discitis: Inflammation of an intervertebral disc or disk space which may lead to disk erosion. Until recently, discitis has been defined as a nonbacterial inflammation and has been attributed to aseptic processes (e.g., chemical reaction to an injected substance). However, recent studies provide evidence that infection may be the initial cause, but perhaps not the promoter, of most cases of discitis. Discitis has been diagnosed in patients following discography, myelography, lumbar puncture, paravertebral injection, and obstetrical epidural anesthesia. Discitis following chemonucleolysis (especially with chymopapain) is attributed to chemical reaction by some and to introduction of microorganisms by others.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
570 |
4. Check minimum number of eventsNone |
570 |
5. Include endpointsNone |
570 |
6. Filter based on genotype QC (FinnGen only) |
570 |
Control definitions (FinnGen only)
- Control exclude
- M13_DORSOPATHY
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M46
- Name in latin
- Discitis non specificata
Similar endpoints
↥List of similar endpoints to
Discitis, unspecified
based on the number of shared cases.
Similar with more cases:
- Autoimmune diseases related-to ILD
- Spondylopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3832 | 1518 | 2294 |
| Only index persons | 3640 | 1453 | 2187 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.04 | 0.06 |
| Only index persons | 0.07 | 0.05 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 64.99 | 67.41 | 63.41 |
| Only index persons | 64.70 | 66.94 | 63.21 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 570 | 218 | 352 |
| Unadjusted period prevalence (%) | 0.12 | 0.07 | 0.16 |
| Median age at first event (years) | 66.27 | 64.83 | 67.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 508
- Matched controls
- 5079
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M46.4
ICD-10 Finland
Discitis, unspecified
+∞
323.0
508
*
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
155.7
133.9
137
12
M46.3
ICD-10 Finland
Infection of intervertebral disc (pyogenic)
+∞
118.5
109
*
M54.5
ICD-10 Finland
Low back pain
9.5
106.0
272
550
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
25.1
101.7
147
81
M48.0
ICD-10 Finland
Spinal stenosis
57.1
95.5
112
25
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
44.6
79.7
98
27
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
33.2
78.8
104
39
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
30.4
74.8
101
41
N02AX02
ATC
tramadol; systemic, rectal
5.5
70.2
319
1190
A49.9
ICD-10 Finland
Bacterial infection, unspecified
8.0
69.5
180
325
NA3DG
NOMESCO Finland
Lumbar spine very extensive MRI examination with high intensity magnet
265.3
69.1
69
*
J01FF01
ATC
clindamycin; systemic
5.6
66.3
256
776
N03AX16
ATC
pregabalin; oral
6.7
64.5
195
433
N02AA05
ATC
oxycodone; systemic
6.6
60.5
183
401
M54.4
ICD-10 Finland
Lumbago with sciatica
10.2
59.7
127
161
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
8.5
57.9
139
216
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
612.3
56.8
55
*
M54.9
ICD-10 Finland
Dorsalgia, unspecified
12.1
52.4
100
101
N03AX12
ATC
gabapentin; oral
7.1
48.9
133
243
L03
ICPC
Low back symptom/complaint
5.3
48.2
176
465
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
246.1
44.7
45
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
8.0
44.7
109
168
J01MA12
ATC
levofloxacin; systemic
4.6
44.2
186
563
R50.9
ICD-10 Finland
Fever, unspecified
5.4
44.0
153
377
ZXD05
NOMESCO Finland
Urgent procedure
3.9
42.6
251
1027
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
34.1
42.4
55
18
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.7
41.2
164
463
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
