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Malignant neoplasm of bone and articular cartilage of limbs, excluding all cancers (controls excluding all cancers)

C3_BONE_CARTILAGE_LIMBS_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C40
  • Hospital discharge: ICD-9 170[4-5]|170[7-8]
  • Hospital discharge: ICD-8 170[4-5]|170[7-8]
  • Cause of death: ICD-10 C40
  • Cause of death: ICD-9 170[4-5]|170[7-8]
  • Cause of death: ICD-8 170[4-5]|170[7-8]
  • Cancer registry: Topography ICD-O-3 C40
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

350

4. Check minimum number of events

None

350

5. Include endpoints

None

350

6. Filter based on genotype QC (FinnGen only)

350

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of bone and articular cartilage of limbs, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 350 165 185
Unadjusted period prevalence (%) 0.07 0.06 0.08
Median age at first event (years) 50.11 50.06 50.15

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
134
Matched controls
1339
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
311.3
69.4
65
*
130
Kela drug reimbursment
Malignant tumour
+∞
57.5
51
*
9180/3-C40.2
ICD-O-3
Osteosarcoma, NOS, of long bones of lower limb and associated joints
+∞
49.0
44
*
C40.21
ICD-10 Finland
Osteosarcoma of the long bones of the lower extremity
+∞
44.2
40
*
C40.20
ICD-10 Finland
Malignant tumor of the long bones of the lower extremity without histology
+∞
33.8
31
*
C40.22
ICD-10 Finland
Chondrosarcoma of the long bones of the lower extremity
+∞
30.4
28
*
NF3AA
NOMESCO Finland
Femur X-ray examination
61.8
29.0
33
7
L03AA02
ATC
filgrastim; parenteral
350.3
28.9
28
*
C40.29
ICD-10 Finland
Malignant tumor of the long bones of the lower extremity other or unspecified histology
+∞
25.9
24
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
24.7
23
*
C40.2
ICD-10 Finland
Malignant neoplasm: Long bones of lower limb
+∞
24.7
23
*
9220/3-C40.2
ICD-O-3
Chondrosarcoma, NOS, of long bones of lower limb and associated joints
+∞
24.7
23
*
NFR30
NOMESCO Finland
Extended excision of soft tissue tumour of hip or thigh
+∞
23.6
22
*
N02AA05
ATC
oxycodone; systemic
11.0
21.7
44
57
JN4BD
NOMESCO Finland
Extensive body CT
17.8
20.9
33
24
H02AB02
ATC
dexamethasone; systemic
68.7
20.6
23
*
NK6CT
NOMESCO Finland
Bone biopsy with CT guidance
+∞
20.3
19
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
20.3
19
*
NG4AA
NOMESCO Finland
Lower leg X-ray examination
22.7
20.2
29
16
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
18.8
20.1
31
21
A04AA01
ATC
ondansetron; systemic, rectal
37.9
20.1
25
8
TPX10
NOMESCO Finland
Implantation of vascular injection port
82.1
19.3
21
*
NGB30
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part - connected prosthesis
206.0
18.0
18
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.2
17.8
84
328
17071
ICD-8 Finland
Malignant neoplasm of bone, Lower limb, long bones
+∞
17.0
16
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
17.0
16
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
54.8
16.5
19
*
D16.2
ICD-10 Finland
Benign neoplasm: Long bones of lower limb
+∞
15.9
15
*
NGR30
NOMESCO Finland
Extensive or radikal excision of tumor of knee or lower leg
+∞
15.9
15
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
15.9
15
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
7.0
15.9
43
85
B01AB05
ATC
enoxaparin; parenteral
5.1
15.4
60
184
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
29.0
15.2
20
8
A03FA01
ATC
metoclopramide; systemic, rectal
7.1
15.1
40
76
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
14.9
14
*
NG1DG
NOMESCO Finland
Knee and lower leg very extensive MRI examination with high intensity magnet
167.4
14.8
15
*
GD1AD
NOMESCO Finland
Thorax CT examination
20.4
14.4
21
12
WX306
NOMESCO Finland
Lumbar epidural anesthesy
12.5
14.0
25
24
A04AA02
ATC
granisetron; systemic, transdermal
83.5
13.9
15
*
NE1DG
NOMESCO Finland
Pelvic, hip and femur very extensive MRI examination with high intensity magnet
83.5
13.9
15
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
13.8
13
*
WX408
NOMESCO Finland
General anesthesy, balanced
4.4
13.3
59
201
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
8.7
13.2
29
41
R4110
NOMESCO Finland
Physiotherapy
4.3
13.0
60
212
C40.02
ICD-10 Finland
Chondrosarcoma of the scapula and long bones of the upper extremity
+∞
12.7
12
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
12.7
12
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
12.7
12
*
WW500
NOMESCO Finland
Blood transfusion
18.2
12.6
19
12
B01AB10
ATC
tinzaparin; parenteral
11.7
12.0
22
22
N03AX16
ATC
pregabalin; oral
4.3
11.8
52
172
TPX15
NOMESCO Finland
Removal of vascular injection port
+∞
11.6
11
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
11.6
11
*
C40.00
ICD-10 Finland
Malignant tumor of the scapula and the long bones of the upper extremity without histology
+∞
11.6
11
*
NGR20
NOMESCO Finland
Intralesional or marginal excision of tumor of knee or lower leg
+∞
11.6
11
*
QX3AT
NOMESCO Finland
Ultrasound guided biopsy of subcutaneous tissue
+∞
11.6
11
*
NG1AD
NOMESCO Finland
Knee CT examination
47.6
11.1
13
*
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
23.9
10.9
15
7
9220/3-C40.0
ICD-O-3
Chondrosarcoma, NOS, of long bones of upper limb, scapula and associated joints
+∞
10.5
10
*
C40.01
ICD-10 Finland
Osteosarcoma of the scapula and the long bones of the upper extremity
+∞
10.5
10
*
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
10.5
10
*
NGA20
NOMESCO Finland
Exploration of soft tissue knee or lower leg, open
+∞
10.5
10
*
NFR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of hip or thigh
+∞
10.5
10
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
10.5
10
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
7.4
10.5
25
40
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
25.8
10.5
14
6
JN4AD
NOMESCO Finland
Body CT examination
11.3
9.9
18
18
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
3.8
9.6
46
160
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
107.2
9.5
10
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
9.5
9
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
9.5
9
*
1707A
ICD-9 Finland
Malignant neoplasm of bone and articular cartilage, Long bones of lower limb[ALARAAJAN PITKIEN LUIDEN SYÖPÄ,OSTEOSARCOMA]
+∞
9.5
9
*
NK6BN
NOMESCO Finland
Bone dynamic isotope examination
+∞
9.5
9
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
9.5
9
*
A04AD12
ATC
aprepitant; systemic
+∞
9.5
9
*
9101
FHL
Bone biopsy
+∞
9.5
9
*
ZXA05
NOMESCO Finland
Left side
3.6
9.3
51
196
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
21.8
8.6
12
6
JN4CD
NOMESCO Finland
Very extensive body CT
29.7
8.6
11
*
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
11.9
8.5
15
14
L71
ICPC
Malignant neoplasm musculoskeletal
+∞
8.4
8
*
9180/3-C40.0
ICD-O-3
Osteosarcoma, NOS, of long bones of upper limb, scapula and associated joints
+∞
8.4
8
*
NFA20
NOMESCO Finland
Exploration of hip joint or femur
+∞
8.4
8
*
NBR30
NOMESCO Finland
Extensive or radical excision of soft tissue tumour of shoulder or upper arm
+∞
8.4
8
*
M84.4
ICD-10 Finland
Pathological fracture, not elsewhere classified
+∞
8.4
8
*
NG1BA
NOMESCO Finland
Knee extensive X-ray examination
15.8
8.4
13
9
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.0
8.4
36
113
N02AX02
ATC
tramadol; systemic, rectal
3.0
8.3
67
335
NB6AA
NOMESCO Finland
Humerus X-ray examination
18.6
8.2
12
7
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.7
8.1
20
34
ZX120
NOMESCO Finland
Intravenous
5.7
8.1
23
47
Z51.5
ICD-10 Finland
Palliative care
10.4
8.0
15
16
NFQ20
NOMESCO Finland
Amputation of femur
47.8
7.8
9
*
J04AB02
ATC
rifampicin; systemic
26.8
7.7
10
*
WX402
NOMESCO Finland
General anaesthesia
3.8
7.5
33
105
2392A
ICD-9 Finland
Neoplasm of unspecified nature, Bone, soft tissue and skin
84.5
7.5
8
*
C40.11
ICD-10 Finland
Osteosarcoma of the short bones of the upper extremity
+∞
7.4
7
*
NBR20
NOMESCO Finland
Intralesional or marginal excision of soft tissue tumour of shoulder or upper arm
+∞
7.4
7
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
+∞
7.4
7
*
C40.91
ICD-10 Finland
Osteosarcoma in unspecified locations in the bones and articular cartilage of the extremities
+∞
7.4
7
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
7.4
7
*
Z85.8
ICD-10 Finland
Personal history of malignant neoplasms of other organs and systems
+∞
7.4
7
*
D70.82
ICD-10 Finland
Drug-induced neutropenia
+∞
7.4
7
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
42.2
6.8
8
*
WF002
NOMESCO Finland
Radical radiotherapy
42.2
6.8
8
*
NB1CG
NOMESCO Finland
Shoulder and humerus extensive MRI examination with high intensity magnet
13.2
6.7
11
9
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.4
6.6
33
117
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
6.1
6.6
17
31
J01MA12
ATC
levofloxacin; systemic
3.4
6.4
34
122
NF3AD
NOMESCO Finland
Femur CT
+∞
6.3
6
*
C40.10
ICD-10 Finland
Malignant tumor of the upper limb's short bones without histology
+∞
6.3
6
*
WB121
NOMESCO Finland
Demanding neoadjuvant cytostatic therapy
+∞
6.3
6
*
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
+∞
6.3
6
*
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
6.3
6
*
WX1DG
NOMESCO Finland
Very extensive total body MRI with high intensity magnet
+∞
6.3
6
*
GDB10
NOMESCO Finland
Wedge resection of lung
+∞
6.3
6
*
NGR40
NOMESCO Finland
Extensive excision of tumor of knee or lower leg with repair
+∞
6.3
6
*
XX1AT
NOMESCO Finland
Other puncture with ultrasound guidance
+∞
6.3
6
*
C40.12
ICD-10 Finland
Chondrosarcoma of the short bones of the upper extremity
+∞
6.3
6
*
C40.23
ICD-10 Finland
Ewing's sarcoma in the long bones of the lower extremity
+∞
6.3
6
*
NGB99
NOMESCO Finland
Other primary prosthetic replacement of knee joint, other or unspecified
+∞
6.3
6
*
N02BE01
ATC
paracetamol; systemic, rectal
3.3
6.2
117
903
WZC30
NOMESCO Finland
Teaching
4.3
6.2
22
58
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
7.0
6.0
14
22

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
53
67
9.14
40.32
1.7
1.3
—
—
—
0
0
101
326
3.95
27.48
13.4
3.8
0.8
0.8
mmol/l
3.42
91
306
158
716
3.20
24.81
4.0
2.0
—
—
—
0
0
165
781
3.11
23.80
2.9
1.6
—
—
—
0
0
198
1093
2.87
20.74
15.0
6.0
1.2
1.2
mmol/l
0.13
181
982
209
1205
2.82
19.85
16.5
6.3
1.2
1.2
mmol/l
0.52
177
1048
157
783
2.82
19.74
8.1
2.0
2.4
2.3
mmol/l
0.05
144
645
125
554
2.95
19.58
4.5
2.0
—
—
—
0
0
209
1220
2.77
19.12
14.3
4.0
9.1
11.8
umol/l
8.28
200
1149
132
624
2.79
18.09
7.0
3.7
—
—
—
0
0
183
1027
2.64
17.69
9.1
4.0
34.1
35.9
g/l
3.99
170
958
60
182
3.77
17.33
1.4
1.1
—
—
—
0
0
16
0
+∞
16.80
31.9
0.0
0.4
—
umol/l
—
16
0
75
272
3.24
16.38
8.4
8.8
1.0
1.4
mmol/l
0.45
61
215
226
1452
2.57
15.79
22.0
6.7
4.0
4.2
e9/l
0.72
206
1257
188
1118
2.47
15.42
5.8
3.6
—
—
—
0
0
80
314
3.01
15.19
12.5
6.1
1.1
1.1
mmol/l
0.03
72
287
85
354
2.85
14.43
2.4
1.9
—
—
—
0
0
134
703
2.47
14.22
8.2
3.1
7.4
7.4
ph
0.03
29
100
119
603
2.47
13.50
17.4
5.2
—
—
—
0
0
168
997
2.32
13.25
10.3
8.6
1.1
1.3
inr
4.34
43
274
95
441
2.58
12.91
6.2
2.1
2.5
2.4
mmol/l
1.93
86
367
263
1944
2.42
11.63
14.9
5.3
88.9
77.1
u/l
1.89
252
1783
40
121
3.60
11.48
4.3
1.5
66.6
5.3
ug/l
0.52
31
93
30
74
4.34
11.38
20.3
7.5
1.2
1.5
mg/l
1.24
30
66
200
1339
2.15
11.04
9.3
5.5
1.7
1.9
e9/l
3.72
181
1179
13
14
9.61
10.83
5.0
2.1
12.6
10.8
%
—
8
8
219
1534
2.14
10.55
10.5
4.5
6.7
6.7
mmol/l
0.10
210
1423
142
849
2.13
10.36
11.8
5.6
—
—
—
0
0
15
21
7.42
10.21
1.6
1.2
—
—
—
0
0
15
21
7.42
10.21
1.6
1.2
—
—
—
0
0
15
21
7.42
10.21
1.6
1.2
—
—
—
0
0
15
21
7.42
10.21
1.6
1.2
—
—
—
0
0
193
1303
2.07
10.09
9.5
5.4
0.6
0.6
e9/l
0.04
173
1123
194
1313
2.07
10.07
9.5
5.4
0.0
0.0
e9/l
2.40
174
1134
37
118
3.39
9.78
8.7
12.9
—
—
—
0
0
53
210
2.80
9.68
16.8
7.8
—
—
—
0
0
18
35
5.37
8.98
1.6
1.6
—
—
—
0
0
13
18
7.46
8.90
2.1
3.6
—
—
—
0
0
195
1362
1.97
8.84
11.4
5.7
0.2
0.2
e9/l
0.21
178
1188
46
178
2.82
8.76
2.9
4.3
1.2
0.7
%
0.91
25
42
43
161
2.90
8.69
2.9
4.5
0.5
0.3
%
0.64
22
29
20
45
4.65
8.48
1.8
2.1
25.5
13.1
u/ml
0.42
14
35
182
1257
1.93
8.37
9.8
5.7
25.5
28.6
%
3.15
175
1165
178
1226
1.92
8.20
10.2
5.9
9.0
8.6
%
1.00
172
1144
177
1218
1.92
8.16
9.8
5.6
2.7
3.0
%
0.88
171
1123
172
1177
1.91
8.03
10.0
5.7
0.6
0.7
%
0.76
166
1089
179
1241
1.91
8.03
9.7
5.5
58.5
56.8
%
1.00
172
1155
14
24
6.03
7.91
1.6
3.2
0.6
0.5
%
0.24
14
19
41
168
2.63
6.98
2.9
4.5
0.0
0.1
%
0.25
22
36
61
305
2.21
6.71
2.3
1.7
—
—
—
0
0
17
42
4.20
6.43
7.6
1.3
—
—
—
0
0
115
733
1.85
6.38
3.6
2.9
0.2
0.4
e6/l
1.37
89
546
43
194
2.39
5.99
2.7
2.6
0.2
0.2
g/l
0.59
43
175
55
284
2.11
5.55
4.5
2.8
4.6
7.8
umol/l
1.71
49
253
37
162
2.44
5.50
3.0
4.5
0.0
0.0
%
0.49
20
30
119
796
1.75
5.48
3.9
3.0
46.0
139.2
e6/l
0.58
94
608
111
733
1.75
5.33
3.5
2.9
—
—
—
0
0
160
1173
1.67
5.20
18.0
7.5
0.0
0.0
e9/l
0.43
137
947
83
507
1.84
5.15
4.0
2.6
542.9
571.8
mosm/kgh2o
0.62
75
416
15
40
3.87
5.14
3.0
3.7
60.6
58.1
%
0.26
15
40
107
707
1.74
5.09
3.7
2.8
—
—
—
0
0
57
309
2.01
5.05
3.2
2.5
21.6
24.4
%
0.77
52
279
8
7
11.66
4.80
1.1
1.0
—
—
—
0
0
14
39
3.70
4.53
2.6
3.2
4.7
4.5
e9/l
0.13
14
39
36
172
2.22
4.41
1.5
1.4
—
—
—
0
0
98
657
1.68
4.34
3.2
2.4
3917.4
8742.8
umol/l
0.58
88
583
128
923
1.61
4.24
5.0
3.5
47.1
89.9
e6/l
1.17
99
655
84
547
1.70
4.12
3.6
2.4
6.5
5.1
e6/l
0.42
78
472
23
94
2.55
3.97
6.1
2.3
20.8
21.0
s
0.12
23
84
31
147
2.22
3.88
5.1
1.4
—
—
—
0
0
34
168
2.13
3.85
4.5
7.8
—
—
—
0
0
10
26
3.93
3.54
1.4
1.0
—
—
—
0
0
11
32
3.52
3.36
1.8
1.6
—
—
—
0
0
14
49
2.93
3.23
3.4
4.4
—
—
—
0
0
46
272
1.80
3.14
25.3
3.9
—
—
—
0
0
39
219
1.88
3.13
4.7
3.0
—
—
—
0
0
8
16
5.09
3.07
1.3
1.1
—
—
—
0
0
7
12
5.93
3.03
2.0
2.0
—
—
—
0
0
15
57
2.70
3.00
1.7
1.7
15122.4
15577.8
e6/l
—
10
41
5
5
10.12
2.98
1.2
3.4
8.6
6.8
%
—
5
5
5
5
10.12
2.98
1.2
3.4
—
—
—
0
0
215
1825
1.46
2.96
5.0
4.0
—
—
—
0
0
39
225
1.83
2.89
26.9
3.5
4.6
4.6
kpa
0.07
39
216
6
9
6.76
2.88
1.2
2.3
0.2
0.2
e9/l
—
6
9
6
9
6.76
2.88
1.0
1.0
—
—
—
0
0
6
9
6.76
2.88
1.0
1.1
—
—
—
0
0
107
798
1.49
2.87
3.6
2.3
52.8
56.1
u/l
0.41
99
743
231
1995
1.46
2.85
4.9
4.1
15.4
11.0
mm/h
3.14
219
1831
8
18
4.52
2.81
2.4
2.2
—
—
—
0
0
8
18
4.52
2.81
1.9
2.5
52.9
55.8
%
—
8
12
50
315
1.69
2.75
1.5
1.4
—
—
—
0
0
13
48
2.77
2.75
2.0
1.2
—
—
—
0
0
15
60
2.57
2.74
3.3
3.2
—
—
—
0
0
14
54
2.66
2.73
40.4
3.0
—
—
—
0
0
6
10
6.08
2.71
2.8
1.4
29.5
19.5
ug/l
—
6
10
6
10
6.08
2.71
1.0
1.1
—
—
—
0
0
48
301
1.69
2.68
1.8
1.5
—
—
—
0
0
25
127
2.04
2.68
28.3
2.6
1.4
1.3
%
0.42
25
127
304
2798
1.66
2.64
34.4
14.1
139.1
139.8
mmol/l
3.80
296
2722
43
263
1.72
2.63
26.8
3.9
5.8
5.8
kpa
0.08
43
254
304
2801
1.65
2.59
34.7
14.2
3.9
4.0
mmol/l
3.32
295
2722
43
265
1.71
2.56
26.8
3.8
1.6
2.0
mmol/l
0.35
37
203
5
7
7.23
2.55
1.4
1.0
—
—
—
0
0
6
11
5.53
2.55
2.8
1.4
3.3
3.3
mg/l
—
6
11
214
1844
1.41
2.52
3.8
3.7
—
—
—
0
0
35
204
1.80
2.52
7.1
2.7
74.0
67.3
e9/l
0.68
30
163
7
16
4.44
2.48
1.6
1.1
—
—
—
0
0
7
16
4.44
2.48
1.0
1.2
—
—
—
0
0
87
639
1.48
2.48
2.3
2.3
3.2
2.9
mg/l
0.39
76
546
12
45
2.73
2.47
2.6
2.7
16.0
16.6
%
—
7
24
8
22
3.70
2.37
1.3
1.1
30.0
22.9
g/l
—
8
17
6
13
4.68
2.28
1.3
1.1
—
—
—
0
0
128
1027
1.39
2.23
4.5
3.6
24.2
46.5
ng/l
1.88
100
682
295
2726
1.52
2.17
28.7
11.8
28.2
22.3
mg/l
1.91
264
2033
155
1291
1.36
2.12
4.8
3.5
0.0
0.0
estimate
0.00
36
215
7
20
3.55
2.06
79.0
1.8
10.0
11.8
%
—
7
20
10
38
2.68
2.02
3.4
1.4
—
—
—
0
0
10
38
2.68
2.02
4.9
3.7
—
—
—
0
0
155
1298
1.35
2.02
6.2
4.8
0.0
0.0
estimate
0.00
35
211
8
27
3.01
1.94
2.0
2.9
—
—
—
0
0
156
1315
1.34
1.92
4.9
3.4
0.0
0.0
estimate
0.00
35
213
246
2676
0.73
1.92
4.4
4.3
4.5
4.6
mmol/l
0.40
224
2484
12
52
2.35
1.90
4.1
4.1
2.3
3.0
mmol/l
—
5
32
7
22
3.22
1.89
1.1
1.1
—
—
—
0
0
11
46
2.44
1.87
52.2
2.0
58.5
63.7
%
0.32
11
46
5
12
4.21
1.83
2.8
2.3
—
—
—
0
0
13
60
2.21
1.80
1.7
1.3
221.4
320.9
ug/g
—
8
31
17
88
1.98
1.78
7.4
6.0
8.8
8.8
kpa
0.02
17
80
7
24
2.95
1.73
2.3
2.0
30.4
32.8
pg
—
7
24
30
188
1.65
1.72
3.6
2.4
3.3
4.0
e9/l
1.37
24
147
15
75
2.04
1.72
1.8
1.8
15.6
7.2
u/l
—
9
67
15
75
2.04
1.72
1.4
1.1
—
—
—
0
0
5
13
3.88
1.72
1.4
1.0
1774.2
1641.1
miu/ml
—
5
13
77
592
1.39
1.69
4.3
3.5
—
—
—
0
0
245
2651
0.75
1.68
4.4
4.3
1.4
1.4
mmol/l
0.25
222
2451
16
287
0.54
1.67
1.6
1.7
—
—
—
0
0
23
135
1.75
1.67
3.3
2.7
0.7
0.2
e6/l
0.37
23
129
54
398
1.42
1.51
1.8
1.6
—
—
—
0
0
6
21
2.89
1.51
1.5
3.1
—
—
—
0
0
75
586
1.36
1.49
4.1
1.8
1.7
1.2
mg/l
0.77
57
433
69
533
1.37
1.47
3.1
3.9
36.0
428.8
ng/l
2.20
59
422
23
141
1.68
1.45
9.9
5.5
—
—
—
0
0
255
2728
0.76
1.45
4.5
4.8
2.7
2.7
mmol/l
0.35
230
2522
32
214
1.55
1.44
6.1
3.0
—
—
—
0
0
18
103
1.79
1.43
11.3
5.2
—
—
—
0
0
84
676
1.32
1.37
1.6
1.4
—
—
—
0
0
5
17
2.97
1.36
1.0
1.4
—
—
—
0
0
23
144
1.64
1.36
1.2
1.2
—
—
—
0
0
10
194
0.50
1.36
1.3
1.4
—
—
—
0
0
237
2552
0.78
1.36
4.1
3.9
1.3
1.3
mmol/l
0.01
213
2350
10
47
2.16
1.35
2.8
2.4
—
—
—
0
0
9
42
2.17
1.34
1.1
1.1
—
—
—
0
0
9
43
2.12
1.31
1.1
1.1
—
—
—
0
0
6
24
2.53
1.31
1.0
1.1
—
—
—
0
0
33
228
1.49
1.30
8.2
3.5
—
—
—
0
0
5
18
2.80
1.29
1.0
1.0
—
—
—
0
0
32
451
0.68
1.27
1.2
1.3
6.5
10.0
u/ml
0.28
12
186
84
686
1.30
1.23
6.1
3.6
0.0
0.0
estimate
0.00
34
210
5
19
2.65
1.22
1.8
1.2
—
—
—
0
0
231
2481
0.80
1.19
5.9
5.8
39.7
40.0
mmol/mol
0.15
210
2314
6
26
2.33
1.19
2.7
1.6
—
—
—
0
0
18
282
0.62
1.18
1.3
1.3
—
—
—
0
0
5
20
2.52
1.15
1.2
1.4
—
—
—
0
0
35
253
1.43
1.12
1.4
1.3
—
—
—
0
0
80
958
0.79
1.10
2.8
2.8
—
—
—
0
0
35
468
0.72
1.05
1.3
1.3
63.9
38.0
iu/ml
0.27
15
148
71
580
1.28
1.04
6.7
4.2
—
—
—
0
0
5
22
2.29
1.03
2.4
2.7
—
—
—
0
0
5
110
0.45
1.02
1.2
1.1
—
—
—
0
0
9
49
1.86
0.99
1.1
1.2
—
—
—
0
0
0
32
0.00
0.95
0.0
1.1
—
—
—
0
0
95
814
1.23
0.93
3.4
2.1
708.7
298.5
u/l
0.50
88
763
15
96
1.59
0.86
1.7
1.3
—
—
—
0
0
27
199
1.39
0.81
2.4
2.1
11.9
15.1
nmol/l
0.63
21
187
0
24
0.00
0.79
0.0
1.3
—
—
—
0
0
5
99
0.50
0.79
4.2
1.6
—
—
—
0
0
0
27
0.00
0.77
0.0
1.2
—
49.2
—
0
8
0
27
0.00
0.77
0.0
1.7
—
—
—
0
0
59
700
0.81
0.74
1.7
1.6
1.2
1.4
mmol/l
0.97
54
588
7
39
1.81
0.73
3.6
2.3
—
—
—
0
0
7
40
1.76
0.71
3.6
2.3
4.0
4.1
mmol/l
—
7
40
7
40
1.76
0.71
3.6
2.3
105.1
105.4
mmol/l
—
7
40
102
904
1.18
0.70
4.3
3.6
1.8
1.9
ug/l
0.12
92
796
251
2621
0.85
0.66
4.5
4.4
6.0
5.9
mmol/l
0.08
224
2382
5
28
1.80
0.66
1.4
1.7
91.3
90.6
%
—
5
28
217
2048
1.16
0.64
4.5
3.7
14.5
14.8
pmol/l
0.85
199
1856
12
79
1.54
0.63
4.3
3.7
—
—
—
0
0
301
2919
1.22
0.62
19.2
8.4
27.9
26.1
u/l
0.68
292
2801
84
740
1.18
0.62
4.8
3.0
—
—
—
0
0
5
30
1.68
0.61
1.4
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.0
—
241.1
—
0
16
11
76
1.46
0.48
1.3
1.2
—
2.9
—
0
14
70
622
1.16
0.47
1.8
1.5
19.4
21.1
nmol/l
0.43
62
541
8
118
0.67
0.46
1.0
1.1
—
—
—
0
0
8
57
1.41
0.42
1.0
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
123
1146
1.11
0.40
3.5
2.7
187.2
109.3
ug/l
1.95
117
1057
5
34
1.48
0.40
1.4
1.1
—
—
—
0
0
296
2892
1.15
0.40
24.0
10.9
—
—
—
0
0
10
71
1.42
0.39
4.2
1.7
—
—
—
0
0
9
68
1.33
0.38
1.0
1.2
1.9
3.5
e6/l
—
9
56
9
68
1.33
0.38
1.0
1.3
76.8
1712.7
e6/l
—
9
57
13
169
0.76
0.38
1.2
1.4
—
—
—
0
0
55
492
1.14
0.35
1.7
1.9
—
—
—
0
0
22
262
0.83
0.32
1.9
1.7
—
—
—
0
0
13
101
1.30
0.32
1.7
1.6
—
—
—
0
0
32
367
0.86
0.31
2.0
2.3
137.3
103.1
ug/g
0.29
26
282
17
138
1.24
0.31
3.6
3.4
—
—
—
0
0
15
185
0.80
0.30
1.0
1.2
—
—
—
0
0
5
73
0.68
0.26
1.6
1.1
—
—
—
0
0
11
138
0.79
0.26
2.3
1.4
—
—
—
0
0
25
287
0.86
0.25
1.3
1.5
—
—
—
0
0
78
729
1.09
0.24
5.5
3.8
—
—
—
0
0
5
39
1.29
0.23
1.8
3.5
0.8
0.8
nmol/l
—
5
27
7
93
0.75
0.22
4.9
9.3
—
—
—
0
0
62
577
1.09
0.22
2.4
1.3
2.4
2.4
g/l
0.00
47
356
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
134.2
—
0
10
12
145
0.82
0.21
2.8
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
11
89
1.24
0.21
1.1
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
12
144
0.83
0.20
2.2
1.4
—
—
—
0
0
12
143
0.83
0.19
2.2
1.4
—
—
—
0
0
12
143
0.83
0.19
2.2
1.4
—
—
—
0
0
94
897
1.07
0.18
3.5
3.1
7.3
7.8
mmol/l
0.57
82
758
7
60
1.17
0.18
2.9
2.1
136.3
129.4
g/l
—
7
40
15
173
0.86
0.17
5.4
2.6
—
—
—
0
0
5
67
0.74
0.17
1.0
1.2
—
—
—
0
0
252
2481
1.06
0.15
5.1
4.5
2.0
1.9
mu/l
0.52
231
2260
81
846
0.94
0.14
4.0
3.9
3.8
6.1
mg/mmol
1.09
56
530
258
2543
1.06
0.14
34.4
13.0
37.2
40.5
%
7.36
180
1858
14
122
1.15
0.14
1.5
1.7
—
—
—
0
0
67
646
1.05
0.09
1.2
1.4
1.0
2.1
u/ml
1.20
18
171
5
48
1.04
0.09
1.0
1.1
—
—
—
0
0
7
66
1.06
0.08
4.0
1.5
—
—
—
0
0
6
70
0.85
0.07
1.0
1.5
0.6
0.8
nmol/l
—
6
60
52
501
1.04
0.07
2.6
2.5
0.8
0.7
ug/l
0.19
37
314
7
83
0.84
0.07
1.0
1.7
228.4
303.9
mu/l
—
7
75
10
109
0.92
0.04
2.4
1.4
—
—
—
0
0
15
141
1.07
0.03
1.9
2.3
—
—
—
0
0
38
370
1.03
0.03
1.2
1.4
464.0
498.4
titre
—
5
87
10
93
1.08
0.02
1.4
1.6
—
—
—
0
0
107
1062
1.01
0.01
1.9
2.0
95.3
94.5
pmol/l
0.06
59
546
63
623
1.01
0.01
5.5
3.6
1.0
1.0
kg/l
—
10
88
23
232
0.99
0.00
1.2
1.2
—
—
—
0
0
310
3098
1.01
0.00
42.6
17.2
128.8
137.5
g/l
16.30
305
3043
14
139
1.01
0.00
1.1
1.1
—
6.2
—
0
5
49
491
1.00
0.00
2.2
1.8
1332.2
1186.9
nmol/l
0.55
37
374
25
253
0.99
0.00
1.3
1.4
—
—
—
0
0
310
3097
1.01
0.00
42.5
17.1
6.8
6.7
e9/l
0.29
304
3007
35
345
1.02
0.00
1.1
1.2
—
—
—
0
0
80
796
1.01
0.00
3.7
3.2
1967.1
125.7
mg/l
0.97
57
511
310
3095
1.01
0.00
42.3
17.1
90.7
90.5
fl
0.26
305
3042
309
3095
0.99
0.00
42.6
17.1
245.0
247.7
e9/l
0.30
303
3011
310
3096
1.01
0.00
42.2
17.0
30.2
30.2
pg
0.06
305
3043
54
544
0.99
0.00
2.4
1.7
449.7
439.5
pmol/l
0.10
45
456
310
3096
1.01
0.00
42.5
17.1
4.3
4.6
e12/l
11.93
304
3004
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
351.0
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
8.7
—
—
—
0
0
0
8
0.00
0.00
0.0
8.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
9
89
1.01
0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
55
0.91
0.00
1.8
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
8.2
—
25.4
—
0
9

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_BONE_CARTILAGE_LIMBS_EXALLC – Malignant neoplasm of bone and articular cartilage of limbs, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).