Hemarthrosis: Bleeding into the joints. It may arise from trauma or spontaneously in patients with hemophilia.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519870 |
1. Apply sex-specific ruleNone |
519870 |
2. Check conditionsNone |
519870 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
112547 |
4. Check minimum number of eventsNone |
112547 |
5. Include endpoints |
115258 |
6. Filter based on genotype QC (FinnGen only) |
112160 |
Control definitions (FinnGen only)
- Control exclude
- M13_ARTHROPATHIES
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Arthrosis
based on the number of shared cases.
Similar with more cases:
- Artrosis, including avohilmo
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
Similar with less cases:
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 759776 | 448305 | 307184 |
| Only index persons | 669720 | 398956 | 270764 |
| Unadjusted period prevalence (%) | |||
| Whole population | 11.07 | 12.84 | 8.58 |
| Only index persons | 12.92 | 14.67 | 10.34 |
| Median age at first event (years) | |||
| Whole population | 61.46 | 62.89 | 59.32 |
| Only index persons | 60.40 | 61.75 | 58.40 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 112160 | 65955 | 46205 |
| Unadjusted period prevalence (%) | 22.50 | 23.42 | 21.19 |
| Median age at first event (years) | 59.96 | 59.67 | 60.39 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 45560
- Matched controls
- 249531
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint M13_ARTHROSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ARTHROSIS | 0.934 [0.87, 1.0] | 0.067 |
| Birth year | 0.997 [0.99, 1.0] | 0.409 |
During the follow-up period (1.1.1998 — 31.12.2019), 62942 out of 321324 females with M13_ARTHROSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ARTHROSIS | 0.903 [0.84, 0.98] | 0.01 |
| Birth year | 0.99 [0.98, 1.0] | 0.016 |
During the follow-up period (1.1.1998 — 31.12.2019), 44034 out of 222299 males with M13_ARTHROSIS died.
Mortality risk
Mortality risk for people of age
years, who have M13_ARTHROSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.101% | 0.152% |
| 5 | 0.482% | 0.993% |
| 10 | 1.26% | 2.429% |
| 15 | 2.552% | 4.775% |
| 20 | 4.424% | 8.195% |
Relationships between endpoints
↥Index endpoint: M13_ARTHROSIS – Arthrosis
GWS hits: 118