hyperpituitarism: Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1894 |
4. Check minimum number of eventsNone |
1894 |
5. Include endpoints |
2081 |
6. Filter based on genotype QC (FinnGen only) |
1982 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E20-E35
- Name in latin
- Hyperfunctio hypophysis
Similar endpoints
↥List of similar endpoints to
Hyperfunction of pituitary gland
based on the number of shared cases.
Similar with more cases:
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13775 | 10007 | 3602 |
| Only index persons | 12382 | 9265 | 3117 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.24 | 0.29 | 0.10 |
| Only index persons | 0.28 | 0.34 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 36.03 | 32.93 | 44.58 |
| Only index persons | 35.04 | 32.51 | 42.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1982 | 1490 | 492 |
| Unadjusted period prevalence (%) | 0.45 | 0.53 | 0.23 |
| Median age at first event (years) | 38.60 | 34.60 | 50.72 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2081
- Matched controls
- 20810
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
312.6
307.7
601
27
G02CB01
ATC
bromocriptine; systemic
40.4
307.7
503
163
N04BC06
ATC
cabergoline; oral
712.6
307.7
531
10
H02AB09
ATC
hydrocortisone; systemic
23.1
307.7
273
135
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
234.9
307.7
444
24
G02CB03
ATC
cabergoline; oral
69.1
307.7
217
35
E22.1
ICD-10 Finland
Hyperprolactinaemia
11983.8
307.7
1402
*
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
+∞
234.9
221
*
E22.2
ICD-10 Finland
Syndrome of inappropriate secretion of antidiuretic hormone
1007.1
190.8
184
*
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
235.7
170.0
173
8
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
157.3
149
*
N91.1
ICD-10 Finland
Secondary amenorrhoea
10.3
156.6
181
190
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
8.7
143.0
189
236
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
40.3
121.5
74
19
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
113.6
108
*
E22.80
ICD-10 Finland
Central precocious puberty
+∞
103.0
98
*
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
6.8
99.8
162
254
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
203.3
94.2
97
5
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
4.1
91.9
280
760
N05AX08
ATC
risperidone; systemic
4.0
88.7
276
760
ZXC86
NOMESCO Finland
Use of endoscopic device
38.1
84.0
52
14
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
5.5
77.1
155
299
G02CB04
ATC
quinagolide; oral
237.7
67.6
69
*
AA4CM
NOMESCO Finland
Extensive MRI examination of sella turcica with 3 Tesla magnet
668.9
66.3
65
*
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
14.0
64.9
60
44
N05AH03
ATC
olanzapine; systemic
3.5
63.8
235
721
G03DB01
ATC
dydrogesterone; oral
2.7
63.1
422
1817
H03AA01
ATC
levothyroxine sodium; systemic
2.3
61.6
596
3040
E22.9
ICD-10 Finland
Hyperfunction of pituitary gland, unspecified
+∞
54.4
52
*
H01CB02
ATC
octreotide; parenteral
99.4
53.1
58
6
F29
ICD-10 Finland
Unspecified nonorganic psychosis
3.9
51.3
157
423
N05AX12
ATC
aripiprazole; systemic
3.6
51.3
180
533
2531A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Other and unspecified anterior pituitary hyperfunction[HYPERPROLACTINAEMIA]
+∞
51.3
49
*
N64.3
ICD-10 Finland
Galactorrhoea not associated with childbirth
10.1
50.9
58
59
2594A
ICD-9 Finland
Other endocrine disorders, Dwarfism, not elsewhere classified
+∞
49.2
47
*
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
11.1
46.1
49
45
2273A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Pituitary gland and craniopharyngeal duct (pouch)
+∞
46.0
44
*
D44.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pituitary gland
60.4
45.5
53
9
102
Kela drug reimbursment
Diabetes insipidus
457.5
45.4
45
*
E23.05
ICD-10 Finland
Lack of TSH
235.1
45.1
46
*
N05AH02
ATC
clozapine; systemic
5.4
45.0
90
172
XCK00
NOMESCO Finland
Perimetry
3.7
44.9
152
439
AA4DG
NOMESCO Finland
Very extensive MRI examination of sella turcica with high intensity magnet
120.2
43.9
47
*
H01AC01
ATC
somatropin; parenteral
+∞
42.9
41
*
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
41.8
40
*
N05AB03
ATC
perphenazine; systemic, rectal
4.0
41.8
123
322
N05AH04
ATC
quetiapine; oral
2.1
41.6
479
2569
H01CB03
ATC
lanreotide; parenteral
76.7
40.0
45
6
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
5.3
39.6
81
158
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.7
39.5
230
912
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
203.8
38.9
40
*
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
5.2
36.6
77
154
N05AA02
ATC
levomepromazine; systemic
3.7
36.3
117
326
AA1AD
NOMESCO Finland
CT of head and brain
2.0
35.6
469
2626
2530A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Acromegaly and gigantism[ACROMEGALIA]
+∞
35.5
34
*
E30.1
ICD-10 Finland
Precocious puberty
342.6
34.0
34
*
XLA10, ,
NOMESCO Finland
3.1
33.9
149
506
N04AA02
ATC
biperiden; systemic
5.2
33.8
70
138
N03AG01
ATC
valproic acid; systemic, rectal
2.8
31.8
169
637
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.0
31.5
144
500
Z51.80
ICD-10 Finland
Manipulation of puberty development with hormone therapy
+∞
31.3
30
*
N04BC01
ATC
bromocriptine; oral
162.4
30.7
32
*
N97.0
ICD-10 Finland
Female infertility associated with anovulation
4.4
30.7
79
187
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.8
30.6
96
263
2542
FHL
Transasal hypophysectomy
+∞
30.3
29
*
E21.0
ICD-10 Finland
Primary hyperparathyroidism
59.3
30.1
35
6
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
5.3
30.1
61
118
L02AE02
ATC
leuprorelin; implant, parenteral
3.6
29.5
101
293
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.2
28.8
286
1433
N97.9
ICD-10 Finland
Female infertility, unspecified
2.5
28.6
191
806
UJF32
NOMESCO Finland
Coloscopy
1.9
28.4
457
2713
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
4.2
28.0
76
187
N05BA06
ATC
lorazepam; systemic, sublingual
3.1
27.8
121
408
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
3.1
26.4
113
377
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.7
25.8
733
5103
N03AX09
ATC
lamotrigine; oral
2.6
25.6
158
642
N91.4
ICD-10 Finland
Secondary oligomenorrhoea
7.9
25.6
35
45
F25.10
ICD-10 Finland
Schizoaffective syndrome, depressive type with only concomitant bipolar and schizophrenic symptoms
7.1
25.5
38
54
N05CD07
ATC
temazepam; oral
2.3
25.2
197
892
N06AX16
ATC
venlafaxine; oral
1.9
24.9
357
2033
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
23.9
506
3241
P72
ICPC
Schizophrenia
4.0
23.8
68
174
N06AB04
ATC
citalopram; systemic
1.8
23.7
436
2682
F20.9
ICD-10 Finland
Schizophrenia, unspecified
3.9
23.5
69
180
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.0
23.5
305
1679
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.9
23.4
340
1943
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
4.9
23.2
51
106
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
+∞
23.0
22
*
25300
ICD-8 Finland
Diseases of pituitary gland, Aeromegalia
+∞
23.0
22
*
121
Kela drug reimbursment
Severe hypofunction of sexual glands
4.7
22.9
53
115
E23.2
ICD-10 Finland
Diabetes insipidus
232.5
22.7
23
*
N05AF03
ATC
chlorprothixene; systemic
3.5
22.6
77
223
N05AF05
ATC
zuclopenthixol; systemic
6.9
22.1
34
50
2591A
ICD-9 Finland
Other endocrine disorders, Precocious sexual development and puberty, not elsewhere classified
+∞
21.9
21
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
21.1
742
5382
E22.88
ICD-10 Finland
Other hyperfunction of pituitary gland
+∞
20.9
20
*
E23.03
ICD-10 Finland
Lack of ACTH
212.0
20.6
21
*
N05AN01
ATC
lithium; oral
3.3
20.5
78
243
N05BA04
ATC
oxazepam; oral
1.7
20.4
527
3539
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.0
20.2
254
1379
H53.4
ICD-10 Finland
Visual field defects
4.3
20.0
52
124
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
19.9
339
2027
D352, E221,
ICD-10 Finland
+∞
19.8
19
*
E23.6
ICD-10 Finland
Other disorders of pituitary gland
+∞
19.8
19
*
2590A
ICD-9 Finland
Other endocrine disorders, Delay in sexual development and puberty, not elsewhere classified
+∞
19.8
19
*
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
3.6
19.6
65
185
F22.0
ICD-10 Finland
Delusional disorder
5.4
19.5
38
71
N06AX11
ATC
mirtazapine; oral
1.6
19.3
674
4857
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
19.3
283
1616
H02AA02
ATC
fludrocortisone; oral
8.4
19.3
25
30
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
19.2
437
2835
T99
ICPC
Endocr/metab/nutrit disease other
4.6
18.9
45
100
A06AC01
ATC
ispaghula (psylla seeds); oral
1.7
18.9
459
3026
AA400
NOMESCO Finland
Electroconvulsive therapy
5.6
18.7
35
63
R42
ICD-10 Finland
Dizziness and giddiness
1.7
18.4
397
2536
R11
ICD-10 Finland
Nausea and vomiting
2.0
18.4
201
1038
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
18.3
513
3501
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.0
18.3
224
1203
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.5
18.1
117
486
R53
ICD-10 Finland
Malaise and fatigue
1.6
18.1
497
3377
188
Kela drug reimbursment
Psychosis requiring demanding treatment
5.1
17.9
37
73
E23.09
ICD-10 Finland
Pituitary insufficiency NOS
+∞
17.7
17
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
17.6
488
3319
N05AE04
ATC
ziprasidone; systemic
5.4
17.3
34
64
R55
ICD-10 Finland
Syncope and collapse
2.1
17.1
181
923
N06AB03
ATC
fluoxetine; oral
1.8
16.9
268
1564
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
4.6
16.6
39
86
E29.1
ICD-10 Finland
Testicular hypofunction
7.3
16.5
24
33
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
171.3
16.5
17
*
ZXC95
NOMESCO Finland
Use of surgical navigator
4.9
16.4
36
75
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
3.1
16.1
69
231
R51.80
ICD-10 Finland
Headache
1.7
16.0
374
2433
N05AA01
ATC
chlorpromazine; systemic, rectal
4.5
15.9
38
85
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
15.9
837
6517
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.8
15.8
233
1328
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.8
15.8
252
1472
ZXE10
NOMESCO Finland
More than one and less than three hours
1.5
15.7
637
4699
Z3231
NOMESCO Finland
Registered nurse
1.6
15.7
505
3542
C07AA05
ATC
propranolol; systemic
1.6
15.5
449
3076
N05AD01
ATC
haloperidol; systemic
3.2
15.4
60
190
Z2446
NOMESCO Finland
Social worker
2.1
15.2
150
744
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.2
15.2
136
650
F83
ICD-10 Finland
Mixed specific developmental disorders
6.8
14.9
23
34
N05CF01
ATC
zopiclone; oral
1.5
14.8
543
3914
A55
ICPC
General and Unspecified, Local injection/infiltration
5.1
14.8
31
62
N06AX21
ATC
duloxetine; oral
1.8
14.7
248
1472
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.6
14.7
344
2235
ZYC01
NOMESCO Finland
Remote contact by phone
2.1
14.7
135
653
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
14.6
14
*
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
3.2
14.6
57
181
A06AD11
ATC
lactulose; oral
1.8
14.5
212
1205
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.3
14.5
106
466
E34.39
ICD-10 Finland
Short stature, not elsewhere classified
151.0
14.5
15
*
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
151.0
14.5
15
*
N05AX13
ATC
paliperidone; systemic
5.8
14.5
26
45
E21.3
ICD-10 Finland
Hyperparathyroidism, unspecified
36.3
14.4
18
5
G47.3
ICD-10 Finland
Sleep apnoea
1.6
14.4
370
2458
F20.3
ICD-10 Finland
Undifferentiated schizophrenia
6.4
14.1
23
36
R41.0
ICD-10 Finland
Disorientation, unspecified
3.5
14.0
48
140
F25.20
ICD-10 Finland
Schizoaffective syndrome, mixed type with only concomitant bipolar and schizophrenic symptoms
5.5
14.0
27
50
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.8
14.0
210
1204
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
3.7
13.9
43
117
WVA30, ,
SPAT
2.4
13.9
97
418
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
2.7
13.8
76
292
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.3
13.6
104
466
2599X
ICD-9 Finland
Other endocrine disorders, Unspecified endocrine disorder
+∞
13.6
13
*
301
Kela drug reimbursment
Growth hormone
+∞
13.6
13
*
F25.00
ICD-10 Finland
Schizoaffective syndrome, manic type with only simultaneous bipolar and schizophrenic symptoms
4.8
13.6
30
63
N91.2
ICD-10 Finland
Amenorrhoea, unspecified
4.8
13.6
30
63
N03AE01
ATC
clonazepam; systemic
2.2
13.5
110
506
T73
ICPC
Neoplasm endocrine other/unspecified
34.3
13.5
17
5
ZXE20
NOMESCO Finland
More than three and less than five hours
1.8
13.5
220
1293
IER04
NOMESCO Finland
Rehabilitative psychiatric group intervention, functional
4.4
13.3
33
76
C03CA01
ATC
furosemide; systemic
1.6
13.3
344
2285
N06AG02
ATC
moclobemide; oral
2.5
13.3
83
340
SPAT1263
SPAT
Sampling
1.4
13.2
809
6416
N05BA01
ATC
diazepam; systemic, rectal
1.7
13.1
232
1397
N05BE01
ATC
buspirone; oral
2.8
13.0
65
238
F20.04
ICD-10 Finland
Paranoid schizophrenia with partial recurrence
5.3
13.0
26
50
A12AA04
ATC
calcium carbonate; oral
5.3
13.0
26
50
X21
ICPC
Breast sympt/compl female other
2.9
12.8
61
217
XF404
NOMESCO Finland
Ambulatory ECG
2.0
12.8
136
694
A02BC02
ATC
pantoprazole; systemic
1.4
12.8
1219
10421
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
12.7
389
2684
BBA40
NOMESCO Finland
Subtotal parathyroidectomy
70.3
12.6
14
*
22620
ICD-8 Finland
Benign neoplasm of endocrine glands, Pituitary gland and craniopharyngeal duct (pouch)
+∞
12.5
12
*
25320
ICD-8 Finland
Diseases of pituitary gland, Chromophobe adenoma, pituitary
+∞
12.5
12
*
2592A
ICD-9 Finland
Other endocrine disorders, Carcinoid syndrome
+∞
12.5
12
*
106
Kela drug reimbursment
Hypoparathyroidism
+∞
12.5
12
*
M14.5*E22.0
ICD-10 Finland
Arthropathy associated with acromegaly
+∞
12.5
12
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
1.8
12.5
177
997
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
3.1
12.5
52
172
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
1.9
12.4
160
873
ZY010
NOMESCO Finland
Hospital outpatient
2.0
12.3
137
711
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.7
12.3
213
1273
J01MA12
ATC
levofloxacin; systemic
1.6
12.2
280
1803
7834C
ICD-9 Finland
Symptoms concerning nutrition, metabolism and development, Lack of expected normal physiological development[HÄIRIINTYNYT PITUUSKASVU]
37.8
12.2
15
*
H47.2
