Tick-borne viral encephalitis

AB1_TICK_BORNE_ENCEPHALITIS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 A84
  • Hospital discharge: ICD-9 06[3]
  • Hospital discharge: ICD-8 06[3]
  • Cause of death: ICD-10 A84
  • Cause of death: ICD-9 06[3]
  • Cause of death: ICD-8 06[3]

2 out of 7 registries used, show all original rules.

130

4. Check minimum number of events

None

130

5. Include endpoints

None

130

6. Filter based on genotype QC (FinnGen only)

130

Control definitions (FinnGen only)

Control exclude
AB1_VIRAL_CNS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1177 458 710
Only index persons 1085 435 650
Unadjusted period prevalence (%)
Whole population 0.02 0.01 0.02
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 49.62 50.46 48.87
Only index persons 50.10 50.59 49.77

-FinnGen-

Key figures

All Female Male
Number of individuals 130 64 66
Unadjusted period prevalence (%) 0.03 0.02 0.03
Median age at first event (years) 54.11 54.54 53.70

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
118
Matched controls
1182
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A84.8
ICD-10 Finland
Other tick-borne viral encephalitis
+∞
55.7
49
*
A84.9
ICD-10 Finland
Tick-borne viral encephalitis, unspecified
+∞
52.0
46
*
A86
ICD-10 Finland
Unspecified viral encephalitis
+∞
28.3
26
*
TAB00
NOMESCO Finland
Lumbar puncture
18.6
20.0
31
22
XA800
NOMESCO Finland
Neuropsychological investigation
17.1
17.6
28
21
A87.9
ICD-10 Finland
Viral meningitis, unspecified
+∞
16.0
15
*
R50.9
ICD-10 Finland
Fever, unspecified
5.4
11.1
36
88
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
+∞
9.5
9
*
A69.2
ICD-10 Finland
Lyme disease
8.7
9.4
20
27
R4120
NOMESCO Finland
Occupational therapy
7.3
8.8
21
34
A84.1
ICD-10 Finland
Central European tick-borne encephalitis
+∞
8.4
8
*
0632A
ICD-9 Finland
Tick-borne viral encephalitis, Central European encephalitis[PUUTIAISEN VÄLITTÄMÄ ENKEFALIITTI (KUMLINGE)]
+∞
8.4
8
*
AA1AD
NOMESCO Finland
CT of head and brain
3.4
7.6
43
170
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
6.0
7.4
20
39
R4150
NOMESCO Finland
Neuropsychological rehabilitation
28.3
6.3
8
*

Mortality – FinRegistry

Association

Association between endpoint AB1_TICK_BORNE_ENCEPHALITIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_TICK_BORNE_ENCEPHALITIS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: AB1_TICK_BORNE_ENCEPHALITIS – Tick-borne viral encephalitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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