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Pervasive developmental disorders excl. Autism + Asperger

DOID EFO Endpoint Browser PheWeb

F5_PERVASIVE

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F84
  • Hospital discharge: ICD-9 — 2998|2999B
  • Hospital discharge: excluded ICD-10 — F84.0, F84.1, F84.5
  • Cause of death: ICD-10 — F84
  • Cause of death: ICD-9 — 2998|2999B
  • Cause of death: excluded ICD-10 — F84.0, F84.1, F84.5

2 out of 7 registries used, show all original rules.

461

4. Check minimum number of events

None

461

5. Include endpoints

None

461

6. Filter based on genotype QC (FinnGen only)

461

Control definitions (FinnGen only)

Control exclude
F5_PSYCHDEV

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F80-F89
Name in latin
Perturbationes formationales pervasivae (in pueritia)

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13185 3541 9638
Only index persons 10180 2894 7286
Unadjusted period prevalence (%)
Whole population 0.22 0.10 0.27
Only index persons 0.23 0.11 0.28
Median age at first event (years)
Whole population 8.61 10.02 8.07
Only index persons 10.22 11.89 9.55

-FinnGen-

Key figures

All Female Male
Number of individuals 461 186 275
Unadjusted period prevalence (%) 0.10 0.06 0.12
Median age at first event (years) 12.92 16.09 10.77

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
401
Matched controls
3995
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F84.9
ICD-10 Finland
Pervasive developmental disorder, unspecified
+∞
323.0
279
*
F84.8
ICD-10 Finland
Other pervasive developmental disorders
+∞
164.0
146
*
F84.5
ICD-10 Finland
Asperger syndrome
833.8
127.8
119
*
F83
ICD-10 Finland
Mixed specific developmental disorders
+∞
88.8
82
*
N05AX08
ATC
risperidone; systemic
19.5
82.9
132
98
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
11.7
53.7
106
119
F84.0
ICD-10 Finland
Childhood autism
+∞
53.3
50
*
N05AX12
ATC
aripiprazole; systemic
12.1
48.0
92
96
Z2445
NOMESCO Finland
Psychologist
8.2
45.2
111
179
F29
ICD-10 Finland
Unspecified nonorganic psychosis
11.5
44.9
88
95
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
9.2
44.5
100
139
ZY010
NOMESCO Finland
Hospital outpatient
7.4
42.3
111
196
N05AH04
ATC
quetiapine; oral
5.6
42.2
145
365
N05AH03
ATC
olanzapine; systemic
9.7
41.6
90
116
Z2446
NOMESCO Finland
Social worker
6.1
41.6
130
290
XA800
NOMESCO Finland
Neuropsychological investigation
11.6
40.7
79
83
N06BA04
ATC
methylphenidate; oral
8.9
38.5
87
120
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
11.6
37.9
73
75
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
9.3
37.8
83
109
F90.0
ICD-10 Finland
Disturbance of activity and attention
7.2
37.4
99
174
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
5.9
36.9
116
256
R62.0
ICD-10 Finland
Delayed milestone
15.6
33.7
56
41
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
6.8
33.2
91
166
IGV01
NOMESCO Finland
Psychiatric network contact
17.2
33.2
53
35
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.6
32.9
136
401
F80.2
ICD-10 Finland
Receptive language disorder
119.2
31.1
33
*
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
14.0
30.5
53
43
F82
ICD-10 Finland
Specific developmental disorder of motor function
73.7
30.4
34
5
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
7.4
30.2
76
122
F80.9
ICD-10 Finland
Developmental disorder of speech and language, unspecified
167.0
30.1
31
*
ZYC01
NOMESCO Finland
Remote contact by phone
8.7
29.8
67
90
IEV99
NOMESCO Finland
Other psychiatric network intervention
21.7
29.4
43
22
N03AG01
ATC
valproic acid; systemic, rectal
7.8
29.4
71
107
Z3226
NOMESCO Finland
Physiotherapist
4.1
29.3
139
460
F88
ICD-10 Finland
Other disorders of psychological development
312.5
29.1
29
*
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
10.3
29.1
59
66
IGY99
NOMESCO Finland
Other psychiatric treatment contact
8.5
29.1
66
90
N06AB03
ATC
fluoxetine; oral
6.1
28.5
84
167
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
10.1
27.5
56
63
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
5.9
26.7
80
161
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
5.3
26.3
88
202
IBZ06
NOMESCO Finland
Evaluation concerning developmental neuropsychiatry
23.8
26.1
37
17
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
11.4
25.8
49
48
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
16.9
25.1
40
26
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
6.4
24.9
69
125
IGP01
NOMESCO Finland
Psychiatric family contact
9.2
24.8
53
65
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
6.9
24.5
64
107
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
17.3
24.1
38
24
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
6.0
23.8
70
137
F80.1
ICD-10 Finland
Expressive language disorder
242.5
22.8
23
*
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
10.8
22.1
43
44
F20.9
ICD-10 Finland
Schizophrenia, unspecified
16.5
21.9
35
23
Z2221
NOMESCO Finland
Medical doctor
3.1
21.6
148
627
IAB03
NOMESCO Finland
Neuropsychiatric consultation
+∞
21.0
20
*
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
3.9
20.5
95
296
IEP99
NOMESCO Finland
Other psychiatric family intervention
14.8
19.9
33
24
F93.89
ICD-10 Finland
Other childhood emotional disorders
9.9
19.8
40
44
N06AB06
ATC
sertraline; oral
4.6
19.7
73
184
N06AB04
ATC
citalopram; systemic
4.4
19.6
76
200
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
6.1
19.6
55
101
ZXY82
NOMESCO Finland
Nurse in multidisciplinary team
21.3
19.3
28
14
N05BA06
ATC
lorazepam; systemic, sublingual
13.7
19.2
33
26
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
15.8
19.2
31
21
F99
ICD-10 Finland
Mental disorder, not otherwise specified
11.8
19.1
35
32
IFA99
NOMESCO Finland
Other psychiatric pharmacotherapy service
19.9
18.9
28
15
R5599
NOMESCO Finland
Other rehabilitation service
10.8
18.8
36
36
N05BA01
ATC
diazepam; systemic, rectal
4.6
18.6
68
169
Z3231
NOMESCO Finland
Registered nurse
2.7
17.9
170
865
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
38.5
17.8
22
6
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
10.2
17.7
35
37
N06AX16
ATC
venlafaxine; oral
4.2
17.7
73
203
F80.8
ICD-10 Finland
Other developmental disorders of speech and language
99.2
17.7
19
*
F89
ICD-10 Finland
Unspecified disorder of psychological development
99.2
17.7
19
*
N05AH02
ATC
clozapine; systemic
11.1
17.5
33
32
IGY02
NOMESCO Finland
Psychiatric monitoring contact
5.6
17.2
52
104
RS140
NOMESCO Finland
NA
26.9
17.1
23
9
N05AD01
ATC
haloperidol; systemic
15.9
16.9
27
18
P29
ICPC
Psychological sympt/compl other
4.3
16.9
67
180
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.3
16.7
94
335
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
5.5
16.6
51
104
RT420
NOMESCO Finland
NA
176.5
16.6
17
*
P85
ICPC
Mental retardation
21.1
16.6
24
12
N03AX09
ATC
lamotrigine; oral
5.5
16.6
50
100
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
6.8
16.4
42
68
R4120
NOMESCO Finland
Occupational therapy
5.6
16.4
49
97
Z50.5
ICD-10 Finland
Speech therapy
6.6
16.1
42
70
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.4
16.0
60
152
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
10.7
15.7
30
30
F92.8
ICD-10 Finland
Other mixed disorders of conduct and emotions
23.1
15.7
22
10
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
5.0
15.7
52
116
G40.9
ICD-10 Finland
Epilepsy, unspecified
7.3
15.3
37
55
F92.9
ICD-10 Finland
Mixed disorder of conduct and emotions, unspecified
14.9
14.7
24
17
F81.3
ICD-10 Finland
Mixed disorder of scholastic skills
+∞
14.7
14
*
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
7.6
14.6
34
48
ZXY80
NOMESCO Finland
Doctor in multidisciplinary team
16.1
14.6
23
15
N05BA04
ATC
oxazepam; oral
3.2
14.5
85
312
IEP03
NOMESCO Finland
Focused parental counselling
8.5
14.3
31
39
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
6.0
14.3
40
73
IBA04
NOMESCO Finland
Extensive initial psychiatric evaluation
5.7
14.2
41
78
ZXE01
NOMESCO Finland
Procedure duration 0 to 9 minutes
9.6
13.9
28
31
F81.8
ICD-10 Finland
Other developmental disorders of scholastic skills
144.2
13.5
14
*
331
Kela drug reimbursment
Atomoxetine, dexamphetamine, guanfacine and lisdexamphetamine
12.0
13.5
24
21
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.3
13.3
51
132
Z01.1
ICD-10 Finland
Examination of ears and hearing
3.0
13.3
83
318
ICC01
NOMESCO Finland
Psychiatric treatment plan, transfer to psychiatric outpatient clinic
12.1
12.9
23
20
F84.2
ICD-10 Finland
Rett syndrome
+∞
12.5
12
*
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
5.9
12.5
35
64
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
3.4
12.5
65
218
F90.9
ICD-10 Finland
Hyperkinetic disorder, unspecified
11.0
12.4
23
22
N06AX12
ATC
bupropion; oral
4.0
12.3
50
137
R4130
NOMESCO Finland
Speech therapy
8.6
12.2
26
32
P99
ICPC
Psychological disorders other
6.1
12.2
33
58
ZY000
NOMESCO Finland
Hospital inpatient
7.4
12.0
28
40
RT150
NOMESCO Finland
NA
13.0
11.7
20
16
SPAT1389
SPAT
Visit based on need for special support
3.1
11.7
69
251
N05AE04
ATC
ziprasidone; systemic
31.0
11.7
15
5
F70.1
ICD-10 Finland
Mild mental retardation, Significant impairment of behaviour requiring attention or treatment
66.7
11.7
13
*
F60.9
ICD-10 Finland
Personality disorder, unspecified
11.6
11.6
21
19
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.8
11.6
50
144
IBA01
NOMESCO Finland
Diagnostic and symptom-mapping evaluation
5.0
11.5
37
80
113
Kela drug reimbursment
Anxiety disorders associated with mental retardation
+∞
11.5
11
*
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
4.4
11.5
42
104
RT160
NOMESCO Finland
NA
15.6
11.4
18
12
R1260
NOMESCO Finland
Evaluation of communicative skills
15.6
11.4
18
12
N05AN01
ATC
lithium; oral
9.3
11.4
23
26
ZYB04
NOMESCO Finland
Outreach service in patient’s home or everyday environment
13.2
11.2
19
15
RT490
NOMESCO Finland
NA
25.8
11.2
15
6
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
5.1
11.1
35
74
N03AF02
ATC
oxcarbazepine; oral
5.7
10.9
31
58
Z71.8
ICD-10 Finland
Other specified counselling
2.3
10.9
127
680
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
5.3
10.9
33
67
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.5
10.8
38
91
F79.1
ICD-10 Finland
Unspecified mental retardation, significant impairment of behaviour requiring attention or treatment
61.5
10.7
12
*
Z3229
NOMESCO Finland
Other healthcare associate professional
3.4
10.5
52
168
2998A
ICD-9 Finland
Psychoses with origin specific to childhood, Other specified early childhood psychoses[LAPSUUDEN LAAJA-ALAIN KEHITYSHÄIR,TÄYDEL OIREYHTYMÄ]
+∞
10.4
10
*
3159X
ICD-9 Finland
Specific delays in development, Unspecified delay in development
+∞
10.4
10
*
F84.4
ICD-10 Finland
Overactive disorder associated with mental retardation and stereotyped movements
+∞
10.4
10
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
9.1
10.4
21
24
N06AA04
ATC
clomipramine; systemic
19.3
10.3
15
8
ZXY83
NOMESCO Finland
Social worker in multidisciplinary team
13.5
10.2
17
13
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
7.2
10.2
24
35
F98.8
ICD-10 Finland
Other specified behavioural and emotional disorders with onset usually occurring in childhood and adolescence
8.8
10.2
21
25
R1210
NOMESCO Finland
Medical assessment of need and possibilities to rehabilitation
10.4
10.1
19
19
F79.9
ICD-10 Finland
Unspecified mental retardation, without mention of impairment of behaviour
20.6
9.8
14
7
IBZ02
NOMESCO Finland
Somatic assessment of psychiatric patient
20.6
9.8
14
7
IBB01
NOMESCO Finland
Psychiatric functioning capacity evaluation
20.6
9.8
14
7
P22
ICPC
Child behaviour symptom/complaint
4.1
9.6
37
97
ZYB05
NOMESCO Finland
Outreach service at patient’s workplace, school or occupational/school health care
30.7
9.4
12
*
ZXY60
NOMESCO Finland
2-person team, nurses
12.7
9.4
16
13
3153A
ICD-9 Finland
Specific delays in development, Developmental speech or language disorder[KIELENKEHITYKSEN ERITYISVAIKEUS]
+∞
9.4
9
*
N03AX11
ATC
topiramate; oral
6.3
9.3
24
40
F61.0
ICD-10 Finland
Mixed personality disorders
9.8
9.3
18
19
F42.2
ICD-10 Finland
Mixed obsessional thoughts and acts
9.8
9.3
18
19
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
4.0
9.3
37
100
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.1
9.1
52
186
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
9.3
9.1
18
20
ZXY01
NOMESCO Finland
Chief Physician, Head of Department or Deputy Chief Physician
9.3
9.1
18
20
RS312
NOMESCO Finland
NA
37.5
9.0
11
*
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
4.7
9.0
30
68
N05BA09
ATC
clobazam; oral
7.7
9.0
20
27
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.1
9.0
50
174
F81.0
ICD-10 Finland
Specific reading disorder
24.6
8.9
12
5
Z63.5
ICD-10 Finland
Disruption of family by separation and divorce
12.9
8.9
15
12
N03AE01
ATC
clonazepam; systemic
5.8
8.9
24
43
N06AB10
ATC
escitalopram; oral
2.3
8.9
91
454
R1250
NOMESCO Finland
Evaluation of functional capability
11.0
8.8
16
15
F93.9
ICD-10 Finland
Childhood emotional disorder, unspecified
11.0
8.8
16
15
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
8.8
78
362
ZXY57
NOMESCO Finland
2-person team, nurse-social worker
16.7
8.6
13
8
N06BA09
ATC
atomoxetine; oral
16.7
8.6
13
8
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
2.7
8.6
61
251
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.7
8.6
58
232
F20.8
ICD-10 Finland
Other schizophrenia
28.1
8.5
11
*
F91.3
ICD-10 Finland
Oppositional defiant disorder
28.1
8.5
11
*
RT190
NOMESCO Finland
NA
20.5
8.5
12
6
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
8.1
8.4
18
23
RL720
NOMESCO Finland
NA
+∞
8.3
8
*
F71.1
ICD-10 Finland
Moderate mental retardation, significant impairment of behaviour requiring attention or treatment
+∞
8.3
8
*
F40.1
ICD-10 Finland
Social phobias
4.2
8.3
31
79
IBA02
NOMESCO Finland
Evaluation of need for psychiatric rehabilitation
6.3
8.2
21
35
F21
ICD-10 Finland
Schizotypal disorder
14.8
8.2
13
9
IER04
NOMESCO Finland
Rehabilitative psychiatric group intervention, functional
7.8
8.2
18
24
F95.2
ICD-10 Finland
Combined vocal and multiple motor tic disorder [de la Tourette]
17.6
8.1
12
7
F81.9
ICD-10 Finland
Developmental disorder of scholastic skills, unspecified
34.0
8.1
10
*
N05AB03
ATC
perphenazine; systemic, rectal
6.8
8.0
19
29
Z31.5
ICD-10 Finland
Genetic counselling
3.3
7.9
39
126
RL140
NOMESCO Finland
NA
11.1
7.8
14
13
ZXY49
NOMESCO Finland
Other health care provider
9.7
7.8
15
16
N05AA02
ATC
levomepromazine; systemic
5.5
7.8
22
42
F93.80
ICD-10 Finland
Generalized anxiety in the bardom age
45.7
7.7
9
*
N03AF01
ATC
carbamazepine; oral, rectal
6.9
7.7
18
27
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.5
7.6
34
102
RS110
NOMESCO Finland
NA
18.7
7.6
11
6
XA820
NOMESCO Finland
NA
12.1
7.6
13
11
183
Kela drug reimbursment
Lamotrigin and topiramate
6.7
7.5
18
28
IEY01
NOMESCO Finland
Psychoeducation, individual
7.9
7.4
16
21
R4170
NOMESCO Finland
Therapy forms involving educational rehabilitation
81.3
7.4
8
*
ZXY54
NOMESCO Finland
2-person team, doctor-occupational therapist
81.3
7.4
8
*
ZXY03
NOMESCO Finland
Occupational therapist
13.7
7.4
12
9
IFB01
NOMESCO Finland
Electroconvulsive Therapy (ECT)
13.7
7.4
12
9
R5140
NOMESCO Finland
Monitoring the use of the aid
4.4
7.3
25
59
F39
ICD-10 Finland
Unspecified mood [affective] disorder
5.3
7.3
21
41
3153X
ICD-9 Finland
Specific delays in development, Developmental speech or language disorder[PUHEEN KEHITYKSEN ERITYISVAIKEUS]
+∞
7.3
7
*
F84
ICD-10 Finland
Pervasive developmental disorders
+∞
7.3
7
*
F84.3
ICD-10 Finland
Other childhood disintegrative disorder
+∞
7.3
7
*
2999A
ICD-9 Finland
Psychoses with origin specific to childhood, Unspecified[LAPSUUDEN LAAJA-AL.KEHITYSHÄIR,NUD,TÄYDEL OIREYHTYM]
+∞
7.3
7
*
H52.1
ICD-10 Finland
Myopia
3.4
7.3
34
106
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
4.0
7.2
27
70
RT130
NOMESCO Finland
NA
30.5
7.2
9
*
F94.9
ICD-10 Finland
Childhood disorder of social functioning, unspecified
30.5
7.2
9
*
IER05
NOMESCO Finland
Rehabilitative psychiatric group intervention, social skills
20.4
7.2
10
5
F34.1
ICD-10 Finland
Dysthymia
4.5
7.1
24
56
Z72.8
ICD-10 Finland
Other problems related to lifestyle
10.3
7.1
13
13
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.3
7.0
34
109
N05AF03
ATC
chlorprothixene; systemic
6.5
7.0
17
27
F33.4
ICD-10 Finland
Recurrent depressive disorder, currently in remission
5.6
7.0
19
35
IEZ99
NOMESCO Finland
Other psychiatric rehabilitation intervention
14.0
6.9
11
8
Z61.8
ICD-10 Finland
Other negative life events in childhood
11.2
6.8
12
11
N06AX03
ATC
mianserin; oral
9.5
6.8
13
14
F92.0
ICD-10 Finland
Depressive conduct disorder
9.5
6.8
13
14
F94.0
ICD-10 Finland
Elective mutism
40.6
6.8
8
*
F90.1
ICD-10 Finland
Hyperkinetic conduct disorder
17.0
6.8
10
6
N06AX21
ATC
duloxetine; oral
3.3
6.7
32
102
U07
ICPC
Urine symptom/complaint other
4.7
6.7
21
46
ZXE21
NOMESCO Finland
Procedure duration at least 3 but less than 4 hours
8.0
6.6
14
18
RL130
NOMESCO Finland
NA
10.2
6.6
12
12
IBB02
NOMESCO Finland
Psychiatric evaluation of working capacity and rehabilitation
10.2
6.6
12
12
ZXY52
NOMESCO Finland
2-person team, doctor-psychologist
10.2
6.6
12
12
RS220
NOMESCO Finland
NA
5.5
6.5
18
34
F84.10
ICD-10 Finland
Autism in atypical age
70.7
6.4
7
*
Z29
ICPC
Social problem NOS
4.5
6.4
21
48
P27
ICPC
Fear of mental disorder
6.7
6.4
15
23
F42.9
ICD-10 Finland
Obsessive-compulsive disorder, unspecified
6.7
6.4
15
23
K03.66
ICD-10 Finland
Tooth plaque
2.3
6.4
60
285
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
6.3
110
670
P28
ICPC
Limited function/disability (P)
11.2
6.3
11
10
ZXY81
NOMESCO Finland
Psychologist in multidisciplinary team
9.4
6.3
12
13
N06BA12
ATC
lisdexamfetamine; oral
9.4
6.3
12
13
N06AB05
ATC
paroxetine; oral
4.5
6.3
21
49
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
4.9
6.3
19
40
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
6.3
72
373
F41.8
ICD-10 Finland
Other specified anxiety disorders
4.2
6.3
22
54
N05AE05
ATC
lurasidone; oral
18.3
6.3
9
5
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
3.9
6.3
24
64
F94.8
ICD-10 Finland
Other childhood disorders of social functioning
+∞
6.3
6
*
2999B
ICD-9 Finland
Psychoses with origin specific to childhood, Unspecified[LAPSUUDEN LAAJA-ALAINEN KEHITYSHÄIRIÖ NUD,JÄLKITILA]
+∞
6.3
6
*
F84.11
ICD-10 Finland
Autism with atypical symptoms
+∞
6.3
6
*
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
7.2
6.3
14
20
T90
ICPC
Diabetes non-insulin dependent
3.5
6.2
27
80
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.8
6.2
37
138
H52.2
ICD-10 Finland
Astigmatism
4.4
6.2
21
50
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
7.8
6.2
13
17
RD210
NOMESCO Finland
NA
3.4
6.1
28
87
AA1AD
NOMESCO Finland
CT of head and brain
2.6
6.1
43
177
P72
ICPC
Schizophrenia
8.8
6.1
12
14
SPAT1229
SPAT
Assessment of need for aid
5.3
6.1
17
33
P23
ICPC
Adolescent behaviour sympt/compl
6.2
6.0
15
25

Mortality – FinRegistry

↥

Association

Association between endpoint F5_PERVASIVE and mortality.

Females

Parameter HR [95% CI] p-value
F5_PERVASIVE 4.437 [2.83, 6.96] < 0.001
Birth year 0.992 [0.98, 1.0] 0.09

During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 2735 females with F5_PERVASIVE died.

Males

Parameter HR [95% CI] p-value
F5_PERVASIVE 2.447 [1.92, 3.12] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 7819 males with F5_PERVASIVE died.

Mortality risk

Mortality risk for people of age

years, who have F5_PERVASIVE.

N-year risk Females Males
1 0.416% 0.596%
5 2.348% 2.963%
10 6.356% 6.658%
15 12.009% 12.015%
20 20.443% 20.517%

Relationships between endpoints

↥

Index endpoint: F5_PERVASIVE – Pervasive developmental disorders excl. Autism + Asperger

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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