brain aneurysm: A congenital or acquired aneurysm within the cranium.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1133 |
4. Check minimum number of eventsNone |
1133 |
5. Include endpointsNone |
1133 |
6. Filter based on genotype QC (FinnGen only) |
1133 |
Control definitions (FinnGen only)
- Control exclude
- I9_CEREBVASC
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- I67
- Name in latin
- Leucoencephalopathia vascularis progressiva
Similar endpoints
↥List of similar endpoints to
Progressive vascular leukoencephalopathy
based on the number of shared cases.
Similar with more cases:
- Cerebrovascular diseases (FINNGEN)
- Cerebrovascular diseases
- Neurological diseases, wide definition
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8396 | 4988 | 3358 |
| Only index persons | 7636 | 4604 | 3032 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.14 | 0.09 |
| Only index persons | 0.15 | 0.17 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 80.45 | 81.63 | 78.75 |
| Only index persons | 80.80 | 81.89 | 79.13 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1133 | 590 | 543 |
| Unadjusted period prevalence (%) | 0.22 | 0.20 | 0.24 |
| Median age at first event (years) | 80.01 | 80.50 | 79.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 964
- Matched controls
- 9639
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I67.3
ICD-10 Finland
Progressive vascular leukoencephalopathy
4503599627370496.0
323.0
963
30
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
155.8
229.4
236
20
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
11.7
204.1
437
637
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
97.8
197.3
214
28
R41.3
ICD-10 Finland
Other amnesia
15.9
132.2
226
182
R4110
NOMESCO Finland
Physiotherapy
5.4
122.0
507
1645
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
4.5
89.3
412
1371
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
+∞
85.7
81
*
G30.1
ICD-10 Finland
Alzheimer disease with late onset
5.1
74.3
269
674
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
7.8
63.7
156
232
Z01.9
ICD-10 Finland
Special examination, unspecified
7.5
63.4
160
249
XF400
NOMESCO Finland
ECG with 12 standard connections
3.7
59.2
316
1111
R4120
NOMESCO Finland
Occupational therapy
9.3
58.5
127
154
R53
ICD-10 Finland
Malaise and fatigue
3.3
54.8
363
1494
AA1AD
NOMESCO Finland
CT of head and brain
3.2
54.4
373
1574
Z71.8
ICD-10 Finland
Other specified counselling
3.4
51.5
317
1225
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
7.6
49.4
122
181
Z03
ICD-10 Finland
Medical observation and evaluation for suspected diseases and conditions, ruled out
5.1
48.2
165
373
XA800
NOMESCO Finland
Neuropsychological investigation
16.6
47.5
77
50
N06DX01
ATC
memantine; oral
3.6
44.5
231
771
R42
ICD-10 Finland
Dizziness and giddiness
2.8
42.8
360
1679
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.6
41.2
447
2409
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.1
41.0
266
1041
Z01.7
ICD-10 Finland
Laboratory examination
3.8
40.7
192
587
A28
ICPC
Limited function/disability NOS
2.8
40.5
346
1618
WX002
NOMESCO Finland
Sedation and analgesia
2.9
40.2
305
1322
ZXA05
NOMESCO Finland
Left side
2.6
40.0
401
2058
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
+∞
39.9
38
*
P20
ICPC
Memory disturbance
2.9
39.8
308
1349
ZXA00
NOMESCO Finland
Right side
2.5
38.3
410
2168
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
8.4
35.8
81
104
Z76.0
ICD-10 Finland
Issue of repeat prescription
3.4
34.7
189
642
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
3.4
33.3
183
625
I67.9
ICD-10 Finland
Cerebrovascular disease, unspecified
64.0
32.2
37
6
F03
ICD-10 Finland
Unspecified dementia
4.0
32.2
138
383
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
3.7
31.3
147
442
C10AA05
ATC
atorvastatin; oral
2.2
31.1
494
3083
F01.9
ICD-10 Finland
Vascular dementia, unspecified
8.9
30.9
67
80
M79.6
ICD-10 Finland
Pain in limb
2.3
30.0
395
2245
B01AC04
ATC
clopidogrel; oral
2.6
29.6
253
1144
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.5
29.4
275
1310
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.5
29.4
110
268
N06AX11
ATC
mirtazapine; oral
2.3
28.4
373
2102
Z01.6
ICD-10 Finland
Radiological examination, not elsewhere classified
3.6
28.2
139
433
I10
ICD-10 Finland
Essential (primary) hypertension
2.3
27.5
733
5617
Z73.6
ICD-10 Finland
Limitation of activities due to disability
15.7
27.5
45
30
TKC20
NOMESCO Finland
Catheterisation of bladder
3.3
26.5
145
486
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
+∞
26.2
25
*
U13
ICPC
Bladder symptom/complaint other
5.3
25.8
82
167
Z71.9
ICD-10 Finland
Counselling, unspecified
4.3
25.6
101
258
XCK10
NOMESCO Finland
Photography of fundus of eye
2.8
25.6
182
730
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
133.4
24.7
26
*
SPAT1053
SPAT
Memory test
2.2
23.9
307
1682
WX892
NOMESCO Finland
Monitored bed care
3.4
23.1
122
399
ZXA10
NOMESCO Finland
Bilateral
2.2
22.9
272
1435
TAB00
NOMESCO Finland
Lumbar puncture
6.0
22.7
64
113
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.3
22.1
254
1314
I63.5
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
224.8
21.7
22
*
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
117.6
21.7
23
*
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
5.2
21.4
68
139
R4130
NOMESCO Finland
Speech therapy
8.7
21.3
46
55
Z71
ICD-10 Finland
Persons encountering health services for other counselling and medical advice, not elsewhere classified
6.6
21.1
55
88
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.8
20.9
151
608
N02BE01
ATC
paracetamol; systemic, rectal
2.3
20.5
838
7121
N05AX08
ATC
risperidone; systemic
2.9
20.4
133
502
M54
ICD-10 Finland
Dorsalgia
2.9
19.8
133
509
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
75.1
19.8
22
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.0
19.6
82
221
N06DA04
ATC
galantamine; oral
4.4
19.6
72
172
F01.2
ICD-10 Finland
Subcortical vascular dementia
15.0
19.5
32
22
C08CA01
ATC
amlodipine; oral
1.9
19.4
471
3250
M54.5
ICD-10 Finland
Low back pain
2.0
18.9
312
1863
N06DA02
ATC
donepezil; oral
2.6
18.8
150
638
K90
ICPC
Stroke/cerebrovascular accident
12.6
18.7
33
27
WX110
SPAT
NA
6.1
18.7
51
87
A98
ICPC
Health maint/preventive medicine
2.3
18.2
850
7357
R51.80
ICD-10 Finland
Headache
2.7
18.2
134
544
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
+∞
17.8
17
*
C07AB07
ATC
bisoprolol; oral
1.8
17.7
592
4493
E11
ICD-10 Finland
Type 2 diabetes mellitus
2.2
17.4
205
1057
Z02.7
ICD-10 Finland
Issue of medical certificate
3.1
17.0
97
334
N30.0
ICD-10 Finland
Acute cystitis
2.2
17.0
189
950
R41.0
ICD-10 Finland
Disorientation, unspecified
4.0
16.6
68
180
S01.0
ICD-10 Finland
Open wound of scalp
2.8
16.5
112
433
J01DB01
ATC
cefalexin; oral
1.9
16.4
728
5985
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
2.1
16.4
218
1184
M25.5
ICD-10 Finland
Pain in joint
2.0
15.8
241
1379
G46.8*I67.9
ICD-10 Finland
Other vascular syndromes of brain in cerebrovascular diseases
61.0
15.8
18
*
SPAT1153
SPAT
Removal of sutures
0.5
15.8
129
2370
N06DA03
ATC
rivastigmine; oral, transdermal
2.9
15.8
101
376
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.2
15.7
84
277
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.0
15.5
247
1436
R5110
SPAT
NA
4.4
15.4
56
133
F06.7
ICD-10 Finland
Mild cognitive disorder
3.6
15.3
71
210
SPAT1256
SPAT
Intramuscular and subcutaneous injection
0.5
15.1
199
3173
I63
ICD-10 Finland
Cerebral infarction
45.7
15.1
18
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
15.0
258
1543
XF404
NOMESCO Finland
Ambulatory ECG
2.4
14.9
135
612
X59
ICD-10 Finland
Exposure to unspecified factor
2.1
14.9
180
933
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
3.7
14.7
64
180
H81
ICPC
Excessive ear wax
2.0
14.6
231
1337
I63.1
ICD-10 Finland
Cerebral infarction due to embolism of precerebral arteries
+∞
14.6
14
*
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
81.3
14.6
16
*
I67.8
ICD-10 Finland
Other specified cerebrovascular diseases
81.3
14.6
16
*
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
14.5
312
2009
N17
ICPC
Vertigo/dizziness
2.2
14.5
164
827
EB1AA
SPAT
NA
4.3
14.4
53
128
WX320
NOMESCO Finland
Spinalanesthesy
1.9
14.2
252
1520
R1260
NOMESCO Finland
Evaluation of communicative skills
5.7
14.2
40
72
A02BC02
ATC
pantoprazole; systemic
1.7
14.2
629
5029
F05.9
ICD-10 Finland
Delirium, unspecified
4.9
14.1
46
98
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.4
14.0
129
588
R60.0
ICD-10 Finland
Localized oedema
2.1
14.0
165
846
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.0
14.0
197
1089
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
13.9
229
1341
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.9
13.8
231
1361
N03AG01
ATC
valproic acid; systemic, rectal
3.5
13.8
64
190
C10AA01
ATC
simvastatin; oral
1.7
13.8
551
4257
Z50.1
ICD-10 Finland
Other physical therapy
2.9
13.6
83
299
SPAT1263
SPAT
Sampling
0.6
13.6
204
3158
M03BC01
ATC
orphenadrine (citrate); systemic
2.1
13.4
163
847
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
13.4
315
2080
Z46.9
ICD-10 Finland
Fitting and adjustment of unspecified device
5.3
13.3
40
78
K03.65
ICD-10 Finland
Deposits [accretions] on teeth betel
2.1
13.2
159
818
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.9
13.2
213
1234
R05
ICD-10 Finland
Cough
1.9
13.0
202
1154
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.9
13.0
210
1217
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.1
13.0
169
902
N05AH04
ATC
quetiapine; oral
2.2
12.9
141
698
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
14.3
12.8
21
15
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
14.3
12.8
21
15
WX110
NOMESCO Finland
Local anesthesy
1.6
12.7
538
4182
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
3.1
12.6
72
248
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.4
12.6
61
187
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.6
12.6
57
166
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.8
12.5
261
1648
PAF14
NOMESCO Finland
Thrombendarterectomy of internal carotid artery
24.7
12.5
17
7
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.2
12.3
134
658
N30
ICD-10 Finland
Cystitis
2.5
12.2
97
411
N03AX16
ATC
pregabalin; oral
1.8
12.2
234
1439
Z48.0
ICD-10 Finland
Attention to surgical dressings and sutures
3.6
12.1
55
161
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.6
12.1
89
360
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.5
12.0
96
407
WYA30
SPAT
NA
13.6
12.0
20
15
PAN14
NOMESCO Finland
Plastic repair of arteries internal carotid artery
47.2
11.9
14
*
IGY02
NOMESCO Finland
Psychiatric monitoring contact
11.9
11.9
21
18
U72
ICPC
Urethritis
4.3
11.8
43
103
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.1
11.8
151
797
I25
ICD-10 Finland
Chronic ischaemic heart disease
2.6
11.7
90
372
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
16.6
11.7
18
11
G04BD12
ATC
mirabegron; oral
2.1
11.7
148
778
GD1LA
NOMESCO Finland
GD
5.1
11.6
36
73
SPAT1312
SPAT
General health counselling
0.5
11.6
119
2068
XF600
NOMESCO Finland
Bloodpressure measurement
2.6
11.5
87
358
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.2
11.5
118
567
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
13.8
11.5
19
14
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
+∞
11.5
11
*
I63.2
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
+∞
11.5
11
*
SPAT1310
SPAT
Counselling related to known health issue
0.5
11.4
132
2218
N06AB04
ATC
citalopram; systemic
1.9
11.4
196
1160
R20.2
ICD-10 Finland
Paraesthesia of skin
3.1
11.3
61
204
J45
ICD-10 Finland
Asthma
2.4
11.2
98
436
G44.2
ICD-10 Finland
Tension-type headache
2.2
11.0
114
548
XF606
NOMESCO Finland
Ortostatic test
7.5
11.0
25
34
SPAT1301
SPAT
No procedures
0.6
10.9
164
2573
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.9
10.9
165
930
F01.20
ICD-10 Finland
Subcortical vascular dementia without additional symptoms
7.9
10.9
24
31
XF402
NOMESCO Finland
ECG with work load test
2.0
10.8
140
742
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.2
10.8
108
512
I50
ICD-10 Finland
Heart failure
2.7
10.8
75
295
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
2.1
10.7
125
636
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.1
10.7
127
651
S30.0
ICD-10 Finland
Contusion of lower back and pelvis
3.4
10.6
50
151
315
Kela drug reimbursment
Clopidogrel
8.1
10.6
23
29
C09CA01
ATC
losartan; oral
1.7
10.6
282
1904
F51.0
ICD-10 Finland
Nonorganic insomnia
2.3
10.6
102
475
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
10.5
164
935
E78
ICD-10 Finland
Disorders of lipoprotein metabolism and other lipidaemias
3.3
10.5
51
158
I67.4
ICD-10 Finland
Hypertensive encephalopathy
+∞
10.4
10
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.9
10.4
161
913
G40.9
ICD-10 Finland
Epilepsy, unspecified
4.0
10.4
41
107
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
2.5
10.4
80
334
TNX99
NOMESCO Finland
Other orthopaedic minor procedure
4.3
10.3
37
88
N06AB10
ATC
escitalopram; oral
2.0
10.3
138
739
I67.2
ICD-10 Finland
Cerebral atherosclerosis
19.0
10.3
15
8
SPAT1097
SPAT
Recording of ECG
0.4
10.3
55
1186
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.0
10.2
145
795
S06.0
ICD-10 Finland
Concussion
2.2
10.2
109
533
G30.8
ICD-10 Finland
Other Alzheimer disease
3.2
10.2
53
173
R06.0
ICD-10 Finland
Dyspnoea
1.7
10.1
288
1976
A06AC01
ATC
ispaghula (psylla seeds); oral
1.7
10.1
281
1918
D07AB08
ATC
desonide; topical
2.1
10.0
114
572
M79.1
ICD-10 Finland
Myalgia
2.1
10.0
114
574
I64
ICD-10 Finland
Stroke, not specified as haemorrhage or infarction
40.5
10.0
12
*
R52.9
ICD-10 Finland
Pain, unspecified
2.3
9.9
88
396
H53.1
ICD-10 Finland
Subjective visual disturbances
2.8
9.9
65
246
M15
ICD-10 Finland
Polyarthrosis
2.5
9.8
79
337
CM2X4
NOMESCO Finland
Follow-up OCT of age-related macular degeneration lesions
6.6
9.8
24
37
R41
ICD-10 Finland
Other symptoms and signs involving cognitive functions and awareness
6.2
9.7
25
41
H02BX01
ATC
methylprednisolone, combinations; systemic
2.4
9.7
86
384
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
5.9
9.7
26
45
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.6
9.6
340
2463
I95.1
ICD-10 Finland
Orthostatic hypotension
2.6
9.6
68
271
I63.8
ICD-10 Finland
Other cerebral infarction
100.9
9.4
10
*
S22.3
ICD-10 Finland
Fracture of rib
2.4
9.4
77
332
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.3
9.4
87
398
I61.1
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, cortical
+∞
9.4
9
*
IAB14
NOMESCO Finland
Geriatric psychiatry consultation
21.9
9.4
13
6
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
2.9
9.3
54
191
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
3.6
9.2
41
119
-44
ICPC
Preventive immunization/medic
0.3
9.2
20
633
B01AF02
ATC
apixaban; oral
1.9
9.2
148
851
A98
ICD-10 Finland
Other viral haemorrhagic fevers, not elsewhere classified
4.2
9.1
33
80
EBA30
NOMESCO Finland
Excision of root of tooth
2.5
9.1
69
286
G45
ICD-10 Finland
Transient cerebral ischaemic attacks and related syndromes
8.4
9.1
19
23
D11
ICPC
Diarrhoea
2.2
9.1
92
439
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.4
9.1
74
318
AXX01
SPAT
NA
4.2
9.0
33
81
N03AX14
ATC
levetiracetam; systemic
4.7
9.0
29
63
M19
ICD-10 Finland
Other arthrosis
3.5
9.0
40
117
F00
ICD-10 Finland
Dementia in Alzheimer disease
7.5
9.0
20
27
C07AA05
ATC
propranolol; systemic
1.9
8.9
144
827
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
8.9
169
1025
N06AX26
ATC
vortioxetine; oral
3.1
8.9
47
156
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.1
8.9
108
557
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
8.7
8.8
18
21
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
2.8
8.8
55
203
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
8.7
382
2892
U07.1
ICD-10 Finland
Emergency use of U07.1 | COVID-19, virus identified
2.4
8.7
77
343
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
8.5
296
2119
S16
ICPC
Bruise/contusion
3.0
8.5
47
161
FP1B5
NOMESCO Finland
Resting ECG, 12 leads
4.6
8.5
28
62
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
90.8
8.4
9
*
R55
ICD-10 Finland
Syncope and collapse
1.9
8.4
135
775
PA6AE
NOMESCO Finland
Ulrasound examination of neck vasculature
7.9
8.4
18
23
L28
ICPC
Limited function/disability (L)
1.7
8.4
214
1417
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
+∞
8.3
8
*
4340A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral thrombosis
+∞
8.3
8
*
I61.4
ICD-10 Finland
Intracerebral haemorrhage in cerebellum
+∞
8.3
8
*
A02BC05
ATC
esomeprazole; systemic
1.5
8.3
362
2732
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
8.3
371
2816
N06AX21
ATC
duloxetine; oral
2.2
8.3
87
424
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.0
8.3
100
517
S20.2
ICD-10 Finland
Contusion of thorax
2.7
8.3
56
217
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
2.8
8.2
50
183
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
14.6
8.2
13
9
Z04
ICD-10 Finland
Examination and observation for other reasons
4.2
8.1
29
70
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.6
8.1
267
1884
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.1
8.1
96
489
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
8.2
8.1
17
21
L84
ICD-10 Finland
Corns and callosities
3.0
8.1
46
160
M03BC51
ATC
orphenadrine, combinations; systemic
1.6
8.1
208
1380
F05.1
ICD-10 Finland
Delirium superimposed on dementia
6.4
8.0
20
32
J01CA04
ATC
amoxicillin; systemic
1.5
8.0
655
5640
RS222
NOMESCO Finland
NA
4.8
8.0
25
53
207
Kela drug reimbursment
Chronic arrhythmias
1.6
8.0
217
1459
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
0.6
8.0
138
2116
N03AF01
ATC
carbamazepine; oral, rectal
2.6
8.0
56
224
G03DA02
ATC
medroxyprogesterone; systemic (pregnen (4) derivatives)
2.1
7.9
91
461
K59.0
ICD-10 Finland
Constipation
2.2
7.9
79
375
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
6.2
7.9
20
33
TNG34
NOMESCO Finland
Major custom moulded orthopaedic cast, knee or lower leg
5.8
7.9
21
37
NA1AD
NOMESCO Finland
Cervical spine CT examination
2.9
7.8
45
158
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
7.8
435
3450
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
7.8
288
2086
F32
ICD-10 Finland
Depressive episode
3.3
7.8
38
120
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
7.8
156
961
N05BA01
ATC
diazepam; systemic, rectal
1.8
7.8
131
763
WX212
NOMESCO Finland
Femoral plexus blockade
3.3
7.8
37
115
H25.1
ICD-10 Finland
Senile nuclear cataract
1.5
7.7
413
3242
IBZ07
NOMESCO Finland
Neurological assessment in psychiatry
45.3
7.7
9
*
J20
ICD-10 Finland
Acute bronchitis
2.1
7.7
91
464
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
7.7
441
3516
X58
ICD-10 Finland
Exposure to other specified factors
2.0
7.6
95
495
N01
ICPC
Headache
2.3
7.6
70
321
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.0
7.6
102
547
F01.29
ICD-10 Finland
Subcortical vascular dementia without information on additional symptoms
10.1
7.5
14
14
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
1.9
7.5
119
680
Z01.3
ICD-10 Finland
Examination of blood pressure
4.2
7.5
27
66
R03AK07
ATC
formoterol and budesonide; inhalant
1.8
7.5
139
833
G21.8
ICD-10 Finland
Other secondary parkinsonism
13.5
7.4
12
9
EBA30
SPAT
NA
13.5
7.4
12
9
A23
ICPC
Risk factor NOS
2.7
7.4
49
190
R51
ICD-10 Finland
Headache
3.0
7.4
42
146
S00
ICD-10 Finland
Superficial injury of head
8.4
7.3
15
18
L82
ICD-10 Finland
Seborrhoeic keratosis
1.7
7.3
158
994
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.2
7.3
75
359
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
11.0
7.3
13
12
I63.0
ICD-10 Finland
Cerebral infarction due to thrombosis of precerebral arteries
+∞
7.3
7
*
G46.7*I67.9
ICD-10 Finland
Other lacunar syndromes
+∞
7.3
7
*
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
+∞
7.3
7
*
I61.8
ICD-10 Finland
Other intracerebral haemorrhage
+∞
7.3
7
*
H81.1
ICD-10 Finland
Benign paroxysmal vertigo
1.9
7.3
104
572
C03CA01
ATC
furosemide; systemic
1.5
7.3
424
3377
G91.0
ICD-10 Finland
Communicating hydrocephalus
15.9
7.2
11
7
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.5
7.2
298
2209
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
3.2
7.2
35
111
B01AC07
ATC
dipyridamole; systemic
2.3
7.2
67
308
G25.8
ICD-10 Finland
Other specified extrapyramidal and movement disorders
3.4
7.2
32
95
ZXC20
NOMESCO Finland
Use of chemical agents
2.8
7.2
43
157
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.7
7.1
161
1026
SFA40
NOMESCO Finland
Replacement of krone of tooth
1.7
7.1
167
1076
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.6
7.1
212
1455
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
8.9
7.1
14
16
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.9
7.1
97
528
Y94.8
ICD-10 Finland
Other leisure activity accident
3.8
7.0
28
76
G81.9
ICD-10 Finland
Hemiplegia, unspecified
7.6
6.9
15
20
N05AH03
ATC
olanzapine; systemic
2.9
6.9
40
143
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.9
6.9
40
143
SPAT1043
SPAT
Audiometry
0.5
6.8
41
854
XKD00
NOMESCO Finland
Uroflowmetry
1.6
6.8
187
1256
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
2.2
6.8
63
292
I11
ICD-10 Finland
Hypertensive heart disease
5.7
6.8
18
32
SPAT1249
SPAT
Treatment-related counselling outside office
0.7
6.8
199
2733
S00.0
ICD-10 Finland
Superficial injury of scalp
3.3
6.7
31
95
G30
ICD-10 Finland
Alzheimer disease
3.4
6.7
30
90
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
2.1
6.7
71
349
G04CA02
ATC
tamsulosin; oral
1.5
6.6
270
1986
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.5
6.6
327
2508
D07AB02
ATC
hydrocortisone butyrate; topical
1.5
6.6
243
1751
D64.9
ICD-10 Finland
Anaemia, unspecified
1.7
6.6
137
851
C09DA01
ATC
losartan and diuretics; oral
1.8
6.6
114
670
R26
ICD-10 Finland
Abnormalities of gait and mobility
10.1
6.5
12
12
IBA04
NOMESCO Finland
Extensive initial psychiatric evaluation
10.1
6.5
12
12
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
3.6
6.5
27
76
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.3
6.5
60
276
SDE03
NOMESCO Finland
Periodontal treatment by dental hygienist, extensive
1.6
6.5
168
1110
KMAK
NOMESCO Finland
NA
1.4
6.5
344
2670
M53.0
ICD-10 Finland
Cervicocranial syndrome
2.2
6.5
65
311
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.0
6.5
84
446
R11
ICD-10 Finland
Nausea and vomiting
1.9
6.4
90
492
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
2.5
6.4
46
187
WX100
NOMESCO Finland
Conjunctival surface anesthesia
1.6
6.4
163
1075
R26.2
ICD-10 Finland
Difficulty in walking, not elsewhere classified
4.4
6.4
21
48
M48.0
ICD-10 Finland
Spinal stenosis
1.7
6.4
152
981
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.1
6.4
65
315
W19
ICD-10 Finland
Unspecified fall
1.9
6.4
97
548
C09AA05
ATC
ramipril; oral
1.5
6.3
290
2182
N03AF02
ATC
oxcarbazepine; oral
3.5
6.3
27
78
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
2.1
6.3
66
320
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.2
6.3
59
273
SPAT1336
SPAT
Request for examination
2.5
6.3
48
201
G25.0
ICD-10 Finland
Essential tremor
3.0
6.3
34
117
Z26.9
ICD-10 Finland
Need for immunization against unspecified infectious disease
4.6
6.3
20
44
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.4
6.3
318
2442
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
0.6
6.3
116
1763
G46.3*I67.9
ICD-10 Finland
Brain stem stroke syndrome (I60-I67+)
+∞
6.3
6
*
C08CA06
ATC
nimodipine; systemic
+∞
6.3
6
*
4380A
ICD-9 Finland
Late effects of cerebrovascular disease[SEQUELAE MORBI CEREBROVASCULARIS]
+∞
6.3
6
*
R35
ICD-10 Finland
Polyuria
2.0
6.2
74
378
F01.24
ICD-10 Finland
Subcortical vascular dementia other additional symptoms of mixed type
26.8
6.2
8
*
J01FF01
ATC
clindamycin; systemic
1.5
6.2
214
1517
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.7
6.2
126
778
Z01.2
ICD-10 Finland
Dental examination
1.5
6.2
265
1966
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
3.0
6.2
33
113
WX290
SPAT
NA
4.5
6.2
20
45
R25.1
ICD-10 Finland
Tremor, unspecified
2.8
6.2
37
136
G04BD08
ATC
solifenacin; oral
1.9
6.2
93
521
130
Kela drug reimbursment
Malignant tumour
0.4
6.2
23
569
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.0
6.2
70
355
R47.0
ICD-10 Finland
Dysphasia and aphasia
7.7
6.1
13
17
S18
ICPC
Laceration/cut
1.4
6.1
384
3069
R07.0
ICD-10 Finland
Pain in throat
2.5
6.1
44
180
R13
ICD-10 Finland
Dysphagia
2.0
6.1
71
361
M05BA04
ATC
alendronic acid; oral
1.7
6.1
125
777
L08
ICD-10 Finland
Other local infections of skin and subcutaneous tissue
4.4
6.1
20
46
G31.8
ICD-10 Finland
Other specified degenerative diseases of nervous system
6.7
6.0
14
21
I84
ICD-10 Finland
Hemorrhoids
2.9
6.0
33
115
N06AB06
ATC
sertraline; oral
2.0
6.0
71
365
WX720
NOMESCO Finland
Own respiration
0.0
6.0
*
150
R31
ICD-10 Finland
Unspecified haematuria
1.7
6.0
121
746
EBA00
SPAT
NA
3.8
6.0
23
61
Mortality – FinRegistry
↥Association
Association between endpoint I9_PROGVASC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_PROGVASC | 1.801 [1.51, 2.14] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.614 |
During the follow-up period (1.1.1998 — 31.12.2019), 1426 out of 3641 females with I9_PROGVASC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_PROGVASC | 2.237 [1.78, 2.82] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1110 out of 2445 males with I9_PROGVASC died.
Mortality risk
Mortality risk for people of age
years, who have I9_PROGVASC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.181% | 0.372% |
| 5 | 1.113% | 2.372% |
| 10 | 2.898% | 6.012% |
| 15 | 5.374% | 11.12% |
| 20 | 9.441% | 18.33% |
Relationships between endpoints
↥Index endpoint: I9_PROGVASC – Progressive vascular leukoencephalopathy
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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