No definition available.
Acquired pure red cell aplasia [erythroblastopenia]
D3_ACQPUREREDCLLAPLASIA
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
158 |
4. Check minimum number of eventsNone |
158 |
5. Include endpointsNone |
158 |
6. Filter based on genotype QC (FinnGen only) |
158 |
Control definitions (FinnGen only)
- Control exclude
- D3_APLASTICANDOTHANAEMIA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D60-D64
- Name in latin
- Erythroblastopenia [pura] acquisita
Similar endpoints
↥List of similar endpoints to
Acquired pure red cell aplasia [erythroblastopenia]
based on the number of shared cases.
Similar with more cases:
- Aplastic and other anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1585 | 812 | 763 |
| Only index persons | 1228 | 642 | 586 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 50.27 | 49.87 | 50.40 |
| Only index persons | 51.23 | 50.58 | 51.94 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 158 | 78 | 80 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | 61.35 | 56.48 | 66.11 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 146
- Matched controls
- 1458
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D60.9
ICD-10 Finland
Acquired pure red cell aplasia, unspecified
+∞
97.0
82
*
D64.9
ICD-10 Finland
Anaemia, unspecified
53.1
54.1
64
21
D60.0
ICD-10 Finland
Chronic acquired pure red cell aplasia
+∞
28.0
26
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.8
21.2
79
245
D60.1
ICD-10 Finland
Transient acquired pure red cell aplasia
+∞
20.3
19
*
122
Kela drug reimbursment
Aplastic anaemia
+∞
17.0
16
*
XW000
NOMESCO Finland
Bone marrow biopsy
14.1
15.3
26
22
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
10.9
14.5
28
31
D60.8
ICD-10 Finland
Other acquired pure red cell aplasias
+∞
13.8
13
*
D61.9
ICD-10 Finland
Aplastic anaemia, unspecified
+∞
12.7
12
*
WW500
NOMESCO Finland
Blood transfusion
13.4
12.3
21
18
UJF32
NOMESCO Finland
Coloscopy
3.8
11.4
58
214
UJF92
NOMESCO Finland
Capsular endoscopy
32.4
9.6
12
*
28404
ICD-8 Finland
Aplastic anaemia, Erythroblastopenia acquisita
+∞
8.4
8
*
L04AD01
ATC
ciclosporin; systemic
12.8
8.3
14
12
J01MA12
ATC
levofloxacin; systemic
3.3
7.6
42
159
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.8
7.5
63
315
D64.8
ICD-10 Finland
Other specified anaemias
31.7
7.2
9
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.1
6.9
27
77
A28
ICPC
Limited function/disability NOS
3.4
6.6
35
125
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
6.5
78
460
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.3
6.4
34
123
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
28.0
6.3
8
*
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
+∞
6.3
6
*
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
+∞
6.3
6
*
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
8.3
6.3
13
17
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
5.7
6.2
17
33
B82
ICPC
Anaemia other/unspecified
13.3
6.2
10
8
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.9
6.1
19
43
R50.9
ICD-10 Finland
Fever, unspecified
3.4
6.0
29
99
Mortality – FinRegistry
↥Association
Association between endpoint D3_ACQPUREREDCLLAPLASIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ACQPUREREDCLLAPLASIA | 2.385 [1.8, 3.16] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.612 |
During the follow-up period (1.1.1998 — 31.12.2019), 214 out of 643 females with D3_ACQPUREREDCLLAPLASIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ACQPUREREDCLLAPLASIA | 3.507 [2.19, 5.62] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 220 out of 570 males with D3_ACQPUREREDCLLAPLASIA died.
Mortality risk
Mortality risk for people of age
years, who have D3_ACQPUREREDCLLAPLASIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.271% | 0.578% |
| 5 | 1.616% | 3.729% |
| 10 | 4.04% | 9.649% |
| 15 | 7.368% | 16.673% |
| 20 | 12.727% | 26.796% |
Relationships between endpoints
↥Index endpoint: D3_ACQPUREREDCLLAPLASIA – Acquired pure red cell aplasia [erythroblastopenia]
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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