Other specified cerebrovascular diseases, other cerebrovascular disorders in diseases classified elsewhere

I9_CEREBDOTH

cerebrovascular disorder: A disorder resulting from inadequate blood flow in the vessels that supply the brain. Representative examples include cerebrovascular ischemia, cerebral embolism, and cerebral infarction.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

2724

4. Check minimum number of events

None

2724

5. Include endpoints

None

2724

6. Filter based on genotype QC (FinnGen only)

2724

Control definitions (FinnGen only)

Control exclude
I9_CEREBVASC

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 35100 17373 17089
Only index persons 20088 10110 9978
Unadjusted period prevalence (%)
Whole population 0.49 0.50 0.48
Only index persons 0.38 0.37 0.38
Median age at first event (years)
Whole population 72.53 75.26 69.77
Only index persons 69.92 72.84 66.95

-FinnGen-

Key figures

All Female Male
Number of individuals 2724 1196 1528
Unadjusted period prevalence (%) 0.56 0.41 0.67
Median age at first event (years) 67.39 66.28 68.25

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2423
Matched controls
24187
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
4045.7
323.0
359
*
I67.9
ICD-10 Finland
Cerebrovascular disease, unspecified
2220.0
323.0
950
7
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
385.9
323.0
916
38
I67.8
ICD-10 Finland
Other specified cerebrovascular diseases
3725.6
323.0
335
*
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
17.2
323.0
599
452
G46.3*I67.9
ICD-10 Finland
Brain stem stroke syndrome (I60-I67+)
+∞
323.0
393
*
G46.4*I67.9
ICD-10 Finland
Cerebellar stroke syndrome
6573.4
323.0
531
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
285.3
323.0
804
42
AA1AD
NOMESCO Finland
CT of head and brain
4.7
230.9
1009
3172
B01AC04
ATC
clopidogrel; oral
4.5
184.2
789
2327
4360A
ICD-9 Finland
Acute but ill-defined cerebrovascular disease[MORBUS CEREBROVASCULARIS ACUTUS NON DEFINITUS]
+∞
155.8
148
*
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
+∞
153.7
146
*
K90
ICPC
Stroke/cerebrovascular accident
36.6
153.6
199
59
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
12.7
145.7
271
238
G46.8*I67.9
ICD-10 Finland
Other vascular syndromes of brain in cerebrovascular diseases
1357.9
133.5
129
*
B01AC07
ATC
dipyridamole; systemic
6.2
129.0
380
708
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
5.7
127.8
406
830
R42
ICD-10 Finland
Dizziness and giddiness
3.3
126.6
822
3264
G46.7*I67.9
ICD-10 Finland
Other lacunar syndromes
+∞
114.4
109
*
I63.0
ICD-10 Finland
Cerebral infarction due to thrombosis of precerebral arteries
+∞
105.9
101
*
XA800
NOMESCO Finland
Neuropsychological investigation
11.5
95.7
185
173
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.6
95.7
303
606
G46.4
ICD-10 Finland
Cerebellar stroke syndrome
324.4
92.4
93
*
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
452.9
88.7
88
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.9
83.0
611
2519
4340A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral thrombosis
+∞
79.5
76
*
C10AA05
ATC
atorvastatin; oral
2.3
77.5
1099
6437
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
8.7
75.7
170
208
I63.5
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
728.0
72.5
71
*
I63.8
ICD-10 Finland
Other cerebral infarction
187.7
70.4
73
*
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
19.2
69.3
107
58
C10AA01
ATC
simvastatin; oral
2.1
65.8
1292
8527
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
82.3
64.3
72
9
43899
ICD-8 Finland
Other and ill-defined cerebrovascular disease, Without mention of hypertension
+∞
63.8
61
*
G46.3
ICD-10 Finland
Brain stem stroke syndrome
632.9
63.1
62
*
4380A
ICD-9 Finland
Late effects of cerebrovascular disease[SEQUELAE MORBI CEREBROVASCULARIS]
+∞
62.7
60
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.4
61.4
240
592
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
5.4
60.2
191
377
I63.1
ICD-10 Finland
Cerebral infarction due to embolism of precerebral arteries
+∞
59.6
57
*
K91
ICPC
Cerebrovascular disease
28.8
59.5
81
29
B01AA03
ATC
warfarin; systemic
2.2
57.4
774
4271
R51.80
ICD-10 Finland
Headache
3.0
57.0
362
1319
R4120
NOMESCO Finland
Occupational therapy
4.9
56.9
197
428
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.2
55.7
332
1158
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
148.2
55.0
58
*
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
148.2
55.0
58
*
I63.2
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
276.4
53.3
54
*
I67.3
ICD-10 Finland
Progressive vascular leukoencephalopathy
31.2
52.6
70
23
315
Kela drug reimbursment
Clopidogrel
13.8
52.1
91
68
I10
ICD-10 Finland
Essential (primary) hypertension
1.9
50.9
1565
11742
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
+∞
48.0
46
*
PAF14
NOMESCO Finland
Thrombendarterectomy of internal carotid artery
101.9
45.9
50
5
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
5.2
45.2
146
293
R53
ICD-10 Finland
Malaise and fatigue
2.1
44.4
578
3077
AAL10
NOMESCO Finland
Intracranial endovascular thrombolysis
423.9
42.2
42
*
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
423.9
42.2
42
*
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
423.9
42.2
42
*
PA2CC
NOMESCO Finland
Cerebral very extensive angiography with X-ray
61.0
41.3
48
8
N18
ICPC
Paralysis/weakness
10.0
40.4
82
84
205
Kela drug reimbursment
Chronic hypertension
1.8
40.0
910
5955
C09AA05
ATC
ramipril; oral
1.9
39.6
734
4465
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.2
39.3
158
398
I63
ICD-10 Finland
Cerebral infarction
43.4
38.2
47
11
G46.5*I67.9
ICD-10 Finland
Pure motor lacunar syndrome
+∞
37.6
36
*
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
83.3
36.9
41
5
I64
ICD-10 Finland
Stroke, not specified as haemorrhage or infarction
83.3
36.9
41
5
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
+∞
36.5
35
*
4378X
ICD-9 Finland
Other and ill-defined cerebrovascular disease, Other[MORBUS CERBROVASCULARIS ALIA DEFINITA]
+∞
36.5
35
*
C08CA01
ATC
amlodipine; oral
1.8
35.8
958
6543
XF400
NOMESCO Finland
ECG with 12 standard connections
2.1
35.6
488
2624
H53.4
ICD-10 Finland
Visual field defects
8.1
34.8
80
102
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.8
34.5
791
5127
G81.9
ICD-10 Finland
Hemiplegia, unspecified
15.4
33.9
56
37
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
12.2
33.9
62
52
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.9
33.2
220
814
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.1
33.1
431
2258
TAB00
NOMESCO Finland
Lumbar puncture
4.5
33.0
122
283
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.8
32.8
226
857
I69.8
ICD-10 Finland
Sequelae of other and unspecified cerebrovascular diseases
118.1
32.7
35
*
PA7CD
NOMESCO Finland
CT angiography of neck and brain, extensive
16.1
30.3
49
31
I67.0
ICD-10 Finland
Dissection of cerebral arteries, nonruptured
+∞
30.2
29
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
4.8
30.0
104
226
G46.8
ICD-10 Finland
Other vascular syndromes of brain in cerebrovascular diseases
68.7
29.9
34
5
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.7
29.1
211
824
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.9
29.1
506
2957
G46.6*I67.9
ICD-10 Finland
Pure sensory lacunar syndrome
+∞
28.2
27
*
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
5.9
27.5
78
135
G44.2
ICD-10 Finland
Tension-type headache
2.3
27.2
273
1268
R20.2
ICD-10 Finland
Paraesthesia of skin
3.2
26.2
144
469
N03AG01
ATC
valproic acid; systemic, rectal
3.2
25.9
142
462
R1260
NOMESCO Finland
Evaluation of communicative skills
6.8
25.5
65
98
F01.9
ICD-10 Finland
Vascular dementia, unspecified
5.1
25.4
82
166
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
7.2
24.9
61
87
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
24.8
1013
7546
WX892
NOMESCO Finland
Monitored bed care
2.5
24.6
204
858
AA5PD
NOMESCO Finland
CT examination of brain pefusion
24.5
24.3
34
14
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
6.3
24.1
65
106
C03CA01
ATC
furosemide; systemic
1.6
23.9
943
6941
N03AF02
ATC
oxcarbazepine; oral
4.4
23.3
85
196
PA7BD
NOMESCO Finland
CT angiography of neck and brain
6.9
23.2
58
85
A28
ICPC
Limited function/disability NOS
1.8
22.9
454
2745
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
9.3
22.3
46
50
R4150
NOMESCO Finland
Neuropsychological rehabilitation
27.5
22.2
30
11
N02BE01
ATC
paracetamol; systemic, rectal
1.6
22.0
1897
16663
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.7
22.0
157
605
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
2.1
21.7
254
1260
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.2
21.7
119
388
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.2
21.6
245
1199
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
21.6
385
2246
C01DA14
ATC
isosorbide mononitrate; oral
1.7
21.5
556
3638
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.1
21.5
270
1381
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.6
21.4
686
4756
N19
ICPC
Speech disorder
11.6
21.2
39
34
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.5
21.2
178
751
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.9
21.1
360
2065
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.0
21.0
300
1614
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.2
21.0
226
1080
A10AE04
ATC
insulin glargine; parenteral
2.1
20.6
242
1201
N06AB04
ATC
citalopram; systemic
1.7
20.6
466
2931
C10AA07
ATC
rosuvastatin; oral
1.7
20.6
527
3437
AAF00
NOMESCO Finland
Ventriculostomy
17.0
20.4
32
19
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
20.4
360
2085
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.9
20.4
356
2058
H53.2
ICD-10 Finland
Diplopia
3.6
19.8
91
259
43399
ICD-8 Finland
Cerebral thrombosis, Without mention of hypertension
+∞
19.8
19
*
R4130
NOMESCO Finland
Speech therapy
5.2
19.5
61
120
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
3.6
19.4
89
253
N06AB10
ATC
escitalopram; oral
1.8
19.3
337
1946
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.6
19.3
145
577
I95.1
ICD-10 Finland
Orthostatic hypotension
2.9
19.3
122
438
N03AX14
ATC
levetiracetam; systemic
4.7
19.2
65
140
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
1.8
19.1
361
2142
103
Kela drug reimbursment
Diabetes, insulin-treated
1.6
18.9
679
4822
C10AX09
ATC
ezetimibe; oral
2.0
18.6
246
1281
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.1
18.6
210
1025
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.6
18.5
687
4904
G46.7
ICD-10 Finland
Other lacunar syndromes
191.0
18.5
19
*
R41.3
ICD-10 Finland
Other amnesia
3.2
18.4
98
313
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
4.2
18.4
70
169
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.6
18.2
602
4178
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.5
17.8
687
4941
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
5.6
17.6
51
92
R47.0
ICD-10 Finland
Dysphasia and aphasia
9.3
17.6
36
39
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
12.5
17.6
31
25
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
17.4
470
3091
R4110
NOMESCO Finland
Physiotherapy
1.6
17.4
561
3866
S06.0
ICD-10 Finland
Concussion
2.0
17.3
224
1157
PA6CG
NOMESCO Finland
Extensive MRI examination of neck vasculature with high intensity magnet
21.0
17.3
25
12
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.2
17.0
178
840
4019X
ICD-9 Finland
Essential hypertension, Unspecified
2.5
17.0
137
567
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
16.9
675
4884
R55
ICD-10 Finland
Syncope and collapse
1.8
16.8
290
1662
2161
FHL
Neck ligation, big brain
+∞
16.7
16
*
PAN14
NOMESCO Finland
Plastic repair of arteries internal carotid artery
90.5
16.6
18
*
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
2.7
16.5
117
449
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.3
16.5
152
675
I67.2
ICD-10 Finland
Cerebral atherosclerosis
27.7
16.5
22
8
N03AF01
ATC
carbamazepine; oral, rectal
2.5
16.1
132
552
I69
ICD-10 Finland
Sequelae of cerebrovascular disease
30.2
16.1
21
7
R47.1
ICD-10 Finland
Dysarthria and anarthria
9.0
15.9
33
37
N06AX11
ATC
mirtazapine; oral
1.5
15.8
631
4553
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.6
15.8
431
2834
43800
ICD-8 Finland
Other and ill-defined cerebrovascular disease, With hypertension (benign)
+∞
15.6
15
*
PA2YT
NOMESCO Finland
Cerebral artery PTA with stent
+∞
15.6
15
*
SPAT1216
SPAT
Assessment of functional ability
1.7
15.4
392
2528
N03AX12
ATC
gabapentin; oral
1.7
15.4
317
1922
280
Kela drug reimbursment
Clopidogrel
3.9
15.3
62
160
P20
ICPC
Memory disturbance
1.7
15.2
355
2234
C07AB07
ATC
bisoprolol; oral
1.4
15.2
1170
9609
N05AH04
ATC
quetiapine; oral
1.8
15.2
297
1775
SPAT1229
SPAT
Assessment of need for aid
2.0
15.1
208
1101
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
15.0
434
2896
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.7
14.9
331
2053
J01DA01
ATC
[U] cefalexin; systemic
1.4
14.9
1344
11349
A02BC02
ATC
pantoprazole; systemic
1.4
14.9
1377
11680
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
1.5
14.9
581
4164
Q28.2
ICD-10 Finland
Arteriovenous malformation of cerebral vessels
31.8
14.8
19
6
R41.0
ICD-10 Finland
Disorientation, unspecified
2.7
14.8
99
369
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.5
14.7
680
5049
N02AX02
ATC
tramadol; systemic, rectal
1.4
14.7
930
7356
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
7.5
14.6
34
46
N03AB02
ATC
phenytoin; systemic
6.0
14.6
40
68
PA2VT
NOMESCO Finland
Intravascular evacuation of brain artery embolus
+∞
14.6
14
*
XCK00
NOMESCO Finland
Perimetry
2.1
14.5
170
843
PA2AC
NOMESCO Finland
Cerebral angiography with X-ray
150.5
14.5
15
*
G43.9
ICD-10 Finland
Migraine, unspecified
3.0
14.4
83
282
N06AA09
ATC
amitriptyline; systemic
1.9
14.1
225
1255
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
14.0
882
6947
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
5.8
14.0
39
68
N05AX08
ATC
risperidone; systemic
1.9
13.9
204
1103
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.7
13.8
337
2145
PA6BG
NOMESCO Finland
MRI examination of neck vasculature with high intensity magnet
23.9
13.8
19
8
R11
ICD-10 Finland
Nausea and vomiting
2.0
13.7
177
914
PA7CC
NOMESCO Finland
Very extensive angiography of arteries of neck and brain
75.4
13.6
15
*
4371A
ICD-9 Finland
Other and ill-defined cerebrovascular disease, Other generalised ischaemic cerebrovascular disease
+∞
13.5
13
*
4300A
ICD-9 Finland
Subarachnoid haemorrhage[HAEMORRHAGIA SUBARACHNOID. POST ANEURYSMA SACCULARE]
+∞
13.5
13
*
I67.6
ICD-10 Finland
Nonpyogenic thrombosis of intracranial venous system
+∞
13.5
13
*
A10BA02
ATC
metformin; oral
1.5
13.5
654
4889
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
3.4
13.5
66
200
I50.9
ICD-10 Finland
Heart failure, unspecified
1.6
13.5
449
3091
R06.0
ICD-10 Finland
Dyspnoea
1.5
13.4
554
4007
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.5
13.4
533
3822
TPX22
NOMESCO Finland
Intravenous arterial thrombolysis
18.3
13.3
20
11
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
1.8
13.3
239
1385
N28
ICPC
Limited function/disability (N)
4.3
13.2
48
113
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.6
13.1
93
359
M03BX01
ATC
baclofen; systemic
5.1
12.9
40
80
2500A
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE,TYYPPI II]
2.3
12.7
116
514
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.6
12.6
385
2591
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
12.6
584
4317
I62.0
ICD-10 Finland
Nontraumatic subdural haemorrhage
70.1
12.6
14
*
I60.8
ICD-10 Finland
Other subarachnoid haemorrhage
+∞
12.5
12
*
I60.7
ICD-10 Finland
Subarachnoid haemorrhage from intracranial artery, unspecified
+∞
12.5
12
*
4349A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral artery occlusion, unspecified[OCCL/STENOS ARTER.CEREBRALES NUD CUM INFARCTU CEREB]
+∞
12.5
12
*
I61.1
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, cortical
+∞
12.5
12
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
4.2
12.5
46
110
J01MA02
ATC
ciprofloxacin; systemic
1.4
12.4
887
7106
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
1.8
12.3
224
1307
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
2.6
12.3
88
341
N03AX16
