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Pneumoconiosis due to dust containing silica

DOID EFO Endpoint Browser PheWeb

J10_SILICAPNEUMOC

silicosis: Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. There are three types of silicosis: Simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20years) to low amounts of silica dust. Simple chronic silicosismay causepeople to have difficulty breathing. Accelerated silicosis occurs after 5 to 15 yearsof exposure of higher levels of silica.Swelling of the lungsand other symptoms occur faster in this type of silicosis than in the simple chronic form. Acute silicosis results from short-term exposure (weeks or months) of large amounts of silica.The lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. A cough, weight loss, and fatigue may also be present. Acute silicosis progresses rapidly and can be fatal within months. People who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — J62
  • Hospital discharge: ICD-9 — 502
  • Hospital discharge: ICD-8 — 5150
  • Cause of death: ICD-10 — J62
  • Cause of death: ICD-9 — 502
  • Cause of death: ICD-8 — 5150

2 out of 7 registries used, show all original rules.

125

4. Check minimum number of events

None

125

5. Include endpoints

None

125

6. Filter based on genotype QC (FinnGen only)

125

Control definitions (FinnGen only)

Control exclude
J10_EXTERLUNG

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
J60-J70
Name in latin
Silicosis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1139 103 997
Only index persons 595 70 525
Unadjusted period prevalence (%)
Whole population 0.03 0.00 0.03
Only index persons 0.02 0.00 0.02
Median age at first event (years)
Whole population 64.26 62.16 64.36
Only index persons 62.00 51.82 63.36

-FinnGen-

Key figures

All Female Male
Number of individuals 125 11 114
Unadjusted period prevalence (%) 0.05 0.00 0.05
Median age at first event (years) 64.12 41.77 66.27

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
108
Matched controls
1081
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J62.8
ICD-10 Finland
Pneumoconiosis due to other dust containing silica
+∞
74.9
63
*
J62.0
ICD-10 Finland
Pneumoconiosis due to talc dust
+∞
48.7
43
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
12.4
24.9
50
70
J92.0
ICD-10 Finland
Pleural plaque with presence of asbestos
34.0
17.3
22
8
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
15.9
14.2
23
18
UGC12
NOMESCO Finland
Flexible bronchoscopy
7.3
12.5
32
59
51500
ICD-8 Finland
Pneumoconiosis due to silica and silicates, Silicosis
+∞
11.7
11
*
J61
ICD-10 Finland
Pneumoconiosis due to asbestos and other mineral fibres
+∞
11.7
11
*
J62
ICD-10 Finland
Pneumoconiosis due to dust containing silica
+∞
11.7
11
*
5020A
ICD-9 Finland
Pneumoconiosis due to other silica or silicates[SILICOSIS]
+∞
10.6
10
*
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
19.8
9.7
14
8
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
4.2
8.4
35
110
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.2
7.6
67
366
H02AB06
ATC
prednisolone; systemic
3.0
7.0
63
343
Z57.2
ICD-10 Finland
Occupational exposure to dust
74.0
6.5
7
*
TGC00
NOMESCO Finland
Bronchial lavation
12.1
6.5
11
10
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
+∞
6.3
6
*

Mortality – FinRegistry

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Association

Association between endpoint J10_SILICAPNEUMOC and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
J10_SILICAPNEUMOC 1.875 [1.51, 2.33] < 0.001
Birth year 0.989 [0.98, 1.0] 0.019

During the follow-up period (1.1.1998 — 31.12.2019), 247 out of 466 males with J10_SILICAPNEUMOC died.

Mortality risk

Mortality risk for people of age

years, who have J10_SILICAPNEUMOC.

N-year risk Females Males
1 No data 0.447%
5 No data 2.501%
10 No data 5.67%
15 No data 10.948%
20 No data 18.021%

Relationships between endpoints

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Index endpoint: J10_SILICAPNEUMOC – Pneumoconiosis due to dust containing silica

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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