hyperprolactinemia: An acquired metabolic disease that has_material_basis_in the presence of abnormally-high levels of prolactin in the blood.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1436 |
4. Check minimum number of eventsNone |
1436 |
5. Include endpointsNone |
1436 |
6. Filter based on genotype QC (FinnGen only) |
1376 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E22
- Name in latin
- Hyperprolactinaemia
Similar endpoints
↥List of similar endpoints to
Hyperprolactinaemia
based on the number of shared cases.
Similar with more cases:
- Hyperfunction of pituitary gland
- Exclusions for E4_PCOS_BROAD
- Disorders of other endocrine glands
- Exclusions for E4_PCOS_CONSORTIUM
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7858 | 6346 | 1386 |
| Only index persons | 7530 | 6218 | 1312 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.18 | 0.04 |
| Only index persons | 0.20 | 0.23 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 35.99 | 33.41 | 47.97 |
| Only index persons | 35.83 | 33.35 | 47.61 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1376 | 1123 | 253 |
| Unadjusted period prevalence (%) | 0.35 | 0.40 | 0.12 |
| Median age at first event (years) | 37.05 | 34.10 | 50.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1436
- Matched controls
- 14360
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G02CB03
ATC
cabergoline; oral
85.6
307.7
212
29
E22.1
ICD-10 Finland
Hyperprolactinaemia
4503599627370496.0
307.7
1402
*
N04BC06
ATC
cabergoline; oral
1097.1
307.7
503
7
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
383.8
307.7
449
17
G02CB01
ATC
bromocriptine; systemic
51.2
307.7
481
140
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
227.6
307.7
346
20
N91.1
ICD-10 Finland
Secondary amenorrhoea
12.7
159.4
162
142
H02AB09
ATC
hydrocortisone; systemic
16.6
148.7
128
84
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
65.8
114.3
63
10
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
5.0
99.2
240
553
N05AX08
ATC
risperidone; systemic
5.2
96.2
222
491
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
9.1
87.8
111
131
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
162.6
73.8
77
5
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
72.5
69
*
G02CB04
ATC
quinagolide; oral
700.5
68.6
67
*
N05AH03
ATC
olanzapine; systemic
4.1
64.9
197
535
G03DB01
ATC
dydrogesterone; oral
2.9
60.2
358
1477
F29
ICD-10 Finland
Unspecified nonorganic psychosis
4.9
59.7
139
306
N64.3
ICD-10 Finland
Galactorrhoea not associated with childbirth
13.5
59.1
56
43
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
58.7
56
*
N05AX12
ATC
aripiprazole; systemic
4.3
57.6
161
410
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
14.7
52.1
47
33
2531A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Other and unspecified anterior pituitary hyperfunction[HYPERPROLACTINAEMIA]
+∞
51.4
49
*
N05AB03
ATC
perphenazine; systemic, rectal
5.1
50.5
112
236
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
91.7
48.2
53
6
AA4CM
NOMESCO Finland
Extensive MRI examination of sella turcica with 3 Tesla magnet
483.3
47.6
47
*
N05AH04
ATC
quetiapine; oral
2.5
45.7
379
1818
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.8
44.7
105
232
N05AH02
ATC
clozapine; systemic
6.1
44.2
78
133
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
6.4
40.2
68
111
H03AA01
ATC
levothyroxine sodium; systemic
2.3
40.0
420
2215
E23.05
ICD-10 Finland
Lack of TSH
345.1
34.1
34
*
N04AA02
ATC
biperiden; systemic
6.1
34.0
60
102
D44.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pituitary gland
94.9
33.9
37
*
N05AA02
ATC
levomepromazine; systemic
4.1
32.4
93
240
XCK00
NOMESCO Finland
Perimetry
3.8
32.1
102
283
2273A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Pituitary gland and craniopharyngeal duct (pouch)
+∞
31.4
30
*
AA4DG
NOMESCO Finland
Very extensive MRI examination of sella turcica with high intensity magnet
112.5
30.8
33
*
N97.0
ICD-10 Finland
Female infertility associated with anovulation
4.8
30.6
71
155
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
+∞
30.3
29
*
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.3
28.8
114
365
N97.9
ICD-10 Finland
Female infertility, unspecified
2.7
28.5
167
667
XLA10, ,
NOMESCO Finland
3.2
28.5
122
410
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
4.9
28.5
64
136
F25.10
ICD-10 Finland
Schizoaffective syndrome, depressive type with only concomitant bipolar and schizophrenic symptoms
8.8
28.5
36
42
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
5.8
28.5
53
95
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
+∞
28.2
27
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.4
27.6
220
1017
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.8
26.7
603
4058
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
26.1
25
*
N03AG01
ATC
valproic acid; systemic, rectal
2.9
26.1
127
459
F20.9
ICD-10 Finland
Schizophrenia, unspecified
4.7
26.1
62
138
P72
ICPC
Schizophrenia
4.7
26.1
61
134
N05BA06
ATC
lorazepam; systemic, sublingual
3.4
24.4
92
286
N91.4
ICD-10 Finland
Secondary oligomenorrhoea
9.0
24.2
30
34
N05AN01
ATC
lithium; oral
3.9
23.9
71
188
N06AB04
ATC
citalopram; systemic
2.0
23.8
337
1938
N03AX09
ATC
lamotrigine; oral
2.8
23.8
129
494
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
3.4
23.7
90
281
N06AX16
ATC
venlafaxine; oral
2.0
22.9
280
1526
N05AF03
ATC
chlorprothixene; systemic
4.1
22.9
65
166
N04BC01
ATC
bromocriptine; oral
122.0
22.6
24
*
N05AF05
ATC
zuclopenthixol; systemic
7.9
22.6
31
40
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
5.3
22.3
45
87
N05CD07
ATC
temazepam; oral
2.6
21.7
131
529
E21.0
ICD-10 Finland
Primary hyperparathyroidism
81.4
21.7
24
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.0
20.9
260
1423
188
Kela drug reimbursment
Psychosis requiring demanding treatment
6.4
20.6
34
54
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
4.1
20.4
56
140
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.0
19.9
247
1350
D352, E221,
ICD-10 Finland
+∞
19.8
19
*
F22.0
ICD-10 Finland
Delusional disorder
6.5
19.7
32
50
A06AC01
ATC
ispaghula (psylla seeds); oral
1.8
19.5
337
2053
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.3
18.4
144
656
E22.9
ICD-10 Finland
Hyperfunction of pituitary gland, unspecified
+∞
17.7
17
*
N05AE04
ATC
ziprasidone; systemic
6.2
17.7
30
49
N05AA01
ATC
chlorpromazine; systemic, rectal
5.5
17.6
34
63
N06AB03
ATC
fluoxetine; oral
2.0
17.0
209
1135
N05BA04
ATC
oxazepam; oral
1.7
16.9
379
2477
AA400
NOMESCO Finland
Electroconvulsive therapy
6.1
16.9
29
48
2542
FHL
Transasal hypophysectomy
+∞
16.7
16
*
F25.20
ICD-10 Finland
Schizoaffective syndrome, mixed type with only concomitant bipolar and schizophrenic symptoms
6.8
16.6
26
39
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
3.1
16.4
68
224
N06AX11
ATC
mirtazapine; oral
1.6
16.2
482
3385
N05AX13
ATC
paliperidone; systemic
7.2
16.1
24
34
C07AA05
ATC
propranolol; systemic
1.7
16.1
349
2255
N91.2
ICD-10 Finland
Amenorrhoea, unspecified
6.2
16.0
27
44
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
4.7
15.9
37
81
F25.00
ICD-10 Finland
Schizoaffective syndrome, manic type with only simultaneous bipolar and schizophrenic symptoms
5.8
15.9
29
51
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
3.4
15.8
58
177
E23.6
ICD-10 Finland
Other disorders of pituitary gland
+∞
15.6
15
*
N05AD01
ATC
haloperidol; systemic
3.9
15.6
46
121
IER04
NOMESCO Finland
Rehabilitative psychiatric group intervention, functional
5.7
15.6
29
52
102
Kela drug reimbursment
Diabetes insipidus
161.7
15.5
16
*
R42
ICD-10 Finland
Dizziness and giddiness
1.8
15.5
268
1622
ZYC01
NOMESCO Finland
Remote contact by phone
2.4
14.8
108
476
N05AF01
ATC
flupentixol; systemic
4.8
14.8
33
70
E23.03
ICD-10 Finland
Lack of ACTH
+∞
14.6
14
*
N03AE01
ATC
clonazepam; systemic
2.6
14.5
85
338
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
4.9
14.5
32
67
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
3.5
14.1
49
145
IFB01
NOMESCO Finland
Electroconvulsive Therapy (ECT)
6.1
13.9
24
40
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.1
13.7
56
183
AA1AD
NOMESCO Finland
CT of head and brain
1.7
13.7
267
1669
R53
ICD-10 Finland
Malaise and fatigue
1.6
13.6
345
2313
IER01
NOMESCO Finland
Psychoeducation, group
5.9
13.5
24
41
P29
ICPC
Psychological sympt/compl other
2.0
13.3
149
781
N06AG02
ATC
moclobemide; oral
2.8
13.1
64
232
F20.04
ICD-10 Finland
Paranoid schizophrenia with partial recurrence
6.0
13.1
23
39
X21
ICPC
Breast sympt/compl female other
3.1
13.1
54
178
N06AX21
ATC
duloxetine; oral
1.8
12.7
192
1110
ZY010
NOMESCO Finland
Hospital outpatient
2.2
12.6
105
491
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
2.5
12.4
76
310
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
12.3
166
925
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.6
12.3
410
2924
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
2.7
12.3
66
252
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
3.1
12.2
51
169
N05AC02
ATC
thioridazine; oral
3.6
12.0
39
110
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
3.4
12.0
42
125
N05AE03
ATC
sertindole; oral
13.5
12.0
20
15
N05BE01
ATC
buspirone; oral
3.0
11.9
51
172
X05
ICPC
Menstruation absent/scanty
3.5
11.9
40
116
UJF32
NOMESCO Finland
Coloscopy
1.7
11.8
276
1803
F20.09
ICD-10 Finland
Paranoid schizophrenia UNS
5.4
11.8
23
43
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.0
11.8
125
642
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
1.9
11.6
154
853
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.7
11.5
222
1378
E22.88
ICD-10 Finland
Other hyperfunction of pituitary gland
+∞
11.5
11
*
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
121.0
11.4
12
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.8
11.4
181
1061
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.5
11.4
468
3483
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
3.4
11.3
40
120
H01CB02
ATC
octreotide; parenteral
35.3
11.3
14
*
F60.9
ICD-10 Finland
Personality disorder, unspecified
3.6
11.2
37
106
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
11.1
321
2207
ZXY49
NOMESCO Finland
Other health care provider
5.8
11.0
20
35
R51.80
ICD-10 Finland
Headache
1.6
11.0
266
1753
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
10.9
291
1963
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.2
10.9
96
459
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
3.4
10.9
38
113
K59.0
ICD-10 Finland
Constipation
2.4
10.8
73
311
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
3.6
10.8
35
99
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
2.0
10.8
118
613
N05AL01
ATC
sulpiride; systemic
4.5
10.8
26
59
L17
ICPC
Foot/toe symptom/complaint
1.5
10.7
363
2585
F21
ICD-10 Finland
Schizotypal disorder
5.6
10.7
20
36
IGY99
NOMESCO Finland
Other psychiatric treatment contact
2.9
10.5
49
174
P98
ICPC
Psychosis NOS/other
5.5
10.4
20
37
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
2.7
10.4
54
203
ZXC86
NOMESCO Finland
Use of endoscopic device
16.2
10.4
16
10
A02BC02
ATC
pantoprazole; systemic
1.4
10.3
856
7249
N05CF01
ATC
zopiclone; oral
1.5
10.2
372
2686
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
10.2
330
2322
IBA02
NOMESCO Finland
Evaluation of need for psychiatric rehabilitation
5.1
10.1
21
42
C03CA01
ATC
furosemide; systemic
1.7
10.0
194
1205
Z35.0
ICD-10 Finland
Supervision of pregnancy with history of infertility
2.4
9.9
68
292
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.3
9.8
75
338
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
9.8
579
4591
F61.0
ICD-10 Finland
Mixed personality disorders
3.2
9.8
39
126
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.2
9.7
84
399
N06AB05
ATC
paroxetine; oral
2.0
9.7
99
502
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
3.5
9.6
33
97
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.6
9.6
231
1515
P01
ICPC
Feeling anxious/nervous/tense
1.6
9.6
248
1656
R11
ICD-10 Finland
Nausea and vomiting
1.9
9.6
125
689
X78
ICD-10 Finland
Intentional self-harm by sharp object
4.8
9.5
21
44
A55
ICPC
General and Unspecified, Local injection/infiltration
4.8
9.5
21
44
F23.90
ICD-10 Finland
Acute and transient psychosis, unspecified without acute stress factor
9.2
9.5
19
21
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
9.5
462
3529
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
2.4
9.5
62
261
N05BA01
ATC
diazepam; systemic, rectal
1.8
9.4
160
956
E23.2
ICD-10 Finland
Diabetes insipidus
100.7
9.4
10
*
D35.31
ICD-10 Finland
Cyst in Rathke's pocket
30.2
9.4
12
*
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
2.8
9.4
45
162
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
1.8
9.4
133
753
25320
ICD-8 Finland
Diseases of pituitary gland, Chromophobe adenoma, pituitary
+∞
9.4
9
*
R07.4
ICD-10 Finland
Chest pain, unspecified
1.5
9.4
296
2069
Z2446
NOMESCO Finland
Social worker
2.0
9.4
96
487
M79.6
ICD-10 Finland
Pain in limb
1.4
9.4
562
4460
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.7
9.3
175
1076
F25.21
ICD-10 Finland
Schizoaffective syndrome, mixed type with prolonged schizophrenic than bipolar symptoms
8.7
9.3
19
22
ZY000
NOMESCO Finland
Hospital inpatient
3.4
9.2
32
95
F23.8
ICD-10 Finland
Other acute and transient psychotic disorders
8.4
9.1
19
23
P99
ICPC
Psychological disorders other
2.4
9.0
59
249
121
Kela drug reimbursment
Severe hypofunction of sexual glands
3.5
8.9
30
87
SPAT1240
SPAT
Therapeutic discussion
1.7
8.9
192
1226
IGY02
NOMESCO Finland
Psychiatric monitoring contact
2.4
8.8
59
251
N06AB06
ATC
sertraline; oral
1.7
8.8
190
1213
G47.3
ICD-10 Finland
Sleep apnoea
1.6
8.8
249
1698
IFA99
NOMESCO Finland
Other psychiatric pharmacotherapy service
4.3
8.7
22
52
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
2.4
8.7
57
241
T99
ICPC
Endocr/metab/nutrit disease other
3.8
8.6
26
70
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.0
8.6
87
439
N03AX16
ATC
[U] pregabalin
1.5
8.6
271
1892
E28.3
ICD-10 Finland
Primary ovarian failure
16.4
8.6
13
8
F28
ICD-10 Finland
Other nonorganic psychotic disorders
9.0
8.5
17
19
E29.1
ICD-10 Finland
Testicular hypofunction
9.0
8.5
17
19
IER02
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, group
4.1
8.5
23
57
E66.8
ICD-10 Finland
Other obesity
1.9
8.5
100
533
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.9
8.4
108
592
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
90.6
8.4
9
*
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
90.6
8.4
9
*
BBA40
NOMESCO Finland
Subtotal parathyroidectomy
90.6
8.4
9
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
8.4
530
4223
IEY08
NOMESCO Finland
Psychiatric coaching, domestic and community skills
8.6
8.3
17
20
R41.0
ICD-10 Finland
Disorientation, unspecified
3.6
8.3
27
77
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
1.8
8.2
123
708
Z3231
NOMESCO Finland
Registered nurse
1.5
8.2
321
2340
IEV99
NOMESCO Finland
Other psychiatric network intervention
4.8
8.1
18
38
R60.0
ICD-10 Finland
Localized oedema
1.8
8.1
120
689
R55
ICD-10 Finland
Syncope and collapse
1.9
8.0
104
572
L28
ICPC
Limited function/disability (L)
1.7
8.0
154
954
F31.20
ICD-10 Finland
Bipolar disorder, manic episode with mood-congruent psychotic symptoms
4.3
7.9
20
47
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.7
7.9
166
1050
E0000UV, ,
ATC
1.4
7.9
564
4575
3018D
ICD-9 Finland
Personality disorders, Other personality disorders[EPÄVAKAA PERSOONALLISUUS]
7.8
7.9
17
22
G44.0
ICD-10 Finland
Cluster headache syndrome
3.5
7.8
26
75
A06AD11
ATC
lactulose; oral
1.8
7.8
118
681
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
2.1
7.8
69
331
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.8
7.8
115
659
O92.6
ICD-10 Finland
Galactorrhoea
10.9
7.8
14
13
SPAT1263
SPAT
Sampling
1.4
7.8
546
4414
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.1
7.7
75
373
Z3229
NOMESCO Finland
Other healthcare associate professional
1.9
7.7
90
479
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.2
7.7
61
281
P28
ICPC
Limited function/disability (P)
4.0
7.6
21
53
A02BC05
ATC
esomeprazole; systemic
1.4
7.6
493
3929
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.7
7.6
150
934
F20.3
ICD-10 Finland
Undifferentiated schizophrenia
6.2
7.5
19
31
ZYC05
NOMESCO Finland
Non-real-time text-based remote communication
3.4
7.5
26
77
N03AX12
ATC
[U] gabapentin; oral
1.6
7.5
193
1285
N06AA04
ATC
clomipramine; systemic
3.3
7.4
27
83
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
7.4
301
2207
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
2.0
7.4
84
443
H53.4
ICD-10 Finland
Visual field defects
3.1
7.3
29
94
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
3.0
7.3
32
110
106
Kela drug reimbursment
Hypoparathyroidism
+∞
7.3
7
*
E22.2
ICD-10 Finland
Syndrome of inappropriate secretion of antidiuretic hormone
+∞
7.3
7
*
E23
ICD-10 Finland
Hypofunction and other disorders of pituitary gland
+∞
7.3
7
*
2370A
ICD-9 Finland
Neoplasm of uncertain behaviour of endocrine glands and nervous system, Pituitary gland and craniopharyngeal duct
+∞
7.3
7
*
IEY01
NOMESCO Finland
Psychoeducation, individual
3.9
7.3
21
55
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.7
7.2
120
713
R06.0
ICD-10 Finland
Dyspnoea
1.5
7.2
283
2060
E21.3
ICD-10 Finland
Hyperparathyroidism, unspecified
30.2
7.2
9
*
IGV01
NOMESCO Finland
Psychiatric network contact
3.5
7.1
24
70
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
2.0
7.1
74
378
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
2.8
7.1
35
129
F25.1
ICD-10 Finland
Schizoaffective disorder, depressive type
8.8
7.1
14
16
ZXY59
NOMESCO Finland
2-person team, nurse-other special worker
10.1
7.0
13
13
ZXE01
NOMESCO Finland
Procedure duration 0 to 9 minutes
2.9
7.0
31
107
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
1.8
7.0
97
546
TPH07
NOMESCO Finland
Cathetrisation of artery
1.9
7.0
91
503
A11
ICPC
Chest pain NOS
1.9
6.9
80
424
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.6
6.9
159
1029
N17
ICPC
Vertigo/dizziness
1.7
6.9
130
799
XF404
NOMESCO Finland
Ambulatory ECG
1.9
6.9
80
425
F31.8
ICD-10 Finland
Other bipolar affective disorders
2.5
6.9
42
172
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.8
6.9
109
639
G03DC02
ATC
norethisterone; oral
1.7
6.8
129
794
K59.00
ICD-10 Finland
Constipation caused by slow bowel passage (SCT)
3.0
6.8
29
98
R02
ICPC
Shortness of breath/dyspnoea
1.7
6.8
135
842
F25.01
ICD-10 Finland
Schizoaffective syndrome, manic type with prolonged schizophrenic than bipolar symptoms
7.2
6.7
15
21
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.7
6.7
109
644
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
2.0
6.7
71
366
WVA30, ,
SPAT
2.1
6.7
59
284
D12
ICPC
Constipation
2.5
6.6
40
163
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.4
6.6
467
3755
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.6
6.6
177
1188
2968A
ICD-9 Finland
Affective psychoses, Manic-depressive psychosis, other and unspecified
5.5
6.6
18
33
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
2.4
6.6
43
182
A99
ICPC
Disease/condition unspecnature/site
1.8
6.6
106
625
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
1.5
6.6
202
1398
A06AC51
ATC
ispaghula, combinations; oral
2.1
6.6
59
286
N06AA10
ATC
nortriptyline; systemic
2.7
6.5
33
123
-50
ICPC
Medication/prescr/renewal
2.3
6.5
47
208
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.5
6.5
206
1434
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.4
6.5
390
3057
F31
ICD-10 Finland
Bipolar affective disorder
3.0
6.4
28
96
N06AX03
ATC
mianserin; oral
2.1
6.4
56
268
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
70.2
6.4
7
*
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.2
6.3
50
230
F61
ICD-10 Finland
Mixed and other personality disorders
8.2
6.3
13
16
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.4
6.3
308
2329
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
2.6
6.3
36
143
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
11.1
6.3
11
10
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
1.9
6.3
77
417
D01
ICPC
Abdominal pain/cramps general
1.5
6.3
171
1152
E23.06
ICD-10 Finland
Empty sella
+∞
6.3
6
*
E23.09
ICD-10 Finland
Pituitary insufficiency NOS
+∞
6.3
6
*
H01CB03
ATC
lanreotide; parenteral
26.8
6.2
8
*
E86
ICD-10 Finland
Volume depletion
3.7
6.2
19
52
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
2.7
6.2
31
115
Z2445
NOMESCO Finland
Psychologist
2.0
6.2
65
334
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
1.4
6.2
307
2327
SPAT1310
SPAT
Counselling related to known health issue
1.4
6.2
390
3076
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
2.9
6.2
27
93
F31.1
ICD-10 Finland
Bipolar affective disorder, current episode manic without psychotic symptoms
3.5
6.2
20
57
N91.5
ICD-10 Finland
Oligomenorrhoea, unspecified
5.4
6.2
17
32
E66.01
ICD-10 Finland
Obesity due to excess calories
1.6
6.1
145
945
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
2.5
6.1
38
157
TLC00
NOMESCO Finland
Insertion of intrauterine device
1.6
6.1
137
883
D11
ICPC
Diarrhoea
1.5
6.1
182
1252
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.8
6.1
94
548
N62
ICD-10 Finland
Hypertrophy of breast
1.9
6.1
70
372
K59.1
ICD-10 Finland
Functional diarrhoea
2.0
6.1
67
351
D19
ICPC
Teeth/gum symptom/complaint
1.4
6.0
403
3205
F23.99
ICD-10 Finland
Acute and transient psychosis, unspecified UNS
6.7
6.0
14
21
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
699
738
17.51
307.65
5.7
1.3
777.07
291.84
mu/l
8.59
673
660
575
1044
8.52
307.65
3.5
1.8
367.85
379.35
nmol/l
0.75
557
970
347
409
10.87
283.30
1.7
1.2
7.68
11.26
u/l
4.03
284
335
271
475
6.80
153.38
4.7
1.8
9.17
11.48
nmol/l
3.68
252
434
195
335
6.58
111.27
1.5
1.3
0.30
0.48
nmol/l
2.28
150
277
65
15
45.34
109.56
1.4
1.2
—
—
—
0
0
119
130
9.89
99.95
2.9
1.5
147.92
190.13
pmol/l
1.78
114
120
322
1128
3.39
73.14
1.5
1.3
16.74
27.04
iu/l
7.61
265
973
129
308
4.50
50.01
1.8
1.4
13.63
25.57
u/l
5.54
117
256
1251
9861
3.09
47.32
6.6
4.0
14.45
14.33
pmol/l
1.03
1207
9234
654
4083
2.11
40.58
6.9
5.0
1.22
1.21
mmol/l
0.96
616
3758
705
4595
2.05
38.21
7.8
5.6
1.22
1.21
mmol/l
1.27
603
3939
1324
11371
3.11
31.43
7.2
4.7
1.69
1.93
mu/l
0.92
1278
10758
205
877
2.56
30.53
2.8
3.4
4.38
4.61
pmol/l
3.01
190
791
40
49
8.37
30.46
1.4
1.3
1.39
1.76
nmol/l
0.26
35
34
1029
8377
1.81
21.86
7.7
6.7
74.71
73.57
u/l
0.43
984
7932
1322
11773
2.55
21.24
16.7
10.6
139.76
139.58
mmol/l
2.44
1297
11465
1322
11814
2.50
20.33
16.8
10.7
3.95
3.92
mmol/l
0.49
1297
11477
1040
8571
1.77
20.26
4.2
3.7
10.92
9.88
mm/h
1.86
980
8034
572
4024
1.70
20.12
4.7
4.4
36.30
36.69
g/l
0.96
528
3783
638
4691
1.65
18.48
2.8
2.1
74.20
74.42
nmol/l
0.08
593
4363
47
111
4.34
18.40
9.0
12.0
0.60
0.63
mmol/l
0.36
41
101
776
6008
1.63
18.16
5.6
4.1
6.26
6.39
mmol/l
1.29
724
5493
483
3319
1.69
18.10
3.2
3.1
2.35
2.34
mmol/l
0.26
437
3004
250
1435
1.90
17.23
1.9
1.6
1172.86
1173.49
nmol/l
0.00
205
1126
194
1024
2.03
17.05
6.8
5.5
1.02
1.04
mmol/l
0.50
181
963
124
555
2.35
16.46
4.5
3.1
95.19
69.76
ng/l
0.91
107
505
49
133
3.78
15.94
2.2
1.8
4.21
4.79
mmol/24h
0.67
43
124
37
83
4.55
15.47
2.1
1.4
290.78
282.26
mosm/kgh2o
1.85
32
66
1161
10164
1.74
15.07
5.2
4.4
37.67
38.02
mmol/mol
0.74
1107
9624
521
3821
1.57
14.20
2.0
1.7
101.89
98.09
pmol/l
0.97
277
2051
1240
11155
1.82
13.49
4.7
3.6
5.65
5.68
mmol/l
0.27
1173
10454
192
1093
1.87
13.40
2.5
2.1
6898.89
6453.61
u/l
0.07
56
440
774
6255
1.51
13.16
3.1
2.8
88.83
80.10
ug/l
0.33
725
5927
456
3295
1.56
13.02
3.0
2.4
53.16
56.93
u/l
0.96
422
3067
818
6731
1.50
12.45
12.9
8.6
4.03
3.93
e9/l
0.66
733
5927
310
2063
1.64
12.42
1.5
1.4
19.29
20.80
nmol/l
1.16
272
1829
22
38
5.86
12.28
1.1
1.2
66.73
67.35
nmol/24h
0.02
22
38
1356
12663
2.27
11.90
16.7
11.3
73.01
68.98
umol/l
3.14
1356
12657
222
1368
1.74
11.84
2.6
2.1
2.47
2.45
g/l
0.26
197
1274
388
2770
1.55
11.43
3.4
2.1
161.16
166.61
u/l
0.07
369
2632
704
5689
1.47
11.28
6.7
5.5
56.09
56.53
%
0.52
671
5379
1228
11159
1.69
11.05
12.8
8.9
89.74
90.97
ml/min/173m2
1.32
1071
9087
376
2685
1.54
11.00
2.4
2.0
2.66
2.73
mg/l
0.33
318
2340
708
5750
1.46
10.92
7.0
5.7
29.59
29.32
%
0.31
676
5449
993
8640
1.48
10.46
3.7
2.8
41.38
37.01
u/l
0.93
958
8281
129
705
1.91
10.15
3.9
2.6
1.23
1.23
mmol/l
0.32
114
602
244
1611
1.62
9.91
2.7
2.6
2.44
2.42
mmol/l
1.89
205
1405
285
1966
1.56
9.59
1.5
1.5
31967680.36
45523680.35
pmol/l
0.15
244
1720
421
3172
1.46
9.24
1.4
1.3
1.72
1.47
u/ml
0.13
110
897
195
1240
1.66
9.16
2.8
2.2
22.01
24.08
%
1.37
164
1077
218
1427
1.62
9.13
3.5
3.4
0.83
0.83
mmol/l
0.06
206
1351
505
3944
1.43
9.13
3.4
3.1
27.52
28.78
u/l
0.61
479
3775
1300
12129
1.76
8.98
15.0
10.5
18.52
20.04
mg/l
0.93
1017
9306
377
2808
1.46
8.70
1.6
1.6
1.48
1.36
mmol/l
1.78
329
2426
228
1527
1.59
8.66
2.7
2.1
13.87
14.45
umol/l
0.55
210
1427
106
585
