No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
887 |
4. Check minimum number of eventsNone |
887 |
5. Include endpointsNone |
887 |
6. Filter based on genotype QC (FinnGen only) |
887 |
Control definitions (FinnGen only)
- Control exclude
- F5_PSYCHDEV
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- F80-F89
- Name in latin
- Perturbationes progressus specificae mixtae
Similar endpoints
↥List of similar endpoints to
Mixed specific developmental disorders
based on the number of shared cases.
Similar with more cases:
- Disorders of psychological development
- Any mental disorder
- Psychiatric diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 32334 | 9898 | 22428 |
| Only index persons | 24048 | 7389 | 16659 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.52 | 0.28 | 0.63 |
| Only index persons | 0.52 | 0.27 | 0.64 |
| Median age at first event (years) | |||
| Whole population | 5.94 | 6.11 | 5.86 |
| Only index persons | 6.45 | 6.68 | 6.35 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 887 | 377 | 510 |
| Unadjusted period prevalence (%) | 0.18 | 0.13 | 0.22 |
| Median age at first event (years) | 6.63 | 7.37 | 6.09 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 727
- Matched controls
- 7031
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F83
ICD-10 Finland
Mixed specific developmental disorders
+∞
323.0
728
*
F82
ICD-10 Finland
Specific developmental disorder of motor function
237.6
121.2
123
6
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
124.7
119.8
128
12
XA800
NOMESCO Finland
Neuropsychological investigation
18.8
113.8
183
123
R62.0
ICD-10 Finland
Delayed milestone
24.1
107.6
158
80
F80.1
ICD-10 Finland
Expressive language disorder
279.2
99.1
100
*
F81.3
ICD-10 Finland
Mixed disorder of scholastic skills
1000.7
93.9
91
*
Z2445
NOMESCO Finland
Psychologist
7.5
77.9
208
358
F80.2
ICD-10 Finland
Receptive language disorder
268.6
73.9
75
*
F80.9
ICD-10 Finland
Developmental disorder of speech and language, unspecified
186.6
67.4
70
*
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
17.8
62.7
101
63
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
6.4
62.0
184
355
Z01.1
ICD-10 Finland
Examination of ears and hearing
4.9
58.5
229
607
N03AG01
ATC
valproic acid; systemic, rectal
8.8
56.4
129
168
F84.9
ICD-10 Finland
Pervasive developmental disorder, unspecified
287.6
54.2
55
*
F70.1
ICD-10 Finland
Mild mental retardation, Significant impairment of behaviour requiring attention or treatment
194.9
54.0
56
*
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
5.9
53.1
165
332
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
7.6
52.6
132
198
N05AX08
ATC
risperidone; systemic
7.2
51.7
136
218
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
22.2
46.7
69
33
F90.0
ICD-10 Finland
Disturbance of activity and attention
5.6
46.4
149
308
N06BA04
ATC
methylphenidate; oral
6.3
45.2
131
238
Z2446
NOMESCO Finland
Social worker
4.3
44.5
189
525
Z3226
NOMESCO Finland
Physiotherapist
3.7
43.3
231
784
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
6.9
43.3
115
185
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.7
42.9
227
762
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
6.1
39.4
116
213
Z50.5
ICD-10 Finland
Speech therapy
8.8
38.8
87
107
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.6
38.2
205
686
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
6.7
38.0
103
169
R4120
NOMESCO Finland
Occupational therapy
7.5
36.8
91
131
F70.9
ICD-10 Finland
Mild mental retardation, Without mention of impairment of behaviour
102.0
36.6
40
*
F81.9
ICD-10 Finland
Developmental disorder of scholastic skills, unspecified
39.4
36.4
46
12
F84.5
ICD-10 Finland
Asperger syndrome
128.8
35.5
38
*
Z31.5
ICD-10 Finland
Genetic counselling
5.5
35.0
111
222
N05BA01
ATC
diazepam; systemic, rectal
5.2
33.5
113
242
183
Kela drug reimbursment
Lamotrigin and topiramate
15.9
33.3
55
36
F80.8
ICD-10 Finland
Other developmental disorders of speech and language
118.2
32.5
35
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
8.2
32.4
75
97
N05AX12
ATC
aripiprazole; systemic
5.6
32.1
100
195
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.0
31.9
222
886
N05BA09
ATC
clobazam; oral
12.6
30.8
56
46
R1260
NOMESCO Finland
Evaluation of communicative skills
20.5
30.7
46
23
RL140
NOMESCO Finland
NA
22.0
30.7
45
21
F29
ICD-10 Finland
Unspecified nonorganic psychosis
5.6
30.6
94
180
F84.0
ICD-10 Finland
Childhood autism
+∞
30.0
29
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
9.3
29.5
63
71
SPAT1365
SPAT
Health check-up performed during first study year due to special need in students of upper secondary schools or vocational schools
14.7
29.5
50
35
N03AX14
ATC
levetiracetam; systemic
8.7
28.9
64
77
N03AX09
ATC
lamotrigine; oral
5.4
28.5
91
182
F84.8
ICD-10 Finland
Other pervasive developmental disorders
+∞
27.9
27
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.1
27.7
116
307
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
3.4
27.5
148
484
N03AF02
ATC
oxcarbazepine; oral
7.0
26.9
69
104
P85
ICPC
Mental retardation
20.4
26.7
40
20
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.2
26.3
108
280
RT150
NOMESCO Finland
NA
15.7
26.1
43
28
EBA15
NOMESCO Finland
Extraction of large number of teeth
8.1
25.5
59
76
N05AH03
ATC
olanzapine; systemic
4.6
24.9
92
215
ZXD10
NOMESCO Finland
Scheduled procedure
2.4
24.9
278
1427
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.9
24.7
110
307
N05AH04
ATC
quetiapine; oral
2.9
24.4
172
676
RL130
NOMESCO Finland
NA
16.5
24.2
39
24
Z01.8
ICD-10 Finland
Other specified special examinations
3.0
24.2
165
635
RT160
NOMESCO Finland
NA
18.8
24.1
37
20
Z3231
NOMESCO Finland
Registered nurse
2.3
23.0
284
1517
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
12.6
22.8
41
33
R4110
NOMESCO Finland
Physiotherapy
2.7
22.8
192
835
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
5.4
22.1
69
134
N03AX11
ATC
topiramate; oral
8.1
22.0
50
63
N05CD08
ATC
midazolam; nasal, systemic
6.9
21.9
56
84
H50.31
ICD-10 Finland
Intermittent exotropia
8.2
21.7
49
61
ZXE00
NOMESCO Finland
One hour or less
2.2
21.4
311
1777
R1410
NOMESCO Finland
Drawing up a rehabilitation plan
23.2
21.0
30
13
WZB00
SPAT
NA
0.1
20.7
11
760
ZXE10
NOMESCO Finland
More than one and less than three hours
2.3
20.5
236
1202
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.6
20.3
74
170
RT490
NOMESCO Finland
NA
27.0
19.8
27
10
ZXE20
NOMESCO Finland
More than three and less than five hours
3.2
19.7
111
371
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.6
19.5
71
163
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
3.3
19.5
104
334
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
19.0
231
1201
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
7.5
18.9
45
61
F81.8
ICD-10 Finland
Other developmental disorders of scholastic skills
54.7
18.7
22
*
Z2221
NOMESCO Finland
Medical doctor
2.3
18.7
212
1063
F89
ICD-10 Finland
Unspecified disorder of psychological development
+∞
18.6
18
*
R1250
NOMESCO Finland
Evaluation of functional capability
11.8
18.5
34
29
P24
ICPC
Specific learning problem
5.4
18.2
56
107
R4130
NOMESCO Finland
Speech therapy
8.5
18.2
40
48
R1210
NOMESCO Finland
Medical assessment of need and possibilities to rehabilitation
10.1
18.1
36
36
K03.66
ICD-10 Finland
Tooth plaque
2.7
17.9
136
549
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
3.3
17.7
94
300
A28
ICPC
Limited function/disability NOS
4.2
17.1
67
166
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
10.1
16.7
33
33
F79.1
ICD-10 Finland
Unspecified mental retardation, significant impairment of behaviour requiring attention or treatment
62.7
16.5
19
*
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
3.3
16.4
86
272
F70
ICD-10 Finland
Mild mental retardation
89.0
16.4
18
*
H52.0
ICD-10 Finland
Hypermetropia
4.6
16.2
57
127
Z3229
NOMESCO Finland
Other healthcare associate professional
3.0
16.2
99
347
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
3.8
16.0
70
191
ZY010
NOMESCO Finland
Hospital outpatient
2.9
16.0
107
400
H01AC01
ATC
somatropin; parenteral
5.4
15.9
48
90
Q87.88
ICD-10 Finland
Other specified congenital malformation syndromes, not elsewhere classified
29.8
15.9
21
7
F71.0
ICD-10 Finland
Moderate mental retardation, with the statement of no, or minimal, impairment of behaviour
24.3
15.8
22
9
F79.9
ICD-10 Finland
Unspecified mental retardation, without mention of impairment of behaviour
20.8
15.8
23
11
N03AX18
ATC
lacosamide; systemic
13.5
15.7
27
20
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.9
15.7
67
179
RS222
NOMESCO Finland
NA
7.5
15.7
37
50
RT420
NOMESCO Finland
NA
33.0
15.5
20
6
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
11.2
15.5
29
26
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
4.4
15.3
57
134
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
5.2
15.2
48
95
SPAT1234
SPAT
Support of social functional capacity
6.6
15.1
39
60
N05AH02
ATC
clozapine; systemic
6.1
15.0
41
68
WX002
NOMESCO Finland
Sedation and analgesia
2.9
15.0
99
366
H81
ICPC
Excessive ear wax
3.3
14.8
78
248
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
3.1
14.5
83
279
Q93.5
ICD-10 Finland
Other deletions of part of a chromosome
+∞
14.4
14
*
N05AA02
ATC
levomepromazine; systemic
6.8
14.4
36
53
R5140
NOMESCO Finland
Monitoring the use of the aid
5.3
14.4
44
84
F88
ICD-10 Finland
Other disorders of psychological development
79.0
14.4
16
*
H52.2
ICD-10 Finland
Astigmatism
4.6
14.4
50
110
K04.5
ICD-10 Finland
Chronic apical periodontitis
2.7
14.3
102
396
IGV01
NOMESCO Finland
Psychiatric network contact
5.9
14.3
40
69
SPAT1229
SPAT
Assessment of need for aid
7.3
14.2
34
47
F81.0
ICD-10 Finland
Specific reading disorder
16.8
14.1
22
13
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.2
14.0
157
770
R5599
NOMESCO Finland
Other rehabilitation service
5.9
13.4
37
63
Z63.7
ICD-10 Finland
Other stressful life events affecting family and household
3.4
13.3
65
195
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
3.0
13.2
77
263
G40.4
ICD-10 Finland
Other generalized epilepsy and epileptic syndromes
9.0
13.0
27
30
XX4AW
NOMESCO Finland
NA
6.3
13.0
34
54
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.7
12.9
56
153
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
9.3
12.7
26
28
R1220
NOMESCO Finland
Psychological examination of need and possibilities to rehabilitation
4.6
12.7
44
97
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
3.1
12.7
72
241
XF400
NOMESCO Finland
ECG with 12 standard connections
2.3
12.6
130
613
IEV99
NOMESCO Finland
Other psychiatric network intervention
6.0
12.5
34
57
G91.1
ICD-10 Finland
Obstructive hydrocephalus
31.5
12.4
16
5
SPAT1396
SPAT
Meeting with multidisciplinary group of experts
4.3
12.4
46
109
DFF20
NOMESCO Finland
Audiometry for children
6.3
12.2
32
51
F20.9
ICD-10 Finland
Schizophrenia, unspecified
6.3
12.2
32
51
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
3.7
12.2
54
150
RS220
NOMESCO Finland
NA
5.4
12.1
36
67
T82
ICPC
Obesity
4.8
12.1
40
84
R62.9
ICD-10 Finland
Lack of expected normal physiological development, unspecified
36.9
12.0
15
*
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
3.0
11.8
71
246
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
3.7
11.7
52
145
SCA02
NOMESCO Finland
Analysis and advice of nutrition with regard to dentistry
1.8
11.7
244
1515
EBA05
NOMESCO Finland
Complicated extraction of tooth
2.4
11.6
105
462
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
4.1
11.6
45
111
ZYB04
NOMESCO Finland
Outreach service in patient’s home or everyday environment
10.4
11.5
22
21
H50.0
ICD-10 Finland
Convergent concomitant strabismus
5.6
11.5
33
59
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.7
11.5
356
2498
N06AB04
ATC
citalopram; systemic
2.8
11.5
75
275
113
Kela drug reimbursment
Anxiety disorders associated with mental retardation
63.8
11.5
13
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
11.5
197
1143
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.6
11.4
90
367
N03AX22
ATC
perampanel; oral
18.6
11.4
17
9
N03AX15
ATC
zonisamide; oral
22.5
11.4
16
7
Z02.7
ICD-10 Finland
Issue of medical certificate
3.4
11.4
55
164
3153X
ICD-9 Finland
Specific delays in development, Developmental speech or language disorder[PUHEEN KEHITYKSEN ERITYISVAIKEUS]
+∞
11.3
11
*
3159X
ICD-9 Finland
Specific delays in development, Unspecified delay in development
+∞
11.3
11
*
F71.1
ICD-10 Finland
Moderate mental retardation, significant impairment of behaviour requiring attention or treatment
117.7
11.3
12
*
L28
ICPC
Limited function/disability (L)
3.1
11.3
64
214
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.8
11.1
280
1841
ADB00
NOMESCO Finland
Implantation of vagus nerve stimulating device
34.4
11.1
14
*
WX110
NOMESCO Finland
Local anesthesy
1.8
11.1
522
4137
H53.0
ICD-10 Finland
Amblyopia ex anopsia
4.9
11.0
35
71
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.8
10.9
71
259
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
3.7
10.9
47
128
Q99.8
ICD-10 Finland
Other specified chromosome abnormalities
13.7
10.8
18
13
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
10.7
117
563
N03AG04
ATC
vigabatrin; oral
11.7
10.6
19
16
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.1
10.6
129
653
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
2.7
10.6
74
284
F90.9
ICD-10 Finland
Hyperkinetic disorder, unspecified
6.4
10.6
27
42
P99
ICPC
Psychological disorders other
4.3
10.5
38
88
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.0
10.5
152
823
G47.3
ICD-10 Finland
Sleep apnoea
3.0
10.5
60
202
H50.30
ICD-10 Finland
Intermittent esotropy
6.3
10.4
27
43
KAY40
NOMESCO Finland
NA
0.1
10.4
*
352
G40.10
ICD-10 Finland
Simple partial seizures
9.9
10.3
20
20
RL720
NOMESCO Finland
NA
+∞
10.3
10
*
3153A
ICD-9 Finland
Specific delays in development, Developmental speech or language disorder[KIELENKEHITYKSEN ERITYISVAIKEUS]
+∞
10.3
10
*
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
6.5
10.3
26
40
T90
ICPC
Diabetes non-insulin dependent
4.2
10.2
38
91
331
Kela drug reimbursment
Atomoxetine, dexamphetamine, guanfacine and lisdexamphetamine
5.8
10.2
28
48
G40.11
ICD-10 Finland
Simple partial epileptic seizure that develops into a complex partial seizure
15.8
10.2
16
10
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
3.0
10.1
59
203
101
Kela drug reimbursment
Anterior pituitary hypofunction
5.7
10.0
28
49
P22
ICPC
Child behaviour symptom/complaint
3.4
10.0
48
143
F93.9
ICD-10 Finland
Childhood emotional disorder, unspecified
6.5
10.0
25
38
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.3
9.9
101
469
F80.0
ICD-10 Finland
Specific speech articulation disorder
7.8
9.9
22
28
SPAT1297
SPAT
Other function in accordance with speech therapy nomenclature
5.6
9.9
28
50
P29
ICPC
Psychological sympt/compl other
2.4
9.9
84
359
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
39.3
9.8
12
*
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
9.0
9.8
20
22
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.0
9.8
143
777
G80.2
ICD-10 Finland
Spastic hemiplegic cerebral palsy
16.4
9.7
15
9
C03CA01
ATC
furosemide; systemic
3.5
9.7
44
126
RS140
NOMESCO Finland
NA
8.0
9.6
21
26
WYA50
NOMESCO Finland
Student oral health check consistent with decree to assess need for oral health guidance and services
0.3
9.6
18
590
602
Kela drug reimbursment
Children's severe malnutrition
3.6
9.5
42
117
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.9
9.5
158
896
UDC00
NOMESCO Finland
Ear microscopy
2.5
9.5
74
302
RT190
NOMESCO Finland
NA
13.1
9.5
16
12
XCK00
NOMESCO Finland
Perimetry
4.6
9.5
32
70
N05BA06
ATC
lorazepam; systemic, sublingual
5.5
9.4
27
49
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
4.8
9.4
30
62
Z72.8
ICD-10 Finland
Other problems related to lifestyle
8.9
9.3
19
21
N29
ICPC
Neurological sympt/complt other
7.0
9.3
22
31
E66.01
ICD-10 Finland
Obesity due to excess calories
2.8
9.3
61
223
AA1AD
NOMESCO Finland
CT of head and brain
2.5
9.3
74
303
3141A
ICD-9 Finland
Hyperkinetic syndrome of childhood, Hyperkinesis with developmental delay
+∞
9.3
9
*
F90.1
ICD-10 Finland
Hyperkinetic conduct disorder
17.2
9.2
14
8
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
5.3
9.1
27
51
EBA00
NOMESCO Finland
Extraction of tooth
1.6
9.1
297
2071
N06BA09
ATC
atomoxetine; oral
8.5
9.1
19
22
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
4.4
9.1
32
73
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.8
9.1
203
1271
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.5
9.1
41
117
R11
ICD-10 Finland
Nausea and vomiting
2.3
9.0
83
367
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
3.5
9.0
41
118
U07.2
ICD-10 Finland
COVID-19, virus not identified
0.5
8.9
59
1133
F80
ICD-10 Finland
Specific developmental disorders of speech and language
35.9
8.9
11
*
F95.2
ICD-10 Finland
Combined vocal and multiple motor tic disorder [de la Tourette]
15.3
8.9
14
9
RS312
NOMESCO Finland
NA
15.3
8.9
14
9
SPAT1262
SPAT
Handing over of treatment supplies
2.5
8.9
70
288
A10BA02
ATC
metformin; oral
3.2
8.9
46
146
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
6.2
8.9
23
37
G40.89
ICD-10 Finland
Other epilepsy
8.9
8.8
18
20
ZXA00
NOMESCO Finland
Right side
2.2
8.8
96
461
N03AF01
ATC
carbamazepine; oral, rectal
7.3
8.7
20
27
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
2.8
8.7
56
205
OAB43
SPAT
NA
0.4
8.7
31
754
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
12.3
8.7
15
12
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
4.4
8.6
30
68
K02.1
ICD-10 Finland
Caries of dentine
1.6
8.5
451
3544
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
2.6
8.5
62
244
SAA03
NOMESCO Finland
Extended examination of mouth
1.6
8.5
402
3071
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
6.5
8.5
21
32
ZXA05
NOMESCO Finland
Left side
2.2
8.4
91
434
UJD02
NOMESCO Finland
Gastroscopy
5.0
8.4
26
52
F60.9
ICD-10 Finland
Personality disorder, unspecified
8.1
8.4
18
22
181
Kela drug reimbursment
Retigabine and vigabatrin
9.8
8.4
16
16
H50.1
ICD-10 Finland
Divergent concomitant strabismus
6.8
8.4
20
29
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
2.7
8.3
57
217
K00.40
ICD-10 Finland
Postnatal enamel hypoplasia
3.2
8.3
43
137
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.2
8.3
43
137
N06AB03
ATC
fluoxetine; oral
2.4
8.3
72
312
KAY20
NOMESCO Finland
NA
0.1
8.3
*
252
Q87.06
ICD-10 Finland
Velocardiofacial syndrome
+∞
8.2
8
*
SPAT1281
SPAT
Other administrative function
2.3
8.2
78
350
Z04.4
ICD-10 Finland
Examination and observation following alleged rape and seduction
6.6
8.2
20
30
P98
ICPC
Psychosis NOS/other
8.4
8.1
17
20
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
1.9
8.1
118
635
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
5.0
8.1
25
50
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
3.9
8.1
32
82
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.8
8.1
51
184
F98.8
ICD-10 Finland
Other specified behavioural and emotional disorders with onset usually occurring in childhood and adolescence
5.4
8.1
23
42
F92.8
ICD-10 Finland
Other mixed disorders of conduct and emotions
6.9
8.1
19
27
F91.3
ICD-10 Finland
Oppositional defiant disorder
14.2
8.1
13
9
K05.18
ICD-10 Finland
Chronic gingivitis
2.8
8.0
50
178
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
1.7
8.0
182
1142
SPAT1395
SPAT
Health check-up of persons outside student and working life
5.9
7.9
21
35
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.6
7.9
58
229
Q89.7
ICD-10 Finland
Multiple congenital malformations, not elsewhere classified
16.8
7.9
12
7
H47.2
ICD-10 Finland
Optic atrophy
16.8
7.9
12
7
SPAT1167
SPAT
Insertion of urinary catheter
21.5
7.9
11
5
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
3.0
7.8
45
153
H66.9
ICD-10 Finland
Otitis media, unspecified
1.8
7.8
155
931
N03AE01
ATC
clonazepam; systemic
4.5
7.8
26
57
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
7.7
119
656
TPH07
NOMESCO Finland
Cathetrisation of artery
2.4
7.7
65
276
-
ICD-10 Finland
NA
12.8
7.7
13
10
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.1
7.7
40
128
E11
ICD-10 Finland
Type 2 diabetes mellitus
6.0
7.7
20
33
IBZ06
NOMESCO Finland
Evaluation concerning developmental neuropsychiatry
6.0
7.7
20
33
SPAT1216
SPAT
Assessment of functional ability
2.4
7.7
62
259
P07.2
ICD-10 Finland
Extreme immaturity
43.9
7.6
9
*
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
4.6
7.6
25
54
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
3.0
7.6
43
144
C01AA05
ATC
digoxin; systemic
14.7
7.6
12
8
A06AD11
ATC
lactulose; oral
2.6
7.5
55
217
ZXD05
NOMESCO Finland
Urgent procedure
1.7
7.5
169
1053
T36
ICD-10 Finland
Poisoning by systemic antibiotics
2.9
7.5
44
153
N03AF03
ATC
rufinamide; oral
17.9
7.5
11
6
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
17.9
7.5
11
6
ZXD20
NOMESCO Finland
Day surgery
2.2
7.5
78
368
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
3.5
7.4
33
94
RF120
NOMESCO Finland
NA
7.9
7.4
16
20
XCD00
NOMESCO Finland
Clinical examination of eye in general anaesthesia
9.8
7.4
14
14
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.3
7.4
65
282
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
6.0
7.4
19
31
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.4
7.3
58
240
N05BE01
ATC
buspirone; oral
5.6
7.3
20
35
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.3
7.3
68
306
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
7.3
95
491
K05.10
ICD-10 Finland
Gingivitis (chronic) NOS
1.9
7.3
120
675
ZXA10
NOMESCO Finland
Bilateral
1.9
7.3
108
587
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.3
7.3
67
298
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.9
7.2
120
677
RS314
NOMESCO Finland
NA
13.1
7.2
12
9
RS311
NOMESCO Finland
NA
13.1
7.2
12
9
F98.00
ICD-10 Finland
Nonorganic enuresis nocturna
3.6
7.2
31
86
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
4.2
7.2
26
62
F92.9
ICD-10 Finland
Mixed disorder of conduct and emotions, unspecified
5.2
7.2
21
40
RS211
NOMESCO Finland
NA
5.5
7.2
20
36
XKD00
NOMESCO Finland
Uroflowmetry
2.8
7.2
43
152
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.9
7.2
102
546
N03AD01
ATC
ethosuximide; oral
10.6
7.2
13
12
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.7
7.1
49
186
Q53.2
ICD-10 Finland
Undescended testicle, bilateral
9.2
7.1
14
15
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
7.1
96
503
Z61.8
ICD-10 Finland
Other negative life events in childhood
6.7
7.1
17
25
K07.24
ICD-10 Finland
Open bite
3.3
7.0
34
104
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
19.5
7.0
10
5
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.6
7.0
48
183
F22.0
ICD-10 Finland
Delusional disorder
7.8
6.9
15
19
Z03
ICPC
Housing/neighbourhood problem
11.8
6.9
12
10
F93.80
ICD-10 Finland
Generalized anxiety in the bardom age
11.8
6.9
12
10
H65.3
ICD-10 Finland
Chronic mucoid otitis media
2.0
6.9
87
445
ZYC01
NOMESCO Finland
Remote contact by phone
2.5
6.9
52
210
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.6
6.9
198
1314
Q53.1
ICD-10 Finland
Undescended testicle, unilateral
5.2
6.9
20
38
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
9.8
6.9
13
13
M41.4
ICD-10 Finland
Neuromuscular scoliosis
9.8
6.9
13
13
N05AF03
ATC
chlorprothixene; systemic
5.5
6.9
19
34
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
3.4
6.9
31
90
F93.89
ICD-10 Finland
Other childhood emotional disorders
2.9
6.8
40
139
H02AB09
ATC
hydrocortisone; systemic
2.7
6.8
44
162
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
3.1
6.8
35
112
SDA02
NOMESCO Finland
Parodonthologic therapy
1.6
6.8
231
1600
N05BA04
ATC
oxazepam; oral
1.9
6.8
97
518
F28
ICD-10 Finland
Other nonorganic psychotic disorders
13.5
6.8
11
8
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.8
6.7
27
71
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
7.4
6.7
15
20
N05AD01
ATC
haloperidol; systemic
5.7
6.7
18
31
SPAT1389
SPAT
Visit based on need for special support
1.9
6.7
95
507
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
3.3
6.7
32
97
E34.39
ICD-10 Finland
Short stature, not elsewhere classified
4.0
6.7
25
62
Z29
ICPC
Social problem NOS
3.4
6.7
30
87
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
3.2
6.7
33
103
G40.21
ICD-10 Finland
Partial epileptic seizure with cloudiness and automatism
10.7
6.7
12
11
TLC00
NOMESCO Finland
Insertion of intrauterine device
2.9
6.7
38
129
N06AX16
ATC
venlafaxine; oral
2.1
6.7
75
367
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
3.5
6.7
29
82
N88
ICPC
Epilepsy
6.6
6.6
16
24
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
6.6
6.6
16
24
H52.3
ICD-10 Finland
Anisometropia and aniseikonia
9.1
6.6
13
14
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
4.3
6.6
23
53
WX402
NOMESCO Finland
General anaesthesia
1.8
6.6
128
759
ZXY82
NOMESCO Finland
Nurse in multidisciplinary team
4.9
6.6
20
40
KAY60
NOMESCO Finland
NA
0.0
6.6
*
157
Z13.4
ICD-10 Finland
Special screening examination for certain developmental disorders in childhood
22.0
6.6
9
*
F95.1
ICD-10 Finland
Chronic motor or vocal tic disorder
22.0
6.6
9
*
G81.1
ICD-10 Finland
Spastic hemiplegia
22.0
6.6
9
*
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
22.0
6.6
9
*
ZXE40
NOMESCO Finland
More than seven and less than nine hours
3.6
6.6
28
78
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
3.1
6.5
34
110
K59.0
ICD-10 Finland
Constipation
2.7
6.5
43
162
A41.9
ICD-10 Finland
Sepsis, unspecified
3.4
6.5
30
89
XX4BW
NOMESCO Finland
NA
7.6
6.5
14
18
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
6.5
62
282
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.0
6.4
87
456
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
5.4
6.4
18
33
SPAT1097
SPAT
Recording of ECG
2.8
6.4
39
140
R62.8
ICD-10 Finland
Other lack of expected normal physiological development
4.5
6.4
21
46
IBB01
NOMESCO Finland
Psychiatric functioning capacity evaluation
9.8
6.4
12
12
H13
ICPC
Plugged feeling ear
2.0
6.3
78
396
7819X
ICD-9 Finland
Symptoms involving nervous and musculoskeletal systems, Other symptoms involving nervous and musculoskeletal systems[SYMPTOMATA ALIA SYSTEMATIS NERVORUM ET MUSCULOSCEL]
14.0
6.3
10
7
F99
ICD-10 Finland
Mental disorder, not otherwise specified
3.6
6.3
26
71
201
Kela drug reimbursment
Chronic cardiac insufficiency
4.2
6.2
22
52
Z71.8
ICD-10 Finland
Other specified counselling
1.6
6.2
182
1209
SPAT1321
SPAT
Health examination of person liable for military service
0.5
6.2
63
1066
SPAT1240
SPAT
Therapeutic discussion
1.8
6.2
116
679
F80.3
ICD-10 Finland
Acquired aphasia with epilepsy [Landau-Kleffner]
+∞
6.2
6
*
7834D
ICD-9 Finland
Symptoms concerning nutrition, metabolism and development, Lack of expected normal physiological development[LAPSEN NORMAALIN KEHITTYMISEN HIDASTUMINEN]
+∞
6.2
6
*
H50.2
ICD-10 Finland
Vertical strabismus
10.8
6.2
11
10
199
Kela drug reimbursment
Rufinamide
17.6
6.2
9
5
F20.8
ICD-10 Finland
Other schizophrenia
17.6
6.2
9
5
G91.0
ICD-10 Finland
Communicating hydrocephalus
17.6
6.2
9
5
ZXE21
NOMESCO Finland
Procedure duration at least 3 but less than 4 hours
5.1
6.1
18
35
AA10D
NOMESCO Finland
NA
26.0
6.1
8
*
RS231
NOMESCO Finland
NA
26.0
6.1
8
*
S18
ICPC
Laceration/cut
1.6
6.1
202
1387
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.2
6.1
30
94
RS120
NOMESCO Finland
NA
6.9
6.1
14
20
EMB30
NOMESCO Finland
Adenotomy
1.7
6.0
121
723
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.8
6.0
37
134
SPAT1307
SPAT
Psychosocial counselling and guidance
1.8
6.0
110
641
TJD20
NOMESCO Finland
Change of gastrostomy tube
6.1
6.0
15
24
C07AB02
ATC
metoprolol; systemic
2.9
6.0
35
122
Mortality – FinRegistry
↥Association
Association between endpoint F5_MIXEDDEV and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_MIXEDDEV | 3.661 [2.58, 5.2] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.032 |
During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 8685 females with F5_MIXEDDEV died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_MIXEDDEV | 2.156 [1.77, 2.62] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 146 out of 19887 males with F5_MIXEDDEV died.
Mortality risk
Mortality risk for people of age
years, who have F5_MIXEDDEV.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.259% | 0.317% |
| 5 | 1.439% | 2.249% |
| 10 | 4.139% | 6.384% |
| 15 | 8.235% | 11.432% |
| 20 | 14.601% | 18.666% |
Relationships between endpoints
↥Index endpoint: F5_MIXEDDEV – Mixed specific developmental disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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