Dissection of cerebral arteries, nonruptured

I9_DISCER

brain aneurysm: A congenital or acquired aneurysm within the cranium.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — I67.0 Cause of death: ICD-10 — I67.0 2 out of 7 registries used, show all original rules.	268
4. Check minimum number of events None	268
5. Include endpoints None	268
6. Filter based on genotype QC (FinnGen only)	268

Control definitions (FinnGen only)

Control exclude: I9_CEREBVASC

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: I67
Name in latin: Dissectio arteriae cerebralis sine ruptura

NAME	I9_DISCER
CONTROL_EXCLUDE	I9_CEREBVASC
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	I670
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	I670
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Dissection of cerebral arteries, nonruptured based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1673	729	931
Only index persons	1553	683	870
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.03
Only index persons	0.03	0.03	0.03
Median age at first event (years)
Whole population	52.52	52.32	52.80
Only index persons	51.96	51.56	52.28

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	268	144	124
Unadjusted period prevalence (%)	0.05	0.05	0.05
Median age at first event (years)	50.75	47.98	53.98

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
244: Matched controls
2441

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

I67.0

ICD-10 Finland

Dissection of cerebral arteries, nonruptured

+∞

323.0

243

B01AA03

ATC

warfarin; systemic

14.7

70.9

141

207

I69.3

ICD-10 Finland

Sequelae of cerebral infarction

839.6

67.3

I63.9

ICD-10 Finland

Cerebral infarction, unspecified

751.9

61.6

PA6BD

NOMESCO Finland

Extensive CT of neck arteries

31.5

46.6

I63.2

ICD-10 Finland

Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries

+∞

40.8

AA1AD

NOMESCO Finland

CT of head and brain

7.5

40.7

118

270

I63.3

ICD-10 Finland

Cerebral infarction due to thrombosis of cerebral arteries

+∞

36.4

I67.1

ICD-10 Finland

Cerebral aneurysm, nonruptured

+∞

34.2

G90.2

ICD-10 Finland

Horner syndrome

+∞

28.7

I65.2

ICD-10 Finland

Occlusion and stenosis of carotid artery

315.8

28.4

B01AC30

ATC

platelet aggregation inhibitors excl. heparin - combinations

17.9

23.7

XA800

NOMESCO Finland

Neuropsychological investigation

15.4

21.8

AAC00

NOMESCO Finland

Ligature of intracranial aneurysm

+∞

21.1

PA6BG

NOMESCO Finland

MRI examination of neck vasculature with high intensity magnet

+∞

20.1

I67.9

ICD-10 Finland

Cerebrovascular disease, unspecified

216.9

19.9

B01AC04

ATC

clopidogrel; oral

4.8

14.9

133

G45.9

ICD-10 Finland

Transient cerebral ischaemic attack, unspecified

7.4

14.8

K90

ICPC

Stroke/cerebrovascular accident

56.8

14.0

I63.0

ICD-10 Finland

Cerebral infarction due to thrombosis of precerebral arteries

+∞

13.7

PA6CG

NOMESCO Finland

Extensive MRI examination of neck vasculature with high intensity magnet

147.9

13.6

XF400

NOMESCO Finland

ECG with 12 standard connections

4.1

13.4

164

PA7AD

NOMESCO Finland

CT angiography of head and neck vasculature

15.2

13.0

R51.80

ICD-10 Finland

Headache

3.8

12.9

199

PA2BC

NOMESCO Finland

Cerebral extensive angiography with X-ray

136.7

12.6

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

4.3

12.0

129

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

5.1

11.8

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

4.9

11.7

I65.0

ICD-10 Finland

Occlusion and stenosis of vertebral artery

+∞

11.5

C10AA05

ATC

atorvastatin; oral

2.7

11.1

102

516

PA6AD

NOMESCO Finland

CT of neck arteries

29.5

10.8

G45.0

ICD-10 Finland

Vertebro-basilar artery syndrome

13.8

10.8

R4150

NOMESCO Finland

Neuropsychological rehabilitation

114.7

10.5

I69.0

ICD-10 Finland

Sequelae of subarachnoid haemorrhage

+∞

10.5

PA2CC

NOMESCO Finland

Cerebral very extensive angiography with X-ray

+∞

10.5

PA2BG

NOMESCO Finland

MRI examination of vessels in the head with high intensity magnet

34.2

10.4

H53.1

ICD-10 Finland

Subjective visual disturbances

5.6

9.8

PA7BD

NOMESCO Finland

CT angiography of neck and brain

22.8

9.5

I63.4

ICD-10 Finland

Cerebral infarction due to embolism of cerebral arteries

+∞

9.4

PA7CC

NOMESCO Finland

Very extensive angiography of arteries of neck and brain

+∞

9.4

G45.1

ICD-10 Finland

Carotid artery syndrome (hemispheric)

10.1

8.9

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

12.2

8.7

PA6DE

NOMESCO Finland

Neck artery ultrasound examination with Doppler method

10.6

8.7

PA2BD

NOMESCO Finland

Extensive CT angiography of brain

13.4

8.5

B01AB05

ATC

enoxaparin; parenteral

2.4

8.5

463

I72.0

ICD-10 Finland

Aneurysm and dissection of carotid artery

+∞

8.4

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

4.0

8.4

C09AA05

ATC

ramipril; oral

2.6

7.6

291

I60.9

ICD-10 Finland

Subarachnoid haemorrhage, unspecified

82.5

7.5

K99

ICPC

Cardiovascular disease other

9.8

7.4

G46.4*I67.9

ICD-10 Finland

Cerebellar stroke syndrome

+∞

7.3

I10

ICD-10 Finland

Essential (primary) hypertension

2.1

7.3

132

880

R42

ICD-10 Finland

Dizziness and giddiness

2.5

7.1

267

N02BE01

ATC

paracetamol; systemic, rectal

2.6

7.0

213

1765

R4120

NOMESCO Finland

Occupational therapy

4.3

6.7

N03AF02

ATC

oxcarbazepine; oral

6.5

6.6

I69.1

ICD-10 Finland

Sequelae of intracerebral haemorrhage

71.6

6.5

I67.8

ICD-10 Finland

Other specified cerebrovascular diseases

71.6

6.5

C10AA01

ATC

simvastatin; oral

2.1

6.3

545

H53.4

ICD-10 Finland

Visual field defects

13.0

6.1

ZXA05

NOMESCO Finland

Left side

2.2

6.0

363

Mortality – FinRegistry

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Association

Association between endpoint I9_DISCER and mortality.

Females

Parameter	HR [95% CI]	p-value
I9_DISCER	1.628 [1.22, 2.17]	< 0.001
Birth year	0.997 [0.99, 1.01]	0.506

During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 624 females with I9_DISCER died.

Males

Parameter	HR [95% CI]	p-value
I9_DISCER	1.389 [1.11, 1.74]	0.004
Birth year	0.99 [0.98, 1.0]	0.035

During the follow-up period (1.1.1998 — 31.12.2019), 128 out of 787 males with I9_DISCER died.

Mortality risk

Mortality risk for people of age

years, who have I9_DISCER.

N-year risk	Females	Males
1	0.099%	0.298%
5	0.878%	1.694%
10	2.544%	4.33%
15	4.874%	8.115%
20	8.809%	14.239%

Relationships between endpoints

↥

Index endpoint: I9_DISCER – Dissection of cerebral arteries, nonruptured

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Dissection of cerebral arteries, nonruptured

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints