Risteys · SCND_OTH_COXARTHROSIS

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M16.7 Hospital discharge: ICD-9 — 7152E Cause of death: ICD-10 — M16.7 Cause of death: ICD-9 — 7152E 2 out of 7 registries used, show all original rules.	1236
4. Check minimum number of events None	1236
5. Include endpoints None	1236
6. Filter based on genotype QC (FinnGen only)	1236

	All	Female	Male
Number of individuals
Whole population	9231	4924	4215
Only index persons	7599	4223	3376
Unadjusted period prevalence (%)
Whole population	0.13	0.14	0.12
Only index persons	0.14	0.16	0.13
Median age at first event (years)
Whole population	57.39	58.73	55.66
Only index persons	54.94	56.62	52.85

	All	Female	Male
Number of individuals	1236	691	545
Unadjusted period prevalence (%)	0.24	0.24	0.24
Median age at first event (years)	55.19	54.66	55.87

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
1093: Matched controls
10931

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

NFB30

NOMESCO Finland

Primary total prosthetic replacement of hip joint not using cement

630.7

323.0

489

M16.1

ICD-10 Finland

Other primary coxarthrosis

261.3

323.0

562

M16.7

ICD-10 Finland

Other secondary coxarthrosis

16384.0

323.0

918

NF1AA

NOMESCO Finland

Hip X-ray examination

27.2

291.2

418

243

M16.0

ICD-10 Finland

Primary coxarthrosis, bilateral

113.9

270.4

287

T84.0

ICD-10 Finland

Mechanical complication of internal joint prosthesis

63.3

219.5

254

7152E

ICD-9 Finland

Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, secondary[OSTEORTHROSIS SECUNDARIA,LONKKANIVEL]

+∞

211.5

196

L13

ICPC

Hip symptom/complaint

8.3

161.2

417

757

NF1BA

NOMESCO Finland

Hip extensive X-ray examination

42.3

144.6

181

9294

FHL

Endoprosthesis replacement of the entire hip joint (eg Charnley)

402.8

144.5

142

M16.9

ICD-10 Finland

Coxarthrosis, unspecified

26.5

140.9

199

NFC20

NOMESCO Finland

Secondary implantation of hip prosthesis

232.6

140.4

142

NFB40

NOMESCO Finland

Primary total prosthetic replacement of hip joint using hybrid technique

102.9

139.2

151

NE1AA

NOMESCO Finland

Pelvis X-ray examination

14.3

137.0

245

216

M16.3

ICD-10 Finland

Other dysplastic coxarthrosis

721.1

132.5

128

B01AB05

ATC

enoxaparin; parenteral

5.0

126.9

581

2036

WX320

NOMESCO Finland

Spinalanesthesy

4.9

106.2

437

1306

L89

ICPC

Osteoarthrosis of hip

32.9

99.0

131

Z96.6

ICD-10 Finland

Presence of orthopaedic joint implants

20.4

98.9

151

NF1DA

NOMESCO Finland

X-ray of hips

37.3

98.1

126

NFB60

NOMESCO Finland

Demanding prosthetic replacement of hip

116.0

97.9

105

M16

ICD-10 Finland

Coxarthrosis [arthrosis of hip]

15.5

78.1

132

NJ3NA

NOMESCO Finland

Measurement of difference in extremity lengty with X-ray

165.4

74.0

B01AF01

ATC

rivaroxaban; oral

5.0

68.2

244

588

NFC40

NOMESCO Finland

Repair of hip prosthesis by bone transplant to acetabulum

699.4

67.7

Y88.3

ICD-10 Finland

Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

17.3

66.5

107

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

4.6

63.0

247

650

NE1BG

NOMESCO Finland

Pelvic, hip and femur MRI examination with high intensity magnet

17.0

62.4

101

M16.5

ICD-10 Finland

Other post-traumatic coxarthrosis

+∞

61.0

N02AX02

ATC

tramadol; systemic, rectal

2.8

54.9

588

3245

7151E

ICD-9 Finland

Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, LONKKANIVEL]

+∞

53.6

M05.8

ICD-10 Finland

Other seropositive rheumatoid arthritis

6.2

52.5

150

271

71300

ICD-8 Finland

Osteo-arthritis and allied conditions, Arthritis (arthrosis) coxae

+∞

52.5

NFB50

NOMESCO Finland

Primary total prosthetic replacement of hip joint using cement

66.7

49.7

NE1CG

NOMESCO Finland

Pelvic, hip and femur extensive MRI examination with high intensity magnet

14.5

49.6

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

4.3

47.1

195

529

M16.6

ICD-10 Finland

Other secondary coxarthrosis, bilateral

477.0

46.6

A07EC01

ATC

sulfasalazine; oral, rectal

4.7

46.4

173

423

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

2.6

46.0

520

2859

ZXA05

NOMESCO Finland

Left side

2.8

44.3

376

1740

NE1AD

NOMESCO Finland

Pelvis and hip bones CT examination

15.0

43.2

M87.0

ICD-10 Finland

Idiopathic aseptic necrosis of bone

28.5

42.0

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

4.6

40.9

154

378

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

2.4

40.8

572

3443

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

6.5

40.1

109

183

M16.2

ICD-10 Finland

Coxarthrosis resulting from dysplasia, bilateral

+∞

39.8

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

8.7

39.3

107

Q65.0

ICD-10 Finland

Congenital dislocation of hip, unilateral

401.1

39.3

L88

ICPC

Rheumatoid/seropositive arthritis

6.2

39.1

111

197

NFC00

NOMESCO Finland

Exchange of a loose part of prosthesis in hip joint

+∞

38.8

N02BE01

ATC

paracetamol; systemic, rectal

3.2

38.6

977

7922

WX002

NOMESCO Finland

Sedation and analgesia

2.8

37.8

292

1256

M01AH05

ATC

etoricoxib; oral

2.3

37.6

700

4761

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

3.4

37.5

201

671

B01AX06

ATC

[U] rivaroxaban; oral

12.4

37.3

ZXA00

NOMESCO Finland

Right side

2.5

37.0

383

1943

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

8.8

37.0

M25.5

ICD-10 Finland

Pain in joint

2.5

36.6

377

1906

WZA00

NOMESCO Finland

Short statement of of health and health related matters

5.3

36.4

118

246

NF1AE

NOMESCO Finland

Hip joint ultrasound examination

8.7

35.7

NE1BA

NOMESCO Finland

Pelvis extensive X-ray examination

34.2

35.6

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

3.4

35.4

188

621

N02AJ06

ATC

codeine and paracetamol; systemic

2.3

35.2

452

2545

SPAT1153

SPAT

Removal of sutures

2.3

34.7

424

2325

P01BA02

ATC

hydroxychloroquine; oral

3.8

34.5

159

468

9321

FHL

The first reartroplast due to detachment, also includes the treatment of a fracture due to detachment

347.3

34.1

M87.9

ICD-10 Finland

Osteonecrosis, unspecified

44.8

32.0

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

4.1

31.9

134

362

NFH30

NOMESCO Finland

Reduction of dislocation prosthesis of hip joint, closed

116.8

31.8

M01AH01

ATC

celecoxib; oral (coxibs)

2.6

31.7

266

1186

S18

ICPC

Laceration/cut

2.2

31.4

512

3167

NFU20

NOMESCO Finland

Removal of internal fixation device from femur

17.6

31.3

N03AX12

ATC

gabapentin; oral

2.8

30.2

226

938

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

4.1

30.2

125

333

7543A

ICD-9 Finland

Certain congenital musculoskeletal deformities, Congenital dislocation of hip[LUXATIO COXAE CONGENITA]

310.4

29.9

75560

ICD-8 Finland

Other congenital anomalies of limbs, Dislocatio congenita coxae (fixata)

+∞

29.3

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

2.6

28.4

234

1023

L28

ICPC

Limited function/disability (L)

2.7

27.8

218

927

M24.8

ICD-10 Finland

Other specific joint derangements, not elsewhere classified

26.2

27.6

NFF25

NOMESCO Finland

Cleaning of hip joint, arthroscopic

48.5

27.6

T84.5

ICD-10 Finland

Infection and inflammatory reaction due to internal joint prosthesis

15.6

27.5

L04AB01

ATC

etanercept; parenteral

12.5

27.2

M17.1

ICD-10 Finland

Other primary gonarthrosis

2.4

26.6

273

1340

WZA90

NOMESCO Finland

Other doctors statement

2.3

26.3

283

1422

NFG00

NOMESCO Finland

Arthroplasty of hip joint

138.2

25.7

X59

ICD-10 Finland

Exposure to unspecified factor

2.4

25.3

242

1140

NGB20

NOMESCO Finland

Primary total prosthetic replacement of knee joint without patellar part

3.1

25.1

146

510

B01AB04

ATC

dalteparin; parenteral

4.6

24.9

210

SAA02

NOMESCO Finland

Basic examination of mouth

2.0

24.7

683

5023

9964A

ICD-9 Finland

Complications peculiar to certain specified procedures, Mechanical complication of internal orthopaedic device, implant and graft

133.0

24.7

M79.6

ICD-10 Finland

Pain in limb

2.0

24.5

416

2538

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

2.1

24.3

351

2003

L04AA13

ATC

leflunomide; oral

5.8

24.1

128

L04AB04

ATC

adalimumab; parenteral

9.0

24.0

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.0

24.0

499

3287

Y83.1

ICD-10 Finland

Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

12.8

23.7

M01CB01

ATC

sodium aurothiomalate; parenteral

8.3

23.4

ZZH31

NOMESCO Finland

Bone allograft, small pieces

17.7

23.2

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

2.5

23.0

208

948

A02BC02

ATC

pantoprazole; systemic

1.9

22.9

717

5442

9165

FHL

Removal of osteosynthesis material

6.3

22.2

100

7140A

ICD-9 Finland

Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]

8.9

22.0

WX130

NOMESCO Finland

Interpleural anesthesia

+∞

21.9

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

2.0

21.8

400

2489

M13.9

ICD-10 Finland

Arthritis, unspecified

3.4

21.6

110

348

TPH04

NOMESCO Finland

Cathetrisation of vein

2.2

21.5

258

1347

M05.9

ICD-10 Finland

Seropositive rheumatoid arthritis, unspecified

6.1

21.1

NF1AT

NOMESCO Finland

Puncture of hip joint with ultrasound guidance

78.3

20.7

M91.1

ICD-10 Finland

Juvenile osteochondrosis of head of femur [Legg-Calvé-Perthes]

213.8

20.6

NF2AT

NOMESCO Finland

Injection to hip joint with ultrasound guidance

42.5

20.5

N02AA05

ATC

oxycodone; systemic

2.4

20.3

189

870

M17.5

ICD-10 Finland

Other secondary gonarthrosis

8.9

20.2

Y88.1

ICD-10 Finland

Sequelae of misadventures to patients during surgical and medical procedures

12.4

20.1

M45

ICD-10 Finland

Ankylosing spondylitis

8.2

20.1

M01AX05

ATC

glucosamine; oral

2.2

20.0

246

1291

7321A

ICD-9 Finland

Osteochondropathies, Juvenile osteochondrosis of hip and pelvis[COXA PLANA (LEGG-CALVô-PERTHES)]

+∞

19.8

Q65.1

ICD-10 Finland

Congenital dislocation of hip, bilateral

+∞

19.8

N03AX16

ATC

pregabalin; oral

2.0

19.3

284

1608

M06.0

ICD-10 Finland

Seronegative rheumatoid arthritis

5.0

19.0

130

NA1EA

NOMESCO Finland

Cervical spine X-ray examination with flexion

9.4

19.0

72211

ICD-8 Finland

Osteochondrosis, Coxae planae

+∞

18.8

H02AB06

ATC

prednisolone; systemic

1.8

18.7

524

3712

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

2.8

18.6

127

488

T84.8

ICD-10 Finland

Other complications of internal orthopaedic prosthetic devices, implants and grafts

67.7

17.8

NFB99

NOMESCO Finland

Other primary prosthetic replacement of hip joint

+∞

17.7

NFC50

NOMESCO Finland

Repair of hip prosthesis by bone transplant to femur and acetabulum

+∞

17.7

Q65.80

ICD-10 Finland

Congenital dysplastic hip or acetabulum, unilateral

+∞

17.7

NFA30

NOMESCO Finland

Exploration of hip joint, arthroscopic

182.7

17.6

A28

ICPC

Limited function/disability NOS

2.3

17.1

178

862

M06.9

ICD-10 Finland

Rheumatoid arthritis, unspecified

4.4

17.1

146

S73.0

ICD-10 Finland

Dislocation of hip

32.0

17.1

NFL22

NOMESCO Finland

Myotomy or tenotomy of hip or thigh

+∞

16.7

NFE15

NOMESCO Finland

Plastic repair of capsule or ligament of hip joint

91.4

16.6

M17.4

ICD-10 Finland

Other secondary gonarthrosis, bilateral

20.4

16.5

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

2.6

16.4

125

513

M01AC06

ATC

meloxicam; systemic, rectal

1.8

16.3

411

2783

M19.0

ICD-10 Finland

Primary arthrosis of other joints

2.5

15.9

128

543

M15.9

ICD-10 Finland

Polyarthrosis, unspecified

3.4

15.7

242

NJ2MA

NOMESCO Finland

Measurement of mechanical axis of lower leg with X-ray

3.1

15.6

312

A02BC05

ATC

esomeprazole; systemic

1.7

15.6

438

3053

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

1.8

15.5

330

2106

NGB40

NOMESCO Finland

Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis

5.1

15.5

100

M19.2

ICD-10 Finland

Other secondary arthrosis

9.1

15.5

ZXM10

NOMESCO Finland

Intraoperative use of conventional X-ray imaging

3.2

15.3

264

SPAT1263

SPAT

Sampling

1.7

15.2

445

3128

G56.0

ICD-10 Finland

Carpal tunnel syndrome

2.2

14.9

157

763

M17.0

ICD-10 Finland

Primary gonarthrosis, bilateral

2.2

14.6

157

767

TNF11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in hip joint

81.2

14.6

M87.3

ICD-10 Finland

Other secondary osteonecrosis

81.2

14.6

M01AB05

ATC

diclofenac; systemic, rectal

1.7

14.5

703

5668

NB1AA

NOMESCO Finland

Shoulder X-ray examination without contrast

2.8

14.5

363

M05BA04

ATC

alendronic acid; oral

2.6

14.4

113

472

M01AE03

ATC

ketoprofen; systemic, rectal

1.7

14.1

421

2961

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

2.6

14.1

107

437

WZB00

NOMESCO Finland

Telephone receipt or other advice

1.8

14.0

294

1858

M01AH02

ATC

rofecoxib; oral

2.1

13.9

161

813

M75.1

ICD-10 Finland

Rotator cuff syndrome

1.8

13.9

266

1631

NC1AA

NOMESCO Finland

Elbow X-ray examination without contrast

4.9

13.9

S70.0

ICD-10 Finland

Contusion of hip

3.8

13.7

159

NFJ62

NOMESCO Finland

Internal fixation of fracture of other parts of femur with plate

14.9

13.6

9322

FHL

Subsequent reartroplast due to detachment also includes treatment of the fracture due to detachment

+∞

13.6

NEK20

NOMESCO Finland

Fenestration or forage of bone of pelvis

+∞

13.6

9292

FHL

Femoral osteotomy

+∞

13.6

L04AB06

ATC

golimumab; parenteral

11.1

13.5

WX602

NOMESCO Finland

Repeated or continuing anesthesia shots throug a catheter

2.7

13.2

372

M01AB55

ATC

diclofenac, combinations; oral

2.6

13.2

391

J01DB01

ATC

cefalexin; oral

1.7

13.0

853

7356

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

2.5

12.9

109

471

R4110

NOMESCO Finland

Physiotherapy

1.7

12.9

296

1916

Z01.2

ICD-10 Finland

Dental examination

1.6

12.8

409

2909

1220

FHL

Arthroscopy

3.5

12.7

170

7151F

ICD-9 Finland

Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]

5.0

12.6

71238

ICD-8 Finland

Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita

10.2

12.5

A02BC01

ATC

omeprazole; systemic

1.7

12.5

309

2042

A02BC03

ATC

lansoprazole; oral

1.7

12.5

327

2199

M70.6

ICD-10 Finland

Trochanteric bursitis

2.2

12.3

135

665

M96.6

ICD-10 Finland

Fracture of bone following insertion of orthopaedic implant, joint prosthesis, or bone plate

21.5

12.0

NG1DA

NOMESCO Finland

X-ray of knees

6.1

12.0

M01AE02

ATC

naproxen; oral, rectal

1.6

12.0

572

4490

M01AX17

ATC

nimesulide; oral

1.7

12.0

272

1751

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

2.2

11.9

123

589

SDA02

NOMESCO Finland

Parodonthologic therapy

1.7

11.9

326

2216

TND11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in joint, wrist or hand

5.5

11.8

Y79.2

ICD-10 Finland

Orthopaedic devices associated with adverse incidents, prosthetic and other implants, materials and accessory devices

30.4

11.7

NH3EA

NOMESCO Finland

Feet X-ray examination with load

4.7

11.6

B01AX05

ATC

fondaparinux; parenteral

11.2

11.6

SAA03

NOMESCO Finland

Extended examination of mouth

1.6

11.5

377

2683

NFC99

NOMESCO Finland

Other secondary prosthetic replacement in hip joint, other or unspecified

121.2

11.4

M15.0

ICD-10 Finland

Primary generalized (osteo)arthrosis

3.8

11.4

127

M15

ICD-10 Finland

Polyarthrosis

3.1

11.3

218

N02AC04

ATC

dextropropoxyphene; oral

3.2

11.3

192

NF3AA

NOMESCO Finland

Femur X-ray examination

5.6

11.2

SPAT1229

SPAT

Assessment of need for aid

2.4

11.2

420

SFA10

NOMESCO Finland

Fillning on one surface of tooth

1.6

11.2

527

4093

M48.0

ICD-10 Finland

Spinal stenosis

2.1

11.1

133

679

J01FF01

ATC

clindamycin; systemic

1.7

11.1

287

1909

E870A

ICD-9 Finland

Accidental cut, puncture, perforation or haemorrhage during medical care

7.2

11.1

7140B

ICD-9 Finland

Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SERONEGATIVA]

14.0

11.0

NE1DG

NOMESCO Finland

Pelvic, hip and femur very extensive MRI examination with high intensity magnet

14.0

11.0

L17

ICPC

Foot/toe symptom/complaint

1.7

10.9

270

1775

WX110

NOMESCO Finland

Local anesthesy

1.6

10.9

688

5709

L04AA01

ATC

[U] ciclosporin; systemic

5.5

10.8

L08

ICPC

Shoulder symptom/complaint

1.8

10.6

206

1257

NFK30

NOMESCO Finland

Angulation, rotation or displacement osteotomy of femur

60.6

10.6

M91.2

ICD-10 Finland

Coxa plana

60.6

10.6

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

2.1

10.6

127

650

72210

ICD-8 Finland

Osteochondrosis, Epiphyseolysis capitis femoris

32.8

10.3

L15

ICPC

Knee symptom/complaint

1.7

10.2

215

1344

WX720

NOMESCO Finland

Own respiration

3.1

10.2

178

WX306

NOMESCO Finland

Lumbar epidural anesthesy

2.9

10.2

213

J01CA04

ATC

amoxicillin; systemic

1.6

10.1

813

7073

S72.3

ICD-10 Finland

Fracture of shaft of femur

8.5

10.1

TNH11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in ankle joint or foot joint

6.5

10.0

SPAT1301

SPAT

No procedures

1.6

10.0

322

2265

NA1AA

NOMESCO Finland

Cervical spine X-ray examination without contrast

3.2

9.9

159

M08.0

ICD-10 Finland

Juvenile rheumatoid arthritis

16.9

9.9

ZSN00

NOMESCO Finland

Procedure related to previous procedure classified in chapter N

16.9

9.9

NK5AT

NOMESCO Finland

Joint injection with ultrasound guidance not elsewhere classified

8.2

9.8

A46

ICD-10 Finland

Erysipelas

1.9

9.6

149

842

NHG20

NOMESCO Finland

Fusion of talocrural joint

11.5

9.6

9407

FHL

Osteotomy of the upper femur

100.8

9.4

NFK99

NOMESCO Finland

Other operation on bone of femur

100.8

9.4

M16.4

ICD-10 Finland

Post-traumatic coxarthrosis, bilateral

+∞

9.4

NFK70

NOMESCO Finland

Bone transport operation of femur

+∞

9.4

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

1.8

9.4

167

988

NF1AA

SPAT

4.3

9.3

SPAT1148

SPAT

Treatment of chronic ulcer or burn

1.9

9.3

139

773

M05BX04

ATC

denosumab; parenteral

2.7

9.3

244

M01AH03

ATC

valdecoxib; oral

2.5

9.3

318

J01MA02

ATC

ciprofloxacin; systemic

1.5

9.2

392

2933

X58

ICD-10 Finland

Exposure to other specified factors

1.9

9.2

138

771

J04AB02

ATC

rifampicin; systemic

6.3

9.1

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

2.4

9.0

325

N06AA09

ATC

amitriptyline; systemic

2.0

9.0

112

582

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

1.6

9.0

296

2080

TNX00

NOMESCO Finland

Puncture and needle biopsy of soft tissue, unspecified region

4.5

8.9

7152F

ICD-9 Finland

Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, secondary[OSTEORTHROSIS SECUNDARIA,POLVI]

12.6

8.9

M01AE01

ATC

ibuprofen; systemic, rectal

1.6

8.9

920

8342

R06.0

ICD-10 Finland

Dyspnoea

1.6

8.8

245

1651

R50.9

ICD-10 Finland

Fever, unspecified

1.9

8.8

142

814

M05BA07

ATC

risedronic acid; oral

3.2

8.7

141

I10

ICD-10 Finland

Essential (primary) hypertension

1.5

8.7

594

4895

NFU00

NOMESCO Finland

Removal of partial prosthesis from hip joint, other or unspecified

50.4

8.7

ACC51

NOMESCO Finland

Release of median nerve

2.3

8.6

378

L04AB05

ATC

certolizumab pegol; parenteral

11.7

8.6

WX006

NOMESCO Finland

Intravenous sedation or analgesia without general anesthesia

11.7

8.6

S73.1

ICD-10 Finland

Sprain and strain of hip

11.7

8.6

J01DA01

ATC

[U] cefalexin; systemic

1.5

8.6

633

5295

L90

ICPC

Osteoarthrosis of knee

2.5

8.5

281

L04AX01

ATC

azathioprine; systemic

2.7

8.4

209

75561

ICD-8 Finland

Other congenital anomalies of limbs, Praeluxatio congenita coxae (non fixata, fenomeno Ortolani positivo)

90.7

8.4

71239

ICD-8 Finland

Rheumatoid arthritis and allied conditions, Arthritis rheumatoides NUD

6.8

8.4

WX704

NOMESCO Finland

Intubation

2.2

8.3

394

N02AJ13

ATC

tramadol and paracetamol; systemic

4.1

8.3

WX111

NOMESCO Finland

Local infiltration anesthesia

3.4

8.3

114

M08.3

ICD-10 Finland

Juvenile polyarthritis (seronegative)

33.6

8.1

NB1BA

NOMESCO Finland

Shoulder extensive X-ray examination without contrast

3.1

8.1

144

WX402

NOMESCO Finland

General anaesthesia

1.7

8.0

169

1053

SPAT1256

SPAT

Intramuscular and subcutaneous injection

1.5

8.0

409

3159

Y89.9

ICD-10 Finland

Sequelae of unspecified external cause

6.3

8.0

T84.9

ICD-10 Finland

Unspecified complication of internal orthopaedic prosthetic device, implant and graft

22.2

8.0

WX212

NOMESCO Finland

Femoral plexus blockade

4.2

8.0

K02.1

ICD-10 Finland

Caries of dentine

1.4

8.0

532

4330

SAA01

NOMESCO Finland

Simple examination of mouth

1.4

7.9

682

5832

S32.4

ICD-10 Finland

Fracture of acetabulum

7.8

7.9

7148X

ICD-9 Finland

Rheumatoid arthritis and other inflammatory polyarthropathies, Other specified inflammatory polyarthropathies

13.1

7.9

L04AA11

ATC

[U] etanercept; parenteral

10.9

7.8

318

Kela drug reimbursment

Teriparatide

15.1

7.7

S72.9

ICD-10 Finland

Fracture of femur, part unspecified

15.1

7.7

SPAT1255

SPAT

Intravenous administration of medicine

2.3

7.7

324

Z50.1

ICD-10 Finland

Other physical therapy

2.4

7.7

264

TNC11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in elbow joint

18.5

7.6

71200

ICD-8 Finland

Rheumatoid arthritis and allied conditions, Juvenile rheumatoid arthritis

18.5

7.6

TNB11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in shoulder joint

8.1

7.6

RT271

NOMESCO Finland

25.2

7.6

NFJ50

NOMESCO Finland

Internal fixation of fracture of neck of femur with nail or screw

10.1

7.5

M04AA01

ATC

allopurinol; systemic

1.8

7.5

135

800

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

1.5

7.5

318

2355

KMAK

NOMESCO Finland

1.4

7.5

492

3978

J01MA12

ATC

levofloxacin; systemic

1.6

7.4

186

1215

SFA20

NOMESCO Finland

Filling on two surfaces of tooth

1.4

7.4

545

4499

9051A

ICD-9 Finland

Late effects of musculoskeletal and connective tissue injuries, Late effect of fracture of spine and trunk without mention of spinal cord lesion

80.6

7.4

NFH10

NOMESCO Finland

Reduction of dislocation of hip joint, closed

80.6

7.4

M87.8

ICD-10 Finland

Other osteonecrosis

80.6

7.4

B01AE05

ATC

ximelagatran; oral

80.6

7.4

WX725

NOMESCO Finland

Noninvasive ventilation

2.5

7.4

233

TNG10

NOMESCO Finland

Puncture of knee

5.3

7.4

ND2DA

NOMESCO Finland

Bilateral hand X-ray examination

3.7

7.4

NG2CA

NOMESCO Finland

X-ray of patella with specialised projection

13.5

7.4

9403

FHL

Adductorotomy

+∞

7.3

72219

ICD-8 Finland

Osteochondrosis, Coxae juvenilis NUD

+∞

7.3

L30.9

ICD-10 Finland

Dermatitis, unspecified

1.7

7.2

172

1108

L04AA17

ATC

[U] adalimumab; parenteral

15.9

7.2

SPAT1253

SPAT

Initiation, adjustment, discontinuation or repetition of medication

1.5

7.2

288

2104

NH3DA

NOMESCO Finland

Bilateral foot X-ray examination

3.4

7.2

NFJ64

NOMESCO Finland

Other internal fixation of fracture of other parts of femur

30.2

7.2

SPAT1216

SPAT

Assessment of functional ability

1.7

7.1

151

941

M08.4

ICD-10 Finland

Pauciarticular juvenile arthritis

20.2

7.1

8200A

ICD-9 Finland

Fracture of neck of femur, Transcervical fracture, closed

20.2

7.1

NDL52

NOMESCO Finland

Tenosynovectomy of hand

8.0

7.1

M17.9

ICD-10 Finland

Gonarthrosis, unspecified

1.8

7.1

116

668

NA2AA

NOMESCO Finland

Thoracal spine X-ray examination without contrast

3.3

7.1

101

7200A

ICD-9 Finland

Ankylosing spondylitis and other inflammatory spondylopathies, Ankylosing spondylitis

12.1

7.1

TNG11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in knee

5.7

7.1

SPAT1249

SPAT

Treatment-related counselling outside office

1.4

7.1

368

2840

M02AA07

ATC

piroxicam; topical

1.4

7.1

369

2849

M06

ICD-10 Finland

Other rheumatoid arthritis

10.1

7.0

Z50.9

ICD-10 Finland

Care involving use of rehabilitation procedure, unspecified

2.6

7.0

183

WX702

NOMESCO Finland

Supraglottic ventilation device

2.3

7.0

280

WYA05

NOMESCO Finland

Emergency visit or other similar visit involving procedures

1.4

6.9

451

3625

SPAT1212

SPAT

Extensive examination of musculoskeletal system

2.1

6.9

405

M54.5

ICD-10 Finland

Low back pain

1.5

6.9

302

2246

-1

NOMESCO Finland

1.5

6.9

298

2214

H02AB04

ATC

methylprednisolone; systemic

1.7

6.9

153

965

EB1AA

NOMESCO Finland

Tooth X-ray examination

1.4

6.9

528

4370

L75

ICPC

Fracture: femur

4.8

6.9

A50

ICPC

General and Unspecified, Medication/prescr/renewal

3.0

6.9

135

M01AE11

ATC

tiaprofenic acid; oral, rectal

2.6

6.8

191

NH3FA

NOMESCO Finland

Weight-bearing X-ray of foot

3.7

6.8

NH1AA

NOMESCO Finland

Ankle X-ray examination without contrast

2.2

6.8

325

M54.4

ICD-10 Finland

Lumbago with sciatica

1.7

6.8

154

981

NE1BM

NOMESCO Finland

Pelvic, hip and femur MRI examination with 3 Tesla magnet

40.3

6.8

M87.1

ICD-10 Finland

Osteonecrosis due to drugs

16.8

6.7

9314

FHL

Total knee endoprosthesis (also includes patellar part)

16.8

6.7

L04AC07

ATC

tocilizumab; parenteral

16.8

6.7

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

1.4

6.7

404

3198

B01AB10

ATC

tinzaparin; parenteral

2.1

6.7

345

WX404

NOMESCO Finland

Intravenous generell anesthesy

1.6

6.7

194

1313

SPAT1156

SPAT

Guidance concerning treatment of rash and skin

1.7

6.7

139

863

SPAT1254

SPAT

Administration of medicine

1.7

6.7

139

863

M03BX02

ATC

tizanidine; oral

1.4

6.7

602

5117

NDG30

NOMESCO Finland

Fusion of wrist, total

7.9

6.6

NBB10

NOMESCO Finland

Primary partial prosthetic replacement of humero-scapular joint not using cement, other or unspecified

7.9

6.6

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.4

6.6

324

2463

NHG76

NOMESCO Finland

Arthroplasty of other tarsometatarsal joint

3.7

6.6

M07.3*L40.5

ICD-10 Finland

Other psoriatic arthropathies

3.4

6.6

E883A

ICD-9 Finland

Fall into hole or other opening in surface

2.4

6.6

239

SPAT1144

SPAT

Treatment of reopened or infected surgical wound

2.0

6.6

393

Y84

ICD-10 Finland

Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

4.8

6.5

SPAT1325

SPAT

Vaccination

1.4

6.5

328

2505

M15.8

ICD-10 Finland

Other polyarthrosis

4.2

6.5

SDE02

NOMESCO Finland

Periodontal treatment by dental hygienist

1.5

6.5

224

1581

T81.3

ICD-10 Finland

Disruption of operation wound, not elsewhere classified

3.3

6.5

L99

ICPC

Musculoskeletal disease other

3.5

6.4

NG1EA

NOMESCO Finland

Knee X-ray examination with wrench

4.7

6.4

NB1AD

NOMESCO Finland

Shoulder CT examination

4.1

6.4

SPAT1231

SPAT

Assessment of adjustments needed in living environment

3.7

6.4

H05AA02

ATC

teriparatide; parenteral

14.4

6.4

9311

FHL

Knee cleansing surgery (synovectomy, debridement)

14.4

6.4

NG2AA

NOMESCO Finland

Patella X-ray examination

3.1

6.4

110

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

1.6

6.3

151

970

ND2BA

NOMESCO Finland

Hand and fingers extensive X-ray examination

3.0

6.3

111

9503

FHL

Tendon or tendon sheath cleansing surgery (tenosynovectomy)

11.1

6.3

L50

ICPC

Musculoskeletal, Medication/prescr/renewal

11.1

6.3

7334B

ICD-9 Finland

Other disorders of bone and cartilage, Aseptic necrosis of bone[NECROSIS ASEPTICA CAPITIS ET COLLI FEMORIS]

+∞

6.3

Q65.81

ICD-10 Finland

Congenital dysplastic hip or acetabulum, bilateral

+∞

6.3

NFC30

NOMESCO Finland

Repair of hip prosthesis by bone transplant to femur

+∞

6.3

Q65.2

ICD-10 Finland

Congenital dislocation of hip, unspecified

+∞

6.3

NFS10

NOMESCO Finland

Incision and debridement of infection of hip joint

+∞

6.3

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

2.0

6.3

359

M47.9

ICD-10 Finland

Spondylosis, unspecified

2.9

6.2

128

R60.0

ICD-10 Finland

Localized oedema

1.8

6.2

106

621

NHG22

NOMESCO Finland

Fusion of subtalar joint

7.7

6.1

VALMI

NOMESCO Finland

1.5

6.1

218

1548

XX1AT

NOMESCO Finland

Other puncture with ultrasound guidance

4.9

6.1

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

1.5

6.1

201

1403

C08CA01

ATC

amlodipine; oral

1.4

6.0

344

2681

C03EA01

ATC

hydrochlorothiazide and potassium-sparing agents; oral

1.6

6.0

163

1085

WZC10

NOMESCO Finland

Extensive specialist consultion with written report

2.4

6.0

212

E66.8

ICD-10 Finland

Other obesity

2.4

6.0

212

NAME	SCND_OTH_COXARTHROSIS
CONTROL_EXCLUDE	COX_ARTHROSIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M167
HD_ICD_9	7152E
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M167
COD_ICD_9	7152E
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
SCND_OTH_COXARTHROSIS	1.241 [1.1, 1.4]	< 0.001
Birth year	0.992 [0.98, 1.0]	0.091

Parameter	HR [95% CI]	p-value
SCND_OTH_COXARTHROSIS	1.309 [1.14, 1.5]	< 0.001
Birth year	0.982 [0.97, 0.99]	< 0.001

N-year risk	Females	Males
1	0.113%	0.202%
5	0.711%	1.345%
10	1.79%	3.359%
15	3.356%	6.236%
20	5.844%	10.313%

Other secondary coxarthrosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints