intracranial embolism: Blocking of a blood vessel in the skull by an embolus which can be a blood clot (thrombus) or other undissolved material in the blood stream. Most emboli are of cardiac origin and are associated with heart diseases. Other non-cardiac sources of emboli are usually associated with vascular diseases.
Occlusion and stenosis of arteries, not leading to stroke
DOID EFO Endpoint Browser PheWeb
I9_STENOSIS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
551 |
4. Check minimum number of eventsNone |
551 |
5. Include endpointsNone |
551 |
6. Filter based on genotype QC (FinnGen only) |
551 |
Control definitions (FinnGen only)
- Control exclude
- I9_CEREBVASC
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- I60-I69
- Name in latin
- Occlusio sive stenosis arteriarum cerebralium sine infarctu
Similar endpoints
↥List of similar endpoints to
Occlusion and stenosis of arteries, not leading to stroke
based on the number of shared cases.
Similar with more cases:
- Cerebrovascular diseases (FINNGEN)
- Cerebrovascular diseases
- Neurological diseases, wide definition
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7018 | 2849 | 3990 |
| Only index persons | 3710 | 1691 | 2019 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.08 | 0.11 |
| Only index persons | 0.07 | 0.06 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 67.81 | 70.75 | 65.76 |
| Only index persons | 65.92 | 68.76 | 63.54 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 551 | 177 | 374 |
| Unadjusted period prevalence (%) | 0.13 | 0.06 | 0.16 |
| Median age at first event (years) | 62.80 | 62.67 | 62.86 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 506
- Matched controls
- 5058
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
4331X
ICD-9 Finland
Occlusion and stenosis of precerebral arteries, Carotid artery[OCCL/STENOSIS ARTERIAE CAROTIS SINE INFARCTU CEREBR]
+∞
235.4
207
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
247.3
157.9
155
9
5541
FHL
Subclavia and / or carotid endarterectomy, reconstruction or bypass surgery
+∞
139.2
127
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
348.7
134.2
130
5
I66.9
ICD-10 Finland
Occlusion and stenosis of unspecified cerebral artery
1256.2
107.5
101
*
B01AC07
ATC
dipyridamole; systemic
10.6
72.9
155
203
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
676.5
62.2
60
*
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
663.7
61.1
59
*
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
11.2
52.9
105
115
G46.0*I66.0
ICD-10 Finland
Middle cerebral artery syndrome
+∞
42.3
40
*
I66.0
ICD-10 Finland
Occlusion and stenosis of middle cerebral artery
+∞
41.2
39
*
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
6.6
38.1
106
195
I63.0
ICD-10 Finland
Cerebral infarction due to thrombosis of precerebral arteries
+∞
34.8
33
*
4340A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral thrombosis
+∞
34.8
33
*
4351A
ICD-9 Finland
Transient cerebral ischaemia, Vertebral artery syndrome
68.3
33.5
38
6
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
344.3
32.2
32
*
4331A
ICD-9 Finland
Occlusion and stenosis of precerebral arteries, Carotid artery[OCCL/STENOSIS ARTERIAE CAROTIS CUM INFARCTU CEREBRI]
+∞
30.5
29
*
PAF14
NOMESCO Finland
Thrombendarterectomy of internal carotid artery
159.1
29.0
30
*
AA1AD
NOMESCO Finland
CT of head and brain
3.2
23.8
151
594
B01AC04
ATC
clopidogrel; oral
3.2
23.0
140
534
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.5
22.6
122
425
I66.8
ICD-10 Finland
Occlusion and stenosis of other cerebral artery
+∞
22.0
21
*
G46.2*I66.2
ICD-10 Finland
Posterior cerebral artery syndrome
+∞
21.0
20
*
I70.9
ICD-10 Finland
Generalized and unspecified atherosclerosis
8.3
20.1
45
59
I66.3
ICD-10 Finland
Occlusion and stenosis of cerebellar arteries
+∞
19.9
19
*
4339X
ICD-9 Finland
Occlusion and stenosis of precerebral arteries, Unspecified precerebral artery[OCCL/STENOSIS ARTER.PRAECEREBRALES NUD SINE INFARCT]
+∞
19.9
19
*
4380A
ICD-9 Finland
Late effects of cerebrovascular disease[SEQUELAE MORBI CEREBROVASCULARIS]
+∞
19.9
19
*
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
8.4
18.2
40
51
I63.5
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
+∞
17.8
17
*
K90
ICPC
Stroke/cerebrovascular accident
16.4
17.7
28
18
4402A
ICD-9 Finland
Atherosclerosis, Of native arteries of the extremities
6.8
17.0
43
68
I66.2
ICD-10 Finland
Occlusion and stenosis of posterior cerebral artery
+∞
16.8
16
*
C10AX09
ATC
ezetimibe; oral
4.0
16.0
67
186
205
Kela drug reimbursment
Chronic hypertension
2.2
15.6
227
1363
B01AA03
ATC
warfarin; systemic
2.3
14.9
185
1026
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
6.6
14.9
38
61
I63.1
ICD-10 Finland
Cerebral infarction due to embolism of precerebral arteries
+∞
14.7
14
*
XA800
NOMESCO Finland
Neuropsychological investigation
10.9
14.4
27
26
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.1
13.8
55
146
C10AA05
ATC
atorvastatin; oral
2.1
13.7
205
1225
I63.2
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
+∞
13.6
13
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
5.8
13.1
37
68
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
2.1
13.0
190
1120
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
2.1
12.9
215
1336
C10AA01
ATC
simvastatin; oral
2.0
12.7
265
1794
I66.4
ICD-10 Finland
Occlusion and stenosis of multiple and bilateral cerebral arteries
+∞
12.5
12
*
4330X
ICD-9 Finland
Occlusion and stenosis of precerebral arteries, Basilar artery[OCCL/STENOS ART.VERTEBRAL.SEU BASILAR.SINE INFARCTU]
+∞
12.5
12
*
4350A
ICD-9 Finland
Transient cerebral ischaemia, Basilar artery syndrome
38.6
12.3
15
*
4019X
ICD-9 Finland
Essential hypertension, Unspecified
4.0
12.0
48
128
I66.1
ICD-10 Finland
Occlusion and stenosis of anterior cerebral artery
+∞
11.5
11
*
I67.9
ICD-10 Finland
Cerebrovascular disease, unspecified
+∞
11.5
11
*
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
+∞
11.5
11
*
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
122.7
11.5
12
*
5651
FHL
Reoperation due to wound complication
122.7
11.5
12
*
R47.0
ICD-10 Finland
Dysphasia and aphasia
25.7
11.2
15
6
C08DB01
ATC
diltiazem; oral
2.8
10.7
72
282
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.3
10.6
114
575
C09AA02
ATC
enalapril; systemic
2.1
10.6
147
832
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.9
10.6
194
1225
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
+∞
10.4
10
*
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
4.9
10.3
33
71
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
8.7
10.1
21
25
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
2.5
9.9
85
383
R42
ICD-10 Finland
Dizziness and giddiness
2.1
9.8
126
687
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.9
9.7
183
1161
N03AF02
ATC
oxcarbazepine; oral
8.3
9.4
20
25
PA2VT
NOMESCO Finland
Intravascular evacuation of brain artery embolus
+∞
9.4
9
*
I65.3
ICD-10 Finland
Occlusion and stenosis of multiple and bilateral precerebral arteries
+∞
9.4
9
*
C03CA01
ATC
furosemide; systemic
1.8
9.2
242
1709
B04AB01
ATC
NA
5.2
9.1
27
54
4409X
ICD-9 Finland
Atherosclerosis, Generalised and unspecified atherosclerosis
15.9
9.1
14
9
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
5.7
9.0
25
46
C08CA01
ATC
amlodipine; oral
1.8
8.9
202
1357
315
Kela drug reimbursment
Clopidogrel
11.0
8.8
16
15
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
2.6
8.8
68
290
4408X
ICD-9 Finland
Atherosclerosis, Of other specified arteries
+∞
8.4
8
*
AAL10
NOMESCO Finland
Intracranial endovascular thrombolysis
+∞
8.4
8
*
N18
ICPC
Paralysis/weakness
11.0
8.3
15
14
B04AB02
ATC
NA
4.0
8.2
32
85
A06AD11
ATC
lactulose; oral
2.0
8.2
113
632
41399
ICD-8 Finland
Angina pectoris, Without mention of hypertensive disease
5.0
8.2
25
52
C01DA14
ATC
isosorbide mononitrate; oral
1.8
8.0
154
974
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
2.2
7.8
79
387
I67.2
ICD-10 Finland
Cerebral atherosclerosis
45.7
7.7
9
*
11
HP
Coronary artery bypass surgery
3.3
7.6
37
118
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
18.7
7.6
11
6
H53.4
ICD-10 Finland
Visual field defects
7.3
7.5
17
24
R51.80
ICD-10 Finland
Headache
2.6
7.5
54
221
4341A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral embolism
+∞
7.3
7
*
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
+∞
7.3
7
*
G46.1*I66.1
ICD-10 Finland
Anterior cerebral artery syndrome
+∞
7.3
7
*
4349A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral artery occlusion, unspecified[OCCL/STENOS ARTER.CEREBRALES NUD CUM INFARCTU CEREB]
+∞
7.3
7
*
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
30.5
7.2
9
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
10.2
7.1
13
13
I50.9
ICD-10 Finland
Heart failure, unspecified
1.8
7.0
127
778
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
2.4
6.9
59
263
C02DE04
ATC
NA
2.8
6.9
44
168
PEF23
NOMESCO Finland
Thrombendarterectomy of femoral artery
4.9
6.9
21
44
C08CA05
ATC
nifedipine; systemic
2.4
6.8
57
255
G45.3
ICD-10 Finland
Amaurosis fugax
5.4
6.8
19
36
4130X
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),MÄÄRITTELEMÄT]
3.1
6.8
36
123
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
2.6
6.8
47
189
N06AB04
ATC
citalopram; systemic
1.9
6.8
99
563
I63.8
ICD-10 Finland
Other cerebral infarction
40.6
6.8
8
*
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
40.6
6.8
8
*
AA5PD
NOMESCO Finland
CT examination of brain pefusion
40.6
6.8
8
*
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.7
6.7
44
173
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.9
6.6
96
546
K89
ICPC
Transient cerebral ischaemia
10.2
6.6
12
12
PA6AD
NOMESCO Finland
CT of neck arteries
10.2
6.6
12
12
81
HP
Angiography of the heart and coronary arteries
2.2
6.5
68
335
SPAT1252
SPAT
Overall medication plan or its review
2.5
6.5
51
219
5314
FHL
Bypass surgery for four or more vessels
4.4
6.5
22
52
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.9
6.5
38
139
N02AX02
ATC
tramadol; systemic, rectal
1.6
6.4
201
1447
N03AX16
ATC
pregabalin; oral
1.9
6.4
96
550
R06.0
ICD-10 Finland
Dyspnoea
1.8
6.4
129
819
B01AC06
ATC
acetylsalicylic acid; oral (platelet aggregation inhibitors excl. heparin)
2.3
6.3
55
250
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
+∞
6.3
6
*
G46.0
ICD-10 Finland
Middle cerebral artery syndrome
+∞
6.3
6
*
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
+∞
6.3
6
*
C02DE02
ATC
NA
3.5
6.2
27
80
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.5
6.2
27
80
N03AF01
ATC
carbamazepine; oral, rectal
3.1
6.2
32
108
N05CF01
ATC
zopiclone; oral
1.6
6.1
174
1221
5253
FHL
Cardiac lung machine
4.7
6.0
19
42
Mortality – FinRegistry
↥Association
Association between endpoint I9_STENOSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_STENOSIS | 1.749 [1.52, 2.02] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.296 |
During the follow-up period (1.1.1998 — 31.12.2019), 656 out of 1237 females with I9_STENOSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_STENOSIS | 1.811 [1.56, 2.1] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 719 out of 1395 males with I9_STENOSIS died.
Mortality risk
Mortality risk for people of age
years, who have I9_STENOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.192% | 0.308% |
| 5 | 1.036% | 2.107% |
| 10 | 2.553% | 5.306% |
| 15 | 4.843% | 9.863% |
| 20 | 8.837% | 16.834% |
Relationships between endpoints
↥Index endpoint: I9_STENOSIS – Occlusion and stenosis of arteries, not leading to stroke
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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