ATC
pregabalin; oral
1.5
12.3
460
3252
C07AB02
ATC
metoprolol; systemic
1.5
12.3
564
4161
C08CA05
ATC
nifedipine; systemic
1.9
12.2
189
1044
PA6AE
NOMESCO Finland
Ulrasound examination of neck vasculature
5.5
12.2
35
64
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.0
12.1
156
805
PA6AD
NOMESCO Finland
CT of neck arteries
7.0
12.1
29
42
PA2BG
NOMESCO Finland
MRI examination of vessels in the head with high intensity magnet
18.1
12.0
18
10
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
1.8
12.0
217
1261
R07.4
ICD-10 Finland
Chest pain, unspecified
1.4
12.0
579
4310
I50.0
ICD-10 Finland
Congestive heart failure
1.7
11.9
250
1525
C09CA01
ATC
losartan; oral
1.5
11.8
528
3865
AN1
HP
Coronary angiography
1.6
11.5
305
1981
I25.2
ICD-10 Finland
Old myocardial infarction
1.7
11.5
222
1318
G45
ICD-10 Finland
Transient cerebral ischaemic attacks and related syndromes
6.5
11.5
29
45
H53.1
ICD-10 Finland
Subjective visual disturbances
2.2
11.5
115
532
I60.0
ICD-10 Finland
Subarachnoid haemorrhage from carotid siphon and bifurcation
+∞
11.5
11
*
I65.3
ICD-10 Finland
Occlusion and stenosis of multiple and bilateral precerebral arteries
+∞
11.5
11
*
AAL00
NOMESCO Finland
Endovascular occlusion of intracranial aneurysm
+∞
11.5
11
*
K89
ICPC
Transient cerebral ischaemia
5.7
11.4
32
57
J01EA01
ATC
trimethoprim; systemic
1.4
11.4
557
4148
N05CF01
ATC
zopiclone; oral
1.4
11.4
757
5968
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
2.8
11.3
70
250
N30.0
ICD-10 Finland
Acute cystitis
1.6
11.1
284
1827
J01DB01
ATC
cefalexin; oral
1.4
11.1
1651
14778
R51
ICD-10 Finland
Headache
2.5
11.0
84
339
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
6.1
11.0
29
48
SPAT1053
SPAT
Memory test
1.5
11.0
418
2955
N03AX09
ATC
lamotrigine; oral
2.9
10.9
65
228
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
1.7
10.9
231
1409
SPAT1254
SPAT
Administration of medicine
1.6
10.9
339
2291
A10AA02
ATC
NA
2.3
10.8
96
422
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.4
10.8
89
375
I70.9
ICD-10 Finland
Generalized and unspecified atherosclerosis
2.9
10.8
65
230
M79.6
ICD-10 Finland
Pain in limb
1.4
10.8
667
5182
A10BB12
ATC
glimepiride; oral
1.7
10.7
209
1245
TKC20
NOMESCO Finland
Catheterisation of bladder
1.8
10.7
183
1047
X59
ICD-10 Finland
Exposure to unspecified factor
1.5
10.6
338
2297
C09AA02
ATC
enalapril; systemic
1.4
10.5
509
3775
43300
ICD-8 Finland
Cerebral thrombosis, Wtih hypertension (benign)
+∞
10.4
10
*
I65.0
ICD-10 Finland
Occlusion and stenosis of vertebral artery
+∞
10.4
10
*
PA2LT
NOMESCO Finland
Endovascular closure of extensive brain aneurysm
+∞
10.4
10
*
N17
ICPC
Vertigo/dizziness
1.7
10.3
234
1457
C10AA03
ATC
pravastatin; oral
1.8
10.3
181
1043
J01FF01
ATC
clindamycin; systemic
1.4
10.2
509
3799
H81.4
ICD-10 Finland
Vertigo of central origin
5.0
10.1
31
62
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.7
10.1
211
1284
N05BA04
ATC
oxazepam; oral
1.4
10.1
507
3785
PA2AD
NOMESCO Finland
CT angiography of brain
14.6
10.0
16
11
C03AA03
ATC
hydrochlorothiazide; oral
1.6
9.8
238
1511
J01CA08
ATC
pivmecillinam; oral
1.4
9.8
715
5695
N06AB03
ATC
fluoxetine; oral
1.7
9.8
222
1384
81
HP
Angiography of the heart and coronary arteries
1.7
9.7
199
1204
XCK10
NOMESCO Finland
Photography of fundus of eye
1.6
9.7
231
1458
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.2
9.7
91
413
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
9.6
625
4883
C10AA04
ATC
fluvastatin; oral
1.6
9.5
224
1407
N06AX21
ATC
duloxetine; oral
1.8
9.5
174
1016
Q28.3
ICD-10 Finland
Other malformations of cerebral vessels
17.6
9.4
14
8
4373A
ICD-9 Finland
Other and ill-defined cerebrovascular disease, Cerebral aneurysm, nonruptured
+∞
9.4
9
*
I61.3
ICD-10 Finland
Intracerebral haemorrhage in brain stem
+∞
9.4
9
*
I65.1
ICD-10 Finland
Occlusion and stenosis of basilar artery
+∞
9.4
9
*
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.5
9.3
339
2371
XF620
NOMESCO Finland
Examination of circulation with color method
10.7
9.3
17
16
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.1
9.3
105
518
G51.0
ICD-10 Finland
Bell palsy
2.9
9.2
53
182
M48.0
ICD-10 Finland
Spinal stenosis
1.5
9.1
283
1908
I20.01
ICD-10 Finland
Unstable angina
2.2
9.1
87
399
F01.19
ICD-10 Finland
Multi-infarct dementia without information on additional symptoms
11.5
9.0
16
14
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.6
9.0
214
1349
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
2.2
8.9
88
409
JDB10
NOMESCO Finland
Percutaneous gastrostomy
3.8
8.9
36
96
XCW99
NOMESCO Finland
Other investigative procedure of eye
1.6
8.9
242
1580
A06AD11
ATC
lactulose; oral
1.4
8.8
403
2949
G91.1
ICD-10 Finland
Obstructive hydrocephalus
8.0
8.8
19
24
P29
ICPC
Psychological sympt/compl other
2.4
8.7
71
301
A12BA01
ATC
potassium chloride; oral
1.8
8.7
160
936
SPAT1301
SPAT
No procedures
1.3
8.6
667
5342
40199
ICD-8 Finland
Essential benign hypertension
2.3
8.6
73
316
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
2.3
8.6
73
316
H81.1
ICD-10 Finland
Benign paroxysmal vertigo
1.7
8.6
183
1120
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
5.8
8.6
23
40
I20.09
ICD-10 Finland
Unstable angina
1.8
8.5
150
866
C08CA02
ATC
felodipine; oral
1.6
8.5
240
1581
F01.10
ICD-10 Finland
Multi-infarct dementia without additional symptoms
9.0
8.5
17
19
R13
ICD-10 Finland
Dysphagia
1.8
8.5
137
769
79199
ICD-8 Finland
Headache
3.1
8.5
44
143
5541
FHL
Subclavia and / or carotid endarterectomy, reconstruction or bypass surgery
27.5
8.5
11
*
R47.8
ICD-10 Finland
Other and unspecified speech disturbances
5.1
8.4
25
49
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.4
8.4
479
3644
A02BC03
ATC
lansoprazole; oral
1.3
8.4
624
4958
F01.30
ICD-10 Finland
Mixed cortical and subcortical vascular dementia without additional symptoms
7.3
8.4
19
26
SPAT1231
SPAT
Assessment of adjustments needed in living environment
2.7
8.4
57
217
N01
ICPC
Headache
1.8
8.4
134
751
XXA00
NOMESCO Finland
Clinical examination requiring general anaesthesia
7.9
8.3
18
23
43099
ICD-8 Finland
Subarachnoid haemorrhage, Without mention of hypertension
+∞
8.3
8
*
I67.5
ICD-10 Finland
Moyamoya disease
+∞
8.3
8
*
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
2.3
8.3
73
321
B01AB05
ATC
enoxaparin; parenteral
1.3
8.3
622
4951
C08CA13
ATC
lercanidipine; oral
1.5
8.3
282
1941
C02AC05
ATC
moxonidine; oral
2.0
8.2
99
499
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.1
8.2
92
453
Z50.5
ICD-10 Finland
Speech therapy
4.5
8.1
27
60
4351A
ICD-9 Finland
Transient cerebral ischaemia, Vertebral artery syndrome
7.5
8.1
18
24
N06AX16
ATC
venlafaxine; oral
1.6
8.1
185
1155
XF404
NOMESCO Finland
Ambulatory ECG
1.6
8.1
193
1219
A10AE05
ATC
insulin detemir; parenteral
2.0
8.1
106
552
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
2.4
8.1
66
281
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
2.0
8.0
102
527
M01AE03
ATC
ketoprofen; systemic, rectal
1.3
8.0
800
6634
Z02.7
ICD-10 Finland
Issue of medical certificate
1.9
8.0
121
666
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
2.0
7.9
97
495
H81.2
ICD-10 Finland
Vestibular neuronitis
3.0
7.9
45
154
N29
ICPC
Neurological sympt/complt other
3.0
7.9
42
140
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.5
7.9
256
1745
F05.9
ICD-10 Finland
Delirium, unspecified
2.6
7.9
54
208
4350A
ICD-9 Finland
Transient cerebral ischaemia, Basilar artery syndrome
7.8
7.9
17
22
F03
ICD-10 Finland
Unspecified dementia
1.7
7.8
149
886
G90.2
ICD-10 Finland
Horner syndrome
9.4
7.8
15
16
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.3
7.7
591
4715
L28
ICPC
Limited function/disability (L)
1.4
7.6
353
2586
XFP96
NOMESCO Finland
Other intraoperative electrophysiological investigation in arhythmia or disturbance of impulse propagation
2.5
7.6
56
225
PA4AC
NOMESCO Finland
Vertebralis angiography with X-ray
25.0
7.6
10
*
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
2.6
7.5
50
191
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.4
7.5
402
3022
F80.1
ICD-10 Finland
Expressive language disorder
6.2
7.5
19
31
SPAT1101
SPAT
Orthostatic test
1.8
7.5
121
679
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.5
7.5
266
1846
A10BH01
ATC
sitagliptin; oral
1.6
7.4
206
1353
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
3.5
7.4
32
91
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
1.6
7.4
172
1080
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
1.7
7.4
165
1021
I61.8
ICD-10 Finland
Other intracerebral haemorrhage
80.2
7.4
8
*
PA6CM
NOMESCO Finland
Extensive MRI examination of neck vasculature with 3 Tesla magnet
80.2
7.4
8
*
I69.2
ICD-10 Finland
Sequelae of other nontraumatic intracranial haemorrhage
80.2
7.4
8
*
ZXA00
NOMESCO Finland
Right side
1.3
7.3
583
4668
UKC02
NOMESCO Finland
Cystoscopy
1.4
7.3
389
2922
C03DA01
ATC
spironolactone; oral
1.5
7.3
261
1813
FN1AT
NOMESCO Finland
Endovascular dilatation of coronary arteries (PTCA)
1.8
7.3
132
770
4331X
ICD-9 Finland
Occlusion and stenosis of precerebral arteries, Carotid artery[OCCL/STENOSIS ARTERIAE CAROTIS SINE INFARCTU CEREBR]
+∞
7.3
7
*
I61.4
ICD-10 Finland
Intracerebral haemorrhage in cerebellum
+∞
7.3
7
*
I69.4
ICD-10 Finland
Sequelae of stroke, not specified as haemorrhage or infarction
+∞
7.3
7
*
4331A
ICD-9 Finland
Occlusion and stenosis of precerebral arteries, Carotid artery[OCCL/STENOSIS ARTERIAE CAROTIS CUM INFARCTU CEREBRI]
+∞
7.3
7
*
I67.4
ICD-10 Finland
Hypertensive encephalopathy
+∞
7.3
7
*
4341A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral embolism
+∞
7.3
7
*
PA2KT
NOMESCO Finland
Endovascular closure of brain aneurysm
+∞
7.3
7
*
S22.3
ICD-10 Finland
Fracture of rib
1.7
7.3
137
811
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.4
7.3
402
3041
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
3.5
7.3
32
93
M54.5
ICD-10 Finland
Low back pain
1.3
7.2
548
4357
S82.6
ICD-10 Finland
Fracture of lateral malleolus
1.9
7.2
105
570
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
2.8
7.2
44
161
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.4
7.1
55
229
C09CA06
ATC
candesartan; oral
1.4
7.1
383
2881
J01FA06
ATC
roxithromycin; oral
1.3
7.1
776
6494
A10BB01
ATC
glibenclamide; oral
1.7
7.1
155
956
4130X
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),MÄÄRITTELEMÄT]
2.1
7.0
75
363
G45.8
ICD-10 Finland
Other transient cerebral ischaemic attacks and related syndromes
5.6
7.0
19
34
I20.99
ICD-10 Finland
Angina pectoris, unspecified
1.6
7.0
180
1163
C02DE04
ATC
NA
1.9
7.0
98
528
N05CD07
ATC
temazepam; oral
1.4
7.0
327
2399
N30
ICD-10 Finland
Cystitis
1.7
7.0
124
724
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
1.6
6.9
193
1270
R04.0
ICD-10 Finland
Epistaxis
1.6
6.9
168
1065
V700A
ICD-9 Finland
General medical examination, Routine general medical examination at a health care facility
2.3
6.9
61
270
N05BA01
ATC
diazepam; systemic, rectal
1.5
6.9
263
1853
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
5.8
6.9
18
31
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
3.4
6.9
31
92
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
4.2
6.9
24
57
F01.2
ICD-10 Finland
Subcortical vascular dementia
4.8
6.8
21
44
N88
ICPC
Epilepsy
8.3
6.8
14
17
PA6AG
NOMESCO Finland
Limited MRI examination of neck vasculature with high intensity magnet
6.7
6.8
16
24
AAD10
NOMESCO Finland
Evacuation of chronic subdural haematoma
3.2
6.8
33
104
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
1.7
6.8
127
750
XX3XW
NOMESCO Finland
NA
6.1
6.8
17
28
C08CA06
ATC
nimodipine; systemic
40.1
6.7
8
*
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.1
6.7
75
370
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.4
6.7
300
2184
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.0
6.7
81
411
C09AA04
ATC
perindopril; oral
1.7
6.7
120
702
A46
ICD-10 Finland
Erysipelas
1.4
6.7
298
2166
N02AJ06
ATC
codeine and paracetamol; systemic
1.3
6.7
603
4914
4359X
ICD-9 Finland
Transient cerebral ischaemia, Unspecified transient cerebral ischaemia
4.9
6.6
20
41
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
6.4
6.6
16
25
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.5
6.6
191
1270
183
Kela drug reimbursment
Lamotrigin and topiramate
5.9
6.6
17
29
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.3
6.6
498
3952
I72.0
ICD-10 Finland
Aneurysm and dissection of carotid artery
8.7
6.5
13
15
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.4
6.5
344
2576
F01.3
ICD-10 Finland
Mixed cortical and subcortical vascular dementia
10.0
6.5
12
12
H25.1
ICD-10 Finland
Senile nuclear cataract
1.3
6.5
689
5727
AA1BD
NOMESCO Finland
Extensive CT of head and brain
2.3
6.4
53
229
H51.2
ICD-10 Finland
Internuclear ophthalmoplegia
69.9
6.4
7
*
TPH07
NOMESCO Finland
Cathetrisation of artery
1.5
6.4
206
1401
7231A
ICD-9 Finland
Other disorders of cervical region, Cervicalgia
3.2
6.4
31
98
Z00.0
ICD-10 Finland
General medical examination
1.4
6.4
337
2524
7840A
ICD-9 Finland
Symptoms involving head and neck, Headache
3.4
6.4
28
82
PA2CG
NOMESCO Finland
Extensive MRI examination of vessels in the head with high intensity magnet
14.3
6.4
10
7
C09DA01
ATC
losartan and diuretics; oral
1.5
6.4
213
1464
C07AG02
ATC
carvedilol; oral
1.6
6.3
143
891
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
2.0
6.3
72
359
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
3.0
6.3
33
110
N30.9
ICD-10 Finland
Cystitis, unspecified
1.7
6.3
116
684
I21.49
ICD-10 Finland
Acute subendocardial infarction unspecified coronary artery status
1.6
6.3
149
942
F01.29
ICD-10 Finland
Subcortical vascular dementia without information on additional symptoms
5.9
6.3
16
27
K59.1
ICD-10 Finland
Functional diarrhoea
1.8
6.3
98
549
E11.6
ICD-10 Finland
Type 2 diabetes mellitus, with other specified complications
2.5
6.3
46
188
H02AB06
ATC
prednisolone; systemic
1.2
6.3
945
8190
I62.9
ICD-10 Finland
Intracranial haemorrhage (nontraumatic), unspecified
+∞
6.2
6
*
I60.1
ICD-10 Finland
Subarachnoid haemorrhage from middle cerebral artery
+∞
6.2
6
*
I67.7
ICD-10 Finland
Cerebral arteritis, not elsewhere classified
+∞
6.2
6
*
G46.5
ICD-10 Finland
Pure motor lacunar syndrome
+∞
6.2
6
*
I60.3
ICD-10 Finland
Subarachnoid haemorrhage from posterior communicating artery
+∞
6.2
6
*
PA2MT
NOMESCO Finland
Endovascular closure of very extensive brain aneurysm
+∞
6.2
6
*
UJF32
NOMESCO Finland
Coloscopy
1.3
6.2
524
4219
PEF23
NOMESCO Finland
Thrombendarterectomy of femoral artery
2.5
6.2
45
183
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.6
6.2
162
1052
M04AA01
ATC
allopurinol; systemic
1.4
6.1
322
2410
N03AE01
ATC
clonazepam; systemic
1.8
6.1
102
582
SPAT1050
SPAT
Extensive neurological examination
2.4
6.1
50
214
G47.3
ICD-10 Finland
Sleep apnoea
1.4
6.1
337
2541
R26.2
ICD-10 Finland
Difficulty in walking, not elsewhere classified
3.2
6.1
29
91
F01.20
ICD-10 Finland
Subcortical vascular dementia without additional symptoms
4.0
6.1
22
55
C10AA02
ATC
lovastatin; oral
1.7
6.1
114
677
AA1AM
NOMESCO Finland
Short MRI examination of brain with 3 Tesla magnet
12.5
6.1
10
8
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
2.8
6.1
36
130
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
1.7
6.0
110
645
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
1.6
6.0
151
967
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
4.9
6.0
18
37

Mortality – FinRegistry

Association

Association between endpoint I9_CEREBDOTH and mortality.

Females

Parameter HR [95% CI] p-value
I9_CEREBDOTH 1.804 [1.65, 1.98] < 0.001
Birth year 0.993 [0.99, 1.0] 0.089

During the follow-up period (1.1.1998 — 31.12.2019), 4689 out of 9333 females with I9_CEREBDOTH died.

Males

Parameter HR [95% CI] p-value
I9_CEREBDOTH 1.745 [1.58, 1.93] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 4617 out of 9686 males with I9_CEREBDOTH died.

Mortality risk

Mortality risk for people of age

years, who have I9_CEREBDOTH.

N-year risk Females Males
1 0.154% 0.319%
5 0.957% 1.904%
10 2.44% 4.433%
15 4.835% 8.401%
20 8.489% 14.215%

Relationships between endpoints

Index endpoint: I9_CEREBDOTH – Other specified cerebrovascular diseases, other cerebrovascular disorders in diseases classified elsewhere

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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