
2.02
7.55
1.4
1.3
0.4
0.9
u/ml
0.80
38
84
66
148
2.25
7.50
1.0
1.0
6.9
17.1
u/ml
—
8
15
163
504
1.64
7.27
1.2
1.2
41.5
35.5
u/l
0.20
147
426
162
501
1.64
7.22
1.9
1.7
66.0
70.4
mmol/l
0.55
142
393
110
305
1.82
7.16
4.2
3.8
53.1
171.8
u/ml
1.49
31
102
102
278
1.85
7.01
3.3
3.1
601.3
498.6
e6/l
0.50
84
225
105
289
1.84
7.00
2.7
2.9
846.0
619.0
e6/l
1.71
37
84
30
45
3.36
6.95
1.3
1.4
—
—
—
0
0
99
270
1.85
6.81
3.4
3.2
0.2
0.2
e9/l
0.06
84
224
124
363
1.73
6.78
3.1
2.9
1.2
1.2
e9/l
0.19
71
237
110
311
1.79
6.76
1.4
1.6
—
—
—
0
0
20
22
4.58
6.72
1.1
1.2
—
—
—
0
0
65
153
2.14
6.65
2.7
1.9
—
—
—
0
0
57
127
2.27
6.62
1.3
1.1
141.1
139.2
nmol/l
0.08
57
127
322
1175
1.39
6.59
10.8
7.2
—
—
—
0
0
123
363
1.71
6.56
3.1
3.2
25.3
23.2
mu/l
0.26
115
340
248
864
1.45
6.56
2.4
2.6
109.3
103.5
ug/min
0.08
153
559
83
216
1.94
6.56
1.1
1.2
—
—
—
0
0
62
144
2.17
6.55
2.0
2.1
9.8
9.5
mmol/l
0.13
49
105
41
78
2.65
6.54
1.4
1.3
102.8
117.9
nmol/l
0.29
30
57
24
32
3.78
6.50
2.3
1.8
—
—
—
0
0
232
800
1.47
6.47
1.9
2.2
4.7
12.7
titre
—
6
24
54
119
2.29
6.44
1.3
2.5
—
—
—
0
0
244
851
1.45
6.42
2.2
2.3
132.4
131.9
g/l
0.10
192
665
167
537
1.57
6.42
1.5
1.4
16.2
19.9
u/l
0.97
147
450
124
371
1.69
6.31
1.8
1.8
—
—
—
0
0
16
15
5.38
6.26
4.8
3.6
—
—
—
0
0
173
566
1.55
6.19
3.7
3.3
287.7
982.7
u/ml
0.94
163
511
118
352
1.69
6.09
1.6
2.2
281.1
288.0
mosm/kgh2o
2.56
88
292
93
259
1.81
6.04
1.3
1.2
1.9
2.0
mmol/l
0.95
88
241
115
342
1.70
6.01
1.1
1.1
—
—
—
0
0
298
1093
1.38
5.97
1.4
1.6
19.1
21.2
u/ml
—
6
20
59
140
2.13
5.96
1.6
2.1
14.9
37.3
umol/l
—
7
9
299
1099
1.38
5.91
1.4
1.7
—
—
—
0
0
63
155
2.05
5.83
1.2
1.2
10.6
8.3
u/ml
—
7
20
31
54
2.90
5.78
1.1
1.1
—
—
—
0
0
31
54
2.90
5.78
1.1
1.1
—
—
—
0
0
31
54
2.90
5.78
1.1
1.1
—
—
—
0
0
177
594
1.51
5.68
3.4
3.4
28.5
2021.1
u/ml
0.93
162
539
101
295
1.73
5.65
2.3
1.9
2.5
1.5
u/field
0.65
46
106
209
727
1.45
5.64
1.1
1.1
—
—
—
0
0
58
141
2.08
5.55
2.0
2.6
558.7
793.8
ug/l
0.14
52
124
112
341
1.66
5.42
1.4
1.5
1.3
1.1
promille
0.70
83
272
172
581
1.50
5.38
3.1
2.9
0.9
0.8
nmol/l
0.85
135
436
57
140
2.05
5.33
2.8
1.9
—
—
—
0
0
63
161
1.98
5.31
1.1
1.4
87.3
67.4
%
—
9
20
54
130
2.10
5.31
3.2
2.1
—
—
—
0
0
131
418
1.58
5.28
7.5
20.0
6.7
7.1
mmol/l
0.56
110
328
220
785
1.42
5.22
1.1
1.1
—
—
—
0
0
282
1050
1.36
5.21
1.4
1.7
102.0
107.3
u/ml
0.48
54
206
68
181
1.90
5.13
1.7
1.6
1.9
3.4
u/field
0.70
50
136
104
316
1.66
5.09
1.0
1.1
2.1
8.5
u/ml
0.54
32
127
366
1425
1.30
5.00
6.2
7.6
1.4
1.4
mg/l
0.26
342
1352
40
87
2.32
4.99
1.1
1.1
—
—
—
0
0
29
54
2.71
4.88
1.2
1.3
323.4
706.4
pmol/l
0.67
19
42
799
3407
1.19
4.81
1.3
1.3
—
—
—
0
0
25
43
2.93
4.81
1.4
1.5
—
—
—
0
0
503
2049
1.24
4.78
3.3
2.8
—
—
—
0
0
180
631
1.44
4.74
1.2
1.3
6.6
4.1
u/ml
0.74
77
328
25
44
2.87
4.64
3.2
1.9
—
—
—
0
0
139
465
1.51
4.62
2.1
3.6
24.5
25.8
nmol/l
0.54
133
455
47
114
2.08
4.59
1.2
1.1
—
—
—
0
0
95
292
1.64
4.51
1.0
1.1
—
—
—
0
0
170
598
1.44
4.42
1.2
1.2
—
—
—
0
0
83
248
1.69
4.38
2.3
1.7
—
—
—
0
0
15
19
3.98
4.37
1.0
1.0
9.0
22.0
iu/ml
—
6
9
205
748
1.39
4.36
4.9
5.7
364.1
391.2
umol/l
1.91
183
674
59
159
1.87
4.35
3.5
2.6
7.4
7.4
ph
0.18
14
47
112
364
1.55
4.27
1.6
1.5
—
—
—
0
0
45
111
2.05
4.24
1.0
1.1
—
—
—
0
0
68
194
1.77
4.22
3.8
4.0
88.7
106.7
au/ml
0.15
14
22
13
15
4.37
4.19
1.2
1.6
37.4
52.4
umol/l
1.20
13
15
25
47
2.68
4.18
1.1
1.1
0.7
0.6
umol/24h
0.49
14
22
108
351
1.55
4.13
1.4
1.5
—
—
—
0
0
39
92
2.14
4.11
2.8
2.9
32.5
29.1
umol/l
0.68
28
69
84
257
1.65
4.09
2.1
1.9
1.1
1.7
g/24h
—
5
30
22
39
2.84
4.06
1.5
2.4
7.9
8.7
mmol/l
0.15
11
19
94
297
1.60
4.05
1.3
1.2
—
—
—
0
0
86
267
1.63
3.98
1.2
1.1
359.3
352.0
nmol/l
0.12
78
215
44
111
2.00
3.94
1.9
1.6
—
—
—
0
0
217
815
1.35
3.90
1.5
1.6
0.3
0.4
nmol/l
0.21
175
697
95
304
1.58
3.90
1.4
1.3
6.4
6.4
mmol/l
0.02
89
287
77
234
1.66
3.87
1.2
1.2
—
—
—
0
0
119
402
1.49
3.85
1.5
1.5
323.3
381.7
pmol/l
0.34
91
325
91
290
1.58
3.81
1.3
1.3
1.5
1.3
nmol/l
0.75
85
264
96
310
1.56
3.80
3.4
2.7
11.4
12.4
%
0.33
61
182
192
711
1.36
3.79
1.2
1.2
—
—
—
0
0
55
154
1.80
3.67
7.2
6.1
—
—
—
0
0
247
955
1.31
3.67
2.6
2.8
4.7
7.4
umol/l
3.63
189
750
9
140
0.32
3.65
11.3
7.7
—
—
—
0
0
31
70
2.23
3.65
1.0
1.2
—
—
—
0
0
25
51
2.47
3.63
2.5
2.6
—
—
—
0
0
128
445
1.45
3.62
1.5
1.4
31.2
31.3
g/l
0.01
111
396
55
155
1.79
3.60
4.3
3.2
215.9
205.6
e6/l
0.07
32
93
82
259
1.60
3.58
8.1
5.6
11.1
11.4
%
0.27
82
259
76
236
1.63
3.55
4.6
4.2
—
—
—
0
0
317
1272
1.26
3.54
1.2
1.3
—
—
—
0
0
127
443
1.45
3.54
1.5
1.8
55.4
64.6
mu/l
0.29
111
401
146
523
1.41
3.53
1.8
1.7
—
—
—
0
0
93
304
1.54
3.53
1.1
1.1
284.0
283.1
mg/l
0.03
82
279
87
280
1.57
3.53
1.0
1.0
5.4
0.8
u/ml
0.44
16
61
86
278
1.56
3.43
2.8
2.7
—
—
—
0
0
73
227
1.62
3.41
1.2
1.3
13.2
15.0
u/l
0.22
67
208
35
86
2.05
3.39
1.5
1.2
—
—
—
0
0
103
348
1.49
3.38
1.3
1.4
—
—
—
0
0
14
21
3.36
3.34
1.2
1.1
1.8
1.3
umol/24h
1.59
14
21
20
38
2.65
3.32
1.1
1.0
—
—
—
0
0
48
135
1.79
3.20
1.0
1.0
15.5
17.0
u/ml
0.07
11
25
57
169
1.70
3.20
1.3
1.4
5.9
6.8
ug/l
0.28
51
154
71
224
1.60
3.16
1.1
1.2
1.0
1.1
ratio
1.04
31
78
42
114
1.86
3.13
1.4
1.4
63.2
60.5
%
0.16
30
93
105
363
1.46
3.11
1.2
1.3
168.0
233.9
titre
0.31
15
70
105
363
1.46
3.11
1.2
1.3
242.9
226.5
titre
—
7
17
71
225
1.59
3.11
4.7
4.6
7.9
9.0
mg/l
0.80
61
190
27
62
2.20
3.10
1.2
1.3
—
—
—
0
0
23
49
2.37
3.10
1.2
1.5
—
—
—
0
0
41
112
1.85
3.01
1.1
1.2
—
—
—
0
0
99
341
1.47
3.00
1.0
1.1
2.8
1.8
u/ml
0.18
38
144
22
47
2.36
2.96
1.1
1.1
—
—
—
0
0
22
47
2.36
2.96
1.1
1.1
—
—
—
0
0
22
47
2.36
2.96
1.1
1.1
—
—
—
0
0
83
277
1.51
2.94
1.7
1.8
6.4
6.3
mmol/l
0.12
60
213
108
381
1.43
2.91
3.1
2.7
41.2
41.0
%
0.01
12
36
16
29
2.78
2.90
1.1
1.1
—
—
—
0
0
129
471
1.38
2.87
1.6
1.6
—
—
—
0
0
49
144
1.72
2.87
1.5
1.6
—
—
—
0
0
22
48
2.31
2.84
1.1
1.0
—
—
—
0
0
37
100
1.87
2.82
1.3
1.5
1.4
3.9
%
1.56
29
89
27
65
2.09
2.80
1.9
2.1
—
—
—
0
0
72
237
1.53
2.73
2.6
3.0
43.8
40.4
%
0.46
20
84
8
8
5.04
2.69
1.3
1.4
—
—
—
0
0
68
222
1.55
2.68
2.5
2.5
51.2
55.4
umol/l
0.49
56
200
32
85
1.90
2.59
1.1
1.1
—
—
—
0
0
42
122
1.74
2.59
1.5
1.6
13.2
14.9
pmol/l
2.21
37
109
79
269
1.48
2.59
1.1
1.2
—
—
—
0
0
109
397
1.39
2.51
1.8
2.2
—
—
—
0
0
39
112
1.76
2.50
2.1
2.0
15.1
18.1
umol/l
1.02
39
112
24
58
2.09
2.49
1.5
1.7
—
—
—
0
0
111
408
1.37
2.43
1.4
1.5
1921.4
2285.1
e6/l
0.34
71
296
83
290
1.44
2.42
1.6
1.5
—
—
—
0
0
121
453
1.35
2.38
2.3
2.4
—
—
—
0
0
23
56
2.07
2.36
1.2
1.1
—
—
—
0
0
54
173
1.57
2.35
1.2
1.3
—
—
—
0
0
12
21
2.88
2.33
1.1
1.1
0.2
0.5
u/ml
—
6
12
44
135
1.64
2.27
1.7
1.7
5.6
21.4
nmol/l
0.42
35
113
79
278
1.43
2.24
1.2
1.2
—
—
—
0
0
63
212
1.50
2.23
1.9
1.6
29.3
24.6
umol/l
0.48
58
203
37
109
1.71
2.22
1.1
1.1
—
—
—
0
0
56
185
1.53
2.16
1.5
1.6
1.3
1.1
nmol/l
0.49
45
150
93
341
1.38
2.12
1.5
1.4
12.2
12.3
umol/l
0.06
85
320
100
372
1.36
2.09
1.4
1.5
23997.9
47865.1
e6/l
1.09
54
223
72
253
1.44
2.08
1.2
1.1
—
—
—
0
0
15
32
2.36
2.08
1.2
1.1
53.1
44.0
%
—
7
14
110
417
1.33
2.04
1.3
1.2
63.0
68.7
pmol/l
0.15
33
75
199
814
1.23
2.04
1.2
1.2
—
—
—
0
0
10
17
2.96
2.03
1.0
1.0
—
—
—
0
0
26
71
1.85
2.00
1.7
3.1
—
—
—
0
0
130
508
1.29
1.96
1.4
1.5
12.5
11.1
mmol/l
0.55
23
85
30
87
1.74
1.93
1.9
3.9
1.2
1.2
mmol/l
0.10
30
79
17
40
2.14
1.92
3.2
1.7
0.4
0.7
u/field
1.39
17
40
47
154
1.54
1.92
1.0
1.0
245.5
374.7
ng/l
3.63
29
119
84
309
1.37
1.91
1.0
1.1
—
—
—
0
0
13
27
2.43
1.90
1.0
1.0
—
—
—
0
0
60
208
1.45
1.89
1.4
1.6
1836.4
2154.4
ml
0.71
12
60
22
58
1.91
1.88
1.0
1.1
12.1
1.5
u/ml
0.40
16
34
36
111
1.64
1.88
1.6
1.3
—
—
—
0
0
10
18
2.80
1.87
1.1
1.0
—
—
—
0
0
15
34
2.22
1.85
1.5
1.3
14.8
24.3
%
—
9
28
19
48
2.00
1.83
1.3
1.1
—
—
—
0
0
9
16
2.83
1.82
1.1
1.0
—
—
—
0
0
54
388
0.70
1.79
2.4
2.5
142.8
160.6
nmol/l
0.78
47
334
47
157
1.51
1.78
1.0
1.0
653.1
711.6
ng/l
0.38
29
115
97
370
1.32
1.77
1.1
1.2
—
—
—
0
0
19
49
1.95
1.74
1.1
1.1
—
—
—
0
0
129
513
1.27
1.74
2.6
1.9
—
—
—
0
0
11
22
2.52
1.74
1.0
1.1
—
—
—
0
0
11
22
2.52
1.74
1.0
1.1
—
—
—
0
0
20
53
1.90
1.71
1.0
1.1
—
—
—
0
0
14
32
2.20
1.71
1.6
1.7
—
—
—
0
0
22
61
1.82
1.66
1.3
1.2
—
—
—
0
0
18
47
1.93
1.61
1.2
1.3
189.3
101.7
titre
—
6
7
98
381
1.30
1.60
4.6
3.7
—
—
—
0
0
39
129
1.52
1.57
14.2
13.3
—
—
—
0
0
7
12
2.94
1.57
1.6
1.2
2.9
2.5
%
—
7
12
26
78
1.68
1.54
1.0
1.1
0.2
6.5
u/ml
2.39
20
64
85
327
1.31
1.51
1.4
1.5
—
—
—
0
0
236
1384
0.86
1.50
1.2
1.2
—
—
—
0
0
5
7
3.60
1.45
2.2
1.1
—
—
—
0
0
76
290
1.32
1.44
1.0
1.1
—
—
—
0
0
19
53
1.81
1.43
1.8
1.4
5.1
136962.1
nmol/l
0.49
14
46
50
347
0.72
1.41
26.1
28.9
138.3
107.8
ug/l
1.68
42
308
40
138
1.46
1.36
1.0
1.1
282.0
559.2
ng/l
—
5
37
10
22
2.29
1.34
1.2
1.2
—
—
—
0
0
14
36
1.96
1.33
1.4
1.2
—
—
—
0
0
26
82
1.60
1.31
1.1
1.3
35.4
73.9
ug/l
0.40
12
36
8
17
2.37
1.27
1.4
1.3
—
—
—
0
0
24
75
1.61
1.26
1.2
1.3
—
—
—
0
0
21
64
1.65
1.22
1.0
1.5
1.0
0.4
mmol/l
0.38
21
53
13
34
1.93
1.19
1.2
1.1
—
—
—
0
0
38
134
1.43
1.19
1.1
1.1
8.0
12.1
u/ml
0.24
31
106
5
9
2.80
1.17
1.0
1.0
—
—
—
0
0
7
14
2.52
1.16
1.0
1.1
—
—
—
0
0
7
14
2.52
1.16
1.0
1.1
0.1
0.1
g/l
—
7
8
7
14
2.52
1.16
1.0
1.0
—
—
—
0
0
82
328
1.26
1.15
2.9
2.9
33.5
61.9
mg/l
0.60
60
237
16
46
1.75
1.13
1.0
1.2
1.2
1.7
mmol/l
—
10
27
169
731
1.17
1.10
2.4
2.6
—
—
—
0
0
24
79
1.53
1.06
1.4
1.4
—
—
—
0
0
38
259
0.74
1.02
2.8
3.3
—
—
—
0
0
31
109
1.43
1.02
2.6
2.4
—
—
—
0
0
17
52
1.65
1.00
1.6
1.6
—
—
—
0
0
17
52
1.65
1.00
1.5
1.5
2.1
14.6
%
—
8
24
19
60
1.60
0.99
1.3
1.1
—
—
—
0
0
7
17
2.07
0.99
1.1
1.3
246.4
344.9
umol/24h
—
7
17
158
688
1.16
0.97
1.2
1.3
—
—
—
0
0
226
1012
1.13
0.94
2.4
1.9
0.9
0.7
nmol/l
2.15
190
850
43
163
1.33
0.94
1.8
2.2
128.1
126.7
ng/l
0.03
35
131
53
209
1.28
0.89
1.1
1.1
15.2
48.4
u/ml
0.36
31
136
507
2372
1.08
0.88
1.4
1.4
—
—
—
0
0
8
22
1.83
0.85
1.8
1.6
—
—
—
0
0
193
863
1.13
0.84
1.2
1.1
135.9
1454.6
iu/ml
0.77
58
204
13
39
1.68
0.83
1.2
1.1
—
—
—
0
0
23
80
1.45
0.83
1.3
1.2
—
—
—
0
0
27
98
1.39
0.79
1.0
1.1
—
—
—
0
0
9
26
1.74
0.77
1.0
1.3
—
—
—
0
0
34
129
1.33
0.77
2.0
2.1
—
—
—
0
0
21
73
1.45
0.77
1.2
2.4
—
—
—
0
0
134
590
1.15
0.76
1.8
1.7
—
—
—
0
0
9
27
1.68
0.75
1.4
1.1
—
—
—
0
0
9
27
1.68
0.75
1.0
1.2
—
—
—
0
0
25
91
1.38
0.73
1.2
1.2
—
—
—
0
0
22
79
1.40
0.70
1.3
1.3
27.0
25.5
%
0.08
14
62
47
191
1.24
0.66
1.6
1.2
—
—
—
0
0
22
80
1.39
0.66
1.2
1.5
—
—
—
0
0
8
23
1.75
0.65
4.1
2.8
—
—
—
0
0
250
1155
1.09
0.65
4.4
2.9
—
—
—
0
0
51
211
1.22
0.62
1.9
9.3
81.1
1681.7
mg/l
0.79
38
167
14
47
1.50
0.62
1.1
1.1
—
—
—
0
0
74
318
1.17
0.61
1.2
1.3
—
—
—
0
0
13
43
1.52
0.61
1.2
1.1
—
—
—
0
0
12
39
1.55
0.60
3.5
2.9
—
—
—
0
0
15
107
0.71
0.60
5.3
5.3
—
—
—
0
0
57
240
1.20
0.60
1.0
1.1
1704.2
1478.3
miu/ml
0.82
57
240
16
56
1.44
0.59
1.0
1.1
1.6
1.4
mmol/l
0.08
11
28
81
470
0.87
0.58
1.4
1.4
34.6
34.4
nmol/l
0.02
69
449
36
225
0.81
0.58
4.4
5.0
—
—
—
0
0
72
311
1.17
0.57
2.6
3.0
—
—
—
0
0
72
311
1.17
0.57
5.1
6.0
—
—
—
0
0
48
200
1.21
0.57
1.3
1.1
—
—
—
0
0
16
57
1.41
0.55
1.8
3.4
236.0
87.6
u/l
—
6
22
53
313
0.85
0.50
33.9
36.1
7.7
7.0
ug/l
1.72
46
288
24
95
1.27
0.46
1.1
1.1
—
1525.7
—
0
7
29
119
1.23
0.42
1.1
1.1
—
—
—
0
0
60
266
1.14
0.39
2.3
2.5
505.4
505.6
min
0.01
42
211
5
40
0.63
0.37
1.0
1.2
—
—
—
0
0
20
80
1.26
0.37
1.3
1.4
—
—
—
0
0
30
126
1.20
0.37
2.4
2.3
—
—
—
0
0
10
69
0.73
0.36
2.0
2.0
148.6
150.5
ng/l
—
10
69
25
105
1.20
0.32
1.2
1.2
11.7
7.5
u/ml
—
8
20
32
139
1.16
0.29
2.1
2.2
954.2
4753.6
e6/l
0.46
27
103
8
31
1.30
0.29
1.1
1.5
—
—
—
0
0
8
32
1.26
0.28
1.4
1.2
—
—
—
0
0
638
3303
0.97
0.28
1.5
1.4
—
—
—
0
0
5
37
0.68
0.27
6.4
2.4
—
—
—
0
0
9
36
1.26
0.26
1.2
1.1
—
—
—
0
0
15
61
1.24
0.26
1.3
1.2
—
—
—
0
0
41
184
1.12
0.25
2.9
2.9
—
—
—
0
0
35
156
1.13
0.24
1.4
1.3
—
—
—
0
0
57
262
1.10
0.24
1.3
1.1
—
1.5
—
0
16
15
62
1.22
0.23
1.1
1.2
19.3
33.7
u/ml
—
6
10
0
7
0.00
0.22
0.0
1.0
—
—
—
0
0
235
1139
1.04
0.21
1.3
1.3
3.6
4.0
ug/l
0.78
220
1075
84
396
1.07
0.21
10.4
12.2
0.6
0.6
mmol/l
0.76
76
368
32
144
1.12
0.20
1.7
1.6
—
—
—
0
0
62
290
1.08
0.19
1.3
1.4
—
—
—
0
0
43
198
1.09
0.18
1.0
1.0
—
—
—
0
0
15
88
0.86
0.17
3.1
4.0
—
—
—
0
0
8
35
1.15
0.17
1.3
1.7
—
—
—
0
0
11
66
0.84
0.15
2.3
2.4
145.6
187.2
ug/g
0.70
11
60
16
70
1.15
0.15
2.2
2.0
165.0
116.4
ng/l
0.14
11
45
42
196
1.08
0.14
1.1
1.1
—
—
—
0
0
12
51
1.19
0.14
10.5
7.9
—
—
—
0
0
71
341
1.05
0.12
1.0
1.0
—
—
—
0
0
25
115
1.10
0.12
2.0
2.1
—
—
—
0
0
10
43
1.17
0.10
10.9
4.2
—
—
—
0
0
47
250
0.95
0.10
1.1
1.2
—
—
—
0
0
5
31
0.81
0.08
2.2
3.3
41.4
35.8
umol/l
—
5
31
75
391
0.97
0.08
2.3
2.5
633.1
638.8
ml
0.05
49
271
7
43
0.82
0.07
3.0
4.7
—
—
—
0
0
24
113
1.07
0.07
1.7
2.3
—
—
—
0
0
13
72
0.91
0.06
9.2
9.4
7.6
5.4
mmol/l
1.03
13
72
22
104
1.07
0.06
1.4
1.3
13.6
13.0
g/l
0.13
16
79
19
90
1.06
0.04
3.7
2.9
—
—
—
0
0
24
115
1.05
0.04
1.5
2.6
1.5
1.8
mmol/l
0.19
19
83
408
2068
0.99
0.03
1.5
1.5
—
—
—
0
0
400
2027
0.99
0.03
1.5
1.5
—
—
—
0
0
17
81
1.06
0.03
9.0
7.1
—
—
—
0
0
21
101
1.05
0.03
1.4
1.4
—
—
—
0
0
153
763
1.01
0.02
1.4
1.5
7.0
6.8
mmol/l
0.37
102
480
46
237
0.98
0.02
1.6
1.8
—
—
—
0
0
104
518
1.01
0.02
1.5
1.4
—
—
—
0
0
402
2032
1.00
0.01
1.5
1.5
—
—
—
0
0
29
142
1.03
0.01
2.7
1.6
5.1
5.7
nmol/l
0.30
29
135
39
193
1.02
0.00
1.2
1.3
—
—
—
0
0
25
128
0.98
0.00
1.8
2.1
78125.9
11716.8
e6/l
0.42
14
71
13
66
0.99
0.00
1.0
1.1
—
—
—
0
0
11
55
1.01
0.00
1.0
1.1
0.2
1.6
u/ml
—
5
38
6
32
0.94
0.00
1.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
8
41
0.98
0.00
1.4
1.1
—
—
—
0
0
6
34
0.89
0.00
1.3
1.7
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint RX_PARACETAMOL_NSAID and mortality.

Females

Parameter HR [95% CI] p-value
RX_PARACETAMOL_NSAID 0.8 [0.75, 0.85] < 0.001
Birth year 0.999 [0.99, 1.01] 0.755

During the follow-up period (1.1.1998 — 31.12.2019), 130281 out of 1353979 females with RX_PARACETAMOL_NSAID died.

Males

Parameter HR [95% CI] p-value
RX_PARACETAMOL_NSAID 0.791 [0.74, 0.84] < 0.001
Birth year 0.992 [0.98, 1.0] 0.03

During the follow-up period (1.1.1998 — 31.12.2019), 135553 out of 1250642 males with RX_PARACETAMOL_NSAID died.

Mortality risk

Mortality risk for people of age

years, who have RX_PARACETAMOL_NSAID.

N-year risk Females Males
1 0.081% 0.135%
5 0.456% 0.91%
10 1.139% 2.333%
15 2.228% 4.747%
20 4.104% 8.188%

Relationships between endpoints

Index endpoint: RX_PARACETAMOL_NSAID – Paracetamol of NSAID medication

GWS hits: 33

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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