ICD-10 Finland
Optic atrophy
16.0
12.1
19
12
F20.09
ICD-10 Finland
Paranoid schizophrenia UNS
4.8
12.1
27
57
N05AL01
ATC
sulpiride; systemic
4.1
12.1
33
82
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
2.4
12.0
84
362
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
1.8
12.0
180
1030
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
1.9
12.0
146
781
N05AC02
ATC
thioridazine; oral
3.2
12.0
47
150
P98
ICPC
Psychosis NOS/other
4.9
11.9
26
54
SPAT1240
SPAT
Therapeutic discussion
1.6
11.9
262
1672
D64.9
ICD-10 Finland
Anaemia, unspecified
2.0
11.8
136
714
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.4
11.7
622
4782
ZXY49
NOMESCO Finland
Other health care provider
5.2
11.7
24
47
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.1
11.7
117
584
E86
ICD-10 Finland
Volume depletion
3.5
11.7
39
112
IFB01
NOMESCO Finland
Electroconvulsive Therapy (ECT)
4.9
11.7
25
51
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
3.2
11.7
45
142
D35.31
ICD-10 Finland
Cyst in Rathke's pocket
30.2
11.6
15
5
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
65.3
11.6
13
*
L28
ICPC
Limited function/disability (L)
1.7
11.6
248
1569
F21
ICD-10 Finland
Schizotypal disorder
5.3
11.5
23
44
N05AF01
ATC
flupentixol; systemic
3.7
11.5
36
99
E22
ICD-10 Finland
Hyperfunction of pituitary gland
+∞
11.5
11
*
E23
ICD-10 Finland
Hypofunction and other disorders of pituitary gland
+∞
11.5
11
*
2370A
ICD-9 Finland
Neoplasm of uncertain behaviour of endocrine glands and nervous system, Pituitary gland and craniopharyngeal duct
+∞
11.5
11
*
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
+∞
11.5
11
*
E89.30
ICD-10 Finland
Postprocedural hypopituitarism
120.7
11.4
12
*
Z3229
NOMESCO Finland
Other healthcare associate professional
1.9
11.4
144
781
K59.09
ICD-10 Finland
Constipation, unspecified
2.1
11.4
109
536
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.5
11.3
484
3571
R07.4
ICD-10 Finland
Chest pain, unspecified
1.5
11.3
433
3126
N03AX16
ATC
[U] pregabalin
1.5
11.3
380
2671
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.4
11.3
544
4105
Z94.0
ICD-10 Finland
Kidney transplant status
5.2
11.3
23
45
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.8
11.1
171
987
P29
ICPC
Psychological sympt/compl other
1.8
11.1
182
1071
N05AE03
ATC
sertindole; oral
10.1
11.0
21
21
R06.0
ICD-10 Finland
Dyspnoea
1.5
10.9
428
3105
TPH07
NOMESCO Finland
Cathetrisation of artery
1.8
10.9
155
874
WX402
NOMESCO Finland
General anaesthesia
1.5
10.8
392
2796
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
2.2
10.8
94
445
IGY99
NOMESCO Finland
Other psychiatric treatment contact
2.5
10.8
65
262
R60.0
ICD-10 Finland
Localized oedema
1.8
10.8
178
1049
F60.9
ICD-10 Finland
Personality disorder, unspecified
3.1
10.8
44
144
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
2.1
10.7
97
467
N06AB05
ATC
paroxetine; oral
1.9
10.6
128
683
WZC00
NOMESCO Finland
Treatment plan or consultation
1.4
10.6
686
5439
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
5.3
10.6
21
40
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.5
10.4
380
2712
186
Kela drug reimbursment
Growth retardation associated with renal failure (growth hormone)
+∞
10.4
10
*
127
Kela drug reimbursment
Transplant complication
3.9
10.4
30
78
P01
ICPC
Feeling anxious/nervous/tense
1.5
10.4
329
2281
N06AB06
ATC
sertraline; oral
1.6
10.4
254
1661
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.7
10.3
219
1381
K59.00
ICD-10 Finland
Constipation caused by slow bowel passage (SCT)
3.0
10.3
45
153
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.5
10.2
316
2178
X05
ICPC
Menstruation absent/scanty
3.0
10.2
45
154
Z2445
NOMESCO Finland
Psychologist
2.1
10.2
100
497
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
3.0
10.1
43
144
UKC02
NOMESCO Finland
Cystoscopy
1.7
10.1
192
1177
G40.9
ICD-10 Finland
Epilepsy, unspecified
2.4
10.1
67
283
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
2.7
10.0
51
189
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.6
10.0
234
1513
A06AC51
ATC
ispaghula, combinations; oral
2.2
10.0
87
413
F61.0
ICD-10 Finland
Mixed personality disorders
2.9
9.8
46
163
N03AX14
ATC
levetiracetam; systemic
2.6
9.8
57
226
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.5
9.8
333
2341
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.8
9.8
155
902
ZY000
NOMESCO Finland
Hospital inpatient
3.1
9.8
40
131
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
3.1
9.8
40
131
L17
ICPC
Foot/toe symptom/complaint
1.4
9.7
497
3776
-50
ICPC
Medication/prescr/renewal
2.3
9.7
73
326
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
9.6
345
2452
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
2.8
9.6
46
165
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.6
9.6
247
1633
TPH04
NOMESCO Finland
Cathetrisation of vein
1.5
9.6
342
2427
M79.6
ICD-10 Finland
Pain in limb
1.4
9.6
770
6297
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.6
9.6
263
1765
J01MA02
ATC
ciprofloxacin; systemic
1.4
9.6
612
4828
F82
ICD-10 Finland
Specific developmental disorder of motor function
8.4
9.6
20
24
F25.21
ICD-10 Finland
Schizoaffective syndrome, mixed type with prolonged schizophrenic than bipolar symptoms
8.4
9.6
20
24
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
2.2
9.5
80
374
E28.3
ICD-10 Finland
Primary ovarian failure
15.1
9.5
15
10
Y28
ICPC
Limited function/disability (Y)
15.1
9.5
15
10
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.7
9.5
162
964
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
2.5
9.5
59
242
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
100.5
9.4
10
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.1
9.4
91
450
D352, E220,
ICD-10 Finland
+∞
9.4
9
*
E30.8
ICD-10 Finland
Other disorders of puberty
+∞
9.4
9
*
2598X
ICD-9 Finland
Other endocrine disorders, Other specified endocrine disorders
+∞
9.4
9
*
H01AX01
ATC
pegvisomant; parenteral
+∞
9.4
9
*
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
1.7
9.4
168
1014
P99
ICPC
Psychological disorders other
2.2
9.3
74
338
F23.8
ICD-10 Finland
Other acute and transient psychotic disorders
8.1
9.3
20
25
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
2.6
9.3
53
208
SPAT1296
SPAT
Other function in accordance with occupational therapy nomenclature
4.9
9.3
20
41
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
1.9
9.3
110
584
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
3.0
9.3
39
130
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.6
9.2
241
1599
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.6
9.2
233
1534
L04AA06
ATC
mycophenolic acid; systemic
3.2
9.2
35
110
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
4.2
9.2
24
58
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.8
9.1
150
883
C07AB07
ATC
bisoprolol; oral
1.4
9.1
650
5210
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
2.7
9.1
46
170
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.7
9.1
158
945
WX882
NOMESCO Finland
High dependency care
2.6
9.1
52
205
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.7
9.1
173
1062
E34.35
ICD-10 Finland
Abnormal growth retardation
36.8
9.0
11
*
UJF30
NOMESCO Finland
Ileoscopy through colon
1.7
9.0
167
1017
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
2.4
9.0
58
242
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.6
9.0
243
1626
F31
ICD-10 Finland
Bipolar affective disorder
3.1
9.0
36
117
WX110
NOMESCO Finland
Infiltration anesthesia
1.4
8.9
1432
12906
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
1.8
8.9
136
783
IEY08
NOMESCO Finland
Psychiatric coaching, domestic and community skills
7.5
8.9
20
27
SPAT1254
SPAT
Administration of medicine
1.5
8.8
252
1705
N06AX22
ATC
agomelatine; oral
2.4
8.8
61
263
R33
ICD-10 Finland
Retention of urine
2.1
8.8
86
427
A28
ICPC
Limited function/disability NOS
1.6
8.8
193
1228
IER01
NOMESCO Finland
Psychoeducation, group
3.8
8.8
26
69
C03DA01
ATC
spironolactone; oral
1.7
8.8
148
878
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
3.2
8.8
33
103
G04BD04
ATC
oxybutynin; oral, transdermal
2.1
8.8
81
394
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.3
8.7
66
296
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
3.9
8.7
25
65
E66.8
ICD-10 Finland
Other obesity
1.8
8.7
121
679
A11CC03
ATC
alfacalcidol; systemic
3.2
8.6
33
104
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
1.8
8.6
126
717
SPAT1153
SPAT
Removal of sutures
1.4
8.6
475
3649
3018D
ICD-9 Finland
Personality disorders, Other personality disorders[EPÄVAKAA PERSOONALLISUUS]
7.0
8.5
20
29
Z00.8
ICD-10 Finland
Other general examinations
1.7
8.5
148
886
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.3
8.5
721
5919
F28
ICD-10 Finland
Other nonorganic psychotic disorders
7.4
8.4
19
26
J01DB01
ATC
cefalexin; oral
1.4
8.4
1635
15093
E34.31
ICD-10 Finland
Short stature, prenatal disorder
90.4
8.4
9
*
N02AX02
ATC
tramadol; systemic, rectal
1.3
8.4
677
5513
N02AA05
ATC
oxycodone; systemic
1.6
8.4
212
1397
E24.0
ICD-10 Finland
Pituitary-dependent Cushing disease
+∞
8.3
8
*
2536X
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Other disorders of neurohypophysis
+∞
8.3
8
*
N03AX12
ATC
[U] gabapentin; oral
1.5
8.3
264
1827
IGY02
NOMESCO Finland
Psychiatric monitoring contact
2.1
8.3
76
369
WX730
NOMESCO Finland
Conventional respirator
3.8
8.2
24
63
SPAT1172
SPAT
Guidance concerning hydration
3.4
8.2
28
82
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
3.2
8.2
31
97
M80.8
ICD-10 Finland
Other osteoporosis with pathological fracture
14.5
8.2
13
9
K59.0
ICD-10 Finland
Constipation
1.9
8.2
94
495
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
1.4
8.2
393
2946
ZXY60
NOMESCO Finland
2-person team, nurses
4.4
8.1
20
46
N91.5
ICD-10 Finland
Oligomenorrhoea, unspecified
4.8
8.1
18
38
ZYB04
NOMESCO Finland
Outreach service in patient’s home or everyday environment
4.8
8.1
18
38
A99
ICPC
Disease/condition unspecnature/site
1.7
8.1
155
952
EP1AE
NOMESCO Finland
Neck ultrasound examination
1.9
8.1
93
490
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
2.8
8.1
39
141
L02AE04
ATC
triptorelin; parenteral
6.8
8.1
19
28
E0000UV, ,
ATC
1.3
8.1
782
6531
A02BC01
ATC
omeprazole; systemic
1.4
8.0
444
3406
G03GA01
ATC
chorionic gonadotrophin; parenteral
1.9
8.0
100
541
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
1.5
8.0
256
1777
Z35.0
ICD-10 Finland
Supervision of pregnancy with history of infertility
2.1
7.9
72
348
A27
ICPC
Fear of other disease NOS
2.0
7.9
83
423
F20.39
ICD-10 Finland
Undifferentiated schizophrenia UNS
4.3
7.9
20
47
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
2.0
7.9
85
437
N06AA04
ATC
clomipramine; systemic
3.0
7.9
33
110
T50.9
ICD-10 Finland
Poisoning: Other and unspecified drugs, medicaments and biological substances
4.6
7.9
18
39
A46
ICD-10 Finland
Erysipelas
1.6
7.9
185
1197
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
1.8
7.9
108
603
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
6.1
7.8
20
33
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.4
7.8
450
3473
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.2
7.8
64
297
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
2.1
7.8
73
357
N06AX03
ATC
mianserin; oral
2.0
7.8
77
385
SPAT1260
SPAT
Consultation of another employee
1.5
7.8
292
2091
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
1.8
7.8
111
628
SPAT1234
SPAT
Support of social functional capacity
2.0
7.7
76
379
A02BC05
ATC
esomeprazole; systemic
1.3
7.7
684
5633
E27.0
ICD-10 Finland
Other adrenocortical overactivity
45.1
7.7
9
*
F23.90
ICD-10 Finland
Acute and transient psychosis, unspecified without acute stress factor
6.4
7.7
19
30
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
2.8
7.7
36
128
F50.9
ICD-10 Finland
Eating disorder, unspecified
2.8
7.7
36
128
F05.9
ICD-10 Finland
Delirium, unspecified
3.4
7.7
27
81
WZA90
NOMESCO Finland
Other medical or dental certificate
1.4
7.7
437
3368
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
2.1
7.7
69
333
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.7
7.6
138
835
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
1.8
7.6
105
587
N06AB10
ATC
escitalopram; oral
1.4
7.6
435
3353
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.4
7.6
48
199
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
1.9
7.6
98
537
JN3AD
NOMESCO Finland
Abdominal CT examination
1.6
7.6
165
1049
ZXE01
NOMESCO Finland
Procedure duration 0 to 9 minutes
2.6
7.5
41
158
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
8.9
7.5
15
17
A03FA01
ATC
metoclopramide; systemic, rectal
1.4
7.5
376
2833
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
2.2
7.5
62
289
SPAT1301
SPAT
No procedures
1.3
7.5
520
4129
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
2.0
7.5
84
439
SPAT1167
SPAT
Insertion of urinary catheter
2.8
7.5
36
130
F31.5
ICD-10 Finland
Bipolar affective disorder, current episode severe depression with psychotic symptoms
4.4
7.4
18
41
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.7
7.4
137
834
IFA99
NOMESCO Finland
Other psychiatric pharmacotherapy service
3.5
7.4
25
73
A41.9
ICD-10 Finland
Sepsis, unspecified
2.4
7.4
49
208
XF400
NOMESCO Finland
ECG with 12 standard connections
1.5
7.4
218
1486
SPAT1229
SPAT
Assessment of need for aid
1.9
7.4
97
535
K07.24
ICD-10 Finland
Open bite
2.8
7.3
35
126
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
2.4
7.3
50
215
F25.1
ICD-10 Finland
Schizoaffective disorder, depressive type
8.4
7.3
15
18
WX002
NOMESCO Finland
Sedation and analgesia
1.5
7.3
281
2020
X78
ICD-10 Finland
Intentional self-harm by sharp object
3.6
7.3
23
64
E23.0
ICD-10 Finland
Hypopituitarism
+∞
7.3
7
*
E27.2
ICD-10 Finland
Addisonian crisis
+∞
7.3
7
*
BBA20
NOMESCO Finland
Exploration of parathyroid gland
+∞
7.3
7
*
E34.30
ICD-10 Finland
Short stature NOS
+∞
7.3
7
*
318
Kela drug reimbursment
Teriparatide
+∞
7.3
7
*
E22.8
ICD-10 Finland
Other hyperfunction of pituitary gland
+∞
7.3
7
*
E23.7
ICD-10 Finland
Disorder of pituitary gland, unspecified
+∞
7.3
7
*
D35.30
ICD-10 Finland
Craniopharyngoma
+∞
7.3
7
*
2535A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Diabetes insipidus
+∞
7.3
7
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.7
7.3
125
747
G44.0
ICD-10 Finland
Cluster headache syndrome
3.0
7.2
31
105
S06.3
ICD-10 Finland
Focal brain injury
3.7
7.2
22
60
JHB30
NOMESCO Finland
Rubber band ligature of haemorrhoids or prolapse of mucosa
1.9
7.2
90
489
A07DA03
ATC
loperamide; oral
2.4
7.2
49
211
J01EA01
ATC
trimethoprim; systemic
1.3
7.1
467
3673
H05BX01
ATC
cinacalcet; oral
20.1
7.1
10
5
P28
ICPC
Limited function/disability (P)
3.4
7.1
25
75
ZXY59
NOMESCO Finland
2-person team, nurse-other special worker
7.9
7.1
15
19
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
1.8
7.1
108
623
S18
ICPC
Laceration/cut
1.3
7.1
719
6017
XF600
NOMESCO Finland
Bloodpressure measurement
1.8
7.1
98
550
G44.2
ICD-10 Finland
Tension-type headache
1.4
7.1
274
1973
M81.9
ICD-10 Finland
Osteoporosis, unspecified
2.3
7.0
53
238
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
1.8
7.0
102
580
X14
ICPC
Vaginal discharge
2.1
7.0
62
297
F31.20
ICD-10 Finland
Bipolar disorder, manic episode with mood-congruent psychotic symptoms
3.6
7.0
22
61
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
2.5
7.0
43
176
K02.1
ICD-10 Finland
Caries of dentine
1.3
7.0
1196
10679
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.4
7.0
273
1967
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
1.7
7.0
116
687
E83.50
ICD-10 Finland
Hypercalcemia
4.4
7.0
17
39
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.6
7.0
143
896
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
0.7
6.9
353
4578
C09CA06
ATC
candesartan; oral
1.4
6.9
366
2783
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.3
6.9
507
4055
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
2.3
6.9
48
209
SPAT1243
SPAT
Psychiatric/psychological examination
2.0
6.8
69
348
183
Kela drug reimbursment
Lamotrigin and topiramate
3.3
6.8
25
77
N30.0
ICD-10 Finland
Acute cystitis
1.4
6.8
295
2166
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
1.6
6.8
142
893
TLW00
NOMESCO Finland
Insemination
2.3
6.8
48
210
J20.8
ICD-10 Finland
Acute bronchitis due to other specified organisms
9.3
6.8
13
14
NH1AD
NOMESCO Finland
Ankle and foot CT
2.5
6.8
42
173
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
2.5
6.8
40
161
R35
ICD-10 Finland
Polyuria
1.8
6.8
91
506
E26.0
ICD-10 Finland
Primary hyperaldosteronism
40.2
6.8
8
*
N75
ICPC
Benign neoplasm nervous system
40.2
6.8
8
*
E21.2
ICD-10 Finland
Other hyperparathyroidism
40.2
6.8
8
*
SPAT1310
SPAT
Counselling related to known health issue
1.3
6.7
556
4519
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.5
6.7
213
1474
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
3.2
6.7
25
78
Z50.1
ICD-10 Finland
Other physical therapy
1.9
6.7
79
421
ZXD10
NOMESCO Finland
Scheduled procedure
1.3
6.7
635
5258
321
Kela drug reimbursment
Paricalcitol and cinacalcet
22.6
6.7
9
*
XF602
NOMESCO Finland
Bloodpressure monitoring
3.7
6.6
20
54
F25.11
ICD-10 Finland
Schizoaffective syndrome, depressive type with prolonged schizophrenic than bipolar symptoms
6.4
6.6
16
25
F25.01
ICD-10 Finland
Schizoaffective syndrome, manic type with prolonged schizophrenic than bipolar symptoms
6.4
6.6
16
25
D01
ICPC
Abdominal pain/cramps general
1.5
6.6
236
1671
R50.9
ICD-10 Finland
Fever, unspecified
1.4
6.6
257
1850
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.7
6.6
127
782
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
1.7
6.6
112
667
N05AX15
ATC
cariprazine; oral
5.5
6.6
18
33
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.1
6.6
59
285
X59
ICD-10 Finland
Exposure to unspecified factor
1.4
6.6
317
2372
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
2.1
6.6
60
292
S06.0
ICD-10 Finland
Concussion
1.5
6.5
186
1258
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
1.5
6.5
185
1250
P03
ICPC
Feeling depressed
1.5
6.5
231
1634
O92.6
ICD-10 Finland
Galactorrhoea
6.9
6.5
15
22
SPAT1216
SPAT
Assessment of functional ability
1.5
6.5
192
1309
2968A
ICD-9 Finland
Affective psychoses, Manic-depressive psychosis, other and unspecified
3.7
6.5
20
55
X57
ICD-10 Finland
Unspecified privation
2.4
6.5
41
171
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.5
6.4
191
1303
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
1.7
6.4
114
687
N03AB02
ATC
phenytoin; systemic
3.5
6.4
21
60
XKD00
NOMESCO Finland
Uroflowmetry
1.6
6.4
142
906
E30.9
ICD-10 Finland
Disorder of puberty, unspecified
70.1
6.4
7
*
H05AA02
ATC
teriparatide; parenteral
70.1
6.4
7
*
N03AF01
ATC
carbamazepine; oral, rectal
1.9
6.4
77
413
E66.01
ICD-10 Finland
Obesity due to excess calories
1.5
6.4
181
1222
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
1.7
6.4
118
719
E87.8
ICD-10 Finland
Other disorders of electrolyte and fluid balance, not elsewhere classified
14.3
6.4
10
7
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.6
6.4
142
908
S97
ICPC
Chronic ulcer skin
1.9
6.3
71
372
N03AX11
ATC
topiramate; oral
2.1
6.3
60
296
K59.1
ICD-10 Finland
Functional diarrhoea
1.8
6.3
93
532
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.4
6.3
359
2759
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
2.6
6.3
35
137
KH1AD
NOMESCO Finland
CT of urinary organs
2.2
6.3
51
237
EBA15
NOMESCO Finland
Extraction of multiple teeth
2.1
6.3
54
257
IGV01
NOMESCO Finland
Psychiatric network contact
2.8
6.3
29
103
Z3226
NOMESCO Finland
Physiotherapist
1.4
6.3
293
2181
E23.08
ICD-10 Finland
Hypopituitarism
+∞
6.3
6
*
25301
ICD-8 Finland
Diseases of pituitary gland, Gigantismus hypophysarius et hyperpituitarismus alius
+∞
6.3
6
*
E220, D352,
ICD-10 Finland
+∞
6.3
6
*
E34.45
ICD-10 Finland
Abnormal growth increase
+∞
6.3
6
*
E23.02
ICD-10 Finland
Neurosecretory dysfunction of the growth hormone
+∞
6.3
6
*
E23.06
ICD-10 Finland
Empty sella
+∞
6.3
6
*
A01
ICPC
Pain general/multiple sites
1.6
6.2
150
977
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
1.8
6.2
90
512
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
1.7
6.2
120
740
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
2.4
6.2
40
168
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.3
6.2
44
193
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.5
6.2
165
1100
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
3.1
6.2
25
82
F20.0
ICD-10 Finland
Paranoid schizophrenia
5.0
6.2
18
36
137
Kela drug reimbursment
Uraemia requiring dialysis
5.0
6.2
18
36
D12
ICPC
Constipation
2.1
6.2
56
272
R04
ICPC
Breathing problem other
2.0
6.2
63
320
IEV99
NOMESCO Finland
Other psychiatric network intervention
3.4
6.1
21
62
E950A
ICD-9 Finland
Suicide and self-inflicted poisoning by solid or liquid substances
3.3
6.1
22
67
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.4
6.1
313
2363
F93.89
ICD-10 Finland
Other childhood emotional disorders
3.0
6.1
26
88
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.0
6.1
26
88
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.5
6.1
220
1561
M05BX04
ATC
denosumab; parenteral
2.0
6.1
63
321
F31.8
ICD-10 Finland
Other bipolar affective disorders
2.2
6.1
49
227
T28
ICPC
Limited function/disability (T)
3.8
6.1
18
48
2989X
ICD-9 Finland
Other nonorganic psychoses, Unspecified psychosis
3.8
6.1
18
48
N06AA09
ATC
amitriptyline; systemic
1.6
6.1
137
880
TPH40
NOMESCO Finland
Insertion of a long peripheral venous catheter
6.7
6.0
14
21
J01MA14
ATC
moxifloxacin; systemic
1.6
6.0
133
849
N03AX18
ATC
lacosamide; systemic
3.5
6.0
20
58
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
871
1500
9.27
307.65
3.9
1.8
372.25
378.74
nmol/l
0.44
831
1383
853
936
14.75
307.65
5.4
1.3
690.67
293.95
mu/l
8.48
823
837
467
559
10.48
307.65
2.0
1.3
7.89
10.33
u/l
2.84
387
441
490
89
71.70
307.65
3.7
1.4
20.25
21.12
nmol/l
0.40
480
84
104
21
52.08
180.98
2.7
1.2
—
—
—
0
0
382
822
5.47
172.02
4.6
1.8
9.74
12.37
nmol/l
6.48
356
742
244
403
6.73
144.05
1.5
1.3
0.29
0.46
nmol/l
2.45
181
327
126
134
9.94
107.51
2.4
1.4
277.17
282.75
mosm/kgh2o
1.37
109
103
418
1358
3.60
106.59
1.8
1.3
16.27
26.29
iu/l
9.31
343
1150
142
184
8.21
103.75
2.4
1.3
77.72
64.81
mmol/l
1.89
124
160
154
226
7.28
100.92
2.8
1.5
152.20
204.10
pmol/l
3.88
148
212
1095
6965
2.21
67.19
8.4
5.8
1.22
1.21
mmol/l
0.80
926
5963
1010
6248
2.20
66.15
7.6
5.2
1.22
1.21
mmol/l
1.17
940
5727
315
1161
3.02
63.20
2.9
3.2
4.35
4.58
pmol/l
4.07
292
1040
1750
13890
2.63
58.26
6.6
4.0
14.68
14.43
pmol/l
3.81
1680
12889
78
102
7.91
56.29
1.6
1.2
5.29
5.34
umol/l
0.03
72
96
151
376
4.25
55.01
1.9
1.4
13.52
24.51
u/l
5.73
138
317
355
1626
2.43
45.42
6.8
5.7
1.03
1.06
mmol/l
1.54
335
1519
1198
8917
1.81
37.17
6.3
4.2
6.39
6.46
mmol/l
0.48
1128
8165
52
71
7.49
36.12
2.0
1.4
1.63
4.38
nmol/l
0.72
47
51
1851
16091
2.36
33.80
7.1
4.6
1.68
1.98
mu/l
1.69
1772
15110
942
6727
1.73
31.93
2.9
2.2
75.23
74.57
nmol/l
0.31
875
6186
1488
12081
1.81
31.84
8.1
6.7
76.39
75.18
u/l
0.55
1419
11421
867
6061
1.74
31.64
5.0
4.4
35.74
36.42
g/l
3.07
801
5659
1901
16886
2.45
30.10
20.3
11.7
139.16
139.59
mmol/l
7.52
1863
16432
56
101
5.67
29.80
1.4
1.7
—
—
—
0
0
1901
16949
2.41
28.72
20.1
11.8
3.96
3.93
mmol/l
0.64
1862
16456
718
4883
1.72
28.10
3.5
3.1
2.35
2.35
mmol/l
0.18
649
4392
196
866
2.39
26.54
4.7
3.3
87.72
70.81
ng/l
0.92
169
779
1215
9634
1.63
25.10
12.2
8.6
4.16
3.98
e9/l
1.71
1085
8483
611
4087
1.70
24.79
3.2
2.1
270.74
183.57
u/l
0.40
584
3884
1469
12260
1.67
24.35
4.5
3.8
11.58
10.27
mm/h
3.28
1385
11454
70
182
3.95
24.00
2.3
1.8
4.38
4.67
mmol/24h
0.32
62
167
366
2128
1.87
23.88
4.1
3.5
0.82
0.82
mmol/l
0.30
348
2001
252
1331
2.02
21.73
8.1
8.3
1.18
1.09
mmol/l
0.14
200
1046
213
1064
2.12
21.34
4.7
2.7
1.23
1.23
mmol/l
0.35
190
908
251
1340
1.99
20.97
8.2
8.2
5.17
5.09
kpa
0.70
233
1283
251
1341
1.99
20.93
8.2
8.2
13.32
12.94
kpa
0.42
232
1285
673
4788
1.60
20.66
3.0
2.4
53.35
58.10
u/l
1.49
621
4440
343
2038
1.82
20.65
2.6
2.1
2.42
2.42
g/l
0.07
313
1901
1036
8162
1.54
20.05
7.1
5.7
56.70
56.49
%
0.25
983
7705
1047
8270
1.54
20.00
7.5
5.9
28.86
29.20
%
0.50
997
7817
803
5995
1.55
19.79
11.0
10.6
1.15
1.15
inr
0.02
271
1878
1008
7918
1.53
19.61
7.4
5.8
2.71
2.81
%
0.77
952
7444
33
54
6.19
19.40
1.8
1.1
76.58
71.16
nmol/24h
0.21
33
54
769
5711
1.55
19.27
2.0
1.8
99.91
97.24
pmol/l
0.76
398
3045
567
3956
1.60
18.52
2.5
2.1
2.71
2.80
mg/l
0.49
482
3403
1072
8606
1.51
18.34
3.3
2.8
94.26
86.81
ug/l
0.37
989
8084
309
1850
1.79
17.97
2.8
2.2
21.54
23.55
%
1.56
270
1608
365
2299
1.71
17.75
1.9
1.6
1202.63
1159.69
nmol/l
0.34
289
1773
1636
14456
1.62
17.42
5.6
4.6
38.29
38.41
mmol/mol
0.21
1558
13592
461
3113
1.62
17.05
1.5
1.5
20.08
20.57
nmol/l
0.31
403
2711
200
1069
1.96
16.55
9.0
7.3
7.93
7.82
mmol/l
0.09
193
1021
975
7790
1.47
16.36
6.4
5.6
10.00
10.37
umol/l
0.62
914
7372
351
2252
1.67
15.79
2.7
2.2
13.12
14.07
umol/l
1.49
328
2110
49
135
3.69
15.55
9.3
11.5
0.60
0.63
mmol/l
0.34
43
123
211
1175
1.89
15.42
9.1
8.8
95.41
96.14
%
0.64
199
1134
608
4460
1.51
15.36
4.0
2.9
57.23
92.68
e6/l
0.63
486
3358
1749
15852
1.65
15.24
4.7
3.8
5.72
5.73
mmol/l
0.13
1644
14707
74
267
2.84
15.14
4.7
2.7
2.21
2.22
mmol/l
0.01
49
164
213
1202
1.86
14.93
5.2
4.0
1.74
1.82
mmol/l
0.13
193
989
27
24
11.38
14.77
1.6
1.2
5.55
3.78
nmol/l
1.23
27
24
1733
15711
1.62
14.62
15.1
9.7
89.60
89.34
ml/min/173m2
0.19
1511
12762
559
4068
1.51
14.53
4.0
2.8
0.27
0.37
e6/l
0.94
440
3034
20
9
22.42
14.21
3.0
2.9
204.52
78.90
pmol/l
—
14
9
211
1208
1.83
14.11
5.2
4.0
5.91
5.82
kpa
0.93
206
1170
447
3117
1.55
14.10
3.2
2.9
814.56
1039.54
ng/l
1.07
381
2586
197
1107
1.86
13.98
9.5
9.0
121.87
121.86
g/l
0.00
189
1077
69
251
2.81
13.93
7.0
5.8
392.19
375.65
umol/l
0.45
64
215
440
3077
1.55
13.65
3.4
2.4
6.77
7.86
e6/l
0.98
397
2747
232
1402
1.74
12.89
2.4
2.2
6541.95
6020.97
u/l
0.09
67
550
716
5585
1.43
12.69
3.4
3.1
31.50
29.74
u/l
0.35
681
5329
225
1360
1.73
12.48
3.2
2.9
1.82
1.73
%
0.77
189
1229
320
2131
1.59
12.18
1.9
2.3
29.40
29.60
s
0.24
309
2058
660
5114
1.43
11.98
4.5
3.0
33.15
44.18
ng/l
0.47
402
2800
89
396
2.30
11.87
2.5
2.4
280.88
349.24
ug/l
0.21
82
358
64
245
2.66
11.76
3.0
2.0
17.16
16.41
%
0.43
28
118
163
912
1.85
11.71
2.9
2.7
66.26
67.13
g/l
0.72
148
854
1365
12002
1.40
11.48
3.8
2.9
42.64
38.99
u/l
0.89
1308
11429
561
4254
1.44
11.36
3.6
3.3
8.03
7.82
mmol/l
0.39
484
3699
353
2447
1.53
11.20
2.8
2.6
2.44
2.43
mmol/l
1.11
298
2132
1853
17311
1.64
11.19
17.0
11.2
20.35
21.02
mg/l
0.39
1491
13305
221
1372
1.68
11.10
3.7
2.6
—
—
—
0
0
536
4063
1.43
10.79
1.6
1.6
1.44
1.36
mmol/l
1.28
471
3491
87
400
2.23
10.76
6.9
5.2
1.49
1.31
mg/l
0.99
76
375
165
952
1.80
10.74
2.8
2.8
73.33
71.22
e9/l
0.33
113
709
513
3863
1.44
10.70
4.6
3.6
95.02
94.39
%
0.22
504
3748
226
1427
1.65
10.63
2.1
1.7
—
—
—
0
0
314
2145
1.55
10.62
2.3
1.8
—
—
—
0
0
226
1449
1.63
9.99
2.2
1.7
—
—
—
0
0
1668
15395
1.42
9.08
21.3
13.4
14.57
14.37
%
0.76
1647
15127
1251
11046
1.33
9.01
5.6
3.9
259.00
1384.02
e6/l
1.23
17
129
21
47
4.50
8.84
2.8
2.4
14.57
16.07
umol/l
0.23
21
47
29
83
3.53
8.80
1.8
1.6
—
—
—
0
0
47
179
2.66
8.80
1.6
1.2
0.56
0.57
nmol/l
0.07
47
170
976
8350
1.32
8.64
4.3
3.2
0.00
0.00
estimate
1.23
233
1645
1912
18178
1.64
8.63
11.8
8.8
26.31
25.28
u/l
1.35
1857
17631
397
2957
1.42
8.58
1.6
1.6
23145865.93
39668542.66
pmol/l
0.28
337
2531
983
8424
1.32
8.57
4.3
3.3
0.00
0.01
estimate
1.06
220
1541
40
143
2.83
8.45
1.6
1.8
—
—
—
0
0
973
8342
1.31
8.39
5.9
4.4
0.01
0.00
estimate
0.72
223
1585
25
67
3.76
8.34
1.0
1.4
159.71
153.94
mmol/24h
0.10
25
67
316
2275
1.46
8.18
3.3
2.6
3.96
3.54
e6/l
0.27
188
1187
572
4561
1.35
8.13
1.4
1.3
1.59
1.58
u/ml
0.01
145
1219
334
2439
1.44
8.01
3.1
2.5
1.23
1.06
e6/l
0.28
206
1339
110
618
1.82
7.86
11.7
11.6
—
—
—
0
0
136
821
1.70
7.60
4.7
3.5
1.50
1.58
mmol/l
0.11
102
602
190
1248
1.57
7.59
2.9
2.7
10.41
10.42
g/l
0.02
163
1146
75
376
2.03
7.52
1.4
1.7
1057.43
1359.76
e6/l
0.09
56
301
495
3902
1.35
7.50
1.6
1.4
2.35
2.21
g/l
0.36
291
2433
75
377
2.03
7.47
1.3
1.6
201.63
20.35
e6/l
0.49
52
289
53
233
2.31
7.38
4.8
3.3
1957.00
1586.68
u/ml
—
5
19
2015
19527
2.01
7.37
26.9
16.5
265.33
260.97
e9/l
2.24
1981
19099
60
279
2.18
7.32
2.0
3.1
31.23
32.37
umol/l
0.21
55
256
2013
19508
1.98
7.25
27.1
16.6
39.82
40.12
%
1.62
1913
18528
136
834
1.67
7.18
1.6
1.5
—
—
—
0
0
139
858
1.66
7.16
4.9
3.4
5.13
5.14
kpa
0.06
133
824
121
721
1.72
7.10
7.0
7.6
25.39
24.44
mmol/l
2.10
109
682
2015
19543
1.98
7.10
26.9
16.6
6.73
6.72
e9/l
0.09
1979
19080
2015
19546
1.97
7.05
26.8
16.5
4.48
4.51
e12/l
1.82
1979
19089
2015
19555
1.96
6.90
27.0
16.6
133.52
134.98
g/l
5.51
2000
19332
14
17
8.28
6.82
1.5
1.9
—
—
—
0
0
36
137
2.66
6.82
1.9
1.6
—
—
—
0
0
189
1272
1.53
6.79
2.6
2.2
0.22
0.22
g/l
0.15
169
1193
153
983
1.60
6.73
1.8
1.7
—
—
—
0
0
44
186
2.40
6.72
1.7
1.5
—
—
—
0
0
74
390
1.93
6.49
1.7
1.6
—
—
—
0
0
767
6531
1.28
6.43
4.4
3.3
—
—
—
0
0
1679
15749
1.34
6.42
3.9
3.4
1.30
1.24
mmol/l
2.32
1589
14795
65
332
1.99
6.25
2.4
1.6
—
—
—
0
0
538
4403
1.30
6.10
4.6
3.5
0.01
0.00
estimate
0.20
222
1564
1740
16455
1.35
5.94
4.4
3.7
4.69
4.76
mmol/l
2.41
1659
15600
1758
16652
1.36
5.93
4.7
4.0
2.82
2.85
mmol/l
0.83
1674
15678
49
230
2.16
5.90
2.4
1.7
—
—
—
0
0
16
40
4.02
5.90
1.8
2.9
73.63
96.38
ug/l
0.28
16
40
330
2533
1.36
5.82
3.9
3.3
618.05
379.56
ng/l
0.33
211
1613
86
494
1.77
5.79
1.6
2.0
1.90
4.64
iu/l
7.37
27
189
58
293
2.01
5.77
3.9
3.6
30.87
66.93
mg/l
1.01
45
241
59
300
1.99
5.77
8.7
5.9
495.56
318.21
iu/ml
—
9
39
46
214
2.18
5.68
1.6
1.4
—
—
—
0
0
63
331
1.93
5.62
2.2
1.6
—
—
—
0
0
219
1579
1.43
5.59
1.2
1.2
111.30
154.47
iu/ml
0.94
79
600
49
236
2.10
5.55
1.8
1.5
—
—
—
0
0
444
3584
1.30
5.52
3.4
3.3
472.36
333.68
mg/l
0.23
282
2289
57
293
1.97
5.43
3.9
3.6
24.25
38.47
mg/l
0.76
45
241
22
73
3.04
5.38
1.6
1.9
—
—
—
0
0
193
1372
1.45
5.32
4.3
4.4
234.78
246.66
u/l
0.42
179
1300
74
418
1.80
5.29
1.8
2.2
10.54
10.69
mg/l
0.06
67
395
1727
16378
1.32
5.28
4.3
3.7
1.45
1.50
mmol/l
4.68
1646
15445
107
672
1.62
5.22
1.5
1.8
—
—
—
0
0
82
486
1.72
4.99
1.6
1.9
1.49
1.45
g/l
0.10
70
427
239
1791
1.38
4.89
2.9
2.7
7.17
6.79
umol/l
0.13
192
1522
62
341
1.84
4.86
1.5
1.2
—
—
—
0
0
32
138
2.34
4.76
1.4
1.7
1.15
1.32
promille
0.29
25
110
24
90
2.69
4.75
2.3
3.3
194.69
148.98
umol/l
0.16
16
53
76
448
1.72
4.74
2.6
2.0
1.41
1.81
ug/l
0.19
68
395
455
3754
1.27
4.70
2.5
2.3
323.59
4398.23
umol/l
9.48
399
3322
41
199
2.08
4.61
4.9
3.2
1.53
1.28
%
0.13
34
183
9
11
8.21
4.56
1.0
1.6
88.67
136.18
ng/l
—
9
11
78
469
1.69
4.54
4.7
6.2
1.60
1.60
%
0.00
72
436
455
3770
1.26
4.52
3.9
3.8
6.04
9.59
mg/mmol
1.74
289
2410
313
2475
1.31
4.48
1.9
2.4
86.73
105.27
ug/g
1.02
245
1964
62
354
1.77
4.34
2.9
3.0
—
—
—
0
0
303
2400
1.31
4.28
1.9
1.7
1.45
1.41
%
0.57
274
2154
69
413
1.69
4.11
1.4
1.4
254.63
300.97
ug/g
1.14
40
215
136
954
1.46
4.07
5.8
2.2
6.19
6.49
ug/l
0.07
117
849
168
1228
1.40
4.02
2.4
2.4
24.62
23.33
au/ml
—
9
119
21
81
2.61
3.97
1.3
1.1
—
—
—
0
0
127
887
1.46
3.90
3.0
2.9
145.07
163.55
ng/l
0.27
114
793
460
3881
1.24
3.85
1.8
1.8
1.35
0.96
mg/l
0.73
351
2873
28
126
2.24
3.83
1.3
2.1
32.11
32.21
pg
0.03
28
126
30
140
2.16
3.77
8.1
5.0
8.23
6.69
mmol/l
0.54
20
114
25
109
2.31
3.69
1.6
1.4
36.06
34.24
%
0.07
18
67
100
674
1.51
3.68
1.8
2.1
40.65
39.28
u/l
0.32
90
620
105
717
1.49
3.63
1.9
1.5
—
—
—
0
0
42
226
1.88
3.60
1.4
1.2
—
—
—
0
0
39
205
1.92
3.59
1.3
1.3
—
—
—
0
0
6
6
10.02
3.50
1.0
1.3
—
—
—
0
0
152
1126
1.38
3.39
1.3
1.3
56.40
38.19
au/ml
—
5
63
24
108
2.24
3.32
2.4
2.3
—
—
—
0
0
50
294
1.72
3.24
1.2
1.3
—
—
—
0
0
50
294
1.72
3.24
1.2
1.3
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
56
341
1.66
3.20
3.0
3.9
0.37
0.37
u/ml
0.07
33
184
61
382
1.61
3.13
2.9
2.0
9.79
10.30
g/l
0.34
55
357
58
359
1.63
3.12
1.5
1.4
—
—
—
0
0
9
20
4.51
3.11
6.0
6.1
—
—
—
0
0
53
322
1.66
3.07
3.0
2.0
0.00
0.00
g/l
0.50
48
306
13
45
2.90
3.02
1.1
1.1
116.69
91.71
%
2.30
13
45
65
418
1.57
3.01
2.8
1.9
7.09
7.34
g/l
0.67
59
394
65
418
1.57
3.01
2.8
1.9
—
—
—
0
0
65
418
1.57
3.01
2.8
1.9
3.56
3.58
g/l
0.06
60
394
62
395
1.59
2.98
2.9
2.0
2.88
2.94
g/l
0.23
57
371
53
325
1.65
2.97
3.1
2.0
38.10
38.11
g/l
0.01
47
301
52
318
1.65
2.95
3.7
3.4
4.46
4.07
e9/l
0.73
52
318
443
3819
1.20
2.94
2.9
2.1
—
—
—
0
0
45
265
1.71
2.93
6.1
8.9
104.20
105.52
mmol/l
0.61
40
238
30
156
1.94
2.90
1.1
1.1
—
—
—
0
0
53
328
1.63
2.88
4.1
3.6
59.28
56.97
%
0.77
53
328
213
1705
1.28
2.81
4.2
3.7
31.30
32.18
%
0.57
169
1240
49
301
1.64
2.75
1.4
1.3
4.38
3.96
u/ml
0.15
21
134
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
20
91
2.21
2.73
1.4
1.2
—
—
—
0
0
15
60
2.51
2.70
2.4
1.5
—
—
—
0
0
15
60
2.51
2.70
2.4
1.4
—
—
—
0
0
6
10
6.01
2.70
6.0
1.9
—
—
—
0
0
36
205
1.77
2.66
2.6
2.3
—
—
—
0
0
12
41
2.94
2.62
4.1
3.9
—
—
—
0
0
45
275
1.65
2.59
2.6
2.0
132.29
131.01
g/l
0.11
35
203
301
2531
1.22
2.58
4.7
4.4
1.52
2.28
ug/l
3.22
277
2268
9
25
3.61
2.57
2.0
3.0
—
—
—
0
0
27
142
1.91
2.56
1.2
1.2
—
—
—
0
0
55
356
1.56
2.52
3.9
2.1
0.72
0.75
g/l
0.03
50
327
101
738
1.39
2.52
1.3
1.3
0.20
1.14
u/ml
—
8
63
10
31
3.24
2.51
3.1
2.1
—
—
—
0
0
415
3607
1.19
2.50
4.4
3.5
1.02
1.02
kg/l
0.35
67
516
22
109
2.03
2.46
3.3
2.9
41436.36
40205.50
ug/l
0.21
22
109
81
572
1.43
2.45
5.6
3.9
24.61
24.72
mmol/l
0.14
74
545
33
188
1.77
2.45
1.2
1.1
—
—
—
0
0
5
8
6.26
2.37
3.0
4.5
—
—
—
0
0
5
8
6.26
2.37
3.0
4.6
—
—
—
0
0
6
13
4.63
2.27
1.2
1.5
37.83
20.48
nmol/l
—
6
13
12
47
2.56
2.27
1.5
1.1
—
—
—
0
0
183
1480
1.26
2.26
3.2
2.4
29.69
72.15
u/l
0.72
157
1261
16
73
2.20
2.21
1.4
1.4
123.61
179.52
pmol/l
1.18
16
73
27
150
1.81
2.20
1.9
2.0
—
—
—
0
0
28
158
1.78
2.18
1.6
1.6
48.13
56.33
%
0.36
15
104
51
338
1.52
2.15
1.5
1.4
100.07
106.18
u/ml
0.21
15
68
7
19
3.69
2.15
1.9
1.2
—
—
—
0
0
11
249
0.44
2.07
1.5
1.5
—
—
—
0
0
7
20
3.51
2.05
1.6
1.7
—
—
—
0
0
846
7852
1.13
2.02
3.0
2.5
—
—
—
0
0
14
63
2.23
2.01
4.4
3.7
—
—
—
0
0
38
240
1.59
1.99
1.9
1.4
—
—
—
0
0
422
3741
1.16
1.99
2.4
2.2
—
—
—
0
0
15
70
2.15
1.98
2.4
1.4
—
—
—
0
0
382
3363
1.17
1.97
2.3
2.1
—
—
—
0
0
161
1969
0.80
1.96
1.6
1.6
—
—
—
0
0
9
33
2.73
1.93
1.2
1.2
—
—
—
0
0
150
1845
0.80
1.93
1.4
1.5
—
—
—
0
0
199
1661
1.22
1.87
8.2
5.4
—
—
—
0
0
12
52
2.32
1.87
1.1
1.2
13.67
11.57
u/l
0.36
12
47
87
656
1.34
1.86
1.4
1.3
—
—
—
0
0
11
46
2.40
1.85
1.5
1.1
—
—
—
0
0
11
46
2.40
1.85
1.5
1.1
—
—
—
0
0
49
334
1.48
1.85
1.7
1.4
—
—
—
0
0
29
175
1.67
1.83
1.9
1.4
—
—
—
0
0
48
328
1.47
1.80
1.6
1.7
13035.53
12444.00
e6/l
0.04
34
241
345
3036
1.16
1.79
1.3
1.3
3.98
10.05
u/ml
2.23
134
1269
11
47
2.35
1.77
1.6
1.1
—
—
—
0
0
27
162
1.68
1.75
2.2
2.1
24.50
22.58
mg/l
—
8
47
6
18
3.34
1.74
2.2
1.3
—
—
—
0
0
6
18
3.34
1.74
2.3
1.6
—
—
—
0
0
33
209
1.59
1.74
1.9
1.4
—
—
—
0
0
25
147
1.71
1.74
1.1
1.1
—
—
—
0
0
9
36
2.51
1.74
1.4
1.4
—
—
—
0
0
20
110
1.83
1.73
2.2
2.0
0.58
2.26
u/field
2.14
12
58
5
13
3.85
1.71
1.6
1.2
—
—
—
0
0
45
309
1.47
1.66
1.2
1.1
—
—
—
0
0
39
261
1.50
1.63
1.6
1.6
—
—
—
0
0
31
197
1.58
1.63
1.1
1.2
18.39
40.92
u/l
1.01
26
172
28
174
1.62
1.61
2.1
1.5
—
—
—
0
0
10
44
2.28
1.55
1.1
1.5
—
—
—
0
0
51
701
0.72
1.53
1.3
1.5
—
—
—
0
0
5
15
3.34
1.52
1.6
1.1
—
—
—
0
0
142
1174
1.22
1.51
2.8
2.2
78.51
75.59
ml/min/173m2
0.34
51
425
29
442
0.65
1.51
1.2
1.2
—
—
—
0
0
16
86
1.87
1.50
1.2
1.2
5.14
6.57
mmol/l
1.60
16
77
18
101
1.79
1.49
1.4
1.6
—
—
—
0
0
21
124
1.70
1.47
3.1
2.6
—
—
—
0
0
6
22
2.73
1.43
1.5
1.0
—
—
—
0
0
21
126
1.67
1.40
1.5
1.5
—
—
—
0
0
9
40
2.26
1.40
1.1
1.1
—
—
—
0
0
11
53
2.08
1.38
1.7
1.9
—
63979.14
—
0
7
98
1211
0.80
1.37
1.4
1.4
—
—
—
0
0
153
1298
1.19
1.28
1.4
1.3
140.14
229.85
u/ml
1.54
138
1200
5
18
2.78
1.28
2.2
1.2
—
—
—
0
0
12
62
1.94
1.27
1.1
1.9
—
—
—
0
0
12
62
1.94
1.27
1.1
1.9
—
—
—
0
0
354
3200
1.13
1.27
1.3
1.3
37.39
26.56
iu/ml
0.54
108
1029
6
25
2.40
1.24
1.0
1.2
—
—
—
0
0
8
36
2.23
1.24
1.5
1.1
—
—
—
0
0
28
187
1.50
1.24
2.0
1.5
—
—
—
0
0
28
188
1.50
1.21
2.0
1.5
—
—
—
0
0
28
189
1.49
1.19
2.0
1.5
—
—
—
0
0
12
64
1.88
1.18
1.3
1.2
—
—
—
0
0
20
125
1.61
1.17
1.2
1.1
1.09
1.01
u/l
—
10
63
11
57
1.93
1.17
4.1
3.4
—
—
—
0
0
28
190
1.48
1.16
2.0
1.5
—
—
—
0
0
26
174
1.50
1.15
1.3
1.1
—
—
—
0
0
8
39
2.06
1.15
1.3
1.1
—
—
—
0
0
28
191
1.47
1.14
2.0
1.5
—
—
—
0
0
108
899
1.21
1.13
1.3
1.3
215.26
230.48
miu/ml
0.16
42
470
41
303
1.36
1.09
1.4
1.2
2.92
4.44
u/ml
0.53
13
105
12
66
1.82
1.09
1.1
1.0
—
—
—
0
0
35
253
1.39
1.06
2.5
1.6
—
—
—
0
0
35
253
1.39
1.06
2.5
1.6
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
13
74
1.76
1.06
1.0
1.1
114.08
112.77
%
0.05
13
69
64
802
0.79
1.06
1.6
1.7
—
—
—
0
0
9
46
1.96
1.03
1.7
1.1
—
—
—
0
0
74
907
0.81
1.02
1.5
1.5
—
—
—
0
0
27
188
1.44
1.01
2.0
1.5
—
—
—
0
0
88
1055
0.83
0.98
1.4
1.5
—
—
—
0
0
60
480
1.26
0.94
1.4
1.3
14.55
9.12
u/ml
—
8
84
118
1012
1.18
0.93
1.9
1.8
—
—
—
0
0
6
27
2.23
0.93
1.7
1.2
—
—
—
0
0
226
2031
1.13
0.93
3.8
3.9
23.48
21.04
%
1.24
95
849
63
508
1.25
0.93
2.0
1.8
—
—
—
0
0
18
118
1.53
0.91
1.0
1.1
3.12
4.93
nmol/l
—
5
17
11
63
1.75
0.90
1.3
1.3
—
—
—
0
0
10
56
1.79
0.87
4.5
2.0
—
—
—
0
0
53
423
1.26
0.86
1.3
1.3
—
—
—
0
0
19
128
1.49
0.86
1.2
1.3
—
—
—
0
0
76
906
0.83
0.83
1.3
1.5
—
—
—
0
0
19
129
1.48
0.83
1.0
1.4
—
—
—
0
0
19
129
1.48
0.83
1.2
1.3
—
—
—
0
0
6
114
0.52
0.83
2.0
1.3
1.43
1.58
g/l
—
6
114
39
500
0.78
0.82
1.3
1.4
52.08
135.71
pmol/l
1.79
39
488
6
32
1.88
0.81
1.2
1.4
—
—
—
0
0
6
32
1.88
0.81
1.3
1.2
—
—
—
0
0
1413
13807
1.07
0.80
3.8
3.6
—
—
—
0
0
0
24
0.00
0.79
0.0
1.0
—
4.75
—
0
18
6
33
1.82
0.79
1.5
2.5
—
—
—
0
0
6
33
1.82
0.79
1.5
2.5
—
—
—
0
0
73
611
1.20
0.79
1.1
1.1
6.20
4.06
u/ml
—
7
96
18
123
1.47
0.77
1.1
1.1
1.02
1.04
ratio
—
5
54
38
296
1.29
0.77
2.8
2.4
54.18
109.98
ug/min
1.00
22
192
12
75
1.60
0.75
1.2
1.2
157.75
402.48
u/l
0.88
12
66
68
570
1.20
0.73
2.4
1.9
—
—
—
0
0
9
55
1.64
0.73
4.9
2.1
—
—
—
0
0
9
55
1.64
0.73
4.9
2.1
—
—
—
0
0
6
106
0.56
0.72
1.2
1.9
—
—
—
0
0
10
60
1.67
0.72
2.6
1.4
—
—
—
0
0
11
68
1.62
0.71
4.2
1.9
—
—
—
0
0
11
68
1.62
0.71
4.2
1.9
—
—
—
0
0
9
58
1.55
0.69
2.8
1.4
—
—
—
0
0
135
1203
1.13
0.68
1.1
1.1
—
—
—
0
0
5
91
0.55
0.67
1.2
2.5
20.74
108.16
ug/l
—
5
78
16
111
1.44
0.66
1.2
1.2
—
—
—
0
0
11
70
1.57
0.65
1.8
1.2
—
—
—
0
0
26
199
1.31
0.62
1.4
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
2.0
—
7.43
—
0
11
69
799
0.86
0.59
1.8
1.9
—
—
—
0
0
30
377
0.79
0.59
1.5
1.9
—
—
—
0
0
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
8
53
1.51
0.58
1.0
1.1
—
68.13
—
0
15
21
158
1.33
0.57
3.6
1.7
—
—
—
0
0
38
310
1.23
0.57
1.1
1.1
—
—
—
0
0
23
176
1.31
0.56
3.4
1.6
—
—
—
0
0
24
185
1.30
0.56
1.7
1.5
—
—
—
0
0
24
185
1.30
0.56
1.7
1.5
—
—
—
0
0
86
974
0.88
0.55
1.3
1.4
—
—
—
0
0
48
403
1.20
0.55
1.3
1.3
271.16
245.08
u/ml
0.24
31
244
86
973
0.88
0.55
1.3
1.4
—
—
—
0
0
86
973
0.88
0.55
1.3
1.4
—
—
—
0
0
8
125
0.64
0.54
1.9
1.4
0.93
0.95
g/l
—
8
125
9
60
1.50
0.54
1.2
1.2
—
—
—
0
0
9
61
1.48
0.53
1.0
1.2
—
—
—
0
0
86
969
0.88
0.52
1.3
1.4
—
—
—
0
0
21
161
1.31
0.51
1.2
1.0
—
—
—
0
0
6
41
1.46
0.50
2.7
2.0
—
—
—
0
0
162
1492
1.09
0.49
2.7
2.8
0.60
0.73
ug/l
2.20
106
879
17
128
1.33
0.47
3.4
1.6
—
—
—
0
0
17
128
1.33
0.47
3.4
1.6
—
—
—
0
0
17
128
1.33
0.47
3.4
1.6
—
—
—
0
0
7
49
1.43
0.46
3.3
1.4
—
—
—
0
0
7
49
1.43
0.46
3.3
1.4
—
—
—
0
0
8
57
1.41
0.42
1.6
1.4
8.46
8.23
ug/l
—
8
57
48
416
1.16
0.41
3.2
3.5
327.22
3381.54
u/ml
0.69
40
359
0
16
0.00
0.41
0.0
2.4
—
3.76
—
0
16
65
577
1.13
0.41
1.6
1.9
—
—
—
0
0
5
35
1.43
0.39
1.0
1.1
—
—
—
0
0
131
1212
1.09
0.39
3.9
4.0
76.17
25.41
ug/l
0.38
106
949
30
252
1.19
0.38
1.1
1.1
—
—
—
0
0
19
152
1.25
0.37
1.6
1.6
—
—
—
0
0
21
171
1.23
0.35
3.0
4.3
22.30
99.52
u/ml
—
7
49
5
78
0.64
0.35
1.0
1.1
119.80
172.71
iu/ml
—
5
78
18
144
1.25
0.35
1.6
1.3
—
—
—
0
0
6
44
1.36
0.34
1.0
1.1
—
—
—
0
0
10
74
1.35
0.32
1.0
1.1
—
—
—
0
0
14
110
1.27
0.31
1.1
1.0
—
—
—
0
0
64
580
1.11
0.31
1.8
1.6
0.14
0.15
iu/ml
0.01
13
109
7
52
1.35
0.31
1.0
1.2
—
—
—
0
0
16
129
1.24
0.30
1.1
1.4
9.88
10.80
umol/l
0.33
16
120
7
55
1.27
0.30
1.3
1.3
—
—
—
0
0
52
468
1.11
0.29
1.8
1.5
—
—
—
0
0
9
119
0.76
0.27
1.1
1.2
—
—
—
0
0
52
471
1.11
0.27
1.1
1.1
1.97
1.36
u/ml
0.17
22
214
19
159
1.20
0.26
1.3
1.2
0.08
1.55
u/ml
2.82
12
77
11
86
1.28
0.26
1.9
1.7
—
881935.71
—
0
7
17
141
1.21
0.26
1.3
1.4
—
—
—
0
0
54
492
1.10
0.25
1.1
1.1
5.22
6.95
u/ml
0.25
25
275
14
114
1.23
0.25
1.4
1.3
74.43
73.65
umol/l
0.02
14
114
477
4658
1.03
0.23
1.8
1.7
—
—
—
0
0
5
41
1.22
0.22
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
16
188
0.85
0.21
1.6
1.4
—
—
—
0
0
11
134
0.82
0.20
1.1
1.1
5.60
9.16
iu/ml
—
5
36
15
176
0.85
0.20
1.1
1.1
—
—
—
0
0
36
396
0.91
0.19
1.1
1.1
0.76
4.17
u/ml
4.65
14
191
6
53
1.13
0.18
2.7
2.2
—
—
—
0
0
6
53
1.13
0.18
1.7
1.2
78.80
101.96
nmol/l
—
6
40
16
138
1.16
0.17
1.0
1.3
—
290.00
—
0
5
10
120
0.83
0.16
1.0
1.1
—
—
—
0
0
57
534
1.07
0.16
1.3
1.1
—
—
—
0
0
41
379
1.08
0.16
1.2
1.3
—
—
—
0
0
33
360
0.92
0.16
1.1
1.1
5.18
5.05
u/ml
—
10
144
57
538
1.06
0.14
1.2
1.1
0.37
2.57
u/ml
5.70
27
288
35
324
1.08
0.14
1.0
1.1
—
—
—
0
0
57
603
0.94
0.14
1.3
1.3
—
—
—
0
0
36
334
1.08
0.13
2.9
3.3
22.40
22.73
mg/l
0.03
25
216
37
344
1.08
0.13
1.1
1.0
2.01
2.07
u/ml
0.03
17
183
11
94
1.17
0.13
1.0
1.1
1466.18
1531.37
miu/ml
0.07
11
94
31
334
0.93
0.12
1.1
1.1
0.07
0.32
u/ml
—
8
98
44
467
0.94
0.12
1.1
1.1
1.84
1.92
u/ml
0.03
21
232
11
96
1.15
0.10
1.5
1.2
—
—
—
0
0
5
47
1.06
0.09
1.8
1.4
—
—
—
0
0
88
906
0.97
0.08
1.4
1.5
—
—
—
0
0
39
372
1.05
0.07
1.4
1.2
—
—
—
0
0
55
531
1.04
0.07
1.3
1.1
—
—
—
0
0
236
2388
0.99
0.05
2.1
1.9
—
—
—
0
0
14
151
0.93
0.05
1.4
1.1
—
—
—
0
0
14
150
0.93
0.04
1.4
1.1
—
—
—
0
0
14
150
0.93
0.04
1.4
1.1
—
—
—
0
0
14
150
0.93
0.04
1.4
1.1
—
—
—
0
0
14
150
0.93
0.04
1.4
1.1
—
—
—
0
0
412
4145
0.99
0.04
1.5
1.5
—
—
—
0
0
43
419
1.03
0.03
2.6
2.3
5.30
4.65
umol/l
0.37
31
311
56
571
0.98
0.03
1.2
1.2
—
—
—
0
0
16
152
1.05
0.02
2.6
3.1
0.80
0.88
nmol/l
—
10
122
86
851
1.01
0.01
1.5
1.7
3.69
4.27
mg/l
0.25
64
599
11
104
1.06
0.01
1.0
1.1
—
—
—
0
0
190
1899
1.00
0.00
1.9
1.8
—
—
—
0
0
11
108
1.02
0.00
3.8
3.6
—
—
—
0
0
119
1188
1.00
0.00
1.4
1.4
—
—
—
0
0
18
183
0.98
0.00
1.4
1.1
—
—
—
0
0
6
66
0.91
0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
7.72
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
30.00
—
0
6
8
79
1.01
-0.00
1.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPERPIT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERPIT | 1.864 [1.59, 2.18] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.314 |
During the follow-up period (1.1.1998 — 31.12.2019), 660 out of 7880 females with E4_HYPERPIT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERPIT | 1.915 [1.63, 2.25] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.036 |
During the follow-up period (1.1.1998 — 31.12.2019), 521 out of 2276 males with E4_HYPERPIT died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPERPIT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.217% | 0.38% |
| 5 | 1.083% | 2.337% |
| 10 | 2.632% | 6.055% |
| 15 | 5.096% | 10.909% |
| 20 | 9.329% | 18.171% |
Relationships between endpoints
↥Index endpoint: E4_HYPERPIT – Hyperfunction of pituitary gland
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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