Adenocarcinomas of cervix, excluding all cancers (controls excluding all cancers)

C3_CERVIX_ADENO_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 C53
  • Cancer registry: Morphology ICD-O-3 8140
  • Cancer registry: Behaviour codes 3

1 out of 7 registries used, show all original rules.

150

4. Check minimum number of events

None

150

5. Include endpoints

None

150

6. Filter based on genotype QC (FinnGen only)

150

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Adenocarcinomas of cervix, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 150 150 -
Unadjusted period prevalence (%) 0.05 0.05 -
Median age at first event (years) 42.97 42.97 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
154
Matched controls
1540
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C53.02
ICD-10 Finland
Adenocarcinoma of the endocervix
+∞
135.0
109
*
8140/3-C53.9
ICD-O-3
Adenocarcinoma, NOS, of cervix uteri
+∞
112.8
94
*
128
Kela drug reimbursment
Cancers of female genital organs
+∞
59.3
53
*
8140/3-C53.0
ICD-O-3
Adenocarcinoma, NOS, of endocervix
+∞
54.5
49
*
ULA02
NOMESCO Finland
Kolposcopy
17.5
51.5
96
133
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
24.4
49.4
74
56
PJD64
NOMESCO Finland
Laparoscopic dissection of iliac lymph nodes
+∞
42.7
39
*
LCD31
NOMESCO Finland
Radical laparoscopic hysterectomy
+∞
40.4
37
*
C53.12
ICD-10 Finland
Adenocarcinoma of the exocervix
+∞
40.4
37
*
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
11.4
38.5
88
161
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
11.9
37.3
80
128
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
34.7
32
*
H02AB02
ATC
dexamethasone; systemic
46.8
32.5
39
11
ZXC96
NOMESCO Finland
Robot assisted procedure
387.2
32.1
31
*
PJA01
NOMESCO Finland
Laparoscopic sentinel node excision
+∞
31.3
29
*
LEB00
NOMESCO Finland
Biopsy of vagina
40.0
29.8
37
12
WF002
NOMESCO Finland
Radical radiotherapy
324.8
27.7
27
*
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
10.3
27.3
59
87
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
73.8
27.1
30
5
B01AB10
ATC
tinzaparin; parenteral
19.0
24.6
38
26
LAF11
NOMESCO Finland
Laparoscopic bilateral salpingo-oophorectomy
25.3
24.3
34
17
JN2DG
NOMESCO Finland
Very extensive MRI examination of lower part of abdoment with high intensity magnet
46.3
22.6
27
7
A04AA55
ATC
palonosetron, combinations; systemic
+∞
22.4
21
*
D06.0
ICD-10 Finland
Carcinoma in situ: Endocervix
134.2
22.2
23
*
LCD30
NOMESCO Finland
Radical hysterectomy
254.7
22.2
22
*
A03FA01
ATC
metoclopramide; systemic, rectal
7.0
22.2
64
142
JN4BD
NOMESCO Finland
Extensive body CT
18.6
22.0
34
23
XX3DW
NOMESCO Finland
Time consuming IT work
15.8
21.8
36
29
PJ5AQ
NOMESCO Finland
Sentinell lymphnode SPECT with low dose CT
+∞
21.3
20
*
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
21.3
20
*
LDA10
NOMESCO Finland
Curettage of cervix uteri
11.9
21.0
40
44
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
228.1
20.1
20
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
5.0
18.9
82
286
121
Kela drug reimbursment
Severe hypofunction of sexual glands
22.0
18.1
26
14
C53.00
ICD-10 Finland
Malignant tumor of endocervix without histology
+∞
18.1
17
*
A04AA02
ATC
granisetron; systemic, transdermal
107.6
18.0
19
*
TLW99
NOMESCO Finland
Other minor surgical procedure in gynaecology
16.8
17.6
28
20
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
17.0
16
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
17.0
16
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
17.0
16
*
B01AB05
ATC
enoxaparin; parenteral
4.5
16.1
73
256
ZX095
NOMESCO Finland
Combined chemoradiotherapy
+∞
15.9
15
*
C53.0
ICD-10 Finland
Malignant neoplasm: Endocervix
+∞
15.9
15
*
C53.01
ICD-10 Finland
Squamous cell carcinoma of the endocervix
+∞
15.9
15
*
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
12.9
15.8
28
26
JN2CG
NOMESCO Finland
Extensive MRI examination of lower part of abdoment with high intensity magnet
20.5
15.7
23
13
A04AA01
ATC
ondansetron; systemic, rectal
14.0
15.3
26
22
YJ2VG
NOMESCO Finland
MRI examination of pelvis with high intensity magnet for dose design of radiotherapy
+∞
14.8
14
*
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
59.1
14.1
16
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
