Gastrointestinal stromal tumor and sarcoma, excluding all cancers (controls excluding all cancers)

C3_GASTRINT_STROM_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 ANY
  • Cancer registry: Morphology ICD-O-3 8936
  • Cancer registry: Behaviour codes ANY

1 out of 7 registries used, show all original rules.

363

4. Check minimum number of events

None

363

5. Include endpoints

None

363

6. Filter based on genotype QC (FinnGen only)

363

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 363 172 191
Unadjusted period prevalence (%) 0.07 0.06 0.08
Median age at first event (years) 67.14 65.24 68.84

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
338
Matched controls
3379
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
130
Kela drug reimbursment
Malignant tumour
+∞
177.1
154
*
189
Kela drug reimbursment
Imatinib
+∞
165.6
145
*
L01XE01
ATC
[U] imatinib; oral
+∞
139.5
124
*
D37.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Stomach
414.7
137.2
129
5
8936/1-C16.9
ICD-O-3
Gastrointestinal stromal tumor, NOS, of stomach, NOS
+∞
109.5
99
*
JDA63
NOMESCO Finland
Local excision of lesion of stomach
1350.3
105.1
97
*
C49.49
ICD-10 Finland
Malignant tumor of connective tissue and soft tissue of the abdomen other or unspecified tumor
+∞
95.4
87
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
10.7
85.5
245
665
JN4BD
NOMESCO Finland
Extensive body CT
25.6
82.4
119
70
JN3BD
NOMESCO Finland
Extensive abdominal CT
14.8
77.0
142
158
L01EA01
ATC
imatinib; oral (bcr-abl tyrosine kinase inhibitors)
+∞
66.9
62
*
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
42.2
65.2
81
25
316
Kela drug reimbursment
Imatinib
+∞
62.5
58
*
8936/3-C16.9
ICD-O-3
Gastrointestinal stromal tumor of stomach, NOS
+∞
61.3
57
*
D37.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Small intestine
222.7
55.8
56
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
27.7
51.5
71
32
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
+∞
50.3
47
*
C16.9
ICD-10 Finland
Malignant neoplasm: Stomach, unspecified
+∞
48.1
45
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
16.9
46.9
77
58
JN4AD
NOMESCO Finland
Body CT examination
17.9
46.8
75
53
WX408
NOMESCO Finland
General anesthesy, balanced
5.7
45.1
169
502
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
28.3
43.2
59
25
B01AB05
ATC
enoxaparin; parenteral
5.3
43.0
182
612
JFB00
NOMESCO Finland
Partial resection of small intestine
32.1
39.5
52
19
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
5.2
38.5
153
465
A03FA01
ATC
metoclopramide; systemic, rectal
6.6
37.5
110
231
JN3AD
NOMESCO Finland
Abdominal CT examination
9.8
36.9
79
102
XJD02
NOMESCO Finland
Peroral endoscopic ultrasonography
85.0
34.6
38
5
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
14.1
33.2
58
49
C61
ICD-10 Finland
Malignant neoplasm of prostate
342.9
31.4
31
*
JN4CD
NOMESCO Finland
Very extensive body CT
22.4
31.0
45
23
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
30.7
29
*
WZC30
NOMESCO Finland
Teaching
6.4
30.4
88
176
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
28.5
27
*
C17.9
ICD-10 Finland
Malignant neoplasm: Small intestine, unspecified
+∞
28.5
27
*
8936/1-C17.9
ICD-O-3
Gastrointestinal stromal tumor, NOS, of small intestine, NOS
+∞
28.5
27
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
22.0
28.2
41
21
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
27.5
26
*
A04AA02
ATC
granisetron; systemic, transdermal
152.1
27.0
28
*
WB501
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of primary tumour
+∞
26.4
25
*
A02BC02
ATC
pantoprazole; systemic
3.9
25.5
270
1715
TPH07
NOMESCO Finland
Cathetrisation of artery
6.0
24.8
74
151
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
257.4
24.0
24
*
197
Kela drug reimbursment
Sunitinib
+∞
23.2
22
*
H02AB02
ATC
dexamethasone; systemic
24.2
22.1
31
14
ZXE10
NOMESCO Finland
More than one and less than three hours
3.1
21.4
167
802
8936/3-C17.9
ICD-O-3
Gastrointestinal stromal tumor of small intestine, NOS
+∞
21.1
20
*
WD515
NOMESCO Finland
Demanding therapy of malignancy with enzyme inhibitors and similar treatments
+∞
21.1
20
*
B01AB10
ATC
tinzaparin; parenteral
9.1
21.0
45
56
JDW97
NOMESCO Finland
Other laparoscopic operation on stomach or duodenum
+∞
20.0
19
*
WX402
NOMESCO Finland
General anaesthesia
4.4
19.7
79
220
JAH00
NOMESCO Finland
Laparotomy
13.4
19.6
34
28
115
Kela drug reimbursment
Breast cancer
+∞
18.9
18
*
D37.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Digestive organ, unspecified
41.0
18.8
23
6
WF002
NOMESCO Finland
Radical radiotherapy
106.0
18.8
20
*
K92.1
ICD-10 Finland
Melaena
6.3
17.3
47
84
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
16.8
16
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
16.8
16
*
C16.29
ICD-10 Finland
Malignant tumor of the corpus ventriculi other or unspecified carcinoma
+∞
16.8
16
*
ZXE20
NOMESCO Finland
More than three and less than five hours
3.9
16.6
76
236
XX3DW
NOMESCO Finland
Time consuming IT work
6.3
16.6
45
80
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
16.4
189
1097
116
Kela drug reimbursment
Prostate cancer
+∞
15.7
15
*
L01XE04
ATC
[U] sunitinib; oral
+∞
15.7
15
*
C49.4
ICD-10 Finland
Malignant neoplasm: Connective and soft tissue of abdomen
+∞
15.7
15
*
C26.9
ICD-10 Finland
Malignant neoplasm: Ill-defined sites within the digestive system
+∞
15.7
15
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.0
15.6
44
82
UJF32
NOMESCO Finland
Coloscopy
2.8
15.6
123
565
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.8
15.3
70
216
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
16.0
15.1
24
16
C17.1
ICD-10 Finland
Malignant neoplasm: Jejunum
+∞
14.7
14
*
XW4AT
NOMESCO Finland
Biopsy of other inner organ with ultrasound guidance
+∞
14.7
14
*
JDC97
NOMESCO Finland
Laparoscopic partial gastrectomy with other reconstruction
+∞
14.7
14
*
WW500
NOMESCO Finland
Blood transfusion
10.4
14.0
27
28
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.1
13.7
83
317
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
13.6
13
*
C17.2
ICD-10 Finland
Malignant neoplasm: Ileum
+∞
13.6
13
*
322
Kela drug reimbursment
Sunitinib
+∞
13.6
13
*
R4190
NOMESCO Finland
Nutritional therapy
13.6
13.6
23
18
ZXC86
NOMESCO Finland
Use of endoscopic device
27.0
13.5
18
7
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
22.3
13.5
19
9
Z51.5
ICD-10 Finland
Palliative care
9.6
13.0
26
29
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
+∞
12.6
12
*
8936/1-C17.1
ICD-O-3
Gastrointestinal stromal tumor, NOS, of jejunum
+∞
12.6
12
*
L01BC06
ATC
capecitabine; oral
+∞
12.6
12
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
12.6
12
*
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
12.6
12
*
ZXE00
NOMESCO Finland
One hour or less
2.4
12.3
156
902
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.1
12.1
49
135
N02BE01
ATC
paracetamol; systemic, rectal
3.2
12.0
303
2477
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
11.1
11.9
22
21
A04AA01
ATC
ondansetron; systemic, rectal
10.2
11.9
23
24
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
7.3
11.9
28
41
ZXD10
NOMESCO Finland
Scheduled procedure
2.3
11.8
150
865
C16.09
ICD-10 Finland
Malignant tumor of cardiac or other unspecified carcinoma
+∞
11.5
11
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
11.5
11
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
11.5
11
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
11.5
11
*
8936/3-C26.9
ICD-O-3
Gastrointestinal stromal tumor of gastrointestinal tract, NOS
+∞
11.5
11
*
8936/1-C17.0
ICD-O-3
Gastrointestinal stromal tumor, NOS, of duodenum
+∞
11.5
11
*
L02AE02
ATC
leuprorelin; implant, parenteral
124.0
11.5
12
*
HA1AA
NOMESCO Finland
X-ray mammography
7.6
11.0
25
35
R4110
NOMESCO Finland
Physiotherapy
2.4
11.0
108
544
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
16.2
10.9
17
11
JFA73
NOMESCO Finland
Excision of lesion of small intestine
+∞
10.5
10
*
L01XX28
ATC
[D] imatinib; oral
+∞
10.5
10
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
10.5
10
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
33.7
10.4
13
*
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
5.7
10.2
29
55
R19.0
ICD-10 Finland
Intra-abdominal and pelvic swelling, mass and lump
8.5
10.0
21
26
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
9.2
9.9
20
23
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
9.8
74
318
JAL30
NOMESCO Finland
Omentectomy
56.6
9.7
11
*
L02BG04
ATC
letrozole; oral
56.6
9.7
11
*
D13.3
ICD-10 Finland
Benign neoplasm: Other and unspecified parts of small intestine
56.6
9.7
11
*
D64.9
ICD-10 Finland
Anaemia, unspecified
3.1
9.7
56
205
NK6AN
NOMESCO Finland
Total body bone isotope imaging
102.8
9.5
10
*
JDC96
NOMESCO Finland
Partial gastrectomy with other reconstruction
102.8
9.5
10
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
9.4
9
*
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
9.4
9
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
9.4
9
*
Y77
ICPC
Malignant neoplasm prostate
+∞
9.4
9
*
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
+∞
9.4
9
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
+∞
9.4
9
*
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
+∞
9.4
9
*
176
Kela drug reimbursment
Regorafenib
+∞
9.4
9
*
L01EX01
ATC
sunitinib; oral
+∞
9.4
9
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.2
9.4
129
750
JKA20
NOMESCO Finland
Cholecystectomy
6.6
9.3
23
37
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
37.8
9.1
11
*
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
37.8
9.1
11
*
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
5.5
8.8
25
48
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
14.5
8.8
14
10
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
8.6
82
401
JDH50
NOMESCO Finland
Local excision of lesion of duodenal bulb
92.2
8.5
9
*
B01AB04
ATC
dalteparin; parenteral
4.2
8.4
31
79
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.5
8.4
39
122
8936/1-C16.3
ICD-O-3
Gastrointestinal stromal tumor, NOS, of gastric antrum
+∞
8.4
8
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
8.4
8
*
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
8.4
8
*
8936/3-C17.1
ICD-O-3
Gastrointestinal stromal tumor of jejunum
+∞
8.4
8
*
HAC20
NOMESCO Finland
Total mastectomy
+∞
8.4
8
*
JDA32
NOMESCO Finland
Endoscopic injection in stomach or pylorus
+∞
8.4
8
*
8936/3-C16.2
ICD-O-3
Gastrointestinal stromal tumor of body of stomach
+∞
8.4
8
*
JDC20
NOMESCO Finland
Partial gastrectomy and Roux-en-Y reconstruction
+∞
8.4
8
*
Q85.00
ICD-10 Finland
Neurofibromatosis, type 1
+∞
8.4
8
*
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
4.0
8.0
31
83
N02AX02
ATC
tramadol; systemic, rectal
2.0
8.0
156
1031
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.1
7.9
44
155
UJD02
NOMESCO Finland
Gastroscopy
4.1
7.9
30
79
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
5.3
7.9
23
46
JMA10
NOMESCO Finland
Transabdominal total splenectomy
18.9
7.6
11
6
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
25.7
7.6
10
*
JFB30
NOMESCO Finland
Right hemicolectomy
25.7
7.6
10
*
JAL20
NOMESCO Finland
Excision or destruction of lesion of peritoneum
81.8
7.4
8
*
308
Kela drug reimbursment
Alprostadil, sildenafil and combination product containing aviptadil and phentolamine
81.8
7.4
8
*
JFB01
NOMESCO Finland
Laparoscopic partial resection of small intestine
81.8
7.4
8
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
81.8
7.4
8
*
D13.2
ICD-10 Finland
Benign neoplasm: Duodenum
13.8
7.4
12
9
WB303
NOMESCO Finland
Simple adjuvant therapy of malignancy with biomodifiers
+∞
7.3
7
*
C17.0
ICD-10 Finland
Malignant neoplasm: Duodenum
+∞
7.3
7
*
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
+∞
7.3
7
*
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
+∞
7.3
7
*
128
Kela drug reimbursment
Cancers of female genital organs
+∞
7.3
7
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
7.3
7
*
369
Kela drug reimbursment
Regorafenib
+∞
7.3
7
*
QX3AT
NOMESCO Finland
Ultrasound guided biopsy of subcutaneous tissue
+∞
7.3
7
*
C20.90
ICD-10 Finland
Malignant tumor of the rectum without histology
+∞
7.3
7
*
JDW96
NOMESCO Finland
Other operation on stomach or duodenum
+∞
7.3
7
*
8140/3-C20.9
ICD-O-3
Adenocarcinoma, NOS, of rectum, NOS
+∞
7.3
7
*
8936/1-C17.2
ICD-O-3
Gastrointestinal stromal tumor, NOS, of ileum
+∞
7.3
7
*
Q85.09
ICD-10 Finland
Unspecified neurofibromatosis
+∞
7.3
7
*
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
6.8
7.2
17
26
JAP00
NOMESCO Finland
Freeing of adhesions in the peritoneal cavity
20.5
7.2
10
5
R50.9
ICD-10 Finland
Fever, unspecified
2.6
7.1
52
220
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
9.1
7.1
14
16
N02AA05
ATC
oxycodone; systemic
2.6
7.0
53
227
WX892
NOMESCO Finland
Monitored bed care
3.1
6.9
36
124
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.9
6.7
26
70
WX600
NOMESCO Finland
Single shot through catheter
23.0
6.7
9
*
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
23.0
6.7
9
*
D37.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Rectum
23.0
6.7
9
*
C03CA01
ATC
furosemide; systemic
1.9
6.5
118
747
JAH01
NOMESCO Finland
Laparoscopy
4.8
6.4
20
44
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.7
6.4
26
74
C20.99
ICD-10 Finland
Malignant tumor of the rectum other or unspecified histology
+∞
6.3
6
*
C67.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bladder
+∞
6.3
6
*
KEC00
NOMESCO Finland
Retropubic radical prostatectomy
+∞
6.3
6
*
8936/1-C26.9
ICD-O-3
Gastrointestinal stromal tumor, NOS, of gastrointestinal tract, NOS
+∞
6.3
6
*
A79
ICPC
Malignancy NOS
+∞
6.3
6
*
WB203
NOMESCO Finland
Simple adjuvant hormone therapy of malignancy
+∞
6.3
6
*
L03AA02
ATC
filgrastim; parenteral
+∞
6.3
6
*
WB121
NOMESCO Finland
Demanding neoadjuvant cytostatic therapy
+∞
6.3
6
*
8936/1-C16.2
ICD-O-3
Gastrointestinal stromal tumor, NOS, of body of stomach
+∞
6.3
6
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
6.3
6
*
C16.39
ICD-10 Finland
Malignant tumor of the antrum ventriculi other or unspecified carcinoma
+∞
6.3
6
*
C16.19
ICD-10 Finland
Malignant tumor of the fundus ventriculi other or unspecified carcinoma
+∞
6.3
6
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
6.3
6
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
6.3
6
*
JDA22
NOMESCO Finland
Endoscopic ligature of varices of stomach
+∞
6.3
6
*
8936/1-C16.0
ICD-O-3
Gastrointestinal stromal tumor, NOS, of cardia, NOS
+∞
6.3
6
*
C16.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of stomach
+∞
6.3
6
*
J01MA12
ATC
levofloxacin; systemic
2.2
6.1
67
346
107
Kela drug reimbursment
Pernicious anaemia
6.9
6.1
14
21

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_GASTRINT_STROM_EXALLC – Gastrointestinal stromal tumor and sarcoma, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).