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This is a non-core endpoint: only basic statistics are computed.

See its core counterpart C3_CERVIX_UTERI_EXALLC for full statistics.

Malignant neoplasm of cervix uteri

C3_CERVIX_UTERI

cervical carcinoma: A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are: squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic carcinoma and undifferentiated carcinoma.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C53
  • Cause of death: ICD-9 180
  • Cause of death: ICD-8 180
  • Cancer registry: Topography ICD-O-3 C53
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

561

4. Check minimum number of events

None

561

5. Include endpoints

None

561

6. Filter based on genotype QC (FinnGen only)

561

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9

Similar endpoints

List of similar endpoints to Malignant neoplasm of cervix uteri based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 561 561 -
Unadjusted period prevalence (%) 0.19 0.19 -
Median age at first event (years) 42.94 42.94 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
519
Matched controls
5190
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8070/3-C53.9
ICD-O-3
Squamous cell carcinoma, NOS, of cervix uteri
1211.2
180.6
166
*
C53.11
ICD-10 Finland
Squamous cell carcinoma and exocervix
1200.4
179.5
165
*
C53.01
ICD-10 Finland
Squamous cell carcinoma of the endocervix
1965.8
155.4
143
*
128
Kela drug reimbursment
Cancers of female genital organs
60.0
144.5
168
41
C53.02
ICD-10 Finland
Adenocarcinoma of the endocervix
1763.0
142.6
132
*
ULA02
NOMESCO Finland
Kolposcopy
12.4
127.8
275
433
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
20.4
126.5
201
156
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
9.7
108.7
272
528
8140/3-C53.9
ICD-O-3
Adenocarcinoma, NOS, of cervix uteri
+∞
102.6
95
*
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
9.7
99.0
238
417
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
10.5
90.0
198
288
PJD64
NOMESCO Finland
Laparoscopic dissection of iliac lymph nodes
80.1
78.2
87
13
LCD31
NOMESCO Finland
Radical laparoscopic hysterectomy
432.8
76.9
75
*
WF002
NOMESCO Finland
Radical radiotherapy
29.5
72.8
99
41
JN2DG
NOMESCO Finland
Very extensive MRI examination of lower part of abdoment with high intensity magnet
50.8
65.1
78
18
LCD30
NOMESCO Finland
Radical hysterectomy
185.3
63.6
65
*
ZX020
NOMESCO Finland
HDR radiotherapy within tissue
+∞
61.7
58
*
ZX040
NOMESCO Finland
Intracavity HDR radiotherapy
333.9
59.6
59
*
JN2CG
NOMESCO Finland
Extensive MRI examination of lower part of abdoment with high intensity magnet
31.4
58.6
78
29
C53.00
ICD-10 Finland
Malignant tumor of endocervix without histology
+∞
57.4
54
*
ZXC96
NOMESCO Finland
Robot assisted procedure
29.0
55.2
75
30
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
49.4
54.1
65
15
LDA10
NOMESCO Finland
Curettage of cervix uteri
9.4
53.8
119
159
8140/3-C53.0
ICD-O-3
Adenocarcinoma, NOS, of endocervix
+∞
52.0
49
*
8076/3-C53.9
ICD-O-3
Squamous cell carcinoma, microinvasive of cervix uteri
+∞
50.9
48
*
C53.12
ICD-10 Finland
Adenocarcinoma of the exocervix
524.9
49.2
48
*
PJA01
NOMESCO Finland
Laparoscopic sentinel node excision
83.9
48.0
53
7
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
9.9
47.5
101
124
LEB00
NOMESCO Finland
Biopsy of vagina
15.9
47.4
79
58
ZX095
NOMESCO Finland
Combined chemoradiotherapy
92.1
45.7
50
6
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
11.9
44.7
85
84
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
56.4
43.5
51
10
121
Kela drug reimbursment
Severe hypofunction of sexual glands
16.8
42.5
69
47
B01AB10
ATC
tinzaparin; parenteral
7.5
40.7
103
166
C53.0
ICD-10 Finland
Malignant neoplasm: Endocervix
+∞
40.1
38
*
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
4.5
38.4
158
456
A03FA01
ATC
metoclopramide; systemic, rectal
3.8
37.6
204
754
XX3DW
NOMESCO Finland
Time consuming IT work
5.8
36.7
114
240
D06.0
ICD-10 Finland
Carcinoma in situ: Endocervix
56.9
36.0
42
8
8070/3-C53.1
ICD-O-3
Squamous cell carcinoma, NOS, of exocervix
+∞
35.8
34
*
H02AB02
ATC
dexamethasone; systemic
5.1
35.8
127
311
C53.09
ICD-10 Finland
Malignant tumor of endocervix, unspecified histology
+∞
34.8
33
*
YJ2VG
NOMESCO Finland
MRI examination of pelvis with high intensity magnet for dose design of radiotherapy
82.0
34.3
38
5
C53.1
ICD-10 Finland
Malignant neoplasm: Exocervix
+∞
33.7
32
*
PJ5AQ
NOMESCO Finland
Sentinell lymphnode SPECT with low dose CT
68.1
33.5
38
6
ZX080
NOMESCO Finland
Image guided radiotherapy
16.2
33.1
54
37
ZX070
NOMESCO Finland
Intensity modified radiotherapy
22.4
32.4
47
23
PJD54
NOMESCO Finland
Block dissection of iliac lymph nodes
32.5
32.2
42
14
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
21.8
31.5
46
23
A04AA01
ATC
ondansetron; systemic, rectal
6.0
30.7
90
174
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
7.7
30.2
73
108
YX9VG
NOMESCO Finland
Other MRI eamination with high intensity magnet for dose design of radiotherapy
+∞
29.5
28
*
A04AA55
ATC
palonosetron, combinations; systemic
7.6
28.3
69
103
C53.90
ICD-10 Finland
Malignant tumor in unspecified localization in cervix uteri without histology
+∞
27.3
26
*
JN4BD
NOMESCO Finland
Extensive body CT
4.8
26.5
96
235
C53.10
ICD-10 Finland
Malignant tumor of the exocervix without histology
+∞
26.3
25
*
TLW99
NOMESCO Finland
Other minor surgical procedure in gynaecology
10.8
26.1
51
52
JN2BG
NOMESCO Finland
MRI examination of lower part of abdoment with high intensity magnet
28.7
26.1
35
13
JN5JS
NOMESCO Finland
Extensive PET-MRI of body metabolism
273.5
25.9
26
*
B01AB05
ATC
enoxaparin; parenteral
2.9
25.6
217
1044
WF003
NOMESCO Finland
Adjuvant radiotherapy
8.9
25.4
55
68
A04AD12
ATC
aprepitant; systemic
13.6
25.4
44
35
1800A
ICD-9 Finland
Malignant neoplasm of cervix uteri, Endocervix
+∞
25.2
24
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.8
24.5
226
1135
C53.99
ICD-10 Finland
Malignant tumor in unspecified localization in cervix, unspecified histology
+∞
24.1
23
*
C53
ICD-10 Finland
Malignant neoplasm of cervix uteri
+∞
24.1
23
*
N87.2
ICD-10 Finland
Severe cervical dysplasia, not elsewhere classified
7.7
23.9
57
82
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
13.9
23.3
40
31
8070/3-C53.0
ICD-O-3
Squamous cell carcinoma, NOS, of endocervix
+∞
23.1
22
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.5
22.4
264
1503
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
30.6
22.1
29
10
YL1AD
NOMESCO Finland
CT examination of pelvis for dose design of radiotherapy
83.8
21.9
24
*
18099
ICD-8 Finland
Malignant neoplasm of cervix uteri
229.3
21.8
22
*
8310
FHL
Radical hysterectomy (includes lymph node removal)
120.1
21.7
23
*
LAF11
NOMESCO Finland
Laparoscopic bilateral salpingo-oophorectomy
5.1
20.9
69
152
KH1BT
NOMESCO Finland
Urinary tract cathetrisation with X-ray guidance
43.6
20.6
25
6
C53.81
ICD-10 Finland
Overall squamous cell carcinoma of the cervix uteri
+∞
19.9
19
*
C53.19
ICD-10 Finland
Malignant tumor of the exocervix, unspecified histology
+∞
19.9
19
*
LAG11
NOMESCO Finland
Laparoscopic oophoropexy
+∞
18.9
18
*
UKC02
NOMESCO Finland
Cystoscopy
3.5
17.2
87
284
KBV15
NOMESCO Finland
Cystoscopic change of ureteral stent
65.6
16.8
19
*
WW500
NOMESCO Finland
Blood transfusion
6.7
16.8
43
69
1801A
ICD-9 Finland
Malignant neoplasm of cervix uteri, Exocervix
+∞
16.8
16
*
WZC30
NOMESCO Finland
Teaching
3.2
16.6
94
333
LCA06
NOMESCO Finland
Biopsy of endometrium
2.8
16.3
124
531
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
6.0
15.8
44
79
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
22.9
15.7
22
10
C53.91
ICD-10 Finland
Squamous cell carcinoma in an unspecified location in the cervix
164.8
15.6
16
*
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
9.3
15.2
31
35
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
10.5
14.6
28
28
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
6.6
14.4
37
60
ZX090
NOMESCO Finland
Other technic of radiotherapy
6.7
14.2
36
57
A04AA02
ATC
granisetron; systemic, transdermal
4.2
14.2
55
142
Z51.5
ICD-10 Finland
Palliative care
4.5
13.9
50
120
KA1FN
NOMESCO Finland
Isotope renography
54.9
13.9
16
*
C53.89
ICD-10 Finland
Overall malignant tumor of the cervix uteri, unspecified histology
+∞
13.6
13
*
D06.1
ICD-10 Finland
Carcinoma in situ: Exocervix
41.2
13.2
16
*
N93.9
ICD-10 Finland
Abnormal uterine and vaginal bleeding, unspecified
6.7
13.1
33
52
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
5.4
13.0
39
77
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
4.0
12.8
52
141
C53.9
ICD-10 Finland
Malignant neoplasm: Cervix uteri, unspecified
+∞
12.5
12
*
D06.9
ICD-10 Finland
Carcinoma in situ: Cervix, unspecified
133.1
12.5
13
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
7.7
12.4
28
38
ZXE20
NOMESCO Finland
More than three and less than five hours
2.8
12.2
84
335
KBV12
NOMESCO Finland
Transluminal endoscopic removal of stent from ureter
13.8
12.0
20
15
ZXE30
NOMESCO Finland
More than five and less than seven hours
4.4
11.9
43
104
8077/2-C53.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of cervix uteri
6.9
11.9
29
44
WB101
NOMESCO Finland
Simple cytostatic neoadjuvant therapy
66.5
11.7
13
*
8140/3-C53.1
ICD-O-3
Adenocarcinoma, NOS, of exocervix
+∞
11.5
11
*
LBE10
NOMESCO Finland
Bilateral salpingectomy
25.7
11.2
15
6
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
6.4
10.9
28
46
YX9BD
NOMESCO Finland
Other extensive CT eamination for dose design of radiotherapy
15.9
10.9
17
11
XX1XW
NOMESCO Finland
Extensive written report from radiologist
9.1
10.9
22
25
N02AA05
ATC
oxycodone; systemic
2.6
10.8
83
353
K52.0
ICD-10 Finland
Gastroenteritis and colitis due to radiation
61.3
10.7
12
*
LBE20
NOMESCO Finland
Laparoscopic bilateral salpingectomy
6.4
10.6
27
44
JN5KS
NOMESCO Finland
Very extensive PET-MRI of body metabolism
+∞
10.4
10
*
I89.0
ICD-10 Finland
Lymphoedema, not elsewhere classified
9.9
10.3
20
21
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
4.6
10.3
35
80
C54.11
ICD-10 Finland
Adenocarcinoma of the endometrium
5.6
10.3
29
54
YL1CD
NOMESCO Finland
Very extensive CT examination of pelvis for dose design of radiotherapy
26.6
9.9
13
5
B02AA02
ATC
tranexamic acid; systemic
2.1
9.7
116
613
X75
ICPC
Malignant neoplasm cervix
101.8
9.4
10
*
C53.92
ICD-10 Finland
Adenocarcinoma in an unspecified location in the cervix
101.8
9.4
10
*
L03AA13
ATC
pegfilgrastim; parenteral
4.2
9.4
35
88
C539, 8085, 3
ICD-O-3
NA
+∞
9.4
9
*
C53.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of cervix uteri
+∞
9.4
9
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
9.3
133
755
WX402
NOMESCO Finland
General anaesthesia
2.2
9.2
101
514
ZX120
NOMESCO Finland
Intravenous
2.8
9.1
60
232
KH1FT
NOMESCO Finland
Exchange of urinary catheter with radiological guidance
37.4
9.0
11
*
PJD63
NOMESCO Finland
Laparoscopic dissection of aortic lymph nodes
19.0
9.0
13
7
WX302
NOMESCO Finland
Thoracal epidural anesthesy
3.8
8.9
37
103
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
8.8
8.9
18
21
N95.0
ICD-10 Finland
Postmenopausal bleeding
2.6
8.7
65
273
KH1YT
NOMESCO Finland
Percutaneous implantation of endoprothesis with radiological guidance
91.5
8.4
9
*
KC1GB
NOMESCO Finland
Cystography with X-ray
91.5
8.4
9
*
K62.7
ICD-10 Finland
Radiation proctitis
91.5
8.4
9
*
JN3AD
NOMESCO Finland
Abdominal CT examination
3.1
8.4
47
164
18011
ICD-8 Finland
NA
+∞
8.4
8
*
LAF10
NOMESCO Finland
Bilateral salpingo-oophorectomy
4.1
8.3
31
79
Y83.8
ICD-10 Finland
Other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.8
8.2
26
56
N87.9
ICD-10 Finland
Dysplasia of cervix uteri, unspecified
12.0
8.1
14
12
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.3
8.0
80
388
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.1
7.9
92
478
KBV00
NOMESCO Finland
Insertion of stent into ureter
15.3
7.7
12
8
Z08.9
ICD-10 Finland
Follow-up examination after unspecified treatment for malignant neoplasm
15.3
7.7
12
8
E89.4
ICD-10 Finland
Postprocedural ovarian failure
45.7
7.7
9
*
JN2CM
NOMESCO Finland
Lower part of abdomen extensive MRI examination with Tesla magnet
45.7
7.7
9
*
N02BE01
ATC
paracetamol; systemic, rectal
2.0
7.7
448
3942
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
4.6
7.5
25
57
WF049
NOMESCO Finland
Radiotherapy of metastasis
5.2
7.5
22
44
LDC00
NOMESCO Finland
Conisation of cervix uteri using knife
81.2
7.4
8
*
KA3EB
NOMESCO Finland
Antegrade pyelography
81.2
7.4
8
*
TPH07
NOMESCO Finland
Cathetrisation of artery
2.6
7.3
53
217
8380/3-C53.9
ICD-O-3
Endometrioid adenocarcinoma, NOS, of cervix uteri
+∞
7.3
7
*
8560/3-C53.9
ICD-O-3
Adenosquamous carcinoma of cervix uteri
+∞
7.3
7
*
N82.0
ICD-10 Finland
Vesicovaginal fistula
+∞
7.3
7
*
LAG10
NOMESCO Finland
Oophoropexy
+∞
7.3
7
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
7.5
7.2
16
22
KBV10
NOMESCO Finland
Removal of stent from ureter
10.2
7.1
13
13
LCD01
NOMESCO Finland
Total laparoscopic hysterectomy
3.6
6.9
29
83
PJ5AN
NOMESCO Finland
Localisation of sentinell lymphnode with isotope imaging
4.0
6.9
26
68
Z08.7
ICD-10 Finland
Follow-up examination after combined treatment for malignant neoplasm
10.2
6.6
12
12
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.2
6.5
62
296
JN4AD
NOMESCO Finland
Body CT examination
2.9
6.5
37
132
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.2
6.3
61
292
D39.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Uterus
9.4
6.3
12
13
C53.80
ICD-10 Finland
Overall malignant tumor of the cervix uteri without histology
+∞
6.3
6
*
8010/3-C53.9
ICD-O-3
Carcinoma, NOS, of cervix uteri
+∞
6.3
6
*
LDW96
NOMESCO Finland
Other operation on cervix uteri
27.0
6.2
8
*
KBJ10
NOMESCO Finland
Cutaneous ureteroenterostomy
27.0
6.2
8
*

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_CERVIX_UTERI – Malignant neoplasm of cervix uteri

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).