hyperpituitarism: Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma.
Hyperfunction of pituitary gland, other and/or unspecified
DOID EFO Endpoint Browser PheWeb
E4_HYPERPITNAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
58 |
4. Check minimum number of eventsNone |
58 |
5. Include endpointsNone |
58 |
6. Filter based on genotype QC (FinnGen only) |
58 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- E22
- Name in latin
- Hyperfunctio hypophysis non specificata
Similar endpoints
↥List of similar endpoints to
Hyperfunction of pituitary gland, other and/or unspecified
based on the number of shared cases.
Similar with more cases:
- Hyperfunction of pituitary gland
- Exclusions for E4_PCOS_BROAD
- Disorders of other endocrine glands
- Exclusions for E4_PCOS_CONSORTIUM
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 363 | 231 | 131 |
| Only index persons | 324 | 212 | 112 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 46.68 | 44.04 | 51.12 |
| Only index persons | 45.20 | 41.70 | 51.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 58 | 37 | 21 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 49.23 | 44.67 | 57.26 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 56
- Matched controls
- 558
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E22.9
ICD-10 Finland
Hyperfunction of pituitary gland, unspecified
+∞
66.6
50
*
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
+∞
29.9
26
*
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
+∞
23.6
21
*
H02AB09
ATC
hydrocortisone; systemic
101.0
19.2
20
*
E22.1
ICD-10 Finland
Hyperprolactinaemia
+∞
18.8
17
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
14.1
13
*
N04BC06
ATC
cabergoline; oral (dopamine agonists)
182.5
14.1
14
*
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
13.0
12
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
+∞
13.0
12
*
G02CB01
ATC
bromocriptine; systemic
33.3
11.9
15
6
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
+∞
10.8
10
*
H03AA01
ATC
levothyroxine sodium; systemic
6.4
9.0
28
75
2530A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Acromegaly and gigantism[ACROMEGALIA]
+∞
8.5
8
*
H01CB02
ATC
octreotide; parenteral
+∞
7.4
7
*
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
7.4
7
*
G02CB03
ATC
cabergoline; oral (prolactine inhibitors)
78.4
6.6
7
*
25301
ICD-8 Finland
Diseases of pituitary gland, Gigantismus hypophysarius et hyperpituitarismus alius
+∞
6.4
6
*
UJF32
NOMESCO Finland
Coloscopy
4.5
6.1
26
91
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3031309) Prolactin monomeric/Prolactin.total in Serum or Plasma
6
0
+∞
6.35
2.0
0.0
%
79.8
—
—
6
0
(21491979) Prolactin monomeric [Units/volume] in Serum or Plasma
6
0
+∞
6.35
2.0
0.0
mu/l
189.7
—
—
6
0
(43055514) Macroprolactin [Presence] in Serum or Plasma
6
0
+∞
6.35
2.2
0.0
—
—
—
0
0
(3017446) Testosterone [Moles/volume] in Serum or Plasma
11
28
4.61
4.19
5.2
2.0
nmol/l
12.2
15.2
0.51
11
28
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
50
376
3.39
3.17
8.1
3.8
pmol/l
15.5
14.8
0.88
50
341
(3029937) Albumin [Presence] in Urine by Test strip
26
139
2.58
3.02
3.9
4.2
estimate
0.0
0.0
—
8
44
(40761536) Microorganisms panel - Urine sediment
11
36
3.54
2.99
2.3
3.3
—
—
—
0
0
(3009261) Glucose [Presence] in Urine by Test strip
39
256
2.60
2.90
3.8
3.6
estimate
0.0
0.0
—
8
45
(4010399)
11
38
3.34
2.75
1.5
1.2
—
—
—
0
0
(3035350) Ketones [Presence] in Urine by Test strip
38
252
2.47
2.68
3.9
3.7
estimate
0.0
0.0
—
9
49
(3018418) pH of Serum or Plasma
26
149
2.35
2.51
7.4
3.8
ph
7.4
7.4
—
6
21
(3017181) Myelocytes/100 leukocytes in Blood
11
43
2.92
2.25
14.4
4.0
%
0.6
0.8
—
5
12
(3020891) Body temperature
7
19
4.04
2.23
3.9
5.1
—
—
—
0
0
(3021601) Nitrite [Presence] in Urine by Test strip
37
257
2.21
2.16
5.2
4.7
estimate
0.0
0.0
—
8
48
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
31
203
2.13
2.08
3.9
3.9
—
—
—
0
0
(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum
6
17
3.81
1.89
1.0
1.6
—
264.0
—
0
7
(3026493) Urate [Moles/volume] in Serum or Plasma
22
134
2.03
1.72
3.5
2.3
umol/l
337.1
9424.6
1.06
22
111
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
26
172
1.93
1.59
4.7
2.8
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
19
113
2.01
1.57
5.2
4.1
—
—
—
0
0
(3025941) Bacteria identified in Stool by Culture
6
21
3.06
1.55
1.5
1.2
—
—
—
0
0
(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood
6
21
3.06
1.55
4.5
4.6
%
38.7
47.7
—
6
21
(40761535) Cells panel - Urine sediment
9
42
2.35
1.41
6.3
3.7
—
—
—
0
0
(3024889) Methemoglobin/Hemoglobin.total in Venous blood
6
23
2.79
1.40
4.5
2.8
%
0.7
0.7
—
6
23
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
6
23
2.79
1.40
4.5
2.8
%
0.9
1.2
—
6
23
(40760892) CBC W Ordered Manual Differential panel - Blood
18
109
1.94
1.40
7.6
5.8
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
37
445
0.53
1.37
25.1
14.1
%
41.2
39.9
0.66
23
330
(3000991) Gas panel - Venous blood
8
34
2.56
1.35
13.4
7.9
—
—
—
0
0
(40758558) Short blood count panel - Blood
20
129
1.84
1.28
7.0
7.4
—
—
—
0
0
(3002032) Base excess in Venous blood by calculation
8
37
2.34
1.27
6.4
3.6
mmol/l
1.1
2.5
—
8
28
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
8
38
2.28
1.24
2.4
3.2
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
16
99
1.85
1.15
5.1
1.9
—
—
—
0
0
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
20
134
1.75
1.12
3.9
3.0
ng/l
954.8
1340.2
0.37
20
112
(3041096) Erythrocytes [Presence] in Urine by Automated
21
143
1.73
1.11
2.7
3.2
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
27
198
1.68
1.09
1.9
2.0
—
—
—
0
0
(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood
7
34
2.20
1.07
5.6
4.4
mmol/l
1.2
1.2
—
7
29
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
5
22
2.39
1.05
1.6
1.1
—
—
—
0
0
(3013512) EKG study
19
128
1.72
1.03
3.8
4.0
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
30
0.00
1.00
0.0
1.4
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
21
147
1.67
0.99
3.6
2.9
—
—
—
0
0
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
11
63
1.92
0.98
2.6
1.7
—
—
—
0
0
(3004119) Hemoglobin [Mass/volume] in Venous blood
6
27
2.36
0.96
4.5
3.2
g/l
118.5
125.5
—
6
27
(3014007) Fractional oxyhemoglobin in Arterial blood
6
27
2.36
0.96
11.7
10.1
%
85.8
93.5
—
6
27
(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma
14
88
1.78
0.95
1.4
1.7
pmol/l
436.6
535.7
0.70
14
80
(3044640) Blood type and Crossmatch panel - Blood
20
140
1.65
0.94
4.5
2.0
—
—
—
0
0
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
10
57
1.91
0.90
2.7
1.6
—
—
—
0
0
(4035726)
6
32
1.97
0.84
2.3
1.3
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
10
59
1.84
0.82
2.2
1.6
—
—
—
0
0
(3027945) Reticulocytes/100 erythrocytes in Blood
10
59
1.84
0.82
2.9
2.9
%
2.0
1.6
—
10
53
(3017143) Hepatitis C virus Ab [Presence] in Serum
9
54
1.79
0.79
2.1
1.6
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
17
119
1.61
0.78
5.3
3.7
—
—
—
0
0
(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
20
146
1.56
0.78
3.2
2.0
u/l
162.2
147.1
0.09
20
139
(3012544) pH of Venous blood
7
39
1.90
0.76
6.9
3.5
—
—
—
0
0
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
5
25
2.09
0.74
2.0
2.2
—
—
—
0
0
(3015377) Calcium [Moles/volume] in Serum or Plasma
21
158
1.52
0.71
5.6
3.1
mmol/l
2.3
2.3
0.42
21
139
(3019832) Treponema pallidum Ab [Presence] in Serum
7
44
1.67
0.68
1.9
1.6
—
—
—
0
0
(3004716) Salmonella sp identified in Stool by Organism specific culture
5
28
1.86
0.68
1.4
1.4
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
24
188
1.47
0.66
1.5
1.8
pmol/l
78.8
94.6
1.28
14
94
(3021879) Hepatitis B virus core Ab [Presence] in Serum
5
29
1.79
0.65
1.2
1.8
—
—
—
0
0
(3019309) Folate [Moles/volume] in Red Blood Cells
13
89
1.59
0.65
1.5
1.6
nmol/l
1316.5
1346.9
0.03
13
73
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
8
51
1.66
0.64
1.6
1.5
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
10
64
1.68
0.63
1.3
1.2
—
—
—
0
0
(40768793) Breast Pathology biopsy report
0
20
0.00
0.61
0.0
1.1
—
—
—
0
0
(3049717) Cytology report of Urine Cyto stain
0
19
0.00
0.61
0.0
2.8
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
18
135
1.48
0.61
3.6
2.5
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
24
191
1.44
0.60
10.0
7.2
inr
1.2
1.3
—
9
58
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
8
54
1.56
0.60
2.0
1.6
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
12
82
1.58
0.60
2.4
1.8
—
—
—
0
0
(3000850) Epithelial cells [#/volume] in Urine
15
109
1.51
0.58
2.8
2.3
e6/l
7.7
5.2
0.32
15
92
(3019060) Gas panel - Arterial blood
6
37
1.69
0.57
2.0
3.8
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
39
341
1.44
0.57
5.4
4.0
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
9
64
1.48
0.55
12.1
8.4
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
6
40
1.56
0.53
11.0
2.6
—
—
—
0
0
(3026782) Osmolality of Urine
13
95
1.47
0.49
3.8
2.5
mosm/kgh2o
517.6
576.6
0.66
13
77
(3020630) Protein [Mass/volume] in Serum or Plasma
7
50
1.45
0.47
9.0
2.7
g/l
67.8
67.3
—
7
44
(3007853) Bacteria identified in Skin by Aerobe culture
8
56
1.50
0.45
2.4
1.5
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
26
219
1.34
0.44
5.4
3.8
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
5
31
1.67
0.44
3.2
1.4
—
—
—
0
0
(3017044) Thyrotropin receptor Ab [Units/volume] in Serum
0
15
0.00
0.42
0.0
1.3
—
9.2
—
0
5
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
5
34
1.51
0.41
1.2
1.3
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
10
72
1.47
0.40
3.5
1.6
—
—
—
0
0
(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma
12
90
1.42
0.40
3.1
3.1
mmol/l
2.4
2.4
0.44
12
81
(1761868) Lipid panel - Serum or Plasma
21
174
1.32
0.39
3.0
2.5
—
—
—
0
0
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
5
36
1.42
0.39
1.6
1.7
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
9
70
1.34
0.39
3.0
1.4
—
—
—
0
0
(3023103) Potassium [Moles/volume] in Serum or Plasma
53
504
1.60
0.39
27.5
14.3
mmol/l
3.9
4.0
0.25
53
490
(3019550) Sodium [Moles/volume] in Serum or Plasma
53
501
1.67
0.38
27.4
14.4
mmol/l
140.0
139.7
0.38
53
487
(3002256) Pathology report gross observation
7
51
1.42
0.33
1.1
1.3
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
50
516
0.78
0.29
20.9
11.8
—
—
—
0
0
(3018010) Neutrophils/100 leukocytes in Blood
26
232
1.22
0.25
12.2
5.3
%
58.2
57.0
0.25
26
218
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
51
490
1.34
0.24
22.6
13.6
mg/l
26.1
22.8
0.26
43
379
(3027944) Amphetamines [Presence] in Urine
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay
0
13
0.00
0.21
0.0
1.2
—
6.6
—
0
7
(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
16
138
1.22
0.20
1.6
1.3
—
—
—
0
0
(3022217) INR in Platelet poor plasma by Coagulation assay
7
58
1.23
0.19
43.3
20.8
—
1.4
—
0
9
(3048689) Calprotectin [Mass/mass] in Stool
7
60
1.19
0.18
1.4
1.8
ug/g
116.9
70.0
—
7
49
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
10
82
1.27
0.18
1.7
1.4
—
—
—
0
0
(3022145) Colonoscopy Study observation
7
61
1.17
0.18
1.0
1.3
—
—
—
0
0
(3013826) Glucose [Moles/volume] in Serum or Plasma
31
287
1.17
0.18
7.1
4.0
mmol/l
7.1
6.5
0.46
31
273
(3006504) Eosinophils/100 leukocytes in Blood
25
228
1.17
0.17
16.2
5.5
%
2.1
2.5
0.66
25
213
(3019069) Monocytes/100 leukocytes in Blood
25
230
1.15
0.15
16.5
5.8
%
7.6
8.4
0.92
25
217
(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum
11
94
1.21
0.14
1.3
1.3
u/ml
1.1
13.4
—
6
35
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
10
85
1.21
0.13
1.9
1.4
—
—
—
0
0
(3013707) Erythrocyte sedimentation rate by Westergren method
39
372
1.15
0.13
5.4
4.5
mm/h
18.8
11.3
0.95
39
342
(3002385) Erythrocyte distribution width [Ratio]
43
414
1.15
0.11
25.7
16.2
%
13.8
13.8
0.04
43
407
(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma
16
145
1.14
0.11
4.9
4.8
ug/l
2.7
2.0
0.52
16
128
(3002030) Lymphocytes/100 leukocytes in Blood
25
235
1.11
0.09
16.3
5.5
%
29.6
27.9
0.32
25
220
(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum
12
107
1.15
0.09
1.5
1.2
u/ml
0.4
0.8
—
6
27
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
28
295
0.90
0.09
3.6
3.0
—
—
—
0
0
(3020564) Creatinine [Moles/volume] in Serum or Plasma
53
520
1.22
0.09
28.1
15.2
umol/l
82.5
76.4
1.03
53
520
(40763571) Iron/Transferrin [Ratio] in Serum or Plasma
7
65
1.09
0.08
1.9
1.9
%
31.4
23.9
—
7
57
(3037522) Nuclear Ab [Titer] in Serum
7
67
1.05
0.08
1.3
1.5
—
498.7
—
0
15
(3022948) Iron [Moles/volume] in Serum or Plasma
7
79
0.87
0.07
1.4
1.8
umol/l
16.4
15.2
—
7
70
(42870588) Differential panel, method unspecified - Blood
16
149
1.10
0.06
18.1
5.3
—
—
—
0
0
(3044889) 12 lead EKG panel
35
341
1.07
0.03
4.4
3.5
—
—
—
0
0
(3020717) Zinc [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.2
—
14.1
—
0
6
(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
2.3
—
4.0
—
0
6
(3023511) Choriogonadotropin [Units/volume] in Urine
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay
0
6
0.00
0.00
0.0
6.2
—
164.8
—
0
6
(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3038026) Centromere Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
(3035999) Lactate [Moles/volume] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.4
—
1.6
—
0
5
(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(4268621)
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
(3044941) Cell count panel - Synovial fluid
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
(4027681)
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay
0
9
0.00
0.00
0.0
3.6
—
2495.1
—
0
9
(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
(3016914) Bacteria identified in Cerebral spinal fluid by Culture
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3023420) DNA double strand Ab [Units/volume] in Serum
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.6
—
2.6
—
0
5
(3047352) Trisomy 18 risk [Likelihood] in Fetus
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3004789) Transferrin [Mass/volume] in Serum or Plasma
7
72
0.97
0.00
1.6
1.8
g/l
2.2
2.4
—
7
65
(3002523) Influenza virus A Ag [Presence] in Specimen
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3005033) Fetal Nuchal fold Thickness US
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3011391) Calcitriol [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
4.3
—
16.0
—
0
9
(3022806) Fractional oxyhemoglobin in Capillary blood
0
5
0.00
0.00
0.0
1.0
—
90.5
—
0
5
(3004616) Nuclear Ab [Presence] in Serum
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3043238) Trisomy 21 risk [Likelihood] in Fetus
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3003740) Influenza virus B Ag [Presence] in Specimen
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPERPITNAS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_HYPERPITNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_HYPERPITNAS – Hyperfunction of pituitary gland, other and/or unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data