57.3
40.3
47
9
N02BE01
ATC
paracetamol; systemic, rectal
6.7
40.1
475
3463
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.6
39.8
283
1325
A41.9
ICD-10 Finland
Sepsis, unspecified
10.5
38.6
78
86
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
7.4
38.1
97
157
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.3
36.6
311
1629
G06.1
ICD-10 Finland
Intraspinal abscess and granuloma
+∞
35.8
34
*
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
+∞
35.8
34
*
C03CA01
ATC
furosemide; systemic
3.4
35.1
239
1050
J04AB02
ATC
rifampicin; systemic
31.4
34.9
46
16
N02AJ06
ATC
codeine and paracetamol; systemic
3.4
34.8
233
1009
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
27.3
32.9
45
18
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
11.8
31.9
60
57
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
28.5
31.1
42
16
A02BC02
ATC
pantoprazole; systemic
3.2
30.7
376
2400
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
17.7
30.0
47
29
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.7
29.7
154
531
A40.8
ICD-10 Finland
Other streptococcal sepsis
26.1
29.7
41
17
M46.2
ICD-10 Finland
Osteomyelitis of vertebra
+∞
29.5
28
*
J01CF05
ATC
flucloxacillin; systemic
9.6
28.6
60
70
M03BC01
ATC
orphenadrine (citrate); systemic
3.7
28.2
143
483
J01DB01
ATC
cefalexin; oral
3.8
28.2
443
3267
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
106.0
28.0
30
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.8
27.8
102
254
TPH04
NOMESCO Finland
Cathetrisation of vein
3.4
27.6
166
638
H02AB06
ATC
prednisolone; systemic
2.8
27.6
281
1540
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
+∞
27.3
26
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
4.1
26.9
117
344
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.0
26.4
121
372
A46
ICD-10 Finland
Erysipelas
3.7
25.3
128
427
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
73.7
25.0
28
*
M03BX02
ATC
tizanidine; oral
2.7
24.7
303
1810
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.0
24.7
183
804
M47.82
ICD-10 Finland
Other spondylosis, cervical region
30.9
24.4
32
11
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
27.0
24.3
33
13
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
+∞
24.1
23
*
L28
ICPC
Limited function/disability (L)
3.6
23.8
123
415
M54.2
ICD-10 Finland
Cervicalgia
9.3
23.7
50
59
B01AB05
ATC
enoxaparin; parenteral
2.7
22.9
206
1013
A41.8
ICD-10 Finland
Other specified sepsis
14.0
22.8
39
30
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
30.6
22.1
29
10
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.2
21.7
89
245
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
21.7
179
829
M47.9
ICD-10 Finland
Spondylosis, unspecified
45.5
21.6
26
6
SPAT1255
SPAT
Intravenous administration of medicine
4.9
21.3
73
167
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
4.0
21.2
93
271
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.7
21.2
195
959
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
+∞
21.0
20
*
NK6CT
NOMESCO Finland
Bone biopsy with CT guidance
34.1
20.4
26
8
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.6
20.2
184
897
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
24.6
20.2
28
12
ABC26
NOMESCO Finland
Open discectomy of lumbar spine
+∞
19.9
19
*
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
+∞
19.9
19
*
NA1DG
NOMESCO Finland
Cervical spine very extensive MRI examination with high intensity magnet
+∞
19.9
19
*
R4110
NOMESCO Finland
Physiotherapy
2.7
19.8
172
814
I50.9
ICD-10 Finland
Heart failure, unspecified
3.2
19.6
117
435
SPAT1254
SPAT
Administration of medicine
3.3
19.4
111
400
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.1
19.2
119
454
JN4BD
NOMESCO Finland
Extensive body CT
3.4
19.2
101
342
S97
ICPC
