Hyperfunction of pituitary gland, other and/or unspecified

E4_HYPERPITNAS

hyperpituitarism: Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma.

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Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E22.9 Hospital discharge: ICD-9 — 2531X Hospital discharge: ICD-8 — 25301 Cause of death: ICD-10 — E22.9 Cause of death: ICD-9 — 2531X Cause of death: ICD-8 — 25301 2 out of 7 registries used, show all original rules.	58
4. Check minimum number of events None	58
5. Include endpoints None	58
6. Filter based on genotype QC (FinnGen only)	58

Control definitions (FinnGen only)

Control exclude: E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: E22
Name in latin: Hyperfunctio hypophysis non specificata

NAME	E4_HYPERPITNAS
CONTROL_EXCLUDE	E4_ENDOGLAND
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E229
HD_ICD_9	2531X
HD_ICD_8	25301
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E229
COD_ICD_9	2531X
COD_ICD_8	25301
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Hyperfunction of pituitary gland, other and/or unspecified based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	363	231	131
Only index persons	324	212	112
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	46.68	44.04	51.12
Only index persons	45.20	41.70	51.83

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	58	37	21
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	49.23	44.67	57.26

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
56: Matched controls
558

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

E22.9

ICD-10 Finland

Hyperfunction of pituitary gland, unspecified

+∞

66.6

D35.2

ICD-10 Finland

Benign neoplasm: Pituitary gland

+∞

29.9

E22.0

ICD-10 Finland

Acromegaly and pituitary gigantism

+∞

23.6

H02AB09

ATC

hydrocortisone; systemic

101.0

19.2

E22.1

ICD-10 Finland

Hyperprolactinaemia

+∞

18.8

101

Kela drug reimbursment

Anterior pituitary hypofunction

+∞

14.1

N04BC06

ATC

cabergoline; oral (dopamine agonists)

182.5

14.1

E23.00

ICD-10 Finland

Panhypopituitarism

+∞

13.0

AA4CG

NOMESCO Finland

Extensive MRI examination of sella turcica with high intensity magnet

+∞

13.0

G02CB01

ATC

bromocriptine; systemic

33.3

11.9

AAE10

NOMESCO Finland

Transsphenoidal total or partial excision of intracranial lesion

+∞

10.8

H03AA01

ATC

levothyroxine sodium; systemic

6.4

9.0

2530A

ICD-9 Finland

Disorders of the pituitary gland and its hypothalamic control, Acromegaly and gigantism[ACROMEGALIA]

+∞

8.5

H01CB02

ATC

octreotide; parenteral

+∞

7.4

E34.9

ICD-10 Finland

Endocrine disorder, unspecified

+∞

7.4

G02CB03

ATC

cabergoline; oral (prolactine inhibitors)

78.4

6.6

25301

ICD-8 Finland

Diseases of pituitary gland, Gigantismus hypophysarius et hyperpituitarismus alius

+∞

6.4

UJF32

NOMESCO Finland

Coloscopy

4.5

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3031309) Prolactin monomeric/Prolactin.total in Serum or Plasma

+∞

6.35

2.0

0.0

79.83

—

(21491979) Prolactin monomeric [Units/volume] in Serum or Plasma

+∞

6.35

2.0

0.0

189.67

—

mu/l

—

(43055514) Macroprolactin [Presence] in Serum or Plasma

+∞

6.35

2.2

0.0

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

4.61

4.19

5.2

2.0

12.21

15.22

nmol/l

0.51

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

376

3.39

3.17

8.1

3.8

15.47

14.78

pmol/l

0.88

341

(3029937) Albumin [Presence] in Urine by Test strip

139

2.58

3.02

3.9

4.2

0.00

estimate

—

(40761536) Microorganisms panel - Urine sediment

3.54

2.99

2.3

3.3

—

(3009261) Glucose [Presence] in Urine by Test strip

256

2.60

2.90

3.8

3.6

0.00

estimate

—

(4010399)

3.34

2.75

1.5

1.2

—

(3035350) Ketones [Presence] in Urine by Test strip

252

2.47

2.68

3.9

3.7

0.00

estimate

—

(3018418) pH of Serum or Plasma

149

2.35

2.51

7.4

3.8

7.39

—

(3017181) Myelocytes/100 leukocytes in Blood

2.92

2.25

14.4

4.0

0.60

0.75

—

(3020891) Body temperature

4.04

2.23

3.9

5.1

—

(3021601) Nitrite [Presence] in Urine by Test strip

257

2.21

2.16

5.2

4.7

0.00

estimate

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

203

2.13

2.08

3.9

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

3.81

1.89

1.0

1.6

—

264.03

—

(3026493) Urate [Moles/volume] in Serum or Plasma

134

2.03

1.72

3.5

2.3

337.14

9424.65

umol/l

1.06

111

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

172

1.93

1.59

4.7

2.8

—

(3023368) Bacteria identified in Blood by Culture

113

2.01

1.57

5.2

4.1

—

(3025941) Bacteria identified in Stool by Culture

3.06

1.55

1.5

1.2

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

3.06

1.55

4.5

4.6

38.72

47.74

—

(40761535) Cells panel - Urine sediment

2.35

1.41

6.3

3.7

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.79

1.40

4.5

2.8

0.65

0.70

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.79

1.40

4.5

2.8

0.88

1.19

—

(40760892) CBC W Ordered Manual Differential panel - Blood

109

1.94

1.40

7.6

5.8

—

(3009542) Hematocrit [Volume Fraction] of Blood

445

0.53

1.37

25.1

14.1

41.17

39.88

0.66

330

(3000991) Gas panel - Venous blood

2.56

1.35

13.4

7.9

—

(40758558) Short blood count panel - Blood

129

1.84

1.28

7.0

7.4

—

(3002032) Base excess in Venous blood by calculation

2.34

1.27

6.4

3.6

1.09

2.54

mmol/l

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.28

1.24

2.4

3.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.85

1.15

5.1

1.9

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

134

1.75

1.12

3.9

3.0

954.84

1340.19

ng/l

0.37

112

(3041096) Erythrocytes [Presence] in Urine by Automated

143

1.73

1.11

2.7

3.2

—

(40768804) Tissue Pathology biopsy report

198

1.68

1.09

1.9

2.0

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

2.20

1.07

5.6

4.4

1.23

1.21

mmol/l

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.39

1.05

1.6

1.1

—

(3013512) EKG study

128

1.72

1.03

3.8

4.0

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

1.00

0.0

1.4

—

(3026008) Bacteria identified in Urine by Culture

147

1.67

0.99

3.6

2.9

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.92

0.98

2.6

1.7

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.36

0.96

4.5

3.2

118.50

125.48

g/l

—

(3014007) Fractional oxyhemoglobin in Arterial blood

2.36

0.96

11.7

10.1

85.82

93.47

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

1.78

0.95

1.4

1.7

436.57

535.71

pmol/l

0.70

(3044640) Blood type and Crossmatch panel - Blood

140

1.65

0.94

4.5

2.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.91

0.90

2.7

1.6

—

(4035726)

1.97

0.84

2.3

1.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.84

0.82

2.2

1.6

—

(3027945) Reticulocytes/100 erythrocytes in Blood

1.84

0.82

2.9

2.04

1.58

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.79

0.79

2.1

1.6

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

119

1.61

0.78

5.3

3.7

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

146

1.56

0.78

3.2

2.0

162.15

147.14

u/l

0.09

139

(3012544) pH of Venous blood

1.90

0.76

6.9

3.5

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.09

0.74

2.0

2.2

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

158

1.52

0.71

5.6

3.1

2.32

2.35

mmol/l

0.42

139

(3019832) Treponema pallidum Ab [Presence] in Serum

1.67

0.68

1.9

1.6

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.86

0.68

1.4

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

188

1.47

0.66

1.5

1.8

78.76

94.59

pmol/l

1.28

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.79

0.65

1.2

1.8

—

(3019309) Folate [Moles/volume] in Red Blood Cells

1.59

0.65

1.5

1.6

1316.54

1346.95

nmol/l

0.03

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.66

0.64

1.6

1.5

—

(40768797) Stomach Pathology biopsy report

1.68

0.63

1.3

1.2

—

(40768793) Breast Pathology biopsy report

0.00

0.61

0.0

1.1

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.61

0.0

2.8

—

(36304419) Bacteria [Presence] in Urine

135

1.48

0.61

3.6

2.5

—

(3032080) INR in Blood by Coagulation assay

191

1.44

0.60

10.0

7.2

1.18

1.26

inr

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.56

0.60

2.0

1.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.58

0.60

2.4

1.8

—

(3000850) Epithelial cells [#/volume] in Urine

109

1.51

0.58

2.8

2.3

7.70

5.19

e6/l

0.32

(3019060) Gas panel - Arterial blood

1.69

0.57

2.0

3.8

—

(3037467) Urinalysis macro (dipstick) panel - Urine

341

1.44

0.57

5.4

4.0

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.48

0.55

12.1

8.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.56

0.53

11.0

2.6

—

(3026782) Osmolality of Urine

1.47

0.49

3.8

2.5

517.62

576.62

mosm/kgh2o

0.66

(3020630) Protein [Mass/volume] in Serum or Plasma

1.45

0.47

9.0

2.7

67.83

67.31

g/l

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.50

0.45

2.4

1.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

219

1.34

0.44

5.4

3.8

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.67

0.44

3.2

1.4

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

0.00

0.42

0.0

1.3

—

9.16

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.51

0.41

1.2

1.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.47

0.40

3.5

1.6

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

1.42

0.40

3.1

2.41

2.45

mmol/l

0.44

(1761868) Lipid panel - Serum or Plasma

174

1.32

0.39

3.0

2.5

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.42

0.39

1.6

1.7

—

(3000494) Fungus identified in Specimen by Culture

1.34

0.39

3.0

1.4

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

504

1.60

0.39

27.5

14.3

3.95

3.97

mmol/l

0.25

490

(3019550) Sodium [Moles/volume] in Serum or Plasma

501

1.67

0.38

27.4

14.4

140.00

139.74

mmol/l

0.38

487

(3002256) Pathology report gross observation

1.42

0.33

1.1

1.3

—

(40761511) CBC panel - Blood by Automated count

516

0.78

0.29

20.9

11.8

—

(3018010) Neutrophils/100 leukocytes in Blood

232

1.22

0.25

12.2

5.3

58.23

56.96

0.25

218

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

490

1.34

0.24

22.6

13.6

26.12

22.81

mg/l

0.26

379

(3027944) Amphetamines [Presence] in Urine

0.00

0.21

0.0

1.2

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.1

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.21

0.0

1.1

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

6.57

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.21

0.0

1.6

—

(3003694) ABO and Rh group [Type] in Blood

138

1.22

0.20

1.6

1.3

—

(3022217) INR in Platelet poor plasma by Coagulation assay

1.23

0.19

43.3

20.8

—

1.39

—

(3048689) Calprotectin [Mass/mass] in Stool

1.19

0.18

1.4

1.8

116.86

70.02

ug/g

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.27

0.18

1.7

1.4

—

(3022145) Colonoscopy Study observation

1.17

0.18

1.0

1.3

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

287

1.17

0.18

7.1

4.0

7.06

6.50

mmol/l

0.46

273

(3006504) Eosinophils/100 leukocytes in Blood

228

1.17

0.17

16.2

5.5

2.12

2.52

0.66

213

(3019069) Monocytes/100 leukocytes in Blood

230

1.15

0.15

16.5

5.8

7.57

8.42

0.92

217

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

1.21

0.14

1.3

1.08

13.44

u/ml

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.21

0.13

1.9

1.4

—

(3013707) Erythrocyte sedimentation rate by Westergren method

372

1.15

0.13

5.4

4.5

18.82

11.32

mm/h

0.95

342

(3002385) Erythrocyte distribution width [Ratio]

414

1.15

0.11

25.7

16.2

13.81

13.79

0.04

407

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

145

1.14

0.11

4.9

4.8

2.72

2.04

ug/l

0.52

128

(3002030) Lymphocytes/100 leukocytes in Blood

235

1.11

0.09

16.3

5.5

29.57

27.87

0.32

220

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

107

1.15

0.09

1.5

1.2

0.43

0.75

u/ml

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

295

0.90

0.09

3.6

3.0

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

520

1.22

0.09

28.1

15.2

82.51

76.40

umol/l

1.03

520

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

1.09

0.08

1.9

31.43

23.90

—

(3037522) Nuclear Ab [Titer] in Serum

1.05

0.08

1.3

1.5

—

498.67

—

(3022948) Iron [Moles/volume] in Serum or Plasma

0.87

0.07

1.4

1.8

16.40

15.19

umol/l

—

(42870588) Differential panel, method unspecified - Blood

149

1.10

0.06

18.1

5.3

—

(3044889) 12 lead EKG panel

341

1.07

0.03

4.4

3.5

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

14.08

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

2.3

—

4.00

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.2

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

6.2

—

164.83

—

(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.3

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.4

—

1.63

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(4268621)

0.00

0.0

1.8

—

(3044941) Cell count panel - Synovial fluid

0.00

0.0

1.4

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.6

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.3

—

(4027681)

0.00

0.0

1.1

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.3

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.0

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

3.6

—

2495.06

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.6

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.3

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.4

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.4

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.4

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

2.56

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.1

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

0.97

0.00

1.6

1.8

2.18

2.38

g/l

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.1

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.1

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

4.3

—

16.00

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

1.0

—

90.54

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.1

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.3

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_HYPERPITNAS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_HYPERPITNAS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: E4_HYPERPITNAS – Hyperfunction of pituitary gland, other and/or unspecified

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Hyperfunction of pituitary gland, other and/or unspecified

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints