Unspecified organic or symptomatic mental disorder

F5_UNSORG

cognitive disorder: Disturbances in mental processes related to learning, thinking, reasoning, and judgment.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — F09 Cause of death: ICD-10 — F09 2 out of 7 registries used, show all original rules.	138
4. Check minimum number of events None	138
5. Include endpoints None	138
6. Filter based on genotype QC (FinnGen only)	138

Control definitions (FinnGen only)

Control exclude: F5_ORGANIC

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: F04-F09
Name in latin: Perturbatio mentis organica sive symptomatica non specificata

NAME	F5_UNSORG
CONTROL_EXCLUDE	F5_ORGANIC
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	F09
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	F09
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Unspecified organic or symptomatic mental disorder based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	2094	1063	995
Only index persons	1489	777	712
Unadjusted period prevalence (%)
Whole population	0.03	0.03	0.03
Only index persons	0.03	0.03	0.03
Median age at first event (years)
Whole population	68.08	72.57	63.10
Only index persons	64.41	69.43	58.93

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	138	62	76
Unadjusted period prevalence (%)	0.03	0.02	0.03
Median age at first event (years)	67.50	67.33	67.64

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
122: Matched controls
1220

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

F09

ICD-10 Finland

Unspecified organic or symptomatic mental disorder

+∞

173.0

121

N05AX08

ATC

risperidone; systemic

21.6

33.3

112

Kela drug reimbursment

Severe psychotic and other severe mental disorders

17.3

27.8

N05AH03

ATC

olanzapine; systemic

37.1

26.2

N05AH04

ATC

quetiapine; oral

9.9

22.8

F29

ICD-10 Finland

Unspecified nonorganic psychosis

32.5

21.6

307

Kela drug reimbursment

Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease

+∞

21.5

F03

ICD-10 Finland

Unspecified dementia

53.1

19.0

N06DX01

ATC

memantine; oral

78.9

18.3

N03AG01

ATC

valproic acid; systemic, rectal

15.4

14.7

N05BA04

ATC

oxazepam; oral

5.3

14.3

155

G30.9

ICD-10 Finland

Alzheimer disease, unspecified

45.5

13.5

F05.9

ICD-10 Finland

Delirium, unspecified

144.2

12.7

N06AB04

ATC

citalopram; systemic

4.9

12.3

133

N05AX12

ATC

aripiprazole; systemic

14.8

11.6

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

8.4

11.3

N05BA06

ATC

lorazepam; systemic, sublingual

9.3

10.7

R41.0

ICD-10 Finland

Disorientation, unspecified

13.9

10.2

N06DA02

ATC

donepezil; oral

44.0

10.2

F05.8

ICD-10 Finland

Other delirium

+∞

9.5

J18.9

ICD-10 Finland

Pneumonia, unspecified

3.6

9.2

214

N05AD01

ATC

haloperidol; systemic

20.5

9.2

G30.1

ICD-10 Finland

Alzheimer disease with late onset

22.0

8.7

F32.9

ICD-10 Finland

Depressive episode, unspecified

5.7

8.6

R53

ICD-10 Finland

Malaise and fatigue

3.9

8.3

121

F32.2

ICD-10 Finland

Severe depressive episode without psychotic symptoms

7.6

8.3

F20.9

ICD-10 Finland

Schizophrenia, unspecified

18.8

8.3

F22.0

ICD-10 Finland

Delusional disorder

36.0

8.2

N05AA02

ATC

levomepromazine; systemic

8.4

8.0

N03AE01

ATC

clonazepam; systemic

8.6

7.7

N05BA01

ATC

diazepam; systemic, rectal

3.9

7.3

N06AX11

ATC

mirtazapine; oral

3.2

7.3

188

F31.7

ICD-10 Finland

Bipolar affective disorder, currently in remission

32.1

7.3

A28

ICPC

Limited function/disability NOS

3.9

7.1

N06DA03

ATC

rivastigmine; oral, transdermal

42.5

6.8

N05AH02

ATC

clozapine; systemic

15.4

6.5

F20

ICD-10 Finland

Schizophrenia

73.5

6.5

N05AB03

ATC

perphenazine; systemic, rectal

10.1

6.5

F10.20

ICD-10 Finland

Alcohol dependence currently independent

19.2

6.4

F00.10*G30.1

ICD-10 Finland

Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms

+∞

6.3

T36

ICD-10 Finland

Poisoning by systemic antibiotics

7.9

6.1

Mortality – FinRegistry

↥

Association

Association between endpoint F5_UNSORG and mortality.

Females

Parameter	HR [95% CI]	p-value
F5_UNSORG	3.123 [2.53, 3.86]	< 0.001
Birth year	0.996 [0.99, 1.0]	0.371

During the follow-up period (1.1.1998 — 31.12.2019), 515 out of 887 females with F5_UNSORG died.

Males

Parameter	HR [95% CI]	p-value
F5_UNSORG	3.978 [2.97, 5.33]	< 0.001
Birth year	0.988 [0.98, 1.0]	0.012

During the follow-up period (1.1.1998 — 31.12.2019), 482 out of 830 males with F5_UNSORG died.

Mortality risk

Mortality risk for people of age

years, who have F5_UNSORG.

N-year risk	Females	Males
1	0.285%	0.828%
5	1.639%	4.349%
10	4.299%	11.111%
15	9.38%	19.664%
20	14.909%	33.032%

Relationships between endpoints

↥

Index endpoint: F5_UNSORG – Unspecified organic or symptomatic mental disorder

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Unspecified organic or symptomatic mental disorder

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints