No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
291 |
4. Check minimum number of eventsNone |
291 |
5. Include endpointsNone |
291 |
6. Filter based on genotype QC (FinnGen only) |
291 |
Control definitions (FinnGen only)
- Control exclude
- D3_NUTRIANAEMIA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D50-D53
- Name in latin
- Anaemia ex deficientia folatorum
Similar endpoints
↥List of similar endpoints to
Folate deficiency anaemia
based on the number of shared cases.
Similar with more cases:
- Nutritional anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2872 | 1482 | 1356 |
| Only index persons | 2205 | 1156 | 1049 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 72.84 | 75.31 | 70.14 |
| Only index persons | 72.08 | 74.17 | 69.79 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 291 | 121 | 170 |
| Unadjusted period prevalence (%) | 0.06 | 0.04 | 0.07 |
| Median age at first event (years) | 65.92 | 60.45 | 69.82 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 250
- Matched controls
- 2500
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D52.9
ICD-10 Finland
Folate deficiency anaemia, unspecified
4077.6
185.9
156
*
D52.0
ICD-10 Finland
Dietary folate deficiency anaemia
+∞
64.4
59
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
28.7
36.1
49
21
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.2
31.6
132
440
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
126.1
31.5
33
*
D64.9
ICD-10 Finland
Anaemia, unspecified
7.8
30.9
79
140
D52.8
ICD-10 Finland
Other folate deficiency anaemias
+∞
23.3
22
*
B03BA03
ATC
hydroxocobalamin; parenteral
11.0
23.0
45
49
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
51.1
16.3
19
*
107
Kela drug reimbursment
Pernicious anaemia
+∞
13.7
13
*
XW000
NOMESCO Finland
Bone marrow biopsy
9.1
13.5
28
34
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
5.9
12.4
35
67
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.3
12.2
70
263
B81
ICPC
Anaemia vit B12/folate deficiency
10.4
12.0
23
24
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.9
12.0
53
162
E87.6
ICD-10 Finland
Hypokalaemia
8.2
11.0
24
32
AA1AD
NOMESCO Finland
CT of head and brain
2.8
10.6
82
372
D53.1
ICD-10 Finland
Other megaloblastic anaemias, not elsewhere classified
+∞
10.5
10
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
10.0
128
761
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
5.9
9.8
27
50
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.0
9.8
61
240
N17.9
ICD-10 Finland
Acute renal failure, unspecified
6.7
9.7
24
39
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.5
9.5
96
500
A02BC02
ATC
pantoprazole; systemic
2.4
9.5
171
1187
D52.1
ICD-10 Finland
Drug-induced folate deficiency anaemia
+∞
9.4
9
*
C03CA01
ATC
furosemide; systemic
2.4
9.2
101
550
R53
ICD-10 Finland
Malaise and fatigue
2.7
8.8
68
305
UJF30
NOMESCO Finland
Ileoscopy through colon
4.2
8.8
33
87
H02AB06
ATC
prednisolone; systemic
2.2
8.6
128
798
WW500
NOMESCO Finland
Blood transfusion
6.6
8.5
21
34
28120
ICD-8 Finland
Other vitamin B12 deficiency anaemia, Folic acid deficiency anaemia
+∞
8.4
8
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.1
8.1
45
163
JN3AD
NOMESCO Finland
Abdominal CT examination
3.7
7.6
33
99
D50.8
ICD-10 Finland
Other iron deficiency anaemias
82.4
7.5
8
*
E55.9
ICD-10 Finland
Vitamin D deficiency, unspecified
82.4
7.5
8
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
7.3
91
513
A04
ICPC
Weakness/tiredness general
3.0
6.9
42
160
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
11.4
6.9
12
11
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
6.8
80
437
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.6
6.8
51
221
L28
ICPC
Limited function/disability (L)
2.5
6.7
54
245
I50.9
ICD-10 Finland
Heart failure, unspecified
2.5
6.6
53
239
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.8
6.6
27
78
N06AX11
ATC
mirtazapine; oral
2.1
6.5
85
486
A41.9
ICD-10 Finland
Sepsis, unspecified
5.1
6.4
19
40
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.2
6.3
77
426
E86
ICD-10 Finland
Volume depletion
5.3
6.3
18
36
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
7.3
6.3
14
20
C07AB07
ATC
bisoprolol; oral
2.0
6.3
127
859
JN4AD
NOMESCO Finland
Body CT examination
3.5
6.3
28
87
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.6
6.2
46
199
A46
ICD-10 Finland
Erysipelas
2.6
6.2
45
192
N05AH04
ATC
quetiapine; oral
2.6
6.0
44
188
Mortality – FinRegistry
↥Association
Association between endpoint D3_ANAEMIA_FOLATEDEF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ANAEMIA_FOLATEDEF | 2.382 [1.91, 2.97] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.288 |
During the follow-up period (1.1.1998 — 31.12.2019), 554 out of 967 females with D3_ANAEMIA_FOLATEDEF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ANAEMIA_FOLATEDEF | 2.386 [1.81, 3.15] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 489 out of 830 males with D3_ANAEMIA_FOLATEDEF died.
Mortality risk
Mortality risk for people of age
years, who have D3_ANAEMIA_FOLATEDEF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.183% | 0.443% |
| 5 | 1.258% | 2.584% |
| 10 | 3.126% | 6.782% |
| 15 | 6.507% | 13.05% |
| 20 | 11.211% | 21.332% |
Relationships between endpoints
↥Index endpoint: D3_ANAEMIA_FOLATEDEF – Folate deficiency anaemia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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