No definition available.
Respiratory conditions due to inhalation of chemicals, gases, fumes and vapours
EFO MESH Endpoint Browser PheWeb
J10_CHEMGASRESP
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
316 |
4. Check minimum number of eventsNone |
316 |
5. Include endpointsNone |
316 |
6. Filter based on genotype QC (FinnGen only) |
316 |
Control definitions (FinnGen only)
- Control exclude
- J10_EXTERLUNG
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- J60-J70
- Name in latin
- Morbositates respiratoriae ex inhalatione chemicalium, gasorum, fumorum et vaporum
Similar endpoints
↥List of similar endpoints to
Respiratory conditions due to inhalation of chemicals, gases, fumes and vapours
based on the number of shared cases.
Similar with more cases:
- Lung diseases due to external agents
- Diagnoses used for exclusion with ILD
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3900 | 1869 | 1984 |
| Only index persons | 2958 | 1403 | 1555 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.06 |
| Only index persons | 0.06 | 0.05 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 46.70 | 48.34 | 45.06 |
| Only index persons | 43.67 | 45.69 | 41.84 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 316 | 124 | 192 |
| Unadjusted period prevalence (%) | 0.07 | 0.04 | 0.08 |
| Median age at first event (years) | 44.73 | 44.13 | 45.12 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 284
- Matched controls
- 2838
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
51610
ICD-8 Finland
Other pneumoconiosis and related diseases, Due to inhalation of other dust
+∞
85.9
78
*
J68.0
ICD-10 Finland
Bronchitis and pneumonitis due to chemicals, gases, fumes and vapours
+∞
60.6
56
*
J68.3
ICD-10 Finland
Other acute and subacute respiratory conditions due to chemicals, gases, fumes and vapours
+∞
55.0
51
*
J68.9
ICD-10 Finland
Unspecified respiratory condition due to chemicals, gases, fumes and vapours
+∞
39.5
37
*
51620
ICD-8 Finland
Other pneumoconiosis and related diseases, Due to inhalation of fumes
+∞
26.5
25
*
4950A
ICD-9 Finland
Extrinsic allergic alveolitis, Farmers' lung
+∞
21.1
20
*
J68.2
ICD-10 Finland
Upper respiratory inflammation due to chemicals, gases, fumes and vapours, not elsewhere classified
+∞
14.7
14
*
J68.4
ICD-10 Finland
Chronic respiratory conditions due to chemicals, gases, fumes and vapours
+∞
14.7
14
*
J67.0
ICD-10 Finland
Farmer lung
+∞
13.6
13
*
R03AC02
ATC
salbutamol; inhalant
2.5
12.0
166
1034
R06.0
ICD-10 Finland
Dyspnoea
2.6
10.3
94
459
J45.9
ICD-10 Finland
Asthma, unspecified
2.8
9.6
70
299
J68.1
ICD-10 Finland
Pulmonary oedema due to chemicals, gases, fumes and vapours
+∞
8.4
8
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.5
8.2
70
327
R03BA02
ATC
budesonide; inhalant
2.6
7.9
63
280
H02AB06
ATC
prednisolone; systemic
2.0
7.4
139
919
5060A
ICD-9 Finland
Respiratory conditions due to chemical fumes and vapours, Bronchitis and pneumonitis due to fumes and vapours
+∞
7.3
7
*
J45.0
ICD-10 Finland
Predominantly allergic asthma
3.1
7.0
39
139
R03BA05
ATC
fluticasone; inhalant
2.4
6.5
55
255
T59.8
ICD-10 Finland
Toxic effect: Other specified gases, fumes and vapours
+∞
6.3
6
*
5062A
ICD-9 Finland
Respiratory conditions due to chemical fumes and vapours, Upper respiratory inflammation due to fumes and vapours
+∞
6.3
6
*
Mortality – FinRegistry
↥Association
Association between endpoint J10_CHEMGASRESP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_CHEMGASRESP | 2.547 [1.64, 3.96] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.057 |
During the follow-up period (1.1.1998 — 31.12.2019), 83 out of 394 females with J10_CHEMGASRESP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_CHEMGASRESP | 2.008 [1.58, 2.55] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.069 |
During the follow-up period (1.1.1998 — 31.12.2019), 143 out of 908 males with J10_CHEMGASRESP died.
Mortality risk
Mortality risk for people of age
years, who have J10_CHEMGASRESP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.175% | 0.377% |
| 5 | 1.164% | 2.493% |
| 10 | 3.067% | 6.557% |
| 15 | 6.139% | 12.833% |
| 20 | 10.725% | 21.588% |
Relationships between endpoints
↥Index endpoint: J10_CHEMGASRESP – Respiratory conditions due to inhalation of chemicals, gases, fumes and vapours
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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