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Hyperprolactinaemia, drug-induced

EFO Endpoint Browser PheWeb

E4_HYPERPRO_ADVERSE

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ATC codes for adverse effects of Drugs — ANY
  • Hospital discharge: ICD-10 — E22.1#

1 out of 7 registries used, show all original rules.

200

4. Check minimum number of events

None

200

5. Include endpoints

None

200

6. Filter based on genotype QC (FinnGen only)

196

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Parent code in ICD-10
E22
Name in latin
Hyperprolactinaemia

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

All Female Male
Number of individuals 196 169 27
Unadjusted period prevalence (%) 0.05 0.06 0.01
Median age at first event (years) 38.63 36.44 52.33

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
200
Matched controls
2000
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G02CB01
ATC
bromocriptine; systemic
221.0
282.0
144
23
E22.1
ICD-10 Finland
Hyperprolactinaemia
+∞
281.7
200
*
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
193.0
56.1
56
*
XLA10, ,
NOMESCO Finland
13.3
50.1
54
54
G02CB03
ATC
cabergoline; oral
165.5
49.4
50
*
G02CB04
ATC
quinagolide; oral
+∞
34.4
32
*
N04BC06
ATC
cabergoline; oral
101.9
31.9
34
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
47.3
21.0
25
6
2273A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Pituitary gland and craniopharyngeal duct (pouch)
+∞
16.9
16
*
G03DB01
ATC
dydrogesterone; oral
3.7
15.7
68
247
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
4.5
11.1
29
72
H02AB09
ATC
hydrocortisone; systemic
11.5
10.5
19
18
E23.00
ICD-10 Finland
Panhypopituitarism
115.8
10.5
11
*
2531A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Other and unspecified anterior pituitary hyperfunction[HYPERPROLACTINAEMIA]
115.8
10.5
11
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
42.4
10.1
12
*
N91.1
ICD-10 Finland
Secondary amenorrhoea
18.1
8.2
12
7
N05AX08
ATC
risperidone; systemic
3.8
7.8
25
72
XCK00
NOMESCO Finland
Perimetry
4.1
7.0
20
53
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
72.1
6.5
7
*
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
72.1
6.5
7
*
N05AA01
ATC
chlorpromazine; systemic, rectal
8.6
6.4
13
16
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
+∞
6.3
6
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.1
6.2
87
531
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
9.0
6.1
12
14
N05AB03
ATC
perphenazine; systemic, rectal
5.9
6.1
16
29
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.6
6.1
38
163

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
18
15
13.05
10.58
5.6
1.0
—
—
—
0
0
78
496
1.94
4.72
5.1
3.6
7.41
7.40
ph
—
10
91
51
295
1.98
3.98
3.0
2.6
2.46
2.44
mmol/l
0.59
43
266
6
5
12.31
3.78
1.5
2.2
1.36
1.86
ug/l
—
6
5
8
12
6.89
3.71
3.9
16.8
819.39
1142.33
nmol/l
—
8
12
8
12
6.89
3.71
8.1
18.1
1723.25
2136.50
nmol/l
—
8
12
19
80
2.52
3.17
4.8
4.5
—
—
—
0
0
86
628
1.65
2.96
2.3
1.9
89.38
98.96
pmol/l
0.98
39
306
102
787
1.60
2.75
3.3
2.7
90.19
88.99
ug/l
0.03
97
735
8
19
4.34
2.70
1.0
1.5
—
—
—
0
0
7
15
4.79
2.62
4.9
2.5
5.70
2.67
nmol/l
—
7
15
27
145
2.00
2.57
1.3
1.3
18.10
29.26
iu/l
1.72
22
127
6
12
5.12
2.42
2.2
4.5
—
—
—
0
0
169
1503
1.80
2.38
25.3
15.6
330.49
331.35
g/l
0.65
169
1498
68
490
1.59
2.37
4.2
2.4
—
—
—
0
0
152
1316
1.65
2.35
4.2
4.0
12.93
10.63
mm/h
1.25
146
1222
6
13
4.72
2.29
1.0
1.2
—
—
—
0
0
40
256
1.70
2.21
1.7
1.7
1152.54
1212.60
nmol/l
0.16
32
196
19
95
2.10
2.19
3.3
2.2
—
—
—
0
0
95
749
1.51
2.17
8.4
8.4
0.00
0.00
e9/l
0.63
76
604
5
144
0.33
2.12
2.0
4.1
—
—
—
0
0
111
914
1.48
2.00
5.8
3.7
6.55
6.45
mmol/l
0.24
104
859
60
438
1.53
1.93
8.9
7.0
—
—
—
0
0
52
368
1.56
1.92
1.7
1.5
18.50
21.28
nmol/l
0.84
46
311
36
233
1.66
1.91
3.3
2.6
5.54
3.07
e6/l
0.40
20
113
98
798
1.45
1.81
8.6
5.8
1.22
1.22
mmol/l
0.22
89
685
100
820
1.44
1.77
5.7
4.6
0.11
0.00
estimate
0.79
19
157
6
18
3.40
1.76
1.0
1.1
—
—
—
0
0
100
822
1.43
1.73
4.1
3.3
0.00
0.00
estimate
-0.00
20
167
100
824
1.43
1.70
4.2
3.4
0.00
0.00
estimate
-0.00
17
151
39
271
1.55
1.56
4.2
3.2
38.00
140.30
ng/l
1.40
26
187
31
449
0.63
1.53
3.0
3.3
—
—
—
0
0
35
239
1.56
1.51
1.7
1.6
—
—
—
0
0
116
996
1.39
1.49
14.2
9.4
3.98
3.80
e9/l
0.36
101
869
136
1201
1.41
1.47
4.2
3.4
—
—
—
0
0
31
207
1.59
1.46
2.0
1.8
29.02
29.41
s
0.19
31
198
60
463
1.42
1.43
3.1
2.7
17.22
39.56
e6/l
0.98
46
346
50
374
1.45
1.40
5.1
3.2
—
—
—
0
0
130
1144
1.39
1.40
5.0
3.8
—
—
—
0
0
27
177
1.61
1.38
1.6
1.6
—
—
—
0
0
82
672
1.37
1.37
4.3
3.1
5.10
5.99
ph
—
5
62
5
18
2.82
1.29
1.6
1.3
—
—
—
0
0
7
145
0.46
1.26
1.4
2.7
19.71
54.80
u/ml
—
7
138
8
38
2.15
1.20
6.5
4.6
28.65
198.23
mg/l
—
8
32
31
218
1.50
1.18
2.0
2.0
—
—
—
0
0
5
20
2.54
1.16
1.4
1.5
3.77
2.83
u/ml
—
5
20
8
40
2.04
1.13
2.1
2.7
—
—
—
0
0
7
31
2.30
1.11
1.0
1.1
—
—
—
0
0
13
74
1.81
1.09
8.2
8.4
—
—
—
0
0
102
886
1.31
1.09
7.3
5.8
0.20
0.18
e9/l
0.50
88
783
53
419
1.36
1.08
3.3
2.7
0.25
0.48
e6/l
0.63
39
306
10
53
1.93
1.03
9.2
4.6
—
—
—
0
0
7
134
0.51
1.03
1.4
1.5
—
—
—
0
0
12
69
1.79
0.99
3.9
3.0
—
—
—
0
0
183
1745
1.57
0.99
5.0
4.3
4.82
4.91
mmol/l
0.62
178
1645
0
30
0.00
0.98
0.0
1.1
—
—
—
0
0
45
355
1.35
0.93
4.9
4.0
—
—
—
0
0
52
420
1.32
0.92
3.3
2.6
—
—
—
0
0
67
564
1.28
0.87
3.9
3.2
100.48
61.37
e6/l
0.20
50
379
96
848
1.25
0.83
6.4
5.4
0.55
0.54
e9/l
0.20
80
737
96
849
1.25
0.82
6.4
5.5
0.04
0.04
e9/l
-0.00
80
736
184
1767
1.52
0.82
5.6
4.8
2.92
2.91
mmol/l
0.04
178
1654
26
191
1.42
0.82
2.8
2.3
22.11
23.79
%
0.24
19
160
177
1689
1.42
0.81
4.9
4.3
5.80
5.79
mmol/l
0.02
171
1574
10
161
0.60
0.79
1.2
1.3
—
—
—
0
0
181
1737
1.44
0.76
15.0
11.5
22.26
19.66
mg/l
0.38
136
1325
181
1737
1.44
0.76
4.7
4.3
1.48
1.56
mmol/l
2.01
174
1629
92
816
1.24
0.75
5.3
5.8
—
—
—
0
0
5
24
2.11
0.75
1.0
1.1
—
—
—
0
0
143
1331
1.26
0.74
8.1
7.0
76.79
76.85
u/l
0.01
137
1261
7
38
1.87
0.74
7.1
4.6
27.69
26.50
mg/l
—
7
32
18
126
1.47
0.73
3.2
3.5
—
—
—
0
0
5
25
2.02
0.73
1.4
1.9
27.40
33.89
umol/l
—
5
19
10
157
0.62
0.72
1.3
1.9
—
—
—
0
0
97
872
1.22
0.68
6.5
5.5
1.90
2.05
e9/l
0.46
84
777
173
1656
1.33
0.66
6.8
4.9
1.77
2.55
mu/l
0.55
165
1534
59
506
1.24
0.65
1.7
1.7
1.56
1.37
mmol/l
0.67
52
440
55
470
1.23
0.62
3.3
2.9
6.68
7.18
mmol/l
0.42
48
398
21
157
1.38
0.62
1.5
1.3
—
—
—
0
0
49
415
1.24
0.60
2.3
2.4
321.03
7590.75
umol/l
2.50
39
369
51
435
1.23
0.59
4.5
3.5
0.00
0.00
estimate
-0.00
19
154
16
115
1.43
0.58
11.6
8.1
—
—
—
0
0
14
99
1.45
0.56
1.4
1.2
—
—
—
0
0
174
1676
1.29
0.55
4.3
3.8
1.35
1.26
mmol/l
0.74
166
1563
9
60
1.52
0.55
1.3
3.0
1.29
1.53
g/l
—
9
51
43
503
0.82
0.53
2.5
2.1
—
—
—
0
0
10
66
1.54
0.53
1.3
1.5
—
—
—
0
0
10
66
1.54
0.53
1.5
4.0
25.02
24.58
mmol/l
—
10
66
6
98
0.60
0.53
1.2
1.1
—
—
—
0
0
166
1593
1.25
0.52
6.0
5.1
39.95
38.99
mmol/mol
0.68
159
1499
189
1844
1.45
0.52
18.8
13.5
71.55
70.27
umol/l
0.29
189
1844
48
414
1.21
0.50
1.3
1.3
0.88
2.13
u/ml
—
9
133
128
1202
1.18
0.50
2.7
2.9
44.13
40.26
u/l
0.24
121
1138
26
209
1.28
0.49
1.5
1.3
—
—
—
0
0
44
377
1.21
0.49
2.4
1.6
1.12
0.81
mg/l
0.56
34
302
21
164
1.31
0.49
12.8
6.5
104.90
104.38
mmol/l
0.22
21
164
74
670
1.17
0.45
6.8
8.4
1.15
1.10
inr
0.21
20
202
18
140
1.31
0.43
1.2
1.1
—
—
—
0
0
5
31
1.63
0.43
1.0
1.6
—
—
—
0
0
51
575
0.85
0.43
5.6
3.1
25.13
22.02
ng/l
0.13
28
350
10
70
1.45
0.42
1.1
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
2.9
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
5
34
1.48
0.40
1.6
1.3
—
—
—
0
0
14
106
1.34
0.40
5.4
6.1
9.27
9.38
mmol/l
0.03
14
99
0
18
0.00
0.40
0.0
3.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
52
462
1.17
0.39
2.8
3.0
—
—
—
0
0
12
89
1.37
0.39
1.6
1.5
—
—
—
0
0
25
209
1.22
0.36
1.4
1.4
—
—
—
0
0
6
45
1.34
0.34
1.3
1.2
—
—
—
0
0
194
1914
1.45
0.34
25.6
17.8
90.45
91.09
fl
1.47
194
1891
194
1914
1.45
0.34
25.7
17.9
40.01
40.06
%
0.04
186
1819
62
676
0.88
0.33
2.6
2.7
—
—
—
0
0
21
176
1.22
0.30
1.5
1.4
—
—
—
0
0
32
280
1.17
0.30
3.1
2.5
519.63
527.89
mosm/kgh2o
0.07
27
239
42
376
1.15
0.29
1.5
1.3
2.16
2.11
g/l
0.08
22
243
28
244
1.17
0.27
4.5
2.5
0.81
0.82
mmol/l
0.16
28
233
6
83
0.71
0.24
1.3
1.3
—
—
—
0
0
194
1916
1.42
0.24
26.0
17.9
134.29
134.41
g/l
0.05
194
1892
194
1915
1.43
0.24
25.6
17.8
29.93
30.25
pg
