No definition available.
Osteosarcoma, excluding all cancers (controls excluding all cancers)
C3_OSTEOSARCOMA_EXALLC
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
136 |
4. Check minimum number of eventsNone |
136 |
5. Include endpointsNone |
136 |
6. Filter based on genotype QC (FinnGen only) |
136 |
Control definitions (FinnGen only)
- Control exclude
- C3_CANCER, C3_CANCER_WIDE_EXALLC
Extra metadata
- First used in FinnGen datafreeze
- DF12
Similar endpoints
↥List of similar endpoints to
Osteosarcoma, excluding all cancers (controls excluding all cancers)
based on the number of shared cases.
Similar with more cases:
- Malignant neoplasm of bone and articular cartilage, excluding all cancers (controls excluding all cancers)
- Malignant neoplasm, excluding all cancers (controls excluding all cancers)
- Malignant neoplasm, wide definition for exclusion
- Malignant neoplasm, wide definition for exclusion, excluding all cancers (controls excluding all cancers)
- Neoplasms
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 136 | 62 | 74 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 33.83 | 29.65 | 37.33 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 71
- Matched controls
- 711
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
130
Kela drug reimbursment
Malignant tumour
+∞
52.8
44
*
9180/3-C40.2
ICD-O-3
Osteosarcoma, NOS, of long bones of lower limb and associated joints
+∞
51.4
43
*
C40.21
ICD-10 Finland
Osteosarcoma of the long bones of the lower extremity
+∞
41.8
36
*
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
120.0
32.3
33
5
TPX10
NOMESCO Finland
Implantation of vascular injection port
272.7
20.7
20
*
L03AA02
ATC
filgrastim; parenteral
254.2
19.6
19
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
127.0
18.6
19
*
C40.20
ICD-10 Finland
Malignant tumor of the long bones of the lower extremity without histology
+∞
18.5
17
*
N02AA05
ATC
oxycodone; systemic
16.7
17.4
29
28
C40.2
ICD-10 Finland
Malignant neoplasm: Long bones of lower limb
+∞
16.2
15
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
15.1
14
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
15.1
14
*
NF3AA
NOMESCO Finland
Femur X-ray examination
67.5
14.5
16
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
7.6
14.2
46
138
C40.29
ICD-10 Finland
Malignant tumor of the long bones of the lower extremity other or unspecified histology
+∞
12.9
12
*
NG4AA
NOMESCO Finland
Lower leg X-ray examination
27.3
12.7
17
8
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
27.3
12.7
17
8
A04AA01
ATC
ondansetron; systemic, rectal
33.7
12.7
16
6
JN4BD
NOMESCO Finland
Extensive body CT
18.0
12.3
19
14
WX408
NOMESCO Finland
General anesthesy, balanced
6.8
12.2
38
102
NFR30
NOMESCO Finland
Extended excision of soft tissue tumour of hip or thigh
+∞
11.8
11
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
11.8
11
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
31.0
11.7
15
6
N03AX16
ATC
pregabalin; oral
7.3
11.4
31
68
GD1AD
NOMESCO Finland
Thorax CT examination
34.2
11.2
14
5
A03FA01
ATC
metoclopramide; systemic, rectal
