vascular dementia: A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
142327 |
4. Check minimum number of eventsNone |
142327 |
5. Include endpoints |
143658 |
6. Filter based on genotype QC (FinnGen only) |
143658 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF9
Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 1752582 | 883234 | 853645 |
Only index persons | 1407999 | 748063 | 659936 |
Unadjusted period prevalence (%) | |||
Whole population | 24.51 | 25.30 | 23.85 |
Only index persons | 26.42 | 27.50 | 25.19 |
Median age at first event (years) | |||
Whole population | 40.42 | 43.71 | 36.80 |
Only index persons | 37.04 | 39.98 | 33.71 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 143658 | 83681 | 59977 |
Unadjusted period prevalence (%) | 27.65 | 28.52 | 26.44 |
Median age at first event (years) | 42.36 | 38.89 | 47.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint KRA_PSY_ANYMENTAL and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
KRA_PSY_ANYMENTAL | 2.698 [2.51, 2.9] | < 0.001 |
Birth year | 0.983 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 143420 out of 609488 females with KRA_PSY_ANYMENTAL died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
KRA_PSY_ANYMENTAL | 3.194 [2.94, 3.48] | < 0.001 |
Birth year | 0.979 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 121373 out of 527573 males with KRA_PSY_ANYMENTAL died.
Mortality risk
Mortality risk for people of age
years, who have KRA_PSY_ANYMENTAL.N-year risk | Females | Males |
---|---|---|
1 | 0.117% | 0.245% |
5 | 0.699% | 1.727% |
10 | 1.767% | 4.522% |
15 | 3.293% | 8.573% |
20 | 5.577% | 14.132% |
Relationships between endpoints
↥Index endpoint: KRA_PSY_ANYMENTAL – Any mental disorder
GWS hits: 45