reactive arthritis: Reactive arthritis (ReA) is an autoimmune disorder belonging to the group of seronegative spondyloarthropathies and is characterized by the classic triad of arthritis, urethritis and conjunctivitis.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
219 |
4. Check minimum number of eventsNone |
219 |
5. Include endpointsNone |
219 |
6. Filter based on genotype QC (FinnGen only) |
219 |
Control definitions (FinnGen only)
- Control exclude
- RHEUMA_ARHTROPAT_REACTIVE
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M02
- Name in latin
- Morbus Reiter
Similar endpoints
↥List of similar endpoints to
Reiter disease
based on the number of shared cases.
Similar with more cases:
- Reactive arthropathies, FINNGEN
- Finngen Rheumatological endpoints
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1810 | 445 | 1350 |
| Only index persons | 1625 | 422 | 1203 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.01 | 0.04 |
| Only index persons | 0.04 | 0.02 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 43.46 | 44.10 | 43.14 |
| Only index persons | 42.52 | 43.47 | 42.19 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 219 | 69 | 150 |
| Unadjusted period prevalence (%) | 0.05 | 0.02 | 0.07 |
| Median age at first event (years) | 42.54 | 38.83 | 44.24 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 202
- Matched controls
- 2020
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M02.3
ICD-10 Finland
Reiter disease
+∞
273.0
195
*
A07EC01
ATC
sulfasalazine; oral, rectal
35.1
84.4
115
73
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
25.5
76.7
118
105
M02.9
ICD-10 Finland
Reactive arthropathy, unspecified
132.0
48.3
50
5
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
14.3
44.4
82
92
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
18.9
39.2
62
46
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
23.7
36.0
52
29
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
12.4
28.2
53
56
M13.9
ICD-10 Finland
Arthritis, unspecified
9.0
20.8
46
64
H02AB06
ATC
prednisolone; systemic
4.0
19.1
134
671
P01BA02
ATC
hydroxychloroquine; oral
7.6
17.7
43
69
13603
ICD-8 Finland
Other and unspecified infective and parasitic diseases, Morbus Reiter, syndroma urethro-oculo-articularis
+∞
16.9
16
*
M02.8
ICD-10 Finland
Other reactive arthropathies
+∞
16.9
16
*
M45
ICD-10 Finland
Ankylosing spondylitis
14.6
16.2
27
21
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
9.5
15.5
32
39
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
12.8
15.3
27
24
L04AA13
ATC
leflunomide; oral
14.1
14.8
25
20
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
12.8
14.2
25
22
L88
ICPC
Rheumatoid/seropositive arthritis
10.9
13.7
26
27
0993A
ICD-9 Finland
Other venereal diseases, Reiter's disease
+∞
12.6
12
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
8.1
11.7
26
36
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
9.5
11.4
23
27
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
26.8
11.3
15
6
S01FA02
ATC
scopolamine; ophthalmic
24.9
10.4
14
6
M02.1
ICD-10 Finland
Postdysenteric arthropathy
+∞
9.4
9
*
7111L
ICD-9 Finland
Arthropathy associated with infections, Arthropathy associated with Reiter's disease and nonspecific urethritis[UROARTHRITIS, USEAT NIVELET]
+∞
9.4
9
*
3640A
ICD-9 Finland
Disorders of iris and ciliary body, Acute and subacute iridocyclitis
+∞
9.4
9
*
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
11.5
9.0
16
15
H02AB07
ATC
prednisone; oral
3.4
8.8
44
151
L04AB01
ATC
etanercept; parenteral
12.3
8.7
15
13
H20.1
ICD-10 Finland
Chronic iridocyclitis
21.1
8.6
12
6
ZX120
NOMESCO Finland
Intravenous
4.1
8.5
34
96
Z3231
NOMESCO Finland
Registered nurse
2.7
8.4
69
327
M02.0
ICD-10 Finland
Arthropathy following intestinal bypass
+∞
8.4
8
*
L04AB04
ATC
adalimumab; parenteral
10.7
8.2
15
15
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
15.8
7.8
12
8
N48.1
ICD-10 Finland
Balanoposthitis
8.6
7.8
16
20
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
8.6
7.8
16
20
M13.1
ICD-10 Finland
Monoarthritis, not elsewhere classified
26.1
7.6
10
*
M13.0
ICD-10 Finland
Polyarthritis, unspecified
14.1
7.5
12
9
71490
ICD-8 Finland
Other specified forms of arthritis, Arthritis postinfectiosa NUD
83.0
7.5
8
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
6.7
65
328
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
8.3
6.7
14
18
R4110
NOMESCO Finland
Physiotherapy
2.4
6.7
65
330
M01AC06
ATC
meloxicam; systemic, rectal
2.2
6.7
85
494
M01AH01
ATC
celecoxib; oral (coxibs)
2.8
6.6
45
189
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.6
6.6
29
90
M01CB01
ATC
sodium aurothiomalate; parenteral
14.9
6.5
10
7
M01AE03
ATC
ketoprofen; systemic, rectal
2.1
6.2
88
535
Mortality – FinRegistry
↥Association
Association between endpoint REITER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| REITER | 1.516 [1.12, 2.06] | 0.008 |
| Birth year | 0.999 [0.99, 1.01] | 0.892 |
During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 387 females with REITER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| REITER | 1.526 [1.28, 1.82] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 189 out of 1071 males with REITER died.
Mortality risk
Mortality risk for people of age
years, who have REITER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.168% | 0.209% |
| 5 | 1.11% | 1.463% |
| 10 | 2.728% | 3.843% |
| 15 | 5.054% | 7.025% |
| 20 | 9.186% | 12.038% |
Relationships between endpoints
↥Index endpoint: REITER – Reiter disease
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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