8.4
10.7
25
43
TPX15
NOMESCO Finland
Removal of vascular injection port
+∞
10.7
10
*
B01AB05
ATC
enoxaparin; parenteral
6.4
10.6
33
85
ZXA05
NOMESCO Finland
Left side
6.3
10.4
32
81
H02AB02
ATC
dexamethasone; systemic
64.0
9.9
11
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
8.6
9.8
22
35
NE1DG
NOMESCO Finland
Pelvic, hip and femur very extensive MRI examination with high intensity magnet
114.5
9.7
10
*
1707A
ICD-9 Finland
Malignant neoplasm of bone and articular cartilage, Long bones of lower limb[ALARAAJAN PITKIEN LUIDEN SYÖPÄ,OSTEOSARCOMA]
+∞
9.6
9
*
NGR30
NOMESCO Finland
Extensive or radikal excision of tumor of knee or lower leg
+∞
9.6
9
*
NK6CT
NOMESCO Finland
Bone biopsy with CT guidance
+∞
9.6
9
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
9.6
9
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
9.6
9
*
R4110
NOMESCO Finland
Physiotherapy
5.7
9.4
31
84
WX302
NOMESCO Finland
Thoracal epidural anesthesy
42.6
9.3
11
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
14.2
9.1
15
13
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
4.8
8.9
38
136
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
9.6
8.8
18
24
WW500
NOMESCO Finland
Blood transfusion
31.9
8.8
11
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
8.0
8.7
20
33
NGB30
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part - connected prosthesis
101.5
8.6
9
*
Z51.5
ICD-10 Finland
Palliative care
101.5
8.6
9
*
C40.11
ICD-10 Finland
Osteosarcoma of the short bones of the upper extremity
+∞
8.5
8
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
8.5
8
*
9180/3-C40.0
ICD-O-3
Osteosarcoma, NOS, of long bones of upper limb, scapula and associated joints
+∞
8.5
8
*
C40.01
ICD-10 Finland
Osteosarcoma of the scapula and the long bones of the upper extremity
+∞
8.5
8
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
8.5
8
*
17071
ICD-8 Finland
Malignant neoplasm of bone, Lower limb, long bones
+∞
8.5
8
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
5.8
8.4
26
64
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
25.5
8.3
11
5
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
25.5
8.3
11
5
N02AX02
ATC
tramadol; systemic, rectal
4.5
8.1
38
144
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
9.5
7.9
16
21
WX404
NOMESCO Finland
Intravenous generell anesthesy
5.1
7.5
26
72
NG1DG
NOMESCO Finland
Knee and lower leg very extensive MRI examination with high intensity magnet
+∞
7.4
7
*
NK6AN
NOMESCO Finland
Total body bone isotope imaging
+∞
7.4
7
*
TPH07
NOMESCO Finland
Cathetrisation of artery
9.9
7.2
14
17
ZXA00
NOMESCO Finland
Right side
4.4
6.7
27
86
WX306
NOMESCO Finland
Lumbar epidural anesthesy
7.6
6.6
15
24
NFQ20
NOMESCO Finland
Amputation of femur
76.3
6.5
7
*
9101
FHL
Bone biopsy
76.3
6.5
7
*
WX402
NOMESCO Finland
General anaesthesia
5.2
6.5
21
53
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
20.2
6.4
9
5
Z63.7
ICD-10 Finland
Other stressful life events affecting family and household
20.2
6.4
9
5
JN4CD
NOMESCO Finland
Very extensive body CT
29.5
6.4
8
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
6.3
6
*
NFQ48
NOMESCO Finland
Revision of exarticulation or amputation stump of hip or femur
+∞
6.3
6
*
C40.91
ICD-10 Finland
Osteosarcoma in unspecified locations in the bones and articular cartilage of the extremities
+∞
6.3
6
*
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
+∞
6.3
6
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
6.3
6
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
6.3
6
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
6.3
6
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
6.3
6
*
Z85.8
ICD-10 Finland
Personal history of malignant neoplasms of other organs and systems
+∞
6.3
6
*
WB121
NOMESCO Finland
Demanding neoadjuvant cytostatic therapy
+∞
6.3
6
*
QX3AT
NOMESCO Finland
Ultrasound guided biopsy of subcutaneous tissue
+∞
6.3
6
*
B01AB10
ATC
tinzaparin; parenteral
14.3
6.3
10
8
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
81
344
4.35
16.16
10.1
4.5
35.0
36.5
g/l
1.54
76
325
27
47
6.92
15.62
15.9
7.5
0.9
0.7
%
0.80
27
47
57
193
4.36
15.41
7.0
1.9
—
—
—
0
0
27
48
6.77
15.30
15.8
7.4
1.3
1.6
%
0.61
27
48
86
397
4.17
14.90
24.2
6.2
1.2
1.2
mmol/l
0.67
80
364
89
435
4.03
13.88
26.5
6.6
1.2
1.2
mmol/l
0.42
75
389
14
12
12.89
13.74
2.1
1.4
—
—
—
0
0
35
89
4.95
13.45
13.1
6.4
14.0
12.0
kpa
1.17
35
84
35
89
4.95
13.45
13.1
6.4
5.4
5.1
kpa
1.10
35
84
42
131
4.19
12.37
2.4
1.6
—
—
—
0
0
14
15
10.29
11.86
1.6
1.2
—
—
—
0
0
14
15
10.29
11.86
1.6
1.3
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
16
23
7.75
10.82
14.8
2.6
0.2
0.3
u/ml
—
9
16
80
411
3.30
10.61
7.4
3.5
—
—
—
0
0
27
67
4.78
10.55
47.4
10.3
25.3
24.5
mmol/l
0.70
27
67
20
38
6.00
10.47
3.6
1.7
28.7
2.9
ug/l
0.48
15
26
26
65
4.71
10.04
2.9
3.4
0.2
0.2
g/l
0.08
26
60
32
95
4.10
9.92
2.6
1.5
—
—
—
0
0
31
95
3.93
9.16
2.5
1.4
—
—
—
0
0
96
586
3.17
8.84
30.9
7.5
3.9
4.2
e9/l
0.86
86
504
24
68
4.07
7.84
5.4
2.6
—
—
—
0
0
12
9
14.47
7.54
1.4
1.2
—
—
—
0
0
13
22
6.43
7.53
1.8
1.4
—
—
—
0
0
10
7
15.28
6.50
1.3
1.1
—
—
—
0
0
32
130
2.91
5.92
3.4
2.8
13.5
14.5
umol/l
0.28
32
117
22
72
3.45
5.80
2.8
1.8
89.6
72.2
ml/min/173m2
0.94
12
27
12
25
5.17
5.61
1.8
2.2
—
—
—
0
0
60
341
2.36
5.54
4.1
3.7
—
—
—
0
0
13
31
4.53
5.22
6.7
3.2
215.2
173.7
%
0.97
13
31
23
84
3.09
5.08
43.1
4.9
1.1
1.5
mmol/l
1.77
23
78
15
42
3.89
4.92
2.1
1.4
—
—
—
0
0
9
10
9.54
4.86
1.1
1.0
—
—
—
0
0
49
274
2.23
4.54
3.1
3.5
0.4
0.3
e6/l
0.08
36
195
17
55
3.39
4.54
1.6
1.5
—
—
—
0
0
9
12
7.94
4.43
1.1
1.2
—
—
—
0
0
8
10
8.41
4.12
1.1
1.2
—
—
—
0
0
8
12
7.00
3.73
1.4
1.0
—
—
—
0
0
5
5
10.31
3.00
1.4
1.6
—
—
—
0
0
5
5
10.31
3.00
2.4
5.8
98.6
107.2
%
—
5
5
6
9
6.91
2.90
1.2
1.0
—
—
—
0
0
22
109
2.21
2.64
13.1
7.3
—
—
—
0
0
56
386
1.77
2.60
2.9
2.7
74.1
75.1
nmol/l
0.10
50
339
6
11
5.65
2.57
1.0
1.5
—
—
—
0
0
5
7
7.36
2.57
9.8
4.0
—
—
—
0
0
18
83
2.35
2.54
7.3
6.9
5.2
4.9
kpa
1.22
18
72
52
353
1.77
2.53
4.3
3.5
15.0
40.7
ng/l
1.89
39
224
35
212
1.88
2.45
7.2
1.9
2.1
1.3
mg/l
0.58
30
160
5
8
6.43
2.39
1.2
1.0
—
—
—
0
0
5
9
5.72
2.23
1.2
1.0
—
—
—
0
0
96
790
1.73
2.21
4.6
3.5
15.1
14.7
pmol/l
0.76
88
721
5
10
5.14
2.09
1.6
1.1
—
—
—
0
0
5
10
5.14
2.09
1.6
1.1
—
—
—
0
0
5
10
5.14
2.09
1.6
1.1
—
—
—
0
0
16
77
2.22
2.06
8.0
7.3
1.4
1.0
mmol/l
0.13
16
55
6
15
4.13
2.06
1.5
1.1
—
—
—
0
0
123
1101
2.23
2.05
35.3
10.4
30.5
22.1
mg/l
1.71
109
813
11
45
2.57
1.98
57.3
2.8
1.3
1.1
%
0.43
11
45
8
27
3.08
1.97
2.0
1.9
—
—
—
0
0
110
955
1.79
1.93
26.6
8.7
91.4
87.5
ml/min/173m2
0.86
99
754
6
17
3.64
1.86
1.7
1.1
—
—
—
0
0
6
17
3.64
1.86
1.7
1.1
—
—
—
0
0
126
1150
2.30
1.80
40.5
11.5
78.6
76.2
umol/l
0.17
126
1150
13
64
2.14
1.60
2.2
1.4
—
—
—
0
0
6
20
3.09
1.60
2.7
2.5
—
—
—
0
0
6
21
2.94
1.52
1.7
1.6
—
—
—
0
0
6
22
2.80
1.45
1.5
1.5
—
—
—
0
0
5
16
3.20
1.45
1.2
1.4
0.1
0.8
nmol/l
—
5
11
11
205
0.50
1.43
1.7
2.3
—
—
—
0
0
10
188
0.49
1.33
1.8
2.2
—
—
—
0
0
16
92
1.84
1.32
3.2
2.4
328.3
351.1
nmol/l
0.25
16
85
6
25
2.46
1.26
2.0
1.8
—
—
—
0
0
6
26
2.37
1.20
1.0
1.2
—
—
—
0
0
7
31
2.32
1.12
1.6
1.5
—
—
—
0
0
28
198
1.52
1.09
3.7
3.2
39.9
205.9
ng/l
1.96
23
142
5
22
2.32
1.04
1.8
1.5
185.2
141.5
u/ml
—
5
10
25
176
1.52
1.00
2.8
2.9
0.9
1.1
e6/l
0.20
12
103
10
54
1.92
0.99
6.0
3.4
5.0
5.1
pmol/l
—
10
47
107
975
1.46
0.99
5.2
4.1
2.1
1.8
mu/l
1.09
100
895
0
28
0.00
0.99
0.0
1.9
—
—
—
0
0
44
354
1.36
0.87
1.7
1.8
96.4
92.4
pmol/l
0.17
22
187
23
166
1.46
0.82
3.0
2.9
3.4
2.8
e6/l
—
9
93
0
25
0.00
0.80
0.0
1.6
—
—
—
0
0
96
1038
0.74
0.78
4.4
3.9
1.4
1.4
mmol/l
0.18
90
969
92
995
0.77
0.69
4.2
3.6
1.2
1.3
mmol/l
0.21
86
928
99
1060
0.76
0.68
4.4
4.3
2.8
2.8
mmol/l
0.21
93
994
5
28
1.81
0.67
1.4
2.4
26.7
22.8
mmol/l
—
5
20
57
494
1.26
0.63
5.9
3.5
0.0
0.0
estimate
0.00
12
85
98
1047
0.77
0.63
4.4
4.0
4.6
4.6
mmol/l
0.05
92
984
5
30
1.69
0.62
1.2
1.3
—
—
—
0
0
87
940
0.79
0.59
5.7
5.2
38.3
39.4
mmol/mol
0.53
81
890
0
23
0.00
0.59
0.0
1.2
—
—
—
0
0
6
36
1.70
0.57
1.0
1.1
—
—
—
0
0
6
36
1.70
0.57
1.0
1.1
—
—
—
0
0
110
1048
1.26
0.44
44.9
11.4
37.5
41.0
%
6.75
79
821
6
94
0.62
0.44
1.3
1.9
—
—
—
0
0
55
493
1.19
0.42
7.5
4.9
0.0
0.0
estimate
0.00
12
80
20
161
1.28
0.40
1.4
1.7
385.5
440.6
pmol/l
0.53
14
143
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
5
80
0.61
0.36
1.2
1.2
—
192.6
—
0
28
31
268
1.20
0.34
7.5
3.7
0.0
0.0
estimate
0.00
12
82
29
250
1.20
0.33
1.3
1.7
—
—
—
0
0
78
828
0.86
0.32
3.7
3.4
—
—
—
0
0
54
503
1.12
0.23
6.0
3.5
0.0
0.0
estimate
0.00
12
81
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
6
75
0.79
0.16
1.3
1.9
—
—
—
0
0
41
383
1.10
0.16
6.6
3.5
—
—
—
0
0
9
81
1.12
0.15
2.0
3.1
3.2
6.3
ug/l
—
9
70
26
280
0.91
0.11
1.1
1.5
2.1
2.2
u/ml
—
6
67
26
276
0.93
0.08
2.7
3.5
27.1
23.3
%
0.66
15
128
7
67
1.05
0.08
1.0
1.3
—
—
—
0
0
16
147
1.10
0.07
1.6
1.5
—
—
—
0
0
10
110
0.90
0.05
1.8
1.8
—
—
—
0
0
99
996
0.98
0.00
4.1
3.9
5.6
5.8
mmol/l
1.01
91
916
19
195
0.97
0.00
1.8
2.5
0.7
0.8
ug/l
0.13
14
117
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
216.8
—
0
5
0
5
0.00
0.00
0.0
1.4
—
17.8
—
0
5
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
2.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: C3_OSTEOSARCOMA_EXALLC – Osteosarcoma, excluding all cancers (controls excluding all cancers)
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).