Cerebral arteritis

I9_CEREBRART

No definition available.

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — I67.7, I68.1, I68.1A18.8, I68.1A32.8, I68.1A52.0, I68.1B02.8, I68.2, I68.2M32.1 Hospital discharge:* ICD-9 — 4374 Cause of death: ICD-10 — I67.7, I68.1, I68.1A18.8, I68.1A32.8, I68.1A52.0, I68.1B02.8, I68.2, I68.2M32.1 Cause of death:* ICD-9 — 4374 2 out of 7 registries used, show all original rules.	95
4. Check minimum number of events None	95
5. Include endpoints None	95
6. Filter based on genotype QC (FinnGen only)	95

Control definitions (FinnGen only)

Control exclude: I9_CEREBVASC

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	I9_CEREBRART
CONTROL_EXCLUDE	I9_CEREBVASC
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	I677\|I68[1-2]
HD_ICD_9	4374
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	I677\|I68[1-2]
COD_ICD_9	4374
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Cerebral arteritis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	614	387	221
Only index persons	486	311	175
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	53.20	52.39	54.98
Only index persons	49.65	48.58	51.56

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	95	62	33
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	48.94	48.69	49.39

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
86: Matched controls
861

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

I67.7

ICD-10 Finland

Cerebral arteritis, not elsewhere classified

+∞

81.7

I63.9

ICD-10 Finland

Cerebral infarction, unspecified

+∞

34.7

I69.3

ICD-10 Finland

Sequelae of cerebral infarction

346.3

26.2

L04AX01

ATC

azathioprine; systemic

34.5

23.3

TAB00

NOMESCO Finland

Lumbar puncture

32.1

17.0

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

15.0

16.9

XA800

NOMESCO Finland

Neuropsychological investigation

23.6

16.3

R51.80

ICD-10 Finland

Headache

8.4

14.0

AA1AD

NOMESCO Finland

CT of head and brain

7.0

13.5

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

24.8

13.1

H02AB06

ATC

prednisolone; systemic

5.5

12.2

274

R4150

NOMESCO Finland

Neuropsychological rehabilitation

+∞

11.7

B01AC04

ATC

clopidogrel; oral

7.7

11.0

I67.6

ICD-10 Finland

Nonpyogenic thrombosis of intracranial venous system

+∞

10.6

I63.3

ICD-10 Finland

Cerebral infarction due to thrombosis of cerebral arteries

+∞

10.6

M32.9

ICD-10 Finland

Systemic lupus erythematosus, unspecified

45.7

10.3

R4120

NOMESCO Finland

Occupational therapy

11.6

9.8

I67.1

ICD-10 Finland

Cerebral aneurysm, nonruptured

+∞

9.5

AA1CM

NOMESCO Finland

Extensive MRI examination of brain with 3 Tesla magnet

22.9

8.7

PA2BD

NOMESCO Finland

Extensive CT angiography of brain

99.3

8.6

TPH04

NOMESCO Finland

Cathetrisation of vein

5.0

8.5

I63.8

ICD-10 Finland

Other cerebral infarction

+∞

8.5

M32.1

ICD-10 Finland

Systemic lupus erythematosus with organ or system involvement

+∞

8.5

PA2CC

NOMESCO Finland

Cerebral very extensive angiography with X-ray

+∞

8.5

B01AA03

ATC

warfarin; systemic

5.4

8.4

H02AB07

ATC

prednisone; oral

5.3

8.0

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

7.3

7.9

PA6BD

NOMESCO Finland

Extensive CT of neck arteries

20.7

7.8

Z01.0

ICD-10 Finland

Examination of eyes and vision

5.2

7.5

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

9.3

7.5

M32.0

ICD-10 Finland

Drug-induced systemic lupus erythematosus

+∞

7.4

I68.2*M32.1

ICD-10 Finland

Cerebral arteritis in systemic lupus erythematosus

+∞

7.4

L04AA06

ATC

mycophenolic acid; systemic

33.0

7.3

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

3.6

7.0

172

AA1DM

NOMESCO Finland

Very extensive MRI examination of brain with 3 Tesla magnet

29.0

6.3

R4130

NOMESCO Finland

Speech therapy

29.0

6.3

XCK00

NOMESCO Finland

Perimetry

7.7

6.3

PA6AG

NOMESCO Finland

Limited MRI examination of neck vasculature with high intensity magnet

+∞

6.3

M32.8

ICD-10 Finland

Other forms of systemic lupus erythematosus

+∞

6.3

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

4.5

6.1

G45.1

ICD-10 Finland

Carotid artery syndrome (hemispheric)

16.5

6.0

Mortality – FinRegistry

↥

Association

Association between endpoint I9_CEREBRART and mortality.

Females

Parameter	HR [95% CI]	p-value
I9_CEREBRART	2.464 [1.74, 3.48]	< 0.001
Birth year	0.994 [0.99, 1.0]	0.153

During the follow-up period (1.1.1998 — 31.12.2019), 75 out of 288 females with I9_CEREBRART died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have I9_CEREBRART.

N-year risk	Females	Males
1	0.188%	No data
5	1.119%	No data
10	3.367%	No data
15	6.757%	No data
20	11.596%	No data

Relationships between endpoints

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Index endpoint: I9_CEREBRART – Cerebral arteritis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Cerebral arteritis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints