This is a non-core endpoint: only basic statistics are computed.
See its core counterpart C3_BONE_CARTILAGE_LIMBS_EXALLC for full statistics.
Malignant neoplasm of bone and articular cartilage of limbs
C3_BONE_CARTILAGE_LIMBS
bone neoplasm: A benign, intermediate, or malignant neoplasm involving the bone or articular cartilage.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
143 |
4. Check minimum number of eventsNone |
143 |
5. Include endpointsNone |
143 |
6. Filter based on genotype QC (FinnGen only) |
143 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF9
Similar endpoints
↥List of similar endpoints to
Malignant neoplasm of bone and articular cartilage of limbs
based on the number of shared cases.
Similar with more cases:
- Malignant neoplasm of bone and articular cartilage
- Malignant neoplasm of bone and articular cartilage of limbs, excluding all cancers (controls excluding all cancers)
- Malignant neoplasm of bone and articular cartilage, excluding all cancers (controls excluding all cancers)
- Malignant neoplasm
- Any event in cancer register
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 143 | 58 | 85 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.04 |
| Median age at first event (years) | 32.53 | 31.58 | 33.18 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 134
- Matched controls
- 1340
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
206.9
67.2
65
6
9180/3-C40.2
ICD-O-3
Osteosarcoma, NOS, of long bones of lower limb and associated joints
+∞
49.0
44
*
C40.21
ICD-10 Finland
Osteosarcoma of the long bones of the lower extremity
+∞
44.2
40
*
C40.20
ICD-10 Finland
Malignant tumor of the long bones of the lower extremity without histology
+∞
33.8
31
*
C40.22
ICD-10 Finland
Chondrosarcoma of the long bones of the lower extremity
+∞
30.4
28
*
130
Kela drug reimbursment
Malignant tumour
16.8
30.4
51
47
NF3AA
NOMESCO Finland
Femur X-ray examination
61.8
29.0
33
7
C40.29
ICD-10 Finland
Malignant tumor of the long bones of the lower extremity other or unspecified histology
+∞
25.9
24
*
9220/3-C40.2
ICD-O-3
Chondrosarcoma, NOS, of long bones of lower limb and associated joints
+∞
24.7
23
*
C40.2
ICD-10 Finland
Malignant neoplasm: Long bones of lower limb
+∞
24.7
23
*
NFR30
NOMESCO Finland
Extended excision of soft tissue tumour of hip or thigh
260.8
22.3
22
*
L03AA02
ATC
filgrastim; parenteral
29.1
21.0
28
12
NK6CT
NOMESCO Finland
Bone biopsy with CT guidance
+∞
20.3
19
*
NG4AA
NOMESCO Finland
Lower leg X-ray examination
17.3
18.3
29
21
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
14.6
18.2
31
27
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
8.4
18.1
43
71
17071
ICD-8 Finland
Malignant neoplasm of bone, Lower limb, long bones
+∞
17.0
16
*
NGB30
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part - connected prosthesis
68.7
16.2
18
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
43.8
15.9
19
5
TPX10
NOMESCO Finland
Implantation of vascular injection port
27.3
15.7
21
9
N02AA05
ATC
oxycodone; systemic
6.4
15.2
44
95
NE1DG
NOMESCO Finland
Pelvic, hip and femur very extensive MRI examination with high intensity magnet
167.5
14.8
15
*
NGR30
NOMESCO Finland
Extensive or radikal excision of tumor of knee or lower leg
167.5
14.8
15
*
N03AX16
ATC
pregabalin; oral
5.2
14.4
52
145
R4110
NOMESCO Finland
Physiotherapy
4.7
14.2
60
198
D16.2
ICD-10 Finland
Benign neoplasm: Long bones of lower limb
83.5
13.9
15
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
24.3
13.8
19
9
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.1
13.8
84
386
ZXE20
NOMESCO Finland
More than three and less than five hours
5.8
13.6
42
97
C40.02
ICD-10 Finland
Chondrosarcoma of the scapula and long bones of the upper extremity
+∞
12.7
12
*
NG1DG
NOMESCO Finland
Knee and lower leg very extensive MRI examination with high intensity magnet
41.8
12.5
15
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
14.5
12.1
20
16
B01AB05
ATC
enoxaparin; parenteral
4.1
12.1
60
223
GD1AD
NOMESCO Finland
Thorax CT examination
12.9
12.0
21
19
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
33.4
11.9
15
5
WX306
NOMESCO Finland
Lumbar epidural anesthesy
9.1
11.8
25
33
TPX15
NOMESCO Finland
Removal of vascular injection port
+∞
11.6
11
*
C40.00
ICD-10 Finland
Malignant tumor of the scapula and the long bones of the upper extremity without histology
+∞
11.6
11
*
ZXA05
NOMESCO Finland
Left side
4.1
11.0
51
176
WW500
NOMESCO Finland
Blood transfusion
12.8
11.0
19
17
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
9.0
11.0
23
30
A04AA01
ATC
ondansetron; systemic, rectal
7.6
10.7
25
39
QX3AT
NOMESCO Finland
Ultrasound guided biopsy of subcutaneous tissue
118.9
10.6
11
*
NGR20
NOMESCO Finland
Intralesional or marginal excision of tumor of knee or lower leg
118.9
10.6
11
*
9220/3-C40.0
ICD-O-3
Chondrosarcoma, NOS, of long bones of upper limb, scapula and associated joints
+∞
10.6
10
*
C40.01
ICD-10 Finland
Osteosarcoma of the scapula and the long bones of the upper extremity
+∞
10.6
10
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
6.2
10.5
29
57
JN4BD
NOMESCO Finland
Extensive body CT
5.3
10.4
33
77
ZXE30
NOMESCO Finland
More than five and less than seven hours
8.2
10.3
23
33
A03FA01
ATC
metoclopramide; systemic, rectal
4.5
10.3
40
116
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
43.6
10.1
12
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.5
10.1
59
244
NG1AD
NOMESCO Finland
Knee CT examination
28.5
10.0
13
5
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
4.0
10.0
46
156
NB6AA
NOMESCO Finland
Humerus X-ray examination
32.7
9.6
12
*
NFR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of hip or thigh
107.3
9.5
10
*
NGA20
NOMESCO Finland
Exploration of soft tissue knee or lower leg, open
107.3
9.5
10
*
NK6BN
NOMESCO Finland
Bone dynamic isotope examination
+∞
9.5
9
*
1707A
ICD-9 Finland
Malignant neoplasm of bone and articular cartilage, Long bones of lower limb[ALARAAJAN PITKIEN LUIDEN SYÖPÄ,OSTEOSARCOMA]
+∞
9.5
9
*
9101
FHL
Bone biopsy
+∞
9.5
9
*
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
15.2
9.4
15
11
B01AB10
ATC
tinzaparin; parenteral
7.1
9.1
22
36
WF049
NOMESCO Finland
Radiotherapy of metastasis
11.9
9.1
16
15
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
6.9
8.9
22
37
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.2
8.8
36
108
2392A
ICD-9 Finland
Neoplasm of unspecified nature, Bone, soft tissue and skin
+∞
8.4
8
*
L71
ICPC
Malignant neoplasm musculoskeletal
+∞
8.4
8
*
NBR30
NOMESCO Finland
Extensive or radical excision of soft tissue tumour of shoulder or upper arm
+∞
8.4
8
*
9180/3-C40.0
ICD-O-3
Osteosarcoma, NOS, of long bones of upper limb, scapula and associated joints
+∞
8.4
8
*
NFA20
NOMESCO Finland
Exploration of hip joint or femur
+∞
8.4
8
*
N02AX02
ATC
tramadol; systemic, rectal
3.0
8.2
67
339
WF004
NOMESCO Finland
Palliative radiotherapy
11.0
7.7
14
14
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.2
7.6
20
37
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
6.2
7.6
20
37
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
7.0
7.6
18
29
M84.4
ICD-10 Finland
Pathological fracture, not elsewhere classified
84.6
7.5
8
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
17.0
7.4
11
7
C40.11
ICD-10 Finland
Osteosarcoma of the short bones of the upper extremity
+∞
7.4
7
*
C40.91
ICD-10 Finland
Osteosarcoma in unspecified locations in the bones and articular cartilage of the extremities
+∞
7.4
7
*
Z85.8
ICD-10 Finland
Personal history of malignant neoplasms of other organs and systems
+∞
7.4
7
*
NBR20
NOMESCO Finland
Intralesional or marginal excision of soft tissue tumour of shoulder or upper arm
+∞
7.4
7
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.8
7.1
65
341
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
9.1
7.0
14
17
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
6.6
6.9
17
29
J04AB02
ATC
rifampicin; systemic
17.8
6.9
10
6
NFQ20
NOMESCO Finland
Amputation of femur
23.9
6.8
9
*
ZX120
NOMESCO Finland
Intravenous
4.6
6.7
23
58
ZXE00
NOMESCO Finland
One hour or less
2.6
6.7
66
360
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
15.3
6.5
10
7
L03AA13
ATC
pegfilgrastim; parenteral
8.9
6.5
13
16
NG1BA
NOMESCO Finland
Knee extensive X-ray examination
8.9
6.5
13
16
NGQ20
NOMESCO Finland
Amputation of lower leg
73.2
6.5
7
*
9102
FHL
Trepanation or removal of the local bone process
73.2
6.5
7
*
NB1CG
NOMESCO Finland
Shoulder and humerus extensive MRI examination with high intensity magnet
11.9
6.4
11
10
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
5.5
6.3
18
37
L28
ICPC
Limited function/disability (L)
3.7
6.3
28
90
NGR40
NOMESCO Finland
Extensive excision of tumor of knee or lower leg with repair
+∞
6.3
6
*
C40.10
ICD-10 Finland
Malignant tumor of the upper limb's short bones without histology
+∞
6.3
6
*
NF3BA
NOMESCO Finland
Femur extensive X-ray examination
+∞
6.3
6
*
Z47.8
ICD-10 Finland
Other specified orthopaedic follow-up care
+∞
6.3
6
*
C40.12
ICD-10 Finland
Chondrosarcoma of the short bones of the upper extremity
+∞
6.3
6
*
C40.23
ICD-10 Finland
Ewing's sarcoma in the long bones of the lower extremity
+∞
6.3
6
*
NGB99
NOMESCO Finland
Other primary prosthetic replacement of knee joint, other or unspecified
+∞
6.3
6
*
NF3AD
NOMESCO Finland
Femur CT
+∞
6.3
6
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.0
6.3
25
73
Z3226
NOMESCO Finland
Physiotherapist
3.2
6.3
35
134
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
6.6
6.2
15
25
NE1AA
NOMESCO Finland
Pelvis X-ray examination
6.6
6.2
15
25
H02AB02
ATC
dexamethasone; systemic
4.1
6.1
23
64
WX402
NOMESCO Finland
General anaesthesia
3.2
6.1
33
123
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: C3_BONE_CARTILAGE_LIMBS – Malignant neoplasm of bone and articular cartilage of limbs
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).