This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Malignant neoplasm of bone and articular cartilage of limbs, excluding all cancers (controls excluding all cancers)
C3_BONE_CARTILAGE_LIMBS_EXALLC
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
350 |
4. Check minimum number of eventsNone |
350 |
5. Include endpointsNone |
350 |
6. Filter based on genotype QC (FinnGen only) |
350 |
Control definitions (FinnGen only)
- Control exclude
- C3_CANCER, C3_CANCER_WIDE_EXALLC
Extra metadata
- First used in FinnGen datafreeze
- DF12
Similar endpoints
↥List of similar endpoints to
Malignant neoplasm of bone and articular cartilage of limbs, excluding all cancers (controls excluding all cancers)
based on the number of shared cases.
Similar with more cases:
- Malignant neoplasm of bone and articular cartilage, excluding all cancers (controls excluding all cancers)
- Malignant neoplasm, excluding all cancers (controls excluding all cancers)
- Malignant neoplasm, wide definition for exclusion
- Malignant neoplasm, wide definition for exclusion, excluding all cancers (controls excluding all cancers)
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 350 | 165 | 185 |
| Unadjusted period prevalence (%) | 0.07 | 0.06 | 0.08 |
| Median age at first event (years) | 50.11 | 50.06 | 50.15 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 134
- Matched controls
- 1339
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
311.3
69.4
65
*
130
Kela drug reimbursment
Malignant tumour
+∞
57.5
51
*
9180/3-C40.2
ICD-O-3
Osteosarcoma, NOS, of long bones of lower limb and associated joints
+∞
49.0
44
*
C40.21
ICD-10 Finland
Osteosarcoma of the long bones of the lower extremity
+∞
44.2
40
*
C40.20
ICD-10 Finland
Malignant tumor of the long bones of the lower extremity without histology
+∞
33.8
31
*
C40.22
ICD-10 Finland
Chondrosarcoma of the long bones of the lower extremity
+∞
30.4
28
*
NF3AA
NOMESCO Finland
Femur X-ray examination
61.8
29.0
33
7
L03AA02
ATC
filgrastim; parenteral
350.3
28.9
28
*
C40.29
ICD-10 Finland
Malignant tumor of the long bones of the lower extremity other or unspecified histology
+∞
25.9
24
*
C40.2
ICD-10 Finland
Malignant neoplasm: Long bones of lower limb
+∞
24.7
23
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
24.7
23
*
9220/3-C40.2
ICD-O-3
Chondrosarcoma, NOS, of long bones of lower limb and associated joints
+∞
24.7
23
*
NFR30
NOMESCO Finland
Extended excision of soft tissue tumour of hip or thigh
+∞
23.6
22
*
N02AA05
ATC
oxycodone; systemic
11.0
21.7
44
57
JN4BD
NOMESCO Finland
Extensive body CT
17.8
20.9
33
24
H02AB02
ATC
dexamethasone; systemic
68.7
20.6
23
*
NK6CT
NOMESCO Finland
Bone biopsy with CT guidance
+∞
20.3
19
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
20.3
19
*
NG4AA
NOMESCO Finland
Lower leg X-ray examination
22.7
20.2
29
16
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
18.8
20.1
31
21
A04AA01
ATC
ondansetron; systemic, rectal
37.9
20.1
25
8
TPX10
NOMESCO Finland
Implantation of vascular injection port
82.1
19.3
21
*
NGB30
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part - connected prosthesis
206.0
18.0
18
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.2
17.8
84
328
ZXE20
NOMESCO Finland
More than three and less than five hours
8.3
17.6
42
70
17071
ICD-8 Finland
Malignant neoplasm of bone, Lower limb, long bones
+∞
17.0
16
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
17.0
16
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
54.8
16.5
19
*
D16.2
ICD-10 Finland
Benign neoplasm: Long bones of lower limb
+∞
15.9
15
*
NGR30
NOMESCO Finland
Extensive or radikal excision of tumor of knee or lower leg
+∞
15.9
15
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
15.9
15
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
7.0
15.9
43
85
B01AB05
ATC
enoxaparin; parenteral
5.1
15.4
60
184
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
29.0
15.2
20
8
A03FA01
ATC
metoclopramide; systemic, rectal
7.1
15.1
40
76
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
14.9
14
*
NG1DG
NOMESCO Finland
Knee and lower leg very extensive MRI examination with high intensity magnet
167.4
14.8
15
*
GD1AD
NOMESCO Finland
Thorax CT examination
20.4
14.4
21
12
WX306
NOMESCO Finland
Lumbar epidural anesthesy
12.5
14.0
25
24
NE1DG
NOMESCO Finland
Pelvic, hip and femur very extensive MRI examination with high intensity magnet
83.5
13.9
15
*
A04AA02
ATC
granisetron; systemic, transdermal
83.5
13.9
15
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
13.8
13
*
WX408
NOMESCO Finland
General anesthesy, balanced
4.4
13.3
59
201
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
8.7
13.2
29
41
R4110
NOMESCO Finland
Physiotherapy
4.3
13.0
60
212
C40.02
ICD-10 Finland
Chondrosarcoma of the scapula and long bones of the upper extremity
+∞
12.7
12
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
12.7
12
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
12.7
12
*
WW500
NOMESCO Finland
Blood transfusion
18.2
12.6
19
12
B01AB10
ATC
tinzaparin; parenteral
11.7
12.0
22
22
N03AX16
ATC
pregabalin; oral
4.3
11.8
52
172
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
11.6
11
*
NGR20
NOMESCO Finland
Intralesional or marginal excision of tumor of knee or lower leg
+∞
11.6
11
*
C40.00
ICD-10 Finland
Malignant tumor of the scapula and the long bones of the upper extremity without histology
+∞
11.6
11
*
QX3AT
NOMESCO Finland
Ultrasound guided biopsy of subcutaneous tissue
+∞
11.6
11
*
TPX15
NOMESCO Finland
Removal of vascular injection port
+∞
11.6
11
*
NG1AD
NOMESCO Finland
Knee CT examination
47.6
11.1
13
*
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
23.9
10.9
15
7
ZXE30
NOMESCO Finland
More than five and less than seven hours
8.7
10.7
23
31
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
10.5
10
*
9220/3-C40.0
ICD-O-3
Chondrosarcoma, NOS, of long bones of upper limb, scapula and associated joints
+∞
10.5
10
*
NGA20
NOMESCO Finland
Exploration of soft tissue knee or lower leg, open
+∞
10.5
10
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
10.5
10
*
C40.01
ICD-10 Finland
Osteosarcoma of the scapula and the long bones of the upper extremity
+∞
10.5
10
*
NFR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of hip or thigh
+∞
10.5
10
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
7.4
10.5
25
40
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
25.8
10.5
14
6
JN4AD
NOMESCO Finland
Body CT examination
11.3
9.9
18
18
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
3.8
9.6
46
160
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
107.2
9.5
10
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
9.5
9
*
A04AD12
ATC
aprepitant; systemic
+∞
9.5
9
*
NK6BN
NOMESCO Finland
Bone dynamic isotope examination
+∞
9.5
9
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
9.5
9
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
9.5
9
*
9101
FHL
Bone biopsy
+∞
9.5
9
*
1707A
ICD-9 Finland
Malignant neoplasm of bone and articular cartilage, Long bones of lower limb[ALARAAJAN PITKIEN LUIDEN SYÖPÄ,OSTEOSARCOMA]
+∞
9.5
9
*
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
7.5
9.4
22
34
ZXA05
NOMESCO Finland
Left side
3.6
9.3
51
196
ZXE40
NOMESCO Finland
More than seven and less than nine hours
26.1
9.1
12
5
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
21.8
8.6
12
6
JN4CD
NOMESCO Finland
Very extensive body CT
29.7
8.6
11
*
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
11.9
8.5
15
14
L71
ICPC
Malignant neoplasm musculoskeletal
+∞
8.4
8
*
NBR30
NOMESCO Finland
Extensive or radical excision of soft tissue tumour of shoulder or upper arm
+∞
8.4
8
*
NFA20
NOMESCO Finland
Exploration of hip joint or femur
+∞
8.4
8
*
M84.4
ICD-10 Finland
Pathological fracture, not elsewhere classified
+∞
8.4
8
*
9180/3-C40.0
ICD-O-3
Osteosarcoma, NOS, of long bones of upper limb, scapula and associated joints
+∞
8.4
8
*
NG1BA
NOMESCO Finland
Knee extensive X-ray examination
15.8
8.4
13
9
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.0
8.4
36
113
N02AX02
ATC
tramadol; systemic, rectal
3.0
8.3
67
335
NB6AA
NOMESCO Finland
Humerus X-ray examination
18.6
8.2
12
7
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
6.9
8.2
20
33
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.7
8.1
20
34
ZX120
NOMESCO Finland
Intravenous
5.7
8.1
23
47
Z51.5
ICD-10 Finland
Palliative care
10.4
8.0
15
16
NFQ20
NOMESCO Finland
Amputation of femur
47.8
7.8
9
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.9
7.8
65
330
J04AB02
ATC
rifampicin; systemic
26.8
7.7
10
*
WX402
NOMESCO Finland
General anaesthesia
3.8
7.5
33
105
2392A
ICD-9 Finland
Neoplasm of unspecified nature, Bone, soft tissue and skin
84.5
7.5
8
*
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
6.8
7.4
18
30
Z85.8
ICD-10 Finland
Personal history of malignant neoplasms of other organs and systems
+∞
7.4
7
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
7.4
7
*
C40.11
ICD-10 Finland
Osteosarcoma of the short bones of the upper extremity
+∞
7.4
7
*
C40.91
ICD-10 Finland
Osteosarcoma in unspecified locations in the bones and articular cartilage of the extremities
+∞
7.4
7
*
D70.82
ICD-10 Finland
Drug-induced neutropenia
+∞
7.4
7
*
NBR20
NOMESCO Finland
Intralesional or marginal excision of soft tissue tumour of shoulder or upper arm
+∞
7.4
7
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
+∞
7.4
7
*
ZXE00
NOMESCO Finland
One hour or less
2.8
7.3
66
346
WF003
NOMESCO Finland
Adjuvant radiotherapy
42.2
6.8
8
*
WF002
NOMESCO Finland
Radical radiotherapy
42.2
6.8
8
*
NB1CG
NOMESCO Finland
Shoulder and humerus extensive MRI examination with high intensity magnet
13.2
6.7
11
9
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.4
6.6
33
117
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
6.1
6.6
17
31
J01MA12
ATC
levofloxacin; systemic
3.4
6.4
34
122
ZXE10
NOMESCO Finland
More than one and less than three hours
2.7
6.4
58
298
C40.10
ICD-10 Finland
Malignant tumor of the upper limb's short bones without histology
+∞
6.3
6
*
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
+∞
6.3
6
*
WX1DG
NOMESCO Finland
Very extensive total body MRI with high intensity magnet
+∞
6.3
6
*
WB121
NOMESCO Finland
Demanding neoadjuvant cytostatic therapy
+∞
6.3
6
*
XX1AT
NOMESCO Finland
Other puncture with ultrasound guidance
+∞
6.3
6
*
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
6.3
6
*
C40.12
ICD-10 Finland
Chondrosarcoma of the short bones of the upper extremity
+∞
6.3
6
*
GDB10
NOMESCO Finland
Wedge resection of lung
+∞
6.3
6
*
NGB99
NOMESCO Finland
Other primary prosthetic replacement of knee joint, other or unspecified
+∞
6.3
6
*
C40.23
ICD-10 Finland
Ewing's sarcoma in the long bones of the lower extremity
+∞
6.3
6
*
NF3AD
NOMESCO Finland
Femur CT
+∞
6.3
6
*
NGR40
NOMESCO Finland
Extensive excision of tumor of knee or lower leg with repair
+∞
6.3
6
*
N02BE01
ATC
paracetamol; systemic, rectal
3.3
6.2
117
903
WZC30
NOMESCO Finland
Teaching
4.3
6.2
22
58
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
7.0
6.0
14
22
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: C3_BONE_CARTILAGE_LIMBS_EXALLC – Malignant neoplasm of bone and articular cartilage of limbs, excluding all cancers (controls excluding all cancers)
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).