152.9
13.7
14
*
PJD54
NOMESCO Finland
Block dissection of iliac lymph nodes
152.9
13.7
14
*
ZX020
NOMESCO Finland
HDR radiotherapy within tissue
+∞
12.7
12
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
12.7
12
*
PJ5AN
NOMESCO Finland
Localisation of sentinell lymphnode with isotope imaging
+∞
12.7
12
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
12.7
12
*
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
4.4
11.9
48
143
LCA06
NOMESCO Finland
Biopsy of endometrium
4.5
11.6
46
134
8140/3-C53.1
ICD-O-3
Adenocarcinoma, NOS, of exocervix
+∞
11.6
11
*
C53.09
ICD-10 Finland
Malignant tumor of endocervix, unspecified histology
+∞
11.6
11
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
+∞
11.6
11
*
ZX040
NOMESCO Finland
Intracavity HDR radiotherapy
+∞
11.6
11
*
A04AD12
ATC
aprepitant; systemic
+∞
11.6
11
*
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
30.5
10.9
14
5
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
117.7
10.6
11
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
10.5
10
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
10.5
10
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
10.5
10
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.8
10.1
49
170
WZC30
NOMESCO Finland
Teaching
5.5
9.9
30
65
ZXE30
NOMESCO Finland
More than five and less than seven hours
11.2
9.8
18
18
WX402
NOMESCO Finland
General anaesthesia
4.3
9.8
39
113
C53.11
ICD-10 Finland
Squamous cell carcinoma and exocervix
+∞
9.5
9
*
C53
ICD-10 Finland
Malignant neoplasm of cervix uteri
+∞
9.5
9
*
C53.92
ICD-10 Finland
Adenocarcinoma in an unspecified location in the cervix
+∞
9.5
9
*
1800A
ICD-9 Finland
Malignant neoplasm of cervix uteri, Endocervix
+∞
9.5
9
*
UKC02
NOMESCO Finland
Cystoscopy
4.5
8.5
31
82
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
95.0
8.5
9
*
I89.0
ICD-10 Finland
Lymphoedema, not elsewhere classified
95.0
8.5
9
*
ZXE20
NOMESCO Finland
More than three and less than five hours
4.6
8.5
30
77
8310
FHL
Radical hysterectomy (includes lymph node removal)
+∞
8.4
8
*
TPH07
NOMESCO Finland
Cathetrisation of artery
6.6
8.3
21
36
WX302
NOMESCO Finland
Thoracal epidural anesthesy
9.8
8.3
16
18
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.7
8.2
80
437
YX9VG
NOMESCO Finland
Other MRI eamination with high intensity magnet for dose design of radiotherapy
+∞
7.3
7
*
C53.90
ICD-10 Finland
Malignant tumor in unspecified localization in cervix uteri without histology
+∞
7.3
7
*
C53.99
ICD-10 Finland
Malignant tumor in unspecified localization in cervix, unspecified histology
+∞
7.3
7
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
21.2
7.2
10
5
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
21.2
7.2
10
5
KBV12
NOMESCO Finland
Transluminal endoscopic removal of stent from ureter
31.6
7.2
9
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
8.9
7.0
14
17
P01AB01
ATC
metronidazole; oral, rectal
2.5
6.9
85
513
Z51.5
ICD-10 Finland
Palliative care
17.7
6.8
10
6
LBE10
NOMESCO Finland
Bilateral salpingectomy
42.0
6.8
8
*
8077/2-C53.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of cervix uteri
8.0
6.6
14
19
KBV15
NOMESCO Finland
Cystoscopic change of ureteral stent
72.7
6.5
7
*
KA1FN
NOMESCO Finland
Isotope renography
72.7
6.5
7
*
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
72.7
6.5
7
*
WW500
NOMESCO Finland
Blood transfusion
11.7
6.4
11
10
JN2BG
NOMESCO Finland
MRI examination of lower part of abdoment with high intensity magnet
19.0
6.3
9
5
C53.9
ICD-10 Finland
Malignant neoplasm: Cervix uteri, unspecified
+∞
6.3
6
*
YL1AD
NOMESCO Finland
CT examination of pelvis for dose design of radiotherapy
+∞
6.3
6
*
TKD00
NOMESCO Finland
Dilatation of urethra
+∞
6.3
6
*
YX9BD
NOMESCO Finland
Other extensive CT eamination for dose design of radiotherapy
+∞
6.3
6
*
C53.1
ICD-10 Finland
Malignant neoplasm: Exocervix
+∞
6.3
6
*
K52.0
ICD-10 Finland
Gastroenteritis and colitis due to radiation
+∞
6.3
6
*
JN5JS
NOMESCO Finland
Extensive PET-MRI of body metabolism
+∞
6.3
6
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
6.3
6
*
N02BE01
ATC
paracetamol; systemic, rectal
3.6
6.1
141
1157

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_CERVIX_ADENO_EXALLC – Adenocarcinomas of cervix, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).