2.29
194
1892
5
38
1.32
0.23
1.2
1.4
—
—
—
0
0
10
79
1.28
0.22
1.7
1.7
—
—
—
0
0
40
365
1.12
0.22
5.4
3.4
1.01
1.02
kg/l
—
5
49
0
11
0.00
0.21
0.0
1.7
—
12.54
—
0
11
0
11
0.00
0.21
0.0
1.8
—
—
—
0
0
0
11
0.00
0.21
0.0
2.3
—
57.20
—
0
5
0
10
0.00
0.21
0.0
3.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
39.84
—
0
10
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
1.53
—
0
12
0
13
0.00
0.21
0.0
1.1
—
771.25
—
0
8
0
13
0.00
0.21
0.0
1.1
—
24.92
—
0
13
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
0.95
—
0
14
0
14
0.00
0.20
0.0
1.3
—
1.72
—
0
9
6
49
1.23
0.20
1.2
1.4
—
—
—
0
0
28
251
1.13
0.20
1.3
1.2
—
—
—
0
0
6
50
1.21
0.20
2.0
1.5
18.75
33.11
u/l
—
6
43
26
232
1.14
0.20
1.2
1.2
—
—
—
0
0
26
232
1.14
0.20
1.3
2.2
88.59
97.02
ug/g
0.09
21
184
15
175
0.85
0.19
1.7
1.3
—
—
—
0
0
6
52
1.16
0.19
1.2
1.4
—
—
—
0
0
6
52
1.16
0.19
1.2
1.4
—
—
—
0
0
6
52
1.16
0.19
1.2
1.4
—
—
—
0
0
6
53
1.14
0.19
1.2
1.4
—
—
—
0
0
49
457
1.10
0.18
4.1
3.7
3.87
4.76
mg/mmol
0.13
37
260
7
59
1.19
0.18
1.3
1.1
—
—
—
0
0
7
60
1.17
0.18
2.4
6.5
—
—
—
0
0
13
110
1.19
0.17
2.2
2.9
0.44
0.72
ug/l
—
8
71
47
440
1.09
0.16
3.6
3.1
31.96
205.64
mg/l
0.49
39
270
33
357
0.91
0.15
1.4
1.3
1.38
8.49
u/ml
2.39
16
147
92
891
1.06
0.12
6.6
5.8
11.94
10.14
umol/l
0.53
85
845
15
167
0.89
0.11
1.6
1.6
—
—
—
0
0
13
146
0.88
0.11
2.9
4.3
3.00
0.91
%
—
5
53
15
166
0.90
0.10
1.1
1.2
122.66
194.77
iu/ml
—
5
74
12
106
1.14
0.10
2.8
2.4
—
—
—
0
0
10
87
1.16
0.09
14.6
6.0
26.69
25.58
mmol/l
—
10
87
182
1804
1.10
0.09
13.6
10.8
—
—
—
0
0
9
88
1.02
0.07
1.1
1.1
—
—
—
0
0
15
138
1.09
0.06
1.5
1.4
—
—
—
0
0
12
110
1.10
0.05
1.5
1.4
—
—
—
0
0
38
367
1.04
0.05
1.4
1.3
11.47
28.98
iu/ml
2.30
14
126
12
111
1.09
0.04
1.8
1.4
1.18
1.21
g/l
0.05
12
100
77
782
0.98
0.03
2.1
2.0
—
—
—
0
0
27
262
1.04
0.02
1.6
1.4
240.00
558.15
titre
—
5
65
14
136
1.03
0.00
1.1
1.2
—
—
—
0
0
13
131
0.99
0.00
6.4
3.2
—
—
—
0
0
22
219
1.01
0.00
1.0
1.3
—
—
—
0
0
20
205
0.97
0.00
1.5
1.4
—
—
—
0
0
42
418
1.01
0.00
1.4
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
3.1
—
9.75
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
1.21
—
0
5
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
94
0.96
-0.00
2.1
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
34.0
—
77.80
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.3
—
34433.33
—
0
6
0
5
0.00
-0.00
0.0
3.4
—
4.74
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
7.43
—
0
9
0
5
0.00
-0.00
0.0
3.4
—
2.50
—
0
5
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
32.44
—
0
9
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
9.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

↥

Index endpoint: E4_HYPERPRO_ADVERSE – Hyperprolactinaemia, drug-induced

GWS hits: -

This endpoint is excluded (not available in FinRegistry).