info icon

This is a non-core endpoint: only basic statistics are computed.

Organic amnesic syndrome, not induced by alcohol and other psychoactive substances

F5_ORGAMN

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 F04
  • Hospital discharge: ICD-9 2940
  • Cause of death: ICD-10 F04
  • Cause of death: ICD-9 2940

2 out of 7 registries used, show all original rules.

44

4. Check minimum number of events

None

44

5. Include endpoints

None

44

6. Filter based on genotype QC (FinnGen only)

44

Control definitions (FinnGen only)

Control exclude
F5_ORGANIC

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF3
Parent code in ICD-10
F04-F09
Name in latin
Syndroma amnesticum organicum non alcoholicum neque ab aliis substantiis psychotropicis inductum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 618 287 325
Only index persons 392 179 213
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 61.45 66.15 57.14
Only index persons 58.87 62.16 56.10

-FinnGen-

Key figures

All Female Male
Number of individuals 44 14 30
Unadjusted period prevalence (%) 0.01 0.00 0.01
Median age at first event (years) 56.85 58.26 56.20

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

Mortality – FinRegistry

Association

Association between endpoint F5_ORGAMN and mortality.

Females

Parameter HR [95% CI] p-value
F5_ORGAMN 2.828 [1.83, 4.37] < 0.001
Birth year 0.996 [0.99, 1.0] 0.35

During the follow-up period (1.1.1998 — 31.12.2019), 104 out of 182 females with F5_ORGAMN died.

Males

Parameter HR [95% CI] p-value
F5_ORGAMN 3.338 [2.2, 5.06] < 0.001
Birth year 0.991 [0.98, 1.0] 0.056

During the follow-up period (1.1.1998 — 31.12.2019), 116 out of 217 males with F5_ORGAMN died.

Mortality risk

Mortality risk for people of age

years, who have F5_ORGAMN.

N-year risk Females Males
1 0.201% 0.622%
5 1.661% 3.742%
10 4.01% 10.027%
15 7.3% 18.649%
20 13.199% 29.477%

Relationships between endpoints

Index endpoint: F5_ORGAMN – Organic amnesic syndrome, not induced by alcohol and other psychoactive substances

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data