Chronic ulcer skin
5.0
19.0
63
139
J01MA02
ATC
ciprofloxacin; systemic
2.4
18.8
237
1361
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
6.8
18.7
48
77
AA1AD
NOMESCO Finland
CT of head and brain
2.7
18.7
159
737
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.4
18.7
226
1270
ZXE10
NOMESCO Finland
More than one and less than three hours
2.4
18.7
218
1203
M79.6
ICD-10 Finland
Pain in limb
2.5
18.6
183
921
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
12.1
18.3
33
29
A06AD11
ATC
lactulose; oral
3.2
18.2
106
385
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.7
18.2
84
255
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.0
18.2
117
456
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
34.3
18.1
23
7
M46.5
ICD-10 Finland
Other infective spondylopathies
+∞
17.8
17
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.6
17.6
162
783
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
6.7
17.4
45
73
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.7
17.4
140
625
N06AX21
ATC
duloxetine; oral
4.5
17.3
64
158
UJF32
NOMESCO Finland
Coloscopy
2.5
17.1
165
814
L86
ICPC
Back syndrome with radiating pain
8.9
17.0
36
43
M04AA01
ATC
allopurinol; systemic
3.0
17.0
107
409
S18
ICPC
Laceration/cut
2.3
17.0
248
1506
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.9
16.9
48
88
M01AH05
ATC
etoricoxib; oral
2.2
16.8
280
1804
NAS20
NOMESCO Finland
Incision and debridement of infection of vertebra, unspecified
+∞
16.8
16
*
WX110
NOMESCO Finland
Local anesthesy
2.3
16.6
348
2485
A01
ICPC
Pain general/multiple sites
4.9
16.5
55
122
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.5
16.0
151
733
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
12.8
16.0
28
23
A41.1
ICD-10 Finland
Sepsis due to other specified staphylococcus
34.6
15.8
20
6
NF1AA
NOMESCO Finland
Hip X-ray examination
3.9
15.8
68
194
TPH07
NOMESCO Finland
Cathetrisation of artery
3.2
15.7
88
309
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
27.3
15.7
21
8
M54.8
ICD-10 Finland
Other dorsalgia
14.3
15.7
26
19
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.0
15.6
65
180
X59
ICD-10 Finland
Exposure to unspecified factor
2.8
15.5
114
479
M13.9
ICD-10 Finland
Arthritis, unspecified
4.3
15.4
59
151
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.9
15.0
103
413
JN4AD
NOMESCO Finland
Body CT examination
3.6
15.0
70
213
M43.1
ICD-10 Finland
Spondylolisthesis
21.8
14.8
21
10
N06AA09
ATC
amitriptyline; systemic
3.9
14.7
62
173
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
11.3
14.7
27
25
M51.9
ICD-10 Finland
Intervertebral disc disorder, unspecified
+∞
14.6
14
*
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
+∞
14.6
14
*
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
5.3
14.5
45
92
JN3AD
NOMESCO Finland
Abdominal CT examination
3.8
14.5
64
186
I10
ICD-10 Finland
Essential (primary) hypertension
2.1
14.5
334
2411
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
17.6
14.4
22
13
L70
ICPC
Infection of musculoskeletal system
28.1
14.4
19
7
NA3SA
NOMESCO Finland
Lumbar spine X-ray examination in standing position
43.8
14.2
17
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.2
14.1
79
276
R06.0
ICD-10 Finland
Dyspnoea
2.4
14.1
150
767
B18.2
ICD-10 Finland
Chronic viral hepatitis C
16.3
14.0
22
14
NA3CM
NOMESCO Finland
Lumbar spine extensive MRI examination with 3 Tesla magnet
77.2
13.6
15
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.3
13.6
72
242
M47.1
ICD-10 Finland
Other spondylosis with myelopathy
+∞
13.6
13
*
7227C
ICD-9 Finland
Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]
+∞
13.6
13
*
M54
ICD-10 Finland
Dorsalgia
3.5
13.4
65
204
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
11.9
13.4
24
21
C07AB07
ATC
bisoprolol; oral
2.0
13.4
277
1885
TKC20
NOMESCO Finland
Catheterisation of bladder
3.5
13.4
65
205
M03BC51
ATC
orphenadrine, combinations; systemic
2.3
13.3
139
702
A28
ICPC
Limited function/disability NOS
2.6
13.3
110
491
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.7
13.2
59
173
WX892
NOMESCO Finland
Monitored bed care
3.4
13.2
66
213
TPX10
NOMESCO Finland
Implantation of vascular injection port
6.7
13.1
33
52
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
4.6
13.1
46
108
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.6
13.1
106
467
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.4
12.6
122
589
NA3DM
NOMESCO Finland
Lumbar spine very extensive MRI examination with 3 Tesla magnet
+∞
12.5
12
*
72510
ICD-8 Finland
Displacement of intervertebral disk, Lumbalis cum prolapsu disci
+∞
12.5
12
*
M54.1
ICD-10 Finland
Radiculopathy
13.6
12.5
21
16
ZXD35
NOMESCO Finland
Usual procedure
5.6
12.5
36
68
M46.1
ICD-10 Finland
Sacroiliitis, not elsewhere classified
133.1
12.5
13
*
NAG63
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, more than 3 vertebraea
133.1
12.5
13
*
M45
ICD-10 Finland
Ankylosing spondylitis
133.1
12.5
13
*
M10.9
ICD-10 Finland
Gout, unspecified
3.5
12.4
60
188
M17.1
ICD-10 Finland
Other primary gonarthrosis
2.4
12.4
125
617
J01CA04
ATC
amoxicillin; systemic
2.1
12.4
383
3011
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.2
12.3
158
875
K02.1
ICD-10 Finland
Caries of dentine
2.0
12.3
267
1827
M54.6
ICD-10 Finland
Pain in thoracic spine
6.0
12.1
33
58
M54.3
ICD-10 Finland
Sciatica
6.7
12.0
30
47
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
3.6
12.0
55
165
J01CF02
ATC
cloxacillin; systemic
6.4
12.0
31
51
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
12.0
166
948
B01AA03
ATC
warfarin; systemic
2.2
11.9
147
798
ZXE00
NOMESCO Finland
One hour or less
2.0
11.9
210
1323
B99
ICD-10 Finland
Other and unspecified infectious diseases
9.3
11.9
24
27
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.0
11.8
47
125
SAA03
NOMESCO Finland
Extended examination of mouth
2.0
11.7
183
1094
P19
ICPC
Drug abuse
19.5
11.7
17
9
L17
ICPC
Foot/toe symptom/complaint
2.2
11.5
135
713
G99.2*M47.1
ICD-10 Finland
Spondylogenic compression of spinal cord
+∞
11.5
11
*
TQW11
NOMESCO Finland
Vacuum treatment of wound
7.2
11.5
27
39
C03DA01
ATC
spironolactone; oral
2.8
11.5
78
310
M46.0
ICD-10 Finland
Spinal enthesopathy
122.6
11.5
12
*
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
2.6
11.4
89
382
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.1
11.4
172
1013
ZX120
NOMESCO Finland
Intravenous
3.0
11.2
68
250
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.6
11.2
51
153
N05CF01
ATC
zopiclone; oral
2.0
11.1
173
1030
M00.9
ICD-10 Finland
Pyogenic arthritis, unspecified
11.5
11.1
20
18
M01AB05
ATC
diclofenac; systemic, rectal
1.9
11.1
318
2373
Z3226
NOMESCO Finland
Physiotherapist
2.4
11.1
106
506
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.2
11.0
58
194
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.4
11.0
54
172
F11.22
ICD-10 Finland
Addiction-induced dependence is currently independent but uses substitute intermittent medication
44.3
11.0
13
*
207
Kela drug reimbursment
Chronic arrhythmias
2.4
10.9
101
475
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
10.9
10.9
20
19
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
3.2
10.8
57
191
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.4
10.8
101
479
J01MA14
ATC
moxifloxacin; systemic
3.1
10.8
62
221
Z3231
NOMESCO Finland
Registered nurse
2.0
10.7
157
910
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.6
10.6
48
143
A07EC01
ATC
sulfasalazine; oral, rectal
3.5
10.6
49
149
N05BA04
ATC
oxazepam; oral
2.2
10.6
127
674
M25.5
ICD-10 Finland
Pain in joint
2.2
10.5
129
692
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.5
