hyperpituitarism: Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma.
Hyperfunction of pituitary gland, other and/or unspecified
DOID EFO Endpoint Browser PheWeb
E4_HYPERPITNAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
58 |
4. Check minimum number of eventsNone |
58 |
5. Include endpointsNone |
58 |
6. Filter based on genotype QC (FinnGen only) |
58 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- E22
- Name in latin
- Hyperfunctio hypophysis non specificata
Similar endpoints
↥List of similar endpoints to
Hyperfunction of pituitary gland, other and/or unspecified
based on the number of shared cases.
Similar with more cases:
- Hyperfunction of pituitary gland
- Exclusions for E4_PCOS_BROAD
- Disorders of other endocrine glands
- Exclusions for E4_PCOS_CONSORTIUM
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 363 | 231 | 131 |
| Only index persons | 324 | 212 | 112 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 46.68 | 44.04 | 51.12 |
| Only index persons | 45.20 | 41.70 | 51.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 58 | 37 | 21 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 49.23 | 44.67 | 57.26 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 56
- Matched controls
- 558
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E22.9
ICD-10 Finland
Hyperfunction of pituitary gland, unspecified
+∞
66.6
50
*
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
+∞
29.9
26
*
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
+∞
23.6
21
*
H02AB09
ATC
hydrocortisone; systemic
101.0
19.2
20
*
E22.1
ICD-10 Finland
Hyperprolactinaemia
+∞
18.8
17
*
N04BC06
ATC
cabergoline; oral (dopamine agonists)
182.5
14.1
14
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
14.1
13
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
+∞
13.0
12
*
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
13.0
12
*
G02CB01
ATC
bromocriptine; systemic
33.3
11.9
15
6
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
+∞
10.8
10
*
H03AA01
ATC
levothyroxine sodium; systemic
6.4
9.0
28
75
2530A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Acromegaly and gigantism[ACROMEGALIA]
+∞
8.5
8
*
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
7.4
7
*
H01CB02
ATC
octreotide; parenteral
+∞
7.4
7
*
G02CB03
ATC
cabergoline; oral (prolactine inhibitors)
78.4
6.6
7
*
25301
ICD-8 Finland
Diseases of pituitary gland, Gigantismus hypophysarius et hyperpituitarismus alius
+∞
6.4
6
*
UJF32
NOMESCO Finland
Coloscopy
4.5
6.1
26
91
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPERPITNAS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_HYPERPITNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_HYPERPITNAS – Hyperfunction of pituitary gland, other and/or unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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