sexual dysfunction: ['Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked distress and interpersonal difficulty.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
555 |
4. Check minimum number of eventsNone |
555 |
5. Include endpointsNone |
555 |
6. Filter based on genotype QC (FinnGen only) |
555 |
Control definitions (FinnGen only)
- Control exclude
- F5_BEHAVE
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- F50-F59
- Name in latin
- Perturbationes sexuales non organicae
Similar endpoints
↥List of similar endpoints to
Sexual dysfunction
based on the number of shared cases.
Similar with more cases:
- Behavioural syndromes associated with physiological disturbances and physical factors
- Any mental disorder
- Psychiatric diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3670 | 859 | 2778 |
| Only index persons | 3531 | 836 | 2695 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.02 | 0.08 |
| Only index persons | 0.09 | 0.03 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 40.63 | 32.07 | 43.31 |
| Only index persons | 40.15 | 31.85 | 42.72 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 555 | 160 | 395 |
| Unadjusted period prevalence (%) | 0.14 | 0.05 | 0.17 |
| Median age at first event (years) | 47.78 | 37.94 | 51.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 479
- Matched controls
- 4788
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F52.2
ICD-10 Finland
Failure of genital response
94.6
186.1
200
36
F52.0
ICD-10 Finland
Lack or loss of sexual desire
211.9
86.4
87
5
F52.9
ICD-10 Finland
Unspecified sexual dysfunction, not caused by organic disorder or disease
297.3
53.3
53
*
F52.6
ICD-10 Finland
Nonorganic dyspareunia
200.0
36.3
37
*
N48.4
ICD-10 Finland
Impotence of organic origin
13.5
34.5
61
51
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
6.6
34.4
95
173
F52
ICD-10 Finland
Sexual dysfunction, not caused by organic disorder or disease
35.4
23.6
30
9
F52.4
ICD-10 Finland
Premature ejaculation
126.1
22.8
24
*
F52.8
ICD-10 Finland
Other sexual dysfunction, not caused by organic disorder or disease
76.8
19.9
22
*
F52.3
ICD-10 Finland
Orgasmic dysfunction
+∞
17.8
17
*
N05AH04
ATC
quetiapine; oral
3.0
17.5
113
443
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.3
16.8
93
326
F52.5
ICD-10 Finland
Nonorganic vaginismus
+∞
16.8
16
*
N06AX11
ATC
mirtazapine; oral
2.4
16.1
168
868
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.5
14.0
70
226
N06AB05
ATC
paroxetine; oral
4.2
13.3
52
136
N94.1
ICD-10 Finland
Dyspareunia
15.6
13.2
21
14
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
4.7
12.9
44
101
N06AB06
ATC
sertraline; oral
3.1
12.7
73
261
N06AX12
ATC
bupropion; oral
3.8
12.4
54
156
Z3231
NOMESCO Finland
Registered nurse
2.3
12.3
136
706
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
5.0
11.9
38
81
N05AX12
ATC
aripiprazole; systemic
4.6
11.9
41
95
N05BA04
ATC
oxazepam; oral
2.3
11.8
121
606
N06AB04
ATC
citalopram; systemic
2.4
11.6
114
557
F50.9
ICD-10 Finland
Eating disorder, unspecified
122.8
11.5
12
*
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
4.7
10.7
36
82
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.2
10.5
55
184
N05CF01
ATC
zopiclone; oral
2.1
10.3
134
741
N05AH03
ATC
olanzapine; systemic
3.5
10.3
49
153
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.0
10.1
59
213
XKD00
NOMESCO Finland
Uroflowmetry
2.5
10.1
86
388
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
9.9
122
658
N06AX16
ATC
venlafaxine; oral
2.6
9.8
77
333
Z2221
NOMESCO Finland
Medical doctor
2.1
9.5
132
748
F34.1
ICD-10 Finland
Dysthymia
5.1
9.5
29
60
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.1
9.4
53
187
N06AB10
ATC
escitalopram; oral
2.2
9.3
111
586
N02AX02
ATC
tramadol; systemic, rectal
1.9
9.2
185
1201
N03AE01
ATC
clonazepam; systemic
3.7
9.2
39
111
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.3
9.1
45
145
R06.0
ICD-10 Finland
Dyspnoea
2.2
9.1
106
558
A04
ICPC
Weakness/tiredness general
2.8
9.0
59
228
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
9.0
164
1028
P29
ICPC
Psychological sympt/compl other
3.4
9.0
43
135
R07.4
ICD-10 Finland
Chest pain, unspecified
2.1
9.0
118
653
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
2.5
8.9
71
307
F51.0
ICD-10 Finland
Nonorganic insomnia
2.6
8.9
65
269
Z01.7
ICD-10 Finland
Laboratory examination
2.8
8.8
58
224
N05CD07
ATC
temazepam; oral
2.9
8.8
54
201
N03AG01
ATC
valproic acid; systemic, rectal
3.3
8.8
43
138
N05BA01
ATC
diazepam; systemic, rectal
2.6
8.7
67
284
K59.09
ICD-10 Finland
Constipation, unspecified
4.2
8.7
32
80
A06AC01
ATC
ispaghula (psylla seeds); oral
2.2
8.6
94
477
Z3226
NOMESCO Finland
Physiotherapist
2.2
8.5
90
453
N03AX09
ATC
lamotrigine; oral
3.6
8.4
37
109
N05AX08
ATC
risperidone; systemic
3.0
8.2
47
168
R51.80
ICD-10 Finland
Headache
2.3
8.1
76
357
H04.10
ICD-10 Finland
Dry eye syndrome
3.2
8.1
41
135
R53
ICD-10 Finland
Malaise and fatigue
2.2
8.0
89
457
SPAT1240
SPAT
Therapeutic discussion
2.4
8.0
66
294
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.1
7.7
91
479
A02BC02
ATC
pantoprazole; systemic
1.7
7.7
272
2076
N06AB03
ATC
fluoxetine; oral
2.5
7.7
61
265
R4110
NOMESCO Finland
Physiotherapy
1.9
7.6
117
683
C07AA05
ATC
propranolol; systemic
2.1
7.6
88
460
F41.1
ICD-10 Finland
Generalized anxiety disorder
3.8
7.5
30
82
Z71.8
ICD-10 Finland
Other specified counselling
1.9
7.4
112
649
R35
ICD-10 Finland
Polyuria
3.2
7.4
38
127
N06AX22
ATC
agomelatine; oral
7.0
7.4
17
25
3027C
ICD-9 Finland
Sexual deviations and disorders, Psychosexual dysfunction[SEKSUAALINEN KIIHOTTUMISVAIKEUS]
+∞
7.3
7
*
N05CF02
ATC
zolpidem; oral
2.1
7.3
84
438
N05AB03
ATC
perphenazine; systemic, rectal
3.9
7.2
28
75
SAA01
NOMESCO Finland
Simple examination of mouth
1.7
7.0
337
2775
XKD06
NOMESCO Finland
Physiologic investigation of micturition
4.8
7.0
22
48
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
6.9
149
972
R06.5
ICD-10 Finland
Mouth breathing
2.4
6.8
56
247
N06AG02
ATC
moclobemide; oral
3.8
6.8
27
74
N01
ICPC
Headache
2.6
6.8
50
209
G04BE04
ATC
yohimbine; oral
17.0
6.8
10
6
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.9
6.7
40
148
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
6.7
151
996
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.9
6.6
97
552
S18
ICPC
Laceration/cut
1.7
6.6
174
1203
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.9
6.4
108
648
F50.2
ICD-10 Finland
Bulimia nervosa
70.8
6.4
7
*
ZY010
NOMESCO Finland
Hospital outpatient
3.3
6.4
30
94
N03AX16
ATC
pregabalin; oral
1.9
6.4
99
574
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
5.6
6.4
17
31
N03AX12
ATC
gabapentin; oral
2.2
6.4
65
320
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.2
6.3
62
298
E73.8
ICD-10 Finland
Other lactose intolerance
+∞
6.3
6
*
Z70.9
ICD-10 Finland
Sex counselling, unspecified
27.1
6.2
8
*
L03
ICPC
Low back symptom/complaint
1.9
6.2
101
596
R10.2
ICD-10 Finland
Pelvic and perineal pain
5.9
6.2
16
28
A02BC03
ATC
lansoprazole; oral
1.8
6.2
112
688
R01AD09
ATC
mometasone; nasal
1.6
6.2
201
1465
N06AX21
ATC
duloxetine; oral
2.3
6.1
54
247
A02BA02
ATC
ranitidine; systemic
2.1
6.1
69
354
Z2446
NOMESCO Finland
Social worker
2.9
6.1
35
127
Mortality – FinRegistry
↥Association
Association between endpoint F5_SEXDYS and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_SEXDYS | 1.439 [1.19, 1.75] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.026 |
During the follow-up period (1.1.1998 — 31.12.2019), 176 out of 1694 males with F5_SEXDYS died.
Mortality risk
Mortality risk for people of age
years, who have F5_SEXDYS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.287% |
| 5 | No data | 1.854% |
| 10 | No data | 4.492% |
| 15 | No data | 8.385% |
| 20 | No data | 14.164% |
Relationships between endpoints
↥Index endpoint: F5_SEXDYS – Sexual dysfunction
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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