1.88
8.12
2.9
2.6
66.51
67.44
g/l
0.69
97
549
120
701
1.78
7.65
8.8
7.5
1.13
1.30
mmol/l
2.03
120
681
387
2974
1.41
7.36
3.5
2.7
68.80
111.35
e6/l
0.46
300
2220
1345
12786
1.82
7.17
11.1
8.6
26.40
25.02
u/l
1.85
1303
12425
1417
13743
3.35
7.16
25.0
15.7
265.89
263.61
e9/l
0.69
1397
13476
1416
13730
3.25
7.12
24.9
15.7
40.18
40.14
%
0.11
1357
13114
354
2700
1.41
6.98
1.4
1.4
2.19
2.17
g/l
0.09
211
1757
353
2695
1.41
6.91
3.5
2.6
0.17
0.35
e6/l
3.02
267
1980
364
2797
1.40
6.86
3.6
3.2
8.18
7.88
mmol/l
0.44
314
2454
1417
13758
3.26
6.85
24.9
15.7
6.64
6.70
e9/l
0.43
1397
13462
1417
13758
3.26
6.85
24.8
15.6
4.51
4.51
e12/l
0.27
1397
13472
258
1866
1.47
6.76
3.3
2.9
662.38
751.23
ng/l
0.34
214
1541
637
5358
1.34
6.74
6.2
5.6
9.80
10.11
umol/l
0.35
595
5084
1246
11656
1.52
6.69
4.4
3.6
4.78
4.81
mmol/l
0.50
1190
11113
1417
13766
3.22
6.68
25.0
15.7
134.29
134.90
g/l
1.11
1408
13629
132
824
1.66
6.64
8.9
9.0
1.49
0.97
mmol/l
0.98
109
638
133
832
1.66
6.64
8.9
8.9
12.80
13.17
kpa
0.31
125
793
133
832
1.66
6.64
8.9
8.9
5.20
5.08
kpa
0.95
126
792
1256
11779
1.53
6.56
4.7
3.9
2.90
2.89
mmol/l
0.21
1196
11158
13
15
8.73
6.55
1.5
1.1
6.00
3.88
nmol/l
1.47
13
15
485
3934
1.35
6.48
9.8
8.3
1.15
1.11
inr
0.48
163
1266
1201
11171
1.46
6.45
3.9
3.3
1.31
1.23
mmol/l
3.67
1136
10575
20
58
3.48
6.02
1.9
4.0
83.58
163.82
umol/l
1.15
12
33
114
706
1.67
5.93
4.8
3.5
2.02
1.80
mmol/l
0.33
101
588
70
375
1.91
5.93
11.8
11.7
24.56
24.25
mmol/l
0.40
70
367
17
34
5.05
5.88
2.5
2.3
15.58
17.08
umol/l
0.19
17
34
130
836
1.61
5.83
2.4
2.6
1.78
1.74
%
0.23
108
754
1236
11616
1.46
5.74
4.3
3.6
1.45
1.51
mmol/l
6.61
1178
11026
269
2037
1.39
5.40
3.1
2.3
7.08
8.35
e6/l
0.77
240
1812
225
1654
1.43
5.35
3.4
3.0
730.52
359.67
ng/l
0.34
135
965
30
120
2.53
5.22
1.2
1.2
0.54
0.53
nmol/l
0.10
30
112
415
3382
1.32
5.15
4.5
2.7
29.85
29.94
ng/l
0.00
211
1683
137
920
1.54
5.12
2.2
1.7
—
—
—
0
0
235
1758
1.40
5.05
1.8
2.4
81.25
100.22
ug/g
0.86
177
1396
1159
10831
1.36
5.03
19.6
12.6
14.68
14.29
%
1.49
1146
10650
856
7682
1.28
4.98
5.3
3.7
45.00
905.30
e6/l
—
9
86
229
1710
1.40
4.98
1.9
1.7
1.40
1.38
%
0.22
211
1552
216
1597
1.41
4.97
2.9
2.3
1.04
0.94
e6/l
0.17
126
853
134
902
1.54
4.96
3.3
2.5
—
—
—
0
0
80
474
1.73
4.93
1.6
1.8
—
—
—
0
0
138
937
1.52
4.91
2.3
1.7
—
—
—
0
0
128
855
1.55
4.90
3.1
2.5
10.41
10.50
g/l
0.09
110
786
204
1498
1.42
4.87
3.0
2.4
4.32
3.71
e6/l
0.30
113
763
8
7
11.48
4.78
1.0
1.3
86.37
127.14
ng/l
—
8
7
9
10
9.05
4.78
1.4
1.4
—
—
—
0
0
77
456
1.73
4.77
3.1
3.4
1.34
1.68
mmol/l
0.41
57
337
192
1406
1.42
4.66
2.4
1.8
—
—
—
0
0
49
255
1.95
4.58
3.2
3.7
1.59
1.29
mg/l
1.33
42
237
328
2624
1.32
4.57
4.2
3.4
97.95
96.45
%
0.54
322
2543
160
1154
1.43
4.22
4.2
3.5
31.20
32.00
%
0.44
133
856
99
647
1.57
4.20
1.7
1.6
—
—
—
0
0
667
5882
1.25
4.19
3.9
3.1
0.00
0.00
estimate
0.50
144
1160
667
5888
1.25
4.13
5.5
4.3
0.01
0.00
estimate
0.73
143
1117
72
437
1.68
4.11
2.0
1.5
—
—
—
0
0
64
376
1.73
4.11
1.7
2.1
1.81
4.97
iu/l
7.04
20
152
49
266
1.87
4.08
1.2
1.6
1525.53
1254.39
e6/l
0.06
36
217
49
266
1.87
4.08
1.1
1.5
279.83
12.15
e6/l
0.48
35
208
164
1199
1.42
4.02
1.3
1.2
122.00
150.56
iu/ml
0.44
62
467
33
157
2.13
3.96
1.6
1.5
—
—
—
0
0
290
2335
1.30
3.81
3.4
3.3
505.78
363.19
mg/l
0.17
176
1510
119
829
1.47
3.78
2.2
2.3
0.22
0.22
g/l
0.05
107
782
180
1353
1.38
3.76
4.7
4.2
1.41
2.28
ug/l
2.08
167
1223
669
5953
1.23
3.72
4.0
3.1
0.00
0.01
estimate
1.06
138
1095
14
46
3.06
3.53
1.3
2.3
—
—
—
0
0
45
251
1.82
3.48
1.7
1.6
—
—
—
0
0
159
1189
1.38
3.43
2.8
2.5
7.49
6.60
umol/l
0.24
126
1007
80
527
1.55
3.33
2.9
2.8
115.58
119.27
ng/l
0.04
69
467
83
552
1.53
3.32
1.6
1.4
—
—
—
0
0
52
310
1.70
3.23
1.8
2.2
10.03
10.51
mg/l
0.21
47
294
18
72
2.52
3.21
3.7
2.8
40372.22
38423.61
ug/l
0.33
18
72
123
895
1.41
3.13
2.4
2.3
27.07
23.04
au/ml
—
8
89
9
20
4.52
3.11
2.0
2.3
49.78
62.60
ug/l
—
9
20
296
2458
1.26
3.00
3.8
3.8
5.70
9.62
mg/mmol
1.41
182
1576
86
591
1.48
2.97
7.6
2.2
5.37
6.64
ug/l
0.26
73
533
10
27
3.72
2.88
1.1
1.1
114.10
91.89
%
—
10
27
299
2503
1.25
2.82
2.3
2.1
—
—
—
0
0
17
71
2.41
2.80
1.6
1.7
—
—
—
0
0
310
2617
1.24
2.70
2.3
2.2
323.01
4291.56
umol/l
6.83
272
2326
330
2807
1.23
2.68
2.4
2.2
—
—
—
0
0
28
147
1.92
2.66
3.0
2.0
18.55
16.91
%
0.68
11
67
23
113
2.05
2.62
1.1
1.1
—
—
—
0
0
47
291
1.64
2.59
1.4
1.4
252.62
305.67
ug/g
1.03
26
150
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
34
195
1.76
2.48
3.0
4.4
0.37
0.39
u/ml
0.08
22
99
18
82
2.21
2.48
11.6
5.4
9.66
7.01
mmol/l
—
10
66
14
57
2.47
2.45
2.3
1.5
—
—
—
0
0
48
304
1.60
2.44
3.5
3.8
24.78
24.86
mmol/l
0.06
43
288
71
491
1.47
2.43
1.8
2.2
41.37
39.75
u/l
0.32
63
458
518
4641
1.18
2.38
4.0
3.1
—
—
—
0
0
322
2765
1.21
2.36
1.8
1.7
0.92
0.88
mg/l
0.09
244
2060
57
380
1.52
2.33
1.9
2.3
95.49
93.83
%
0.25
57
366
37
222
1.68
2.32
2.6
2.7
—
—
—
0
0
5
9
5.57
2.21
2.2
1.7
—
—
—
0
0
35
211
1.68
2.18
1.7
1.2
—
—
—
0
0
35
211
1.68
2.18
9.3
6.4
384.60
354.17
iu/ml
—
5
30
127
989
1.31
2.17
2.9
2.3
30.02
40.22
u/l
1.17
108
832
20
101
1.99
2.16
1.1
1.2
—
—
—
0
0
30
174
1.74
2.14
5.2
3.5
32.55
78.10
mg/l
0.71
22
148
42
267
1.59
2.13
3.3
1.7
—
—
—
0
0
36
221
1.65
2.10
1.5
1.3
4.38
4.41
u/ml
0.01
16
96
293
2521
1.20
2.10
4.1
3.4
1.02
1.02
kg/l
0.01
45
334
27
153
1.78
2.09
1.3
1.2
—
—
—
0
0
268
2288
1.21
2.08
1.3
1.3
4.67
10.18
u/ml
1.29
101
957
13
56
2.33
2.05
1.2
1.1
—
—
—
0
0
353
3103
1.18
1.99
4.1
3.5
0.00
0.00
estimate
1.34
142
1112
106
818
1.32
1.95
1.0
1.1
—
—
—
0
0
12
51
2.36
1.95
1.1
1.3
133.25
153.75
mmol/24h
0.70
12
51
5
11
4.56
1.94
1.2
1.6
44.08
22.80
nmol/l
—
5
11
8
186
0.43
1.94
1.4
1.5
—
—
—
0
0
29
174
1.68
1.87
5.3
3.5
24.13
26.89
mg/l
0.23
22
147
25
146
1.72
1.78
1.4
1.4
—
—
—
0
0
30
185
1.63
1.76
1.1
1.3
—
—
—
0
0
30
185
1.63
1.76
1.1
1.3
—
—
—
0
0
17
88
1.94
1.75
1.5
1.4
—
—
—
0
0
111
879
1.28
1.72
4.7
4.5
228.45
249.57
u/l
0.56
104
832
71
527
1.37
1.71
1.3
1.3
0.20
1.00
u/ml
—
6
42
11
48
2.30
1.70
1.4
1.4
107.00
161.17
pmol/l
1.04
11
48
26
156
1.68
1.69
2.8
2.3
—
—
—
0
0
134
1088
1.26
1.69
3.9
3.7
24.00
20.90
%
1.12
49
438
15
76
1.98
1.64
2.0
1.5
32.20
34.44
%
—
10
43
118
1455
0.79
1.63
1.4
1.5
—
—
—
0
0
36
238
1.53
1.61
1.4
1.4
102.55
106.22
u/ml
0.09
11
49
135
1105
1.24
1.60
6.8
5.2
—
—
—
0
0
22
130
1.70
1.53
2.0
1.4
—
—
—
0
0
38
258
1.49
1.51
1.4
1.4
—
20.40
—
0
5
63
470
1.36
1.50
1.4
1.3
—
—
—
0
0
74
956
0.76
1.50
1.4
1.4
—
—
—
0
0
22
131
1.69
1.50
2.0
1.4
—
—
—
0
0
22
131
1.69
1.50
2.0
1.4
—
—
—
0
0
38
546
0.69
1.49
1.3
1.5
—
—
—
0
0
34
227
1.51
1.47
1.2
1.1
—
—
—
0
0
19
109
1.75
1.47
2.1
2.0
—
—
—
0
0
100
800
1.27
1.46
2.9
2.6
0.62
0.69
ug/l
0.58
65
472
11
52
2.12
1.44
1.7
1.6
1.05
1.43
nmol/l
0.82
11
43
36
245
1.48
1.43
1.7
1.4
—
—
—
0
0
22
133
1.66
1.43
2.0
1.4
—
—
—
0
0
58
432
1.36
1.41
1.0
1.1
7.13
4.59
u/ml
—
6
68
22
134
1.65
1.39
2.0
1.4
—
—
—
0
0
42
297
1.43
1.38
1.7
2.1
1.38
1.39
g/l
0.03
36
258
22
347
0.63
1.37
1.2
1.2
—
—
—
0
0
6
23
2.62
1.37
1.0
1.2
—
—
—
0
0
15
82
1.84
1.36
1.5
3.0
—
—
—
0
0
0
37
0.00
1.34
0.0
2.4
—
1.83
—
0
19
114
939
1.23
1.31
1.3
1.3
127.29
216.67
u/ml
1.43
100
872
6
24
2.51
1.30
1.2
1.5
—
—
—
0
0
33
227
1.46
1.27
3.0
1.6
—
—
—
0
0
14
77
1.83
1.25
1.4
1.8
32.00
32.25
pg
0.05
14
77
33
229
1.45
1.22
2.8
1.6
—
—
—
0
0
21
132
1.60
1.20
2.0
1.4
—
—
—
0
0
8
39
2.06
1.15
5.3
2.2
—
—
—
0
0
5
20
2.51
1.15
2.8
4.7
—
—
—
0
0
5
20
2.51
1.15
1.4
1.1
—
—
—
0
0
8
41
1.96
1.09
5.3
3.1
—
—
—
0
0
264
2377
1.14
1.08
1.4
1.3
26.86
25.43
iu/ml
0.09
76
773
129
1504
0.84
1.07
1.6
1.6
—
—
—
0
0
17
105
1.63
1.06
1.9
1.6
46.67
56.28
%
—
9
64
84
688
1.23
1.06
1.3
1.3
219.22
228.93
miu/ml
0.08
32
365
25
170
1.48
1.05
2.1
2.1
136.18
132.79
g/l
0.23
17
124
14
83
1.69
1.01
1.0
1.4
—
—
—
0
0
23
155
1.49
1.01
3.3
1.7
—
—
—
0
0
17
261
0.65
0.99
1.4
1.9
—
—
—
0
0
35
257
1.37
0.99
5.0
4.2
1.10
1.42
mmol/l
2.01
35
251
57
715
0.79
0.98
1.5
1.5
—
—
—
0
0
9
49
1.84
0.98
4.8
2.0
—
—
—
0
0
9
49
1.84
0.98
1.7
1.2
—
—
—
0
0
9
49
1.84
0.98
4.8
2.0
—
—
—
0
0
7
36
1.95
0.97
1.4
1.1
—
—
—
0
0
19
124
1.54
0.97
2.1
1.5
—
—
—
0
0
21
141
1.50
0.95
1.2
1.1
—
—
—
0
0
14
85
1.65
0.94
1.1
1.5
10.29
10.42
umol/l
0.03
14
78
32
235
1.37
0.92
1.8
1.4
—
—
—
0
0
8
42
1.91
0.88
1.9
2.7
—
—
—
0
0
6
30
2.00
0.87
1.3
1.1
—
—
—
0
0
12
72
1.67
0.85
1.6
2.3
—
—
—
0
0
14
89
1.58
0.81
2.3
1.6
—
—
—
0
0
38
294
1.30
0.80
1.4
1.3
—
—
—
0
0
26
190
1.38
0.79
2.5
2.5
48.57
140.27
ug/min
1.36
14
127
6
33
1.82
0.79
1.5
1.1
—
—
—
0
0
29
216
1.35
0.79
3.6
3.9
57.90
56.94
%
0.22
29
216
16
106
1.52
0.79
1.6
1.3
—
—
—
0
0
5
100
0.50
0.77
2.0
1.4
0.85
0.96
g/l
—
5
100
6
34
1.77
0.76
1.0
1.8
—
—
—
0
0
6
34
1.77
0.76
1.0
1.8
—
—
—
0
0
28
209
1.35
0.76
3.4
3.6
4.34
4.10
e9/l
0.37
28
209
9
54
1.67
0.74
1.0
1.1
—
—
—
0
0
7
38
1.85
0.73
3.4
1.6
—
—
—
0
0
7
38
1.85
0.73
5.9
2.2
—
—
—
0
0
7
38
1.85
0.73
5.9
2.2
—
—
—
0
0
48
588
0.81
0.72
1.8
2.0
—
—
—
0
0
7
39
1.80
0.72
3.4
1.6
—
—
—
0
0
30
230
1.31
0.69
1.6
1.7
9773.65
11401.56
e6/l
0.15
20
174
13
85
1.53
0.69
1.0
1.2
—
184.00
—
0
15
71
831
0.85
0.68
1.4
1.5
—
—
—
0
0
90
784
1.16
0.65
1.8
1.8
—
—
—
0
0
7
44
1.59
0.65
1.0
1.2
—
—
—
0
0
7
44
1.59
0.65
3.4
1.5
—
—
—
0
0
19
137
1.39
0.64
1.3
1.2
—
—
—
0
0
12
79
1.52
0.62
3.9
2.4
—
—
—
0
0
16
113
1.42
0.61
1.3
1.2
0.09
0.86
u/ml
1.09
11
52
11
72
1.53
0.59
1.4
1.3
5.75
6.96
u/l
0.42
11
59
13
89
1.46
0.58
3.9
1.7
—
—
—
0
0
13
89
1.46
0.58
3.9
1.7
—
—
—
0
0
13
89
1.46
0.58
3.9
1.7
—
—
—
0
0
6
35
1.72
0.57
1.7
1.1
—
—
—
0
0
6
35
1.72
0.57
1.5
1.0
—
—
—
0
0
15
207
0.72
0.57
1.4
1.6
7.41
7.61
mmol/l
0.18
15
200
14
98
1.43
0.56
1.4
1.3
—
—
—
0
0
40
329
1.22
0.56
1.1
1.1
2.10
1.28
u/ml
0.19
18
136
21
159
1.33
0.55
1.8
1.6
—
—
—
0
0
47
394
1.20
0.55
2.6
1.9
—
—
—
0
0
12
82
1.47
0.54
1.1
1.2
—
—
—
0
0
6
38
1.58
0.54
3.5
1.4
—
—
—
0
0
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
6
38
1.58
0.54
1.0
1.2
—
67.20
—
0
10
55
642
0.85
0.54
1.6
1.7
—
—
—
0
0
6
39
1.54
0.53
1.0
1.1
—
82.10
—
0
10
13
91
1.43
0.53
1.5
1.5
5.55
5.61
mmol/l
0.06
13
91
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
10
66
1.52
0.52
1.2
1.1
—
—
—
0
0
44
369
1.20
0.52
1.5
1.3
18.53
9.65
u/ml
—
6
66
6
40
1.50
0.51
3.5
1.4
—
—
—
0
0
9
65
1.39
0.50
1.3
1.2
—
—
—
0
0
7
45
1.56
0.49
1.0
1.0
—
—
—
0
0
360
3431
1.07
0.47
1.8
1.6
—
—
—
0
0
17
128
1.33
0.47
1.4
1.1
—
—
—
0
0
12
85
1.42
0.47
1.4
1.3
78.33
70.73
umol/l
0.21
12
85
277
2621
1.07
0.45
2.6
2.0
—
—
—
0
0
68
768
0.88
0.45
1.4
1.4
—
—
—
0
0
28
228
1.23
0.45
1.6
1.2
4.00
5.06
u/ml
—
8
79
536
5543
0.95
0.45
2.7
2.4
—
—
—
0
0
41
348
1.18
0.44
1.0
1.1
6.25
6.61
u/ml
0.03
19
187
68
767
0.88
0.44
1.4
1.4
—
—
—
0
0
68
766
0.88
0.44
1.4
1.4
—
—
—
0
0
93
840
1.11
0.44
2.3
2.2
80.51
76.91
ml/min/173m2
0.43
34
302
19
148
1.29
0.43
2.1
1.4
—
—
—
0
0
43
368
1.17
0.43
1.3
1.2
—
—
—
0
0
68
764
0.88
0.42
1.4
1.4
—
—
—
0
0
5
32
1.56
0.42
3.0
1.8
—
—
—
0
0
5
32
1.56
0.42
1.6
1.1
—
—
—
0
0
36
424
0.85
0.42
1.3
1.3
—
—
—
0
0
33
277
1.20
0.41
1.4
1.3
186.81
242.56
u/ml
0.78
21
178
34
401
0.84
0.41
1.2
1.2
—
—
—
0
0
41
352
1.17
0.40
1.9
1.8
—
—
—
0
0
0
18
0.00
0.40
0.0
2.3
—
0.94
—
0
18
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
5
35
1.43
0.39
1.0
1.1
—
—
—
0
0
16
124
1.29
0.38
2.1
1.4
—
—
—
0
0
27
224
1.21
0.38
1.0
1.1
—
—
—
0
0
9
68
1.33
0.37
1.2
1.6
—
—
—
0
0
44
383
1.15
0.37
1.2
1.1
0.42
2.95
u/ml
4.43
21
190
31
262
1.19
0.37
1.0
1.0
2.15
2.09
u/ml
0.02
15
141
1024
10091
1.05
0.37
3.8
3.7
—
—
—
0
0
19
234
0.81
0.36
1.3
1.4
6.64
7.02
mmol/l
0.55
19
210
42
367
1.15
0.35
1.2
1.2
—
—
—
0
0
13
100
1.30
0.33
4.2
1.8
—
—
—
0
0
6
46
1.31
0.33
1.0
1.2
—
—
—
0
0
94
866
1.09
0.33
1.4
1.4
—
—
—
0
0
14
110
1.28
0.31
4.0
1.7
—
—
—
0
0
34
387
0.88
0.29
1.4
1.4
47.95
113.14
pmol/l
1.42
34
380
7
57
1.23
0.29
1.3
1.2
181.86
414.24
u/l
—
7
50
20
167
1.20
0.28
2.1
1.4
—
—
—
0
0
8
63
1.27
0.27
1.0
1.1
1419.00
1540.95
miu/ml
—
8
63
84
783
1.08
0.24
3.7
4.2
4.42
32.18
ug/l
1.48
64
601
32
284
1.13
0.23
1.1
1.1
0.76
4.54
u/ml
3.48
14
126
5
39
1.28
0.23
1.6
1.5
8.69
8.00
ug/l
—
5
39
69
740
0.93
0.21
1.3
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.8
—
7.88
—
0
8
7
60
1.17
0.17
1.0
1.0
—
—
—
0
0
36
329
1.10
0.17
1.1
1.1
0.69
1.89
u/ml
1.70
17
156
14
119
1.18
0.17
2.5
1.5
—
—
—
0
0
11
91
1.21
0.17
1.1
1.1
—
—
—
0
0
7
61
1.15
0.17
1.1
1.1
126.00
110.19
%
—
7
53
20
176
1.14
0.17
3.1
1.6
—
—
—
0
0
20
176
1.14
0.17
3.1
1.6
—
—
—
0
0
27
243
1.11
0.17
1.1
1.0
0.07
0.20
u/ml
—
8
67
30
272
1.11
0.17
3.8
3.7
65.71
1324.54
u/ml
1.14
24
235
8
70
1.14
0.16
1.0
1.0
—
—
—
0
0
8
70
1.14
0.16
3.9
3.7
—
—
—
0
0
13
111
1.17
0.15
1.2
1.0
—
—
—
0
0
9
78
1.15
0.15
1.0
1.1
—
—
—
0
0
15
131
1.15
0.14
1.5
1.1
—
—
—
0
0
33
305
1.08
0.13
2.8
2.3
5.20
4.47
umol/l
0.38
23
225
11
127
0.87
0.12
1.6
1.4
—
—
—
0
0
11
127
0.87
0.12
1.6
1.4
—
—
—
0
0
13
147
0.88
0.11
1.8
1.5
—
—
—
0
0
15
135
1.11
0.09
1.4
1.2
—
—
—
0
0
5
46
1.09
0.09
1.6
1.4
—
—
—
0
0
5
46
1.09
0.09
1.0
1.2
—
—
—
0
0
71
735
0.96
0.08
1.5
1.5
—
—
—
0
0
68
656
1.04
0.08
1.6
1.6
4.09
4.27
mg/l
0.05
49
465
5
61
0.82
0.08
1.8
1.7
—
880710.00
—
0
5
22
234
0.94
0.06
1.0
1.1
—
—
—
0
0
14
129
1.09
0.05
1.1
1.2
16.75
20.36
u/l
—
9
111
327
3294
0.99
0.04
1.5
1.5
—
—
—
0
0
27
259
1.04
0.04
1.3
1.3
—
—
—
0
0
12
111
1.08
0.04
1.4
1.1
—
—
—
0
0
12
111
1.08
0.04
1.4
1.1
—
—
—
0
0
12
111
1.08
0.04
1.4
1.1
—
—
—
0
0
12
111
1.08
0.04
1.4
1.1
—
—
—
0
0
27
260
1.04
0.03
1.3
1.2
—
—
—
0
0
42
431
0.97
0.03
1.6
1.9
—
—
—
0
0
12
112
1.07
0.03
1.4
1.1
—
—
—
0
0
184
1827
1.01
0.02
2.1
1.9
—
—
—
0
0
10
93
1.08
0.02
1.3
1.3
—
—
—
0
0
35
358
0.98
0.01
1.9
1.5
—
—
—
0
0
22
227
0.97
0.01
3.5
3.3
17.14
23.19
mg/l
0.84
15
144
10
94
1.06
0.01
1.3
1.3
—
—
—
0
0
11
104
1.06
0.01
1.1
1.7
—
—
—
0
0
41
408
1.01
0.00
1.9
1.6
0.21
0.17
iu/ml
—
5
72
146
1459
1.00
0.00
1.9
1.8
—
—
—
0
0
18
177
1.02
0.00
1.1
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
7.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
84
0.95
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.6
—
—
—
0
0
5
57
0.88
-0.00
3.0
3.4
11.13
7.85
mg/l
—
5
50
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
7.72
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
5.8
—
20.75
—
0
8
0
8
0.00
-0.00
0.0
2.4
—
4.86
—
0
8
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPERPRO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERPRO | 1.537 [1.32, 1.79] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.271 |
During the follow-up period (1.1.1998 — 31.12.2019), 228 out of 5615 females with E4_HYPERPRO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERPRO | 1.183 [1.0, 1.41] | 0.056 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 183 out of 1157 males with E4_HYPERPRO died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPERPRO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.122% | 0.213% |
| 5 | 0.784% | 1.263% |
| 10 | 2.184% | 3.222% |
| 15 | 4.019% | 6.2% |
| 20 | 7.392% | 10.984% |
Relationships between endpoints
↥Index endpoint: E4_HYPERPRO – Hyperprolactinaemia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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