10.5
89
399
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.9
10.5
235
1592
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
2.8
10.5
71
279
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
112.2
10.5
11
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
10.4
109
544
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.0
10.4
160
945
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.3
10.2
101
488
J01XX08
ATC
linezolid; systemic
13.5
10.2
17
13
XX1AT
NOMESCO Finland
Other puncture with ultrasound guidance
13.5
10.2
17
13
TK800
NOMESCO Finland
Hemodialysis
6.7
10.1
25
39
R60.0
ICD-10 Finland
Localized oedema
2.7
10.0
72
295
F11.25
ICD-10 Finland
Relationship caused by opiates continuously used
40.9
10.0
12
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
4.2
9.9
37
93
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.5
9.9
46
141
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.2
9.8
113
587
SPAT1229
SPAT
Assessment of need for aid
3.1
9.8
55
191
Z49.1
ICD-10 Finland
Extracorporeal dialysis
9.8
9.8
19
20
A29
ICPC
General symptom/complaint other
2.8
9.8
67
265
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
7.6
9.8
22
30
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.9
9.8
40
110
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
56.1
9.7
11
*
R51.80
ICD-10 Finland
Headache
3.0
9.7
57
207
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.4
9.7
84
382
S22.0
ICD-10 Finland
Fracture of thoracic vertebra
8.6
9.6
20
24
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.8
9.6
64
252
C09AA02
ATC
enalapril; systemic
2.1
9.6
126
695
R60.9
ICD-10 Finland
Oedema, unspecified
4.2
9.5
35
87
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
3.9
9.5
38
102
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.5
9.5
80
355
T36
ICD-10 Finland
Poisoning by systemic antibiotics
5.3
9.5
28
55
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.6
9.5
70
291
WX290
NOMESCO Finland
Other blockade of nerve
1.9
9.5
194
1261
WZB00
NOMESCO Finland
Telephone receipt or other advice
2.1
9.5
129
719
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
5.8
9.5
26
47
N05BA01
ATC
diazepam; systemic, rectal
2.6
9.4
72
305
F15.2
ICD-10 Finland
Mental and behavioural disorders due to use of other stimulants, including caffeine, dependence syndrome
101.8
9.4
10
*
NA2DG
NOMESCO Finland
Thoracal spine very extensive MRI examination with high intensity magnet
+∞
9.4
9
*
ABC60
NOMESCO Finland
Decompression of cervical spinal cord
+∞
9.4
9
*
NAG65
NOMESCO Finland
Anterior and posterior fusion of lumbar spine
+∞
9.4
9
*
S29
ICPC
Skin symptom/complaint other
2.3
9.4
94
459
N05AH04
ATC
quetiapine; oral
2.5
9.4
77
340
B01AF02
ATC
apixaban; oral
2.6
9.4
71
299
SPAT1216
SPAT
Assessment of functional ability
2.3
9.3
93
452
SPAT1211
SPAT
Application of soft bandage
2.8
9.3
59
225
N06AX11
ATC
mirtazapine; oral
1.9
9.2
156
948
ZXA00
NOMESCO Finland
Right side
1.9
9.1
148
884
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
8.5
9.1
19
23
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
8.5
9.1
19
23
SPAT1263
SPAT
Sampling
1.8
9.1
208
1401
Z71.8
ICD-10 Finland
Other specified counselling
2.1
9.1
116
631
J45.9
ICD-10 Finland
Asthma, unspecified
2.3
9.1
88
423
M01AC06
ATC
meloxicam; systemic, rectal
1.9
9.1
164
1018
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.4
9.1
80
366
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.8
9.0
37
102
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.5
9.0
31
73
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.9
9.0
154
938
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.2
8.9
47
158
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
24.5
8.9
12
5
G47.3
ICD-10 Finland
Sleep apnoea
2.1
8.9
111
596
L04AA13
ATC
leflunomide; oral
7.0
8.9
21
31
SPAT1262
SPAT
Handing over of treatment supplies
2.1
8.8
110
589
L99
ICPC
Musculoskeletal disease other
9.7
8.8
17
18
EBA00
NOMESCO Finland
Extraction of tooth
1.9
8.8
165
1037
A02BC05
ATC
esomeprazole; systemic
1.8
8.8
191
1258
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.2
8.7
98
505
N06AB04
ATC
citalopram; systemic
2.1
8.6
103
542
TNX92
NOMESCO Finland
Supporting bandage or orthosis of lower limb
9.2
8.6
17
19
C08CA01
ATC
amlodipine; oral
1.8
8.6
197
1322
M01AH01
ATC
celecoxib; oral (coxibs)
2.3
8.5
84
406
Z50.1
ICD-10 Finland
Other physical therapy
3.7
8.5
36
103
G55.2*M47.9
ICD-10 Finland
Nerve root and plexus compressions in spondylosis
91.5
8.4
9
*
L15
ICPC
Knee symptom/complaint
2.1
8.4
103
548
UKC02
NOMESCO Finland
Cystoscopy
2.1
8.4
101
533
R03AC02
ATC
salbutamol; inhalant
1.7
8.4
235
1675
TAB20
NOMESCO Finland
Epidural puncture
+∞
8.4
8
*
XX1CT
NOMESCO Finland
Other puncture with CT guidance
+∞
8.4
8
*
NAW10
NOMESCO Finland
Reoperation for superficial infection in in surgery of spine or neck
+∞
8.4
8
*
M48.9
ICD-10 Finland
Spondylopathy, unspecified
+∞
8.4
8
*
ABC30
NOMESCO Finland
Decompression of cervical nerve roots
+∞
8.4
8
*
M43.0
ICD-10 Finland
Spondylolysis
+∞
8.4
8
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.1
8.3
44
149
L03.0
ICD-10 Finland
Cellulitis of finger and toe
3.2
8.3
43
144
EBA15
NOMESCO Finland
Extraction of large number of teeth
3.8
8.2
34
95
205
Kela drug reimbursment
Chronic hypertension
1.8
8.2
167
1076
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.7
8.1
239
1723
R33
ICD-10 Finland
Retention of urine
2.6
8.1
61
256
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
33.9
8.1
10
*
M15.0
ICD-10 Finland
Primary generalized (osteo)arthrosis
6.5
8.1
20
32
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
10.3
8.1
15
15
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
4.4
8.0
28
67
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.2
7.9
84
420
R05
ICD-10 Finland
Cough
2.1
7.9
94
494
NA1AD
NOMESCO Finland
Cervical spine CT examination
4.6
7.9
26
59
M86.9
ICD-10 Finland
Osteomyelitis, unspecified
8.7
7.9
16
19
R53
ICD-10 Finland
Malaise and fatigue
2.1
7.8
101
546
ZXA05
NOMESCO Finland
Left side
1.9
7.8
133
804
ZXD10
NOMESCO Finland
Scheduled procedure
1.7
7.8
192
1309
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.9
7.8
48
178
A49.8
ICD-10 Finland
Other bacterial infections of unspecified site
15.3
7.7
12
8
M01AB01
ATC
indometacin; systemic, rectal
2.7
7.7
52
204
M53.2
ICD-10 Finland
Spinal instabilities
45.7
7.7
9
*
R02
ICPC
Shortness of breath/dyspnoea
2.4
7.7
67
305
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.7
7.6
251
1857
M50.3
ICD-10 Finland
Other cervical disc degeneration
18.7
7.6
11
6
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.7
7.6
51
199
P01AB01
ATC
metronidazole; oral, rectal
1.8
7.6
172
1140
X58
ICD-10 Finland
Exposure to other specified factors
2.4
7.6
66
300
XA402
NOMESCO Finland
ENMG
7.3
7.5
17
24
N03AE01
ATC
clonazepam; systemic
3.6
7.5
32
92
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
5.7
7.4
20
36
A02BC03
ATC
lansoprazole; oral
1.8
7.4
142
888
A03
ICPC
Fever
2.3
7.4
72
346
N05BA12
ATC
alprazolam; oral
2.6
7.4
53
216
M03BX01
ATC
baclofen; systemic
8.5
7.4
15
18
L03.1
ICD-10 Finland
Cellulitis of other parts of limb
5.1
7.4
22
45
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
4.6
7.4
24
54
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.4
7.3
34
105
M60.0
ICD-10 Finland
Infective myositis
+∞
7.3
7
*
9211
FHL
Exploration or removal of diskusprolapse
+∞
7.3
7
*
AB5BT
NOMESCO Finland
Blockage of nerv root with X-ray guidance
+∞
7.3
7
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.6
7.3
54
226
R06.2
ICD-10 Finland
Wheezing
3.7
7.3
30
84
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
5.6
7.3
20
37
WX002
NOMESCO Finland
Sedation and analgesia
1.9
7.3
108
619
ZXE20
NOMESCO Finland
More than three and less than five hours
2.1
7.3
82
421
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
16.0
7.3
11
7
R06AE07
ATC
cetirizine; oral
1.7
7.2
182
1240
Z2446
NOMESCO Finland
Social worker
3.0
7.2
39
135
N06AX16
ATC
venlafaxine; oral
2.4
7.2
59
262
M00.0
ICD-10 Finland
Staphylococcal arthritis and polyarthritis
20.3
7.2
10
5
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
3.2
7.1
35
113
WX872
NOMESCO Finland
Intensive care
2.8
7.1
43
160
L88
ICPC
Rheumatoid/seropositive arthritis
4.4
7.1
24
56
SAA01
NOMESCO Finland
Simple examination of mouth
1.7
7.1
312
2483
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.3
7.1
65
301
N05CF02
ATC
zolpidem; oral
2.1
7.1
85
448
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.4
7.0
33
103
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
7.0
94
517
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
3.0
7.0
40
142
A04
ICPC
Weakness/tiredness general
2.2
7.0
68
327
SPAT1301
SPAT
No procedures
1.7
7.0
160
1058
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
6.5
7.0
17
27
R1250
NOMESCO Finland
Evaluation of functional capability
6.5
7.0
17
27
SPAT1260
SPAT
Consultation of another employee
2.0
7.0
92
504
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
3.2
7.0
35
115
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
3.2
7.0
35
115
M01AB51
ATC
indometacin, combinations; oral, rectal
6.0
7.0
18
31
N02AJ13
ATC
tramadol and paracetamol; systemic
7.7
6.9
15
20
TK810
NOMESCO Finland
Hemofiltration
14.0
6.9
11
8
L84
ICPC
Back syndrome without radiat pain
3.8
6.9
27
73
M53.1
ICD-10 Finland
Cervicobrachial syndrome
3.0
6.9
37
128
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.4
6.8
59
267
E66.00
ICD-10 Finland
Metabolic syndrome
3.3
6.8
32
100
G04CA02
ATC
tamsulosin; oral
1.8
6.8
146
944
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
4.8
6.8
21
45
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.8
6.8
128
795
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
3.2
6.8
34
112
ZXM20
NOMESCO Finland
Intraoperative use of computerised tomography
40.6
6.8
8
*
I50.1
ICD-10 Finland
Left ventricular failure
3.1
6.8
35
118
B01AB10
ATC
tinzaparin; parenteral
2.7
6.7
46
183
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
3.6
6.7
28
80
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.2
6.7
34
113
WW200
NOMESCO Finland
Immunization
4.3
6.7
23
55
NA2AD
NOMESCO Finland
Thoracic spine CT examination
22.8
6.7
9
*
R5599
NOMESCO Finland
Other rehabilitation service
6.6
6.7
16
25
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
6.0
6.7
17
29
S06.0
ICD-10 Finland
Concussion
2.5
6.7
52
223
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.5
6.6
49
204
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.9
6.6
39
143
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
3.6
6.6
28
81
A02BC01
ATC
omeprazole; systemic
1.8
6.6
134
851
Z49.2
ICD-10 Finland
Other dialysis
12.5
6.6
11
9
QDA10
NOMESCO Finland
Incision of skin of lower limb
12.5
6.6
11
9
WX202
NOMESCO Finland
Supraclavicular plexus blockade
8.9
6.6
13
15
M01AX05
ATC
glucosamine; oral
1.9
6.6
101
585
S10
ICPC
Boil/carbuncle
3.2
6.6
33
109
I50.0
ICD-10 Finland
Congestive heart failure
2.5
6.5
51
218
M10.0
ICD-10 Finland
Idiopathic gout
3.6
6.5
27
77
KA1AE
NOMESCO Finland
Kidney ultrasound examination
3.9
6.5
25
67
P01BA02
ATC
hydroxychloroquine; oral
2.7
6.4
42
164
NA3BD
NOMESCO Finland
Extensive lumbar spine and sacrum CT examination
70.7
6.4
7
*
NAU20
NOMESCO Finland
Removal of internal fixation device from spine or neck
70.7
6.4
7
*
E66.8
ICD-10 Finland
Other obesity
3.5
6.4
28
83
L01
ICPC
Neck symptom/complaint
2.3
6.4
59
276
C09BA02
ATC
enalapril and diuretics; systemic
2.4
6.4
54
242
SPAT1265
SPAT
Breathalyser
8.3
6.4
13
16
J01CF01
ATC
dicloxacillin; systemic
8.3
6.4
13
16
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
3.9
6.4
24
63
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.6
6.3
247
1881
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
3.5
6.3
28
84
ACC51
NOMESCO Finland
Release of median nerve
2.9
6.3
36
129
F19.29
ICD-10 Finland
Addiction caused by several drugs in combination and by other psychoactive substances UNS
18.3
6.3
9
5
M54.0
ICD-10 Finland
Panniculitis affecting regions of neck and back
18.3
6.3
9
5
SAA02
NOMESCO Finland
Basic examination of mouth
1.6
6.3
267
2078
72880
ICD-8 Finland
Vertebrogenic pain syndrome, Radicula syndrome of lower limbs
+∞
6.3
6
*
M46.8
ICD-10 Finland
Other specified inflammatory spondylopathies
+∞
6.3
6
*
NA3BA
NOMESCO Finland
Lumbar spine extensive X-ray examination without contrast
+∞
6.3
6
*
NA7DM
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with 3 Tesla magnet
+∞
6.3
6
*
XF600
NOMESCO Finland
Bloodpressure measurement
2.8
6.2
38
143
NH1AE
NOMESCO Finland
Ankle joint ultrasound examination
27.0
6.2
8
*
A40.1
ICD-10 Finland
Sepsis due to streptococcus, group B
27.0
6.2
8
*
F13.22
ICD-10 Finland
Addiction relationship caused by sedatives and hypnotics currently independent but uses substitute intermittent medication
27.0
6.2
8
*
M19.0
ICD-10 Finland
Primary arthrosis of other joints
2.5
6.2
45
187
M02AA07
ATC
piroxicam; topical
1.7
6.2
169
1166
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.0
6.2
35
123
M05BA04
ATC
alendronic acid; oral
2.6
6.2
44
181
M01AE03
ATC
ketoprofen; systemic, rectal
1.7
6.2
175
1221
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
4.0
6.2
23
60
R52.0
ICD-10 Finland
Acute pain
4.8
6.2
19
41
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.7
6.1
40
156
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.6
6.1
181
1280
M01AE01
ATC
ibuprofen; systemic, rectal
1.7
6.1
412
3609
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
12.7
6.1
10
8
WX402
NOMESCO Finland
General anaesthesia
2.0
6.1
74
392
S19
ICPC
Skin injury other
3.6
6.1
25
71
A40.3
ICD-10 Finland
Sepsis due to Streptococcus pneumoniae
8.7
6.1
12
14
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
4.2
6.1
21
51
Z01.2
ICD-10 Finland
Dental examination
1.7
6.1
169
1175
NGF00
NOMESCO Finland
Excision of plica of synovy of knee
5.3
6.1
17
33
D07AC01
ATC
betamethasone; topical
1.7
6.1
165
1140
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.8
6.0
37
140
127
Kela drug reimbursment
Transplant complication
6.1
6.0
15
25
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
5.7
6.0
16
29
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.2
6.0
30
99
Mortality – FinRegistry
↥Association
Association between endpoint M13_DISCITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_DISCITIS | 2.337 [1.84, 2.97] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.524 |
During the follow-up period (1.1.1998 — 31.12.2019), 358 out of 1285 females with M13_DISCITIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_DISCITIS | 2.407 [1.94, 2.98] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 569 out of 1892 males with M13_DISCITIS died.
Mortality risk
Mortality risk for people of age
years, who have M13_DISCITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.203% | 0.437% |
| 5 | 1.306% | 2.524% |
| 10 | 3.654% | 6.535% |
| 15 | 7.338% | 12.408% |
| 20 | 12.465% | 20.51% |
Relationships between endpoints
↥Index endpoint: M13_DISCITIS – Discitis, unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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