Liver disorders in diseases classified elsewhere

K11_LIVDISINOTH

liver disease: A disease involving the liver.

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — K77, K77.0B96.8 Cause of death: ICD-10 — K77, K77.0B96.8 2 out of 7 registries used, show all original rules.	103
4. Check minimum number of events None	103
5. Include endpoints None	103
6. Filter based on genotype QC (FinnGen only)	103

Control definitions (FinnGen only)

Control exclude: K11_LIVER

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	K11_LIVDISINOTH
CONTROL_EXCLUDE	K11_LIVER
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	K77
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	K77
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Liver disorders in diseases classified elsewhere based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	658	357	293
Only index persons	589	326	263
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	41.72	45.97	36.16
Only index persons	40.95	45.13	35.77

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	103	68	35
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	47.02	46.22	48.59

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
93: Matched controls
928

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

K77.0*B25.1

ICD-10 Finland

Cytomegaloviral hepatitis

+∞

54.7

K77.8*D86.8

ICD-10 Finland

Hepatic granulomas in sarcoidosis

+∞

24.0

K75.9

ICD-10 Finland

Inflammatory liver disease, unspecified

+∞

19.4

JJ2AT

NOMESCO Finland

Biopsy of liver with ultrasound guidance

41.8

16.5

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

10.5

15.1

D86.8

ICD-10 Finland

Sarcoidosis of other and combined sites

176.6

14.9

K76.9

ICD-10 Finland

Liver disease, unspecified

+∞

13.9

A05AA02

ATC

ursodeoxycholic acid; oral

58.9

13.3

K77.8

ICD-10 Finland

Liver disorders in other diseases classified elsewhere

+∞

12.8

R50.9

ICD-10 Finland

Fever, unspecified

6.9

12.2

K77.0

ICD-10 Finland

Liver disorders in infectious and parasitic diseases classified elsewhere

+∞

11.7

GD1AA

NOMESCO Finland

Thorax X-ray examination

4.7

11.3

235

L04AA06

ATC

mycophenolic acid; systemic

29.8

10.1

TJJ00

NOMESCO Finland

Percutaneous needle biopsy of liver

+∞

8.5

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

5.7

8.2

D86.0

ICD-10 Finland

Sarcoidosis of lung

49.3

7.9

Z94.4

ICD-10 Finland

Liver transplant status

+∞

7.4

R74.0

ICD-10 Finland

Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]

43.3

6.9

TK800

NOMESCO Finland

Hemodialysis

24.6

6.8

127

Kela drug reimbursment

Transplant complication

24.6

6.8

GD1DD

NOMESCO Finland

High resolution CT examination of lungs

10.4

6.5

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

8.0

6.5

JJC00

NOMESCO Finland

Allogenic transplantation of liver

+∞

6.3

Mortality – FinRegistry

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Association

Association between endpoint K11_LIVDISINOTH and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have K11_LIVDISINOTH.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: K11_LIVDISINOTH – Liver disorders in diseases classified elsewhere

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Liver disorders in diseases classified elsewhere

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints