Osteomyelitis of vertebra

M13_OSTEOMYELVERTEB

spondyloarthropathy: A group of inflammatory rheumatic diseases associated with arthritis and enthesitis, and often involving the axial skeleton. The most common form of spondyloarthritis is ankylosing spondylitis. Other forms include axial spondyloarthritis, peripheral spondyloarthritis, reactive arthritis, psoriatic arthritis/spondylitis and enteropathic arthritis/spondylitis.

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Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M46.2 Cause of death: ICD-10 — M46.2 2 out of 7 registries used, show all original rules.	115
4. Check minimum number of events None	115
5. Include endpoints None	115
6. Filter based on genotype QC (FinnGen only)	115

Control definitions (FinnGen only)

Control exclude: M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M46
Name in latin: Osteomyelitis vertebrae

NAME	M13_OSTEOMYELVERTEB
CONTROL_EXCLUDE	M13_DORSOPATHY
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M462
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M462
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Osteomyelitis of vertebra based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	937	363	565
Only index persons	806	323	483
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.02
Only index persons	0.02	0.01	0.02
Median age at first event (years)
Whole population	63.49	65.55	62.11
Only index persons	62.54	64.59	61.16

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	115	40	75
Unadjusted period prevalence (%)	0.03	0.01	0.03
Median age at first event (years)	63.56	59.04	65.98

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
108: Matched controls
1079

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M46.2

ICD-10 Finland

Osteomyelitis of vertebra

+∞

155.8

108

M46.3

ICD-10 Finland

Infection of intervertebral disc (pyogenic)

+∞

35.4

NA3CG

NOMESCO Finland

Lumbar spine extensive MRI examination with high intensity magnet

224.3

32.7

M46.4

ICD-10 Finland

Discitis, unspecified

+∞

31.8

A41.0

ICD-10 Finland

Sepsis due to Staphylococcus aureus

78.2

26.6

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

21.3

20.3

M48.0

ICD-10 Finland

Spinal stenosis

242.7

20.3

J01MA12

ATC

levofloxacin; systemic

6.9

17.4

127

N02AA05

ATC

oxycodone; systemic

8.7

15.9

N03AX16

ATC

pregabalin; oral

7.4

15.8

N02AX02

ATC

tramadol; systemic, rectal

5.5

15.6

232

M54.5

ICD-10 Finland

Low back pain

6.5

15.1

111

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

172.4

14.9

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

49.9

14.6

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

13.8

14.5

GD1AA

NOMESCO Finland

Thorax X-ray examination

5.1

14.4

321

J01FF01

ATC

clindamycin; systemic

5.5

14.3

167

A49.9

ICD-10 Finland

Bacterial infection, unspecified

7.9

14.0

J04AB02

ATC

rifampicin; systemic

46.4

13.6

M46.9

ICD-10 Finland

Inflammatory spondylopathy, unspecified

+∞

12.7

M54.9

ICD-10 Finland

Dorsalgia, unspecified

11.4

12.3

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

26.5

12.0

A41.9

ICD-10 Finland

Sepsis, unspecified

12.7

11.9

N06AX21

ATC

duloxetine; oral

10.7

11.5

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

4.4

10.4

151

N03AX12

ATC

gabapentin; oral

7.8

9.6

NA3DG

NOMESCO Finland

Lumbar spine very extensive MRI examination with high intensity magnet

109.2

9.6

NA7CG

NOMESCO Finland

Spine and spinal cord extensive MRI examination with high intensity magnet

+∞

9.5

ABC36

NOMESCO Finland

Decompression of lumbar nerve roots

+∞

9.5

UJF32

NOMESCO Finland

Coloscopy

4.2

9.4

136

J18.9

ICD-10 Finland

Pneumonia, unspecified

4.0

9.3

157

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

3.9

8.9

160

L28

ICPC

Limited function/disability (L)

5.0

8.8

A40.8

ICD-10 Finland

Other streptococcal sepsis

54.5

8.8

M54.4

ICD-10 Finland

Lumbago with sciatica

7.7

8.7

L03

ICPC

Low back symptom/complaint

4.8

8.7

GD1PA

NOMESCO Finland

X-ray examination of the lungs in one projection

6.6

8.6

ZXD05

NOMESCO Finland

Urgent procedure

3.6

8.4

191

NK6CT

NOMESCO Finland

Bone biopsy with CT guidance

48.6

7.8

C03CA01

ATC

furosemide; systemic

3.4

7.7

207

ZXM10

NOMESCO Finland

Intraoperative use of conventional X-ray imaging

12.1

7.5

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

4.2

7.5

FM1BE

NOMESCO Finland

Cardiac ultrasound examination through oesophagus

6.5

7.5

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

7.5

G06.1

ICD-10 Finland

Intraspinal abscess and granuloma

+∞

7.4

NA2CG

NOMESCO Finland

Thoracal spine extensive MRI examination with high intensity magnet

+∞

7.4

N02BE01

ATC

paracetamol; systemic, rectal

4.8

7.4

724

NA2BG

NOMESCO Finland

Thoracal spine MRI examination with high intensity magnet

32.4

7.3

R50.9

ICD-10 Finland

Fever, unspecified

4.4

7.2

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

3.9

7.2

100

A41.5

ICD-10 Finland

Sepsis due to other Gram-negative organisms

15.1

7.1

N02AJ06

ATC

codeine and paracetamol; systemic

3.3

7.0

194

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

3.0

7.0

291

WX408

NOMESCO Finland

General anesthesy, balanced

3.4

6.9

154

NA1CG

NOMESCO Finland

Cervical spine extensive MRI examination with high intensity magnet

42.8

6.9

KH1AE

NOMESCO Finland

Urinary tract ultrasound examination

7.0

6.8

AA1AD

NOMESCO Finland

CT of head and brain

3.6

6.6

123

NA1AA

NOMESCO Finland

Cervical spine X-ray examination without contrast

15.6

6.5

M50.1

ICD-10 Finland

Cervical disc disorder with radiculopathy

74.0

6.5

NA2AA

NOMESCO Finland

Thoracal spine X-ray examination without contrast

12.1

6.5

NF1AE

NOMESCO Finland

Hip joint ultrasound examination

28.5

6.3

A06AD11

ATC

lactulose; oral

4.4

6.3

205

Kela drug reimbursment

Chronic hypertension

3.0

6.3

194

7227C

ICD-9 Finland

Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]

+∞

6.3

NA3EA

NOMESCO Finland

Lumbar spine X-ray examination with flexion

+∞

6.3

A41.1

ICD-10 Finland

Sepsis due to other specified staphylococcus

+∞

6.3

J01CF02

ATC

cloxacillin; systemic

13.6

6.2

I50.9

ICD-10 Finland

Heart failure, unspecified

3.7

6.2

N03AE01

ATC

clonazepam; systemic

11.0

6.2

L08.9

ICD-10 Finland

Local infection of skin and subcutaneous tissue, unspecified

11.0

6.2

Z76.9

ICD-10 Finland

Person encountering health services in unspecified circumstances

7.1

6.1

M03BX02

ATC

tizanidine; oral

2.7

6.1

394

Mortality – FinRegistry

↥

Association

Association between endpoint M13_OSTEOMYELVERTEB and mortality.

Females

Parameter	HR [95% CI]	p-value
M13_OSTEOMYELVERTEB	1.996 [1.5, 2.65]	< 0.001
Birth year	0.99 [0.98, 1.0]	0.024

During the follow-up period (1.1.1998 — 31.12.2019), 121 out of 325 females with M13_OSTEOMYELVERTEB died.

Males

Parameter	HR [95% CI]	p-value
M13_OSTEOMYELVERTEB	2.433 [1.84, 3.22]	< 0.001
Birth year	0.985 [0.98, 0.99]	0.002

During the follow-up period (1.1.1998 — 31.12.2019), 201 out of 503 males with M13_OSTEOMYELVERTEB died.

Mortality risk

Mortality risk for people of age

years, who have M13_OSTEOMYELVERTEB.

N-year risk	Females	Males
1	0.15%	0.363%
5	0.982%	2.718%
10	2.528%	6.78%
15	4.728%	12.398%
20	8.398%	20.461%

Relationships between endpoints

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Index endpoint: M13_OSTEOMYELVERTEB – Osteomyelitis of vertebra

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Osteomyelitis of vertebra

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints