No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
200 |
4. Check minimum number of eventsNone |
200 |
5. Include endpointsNone |
200 |
6. Filter based on genotype QC (FinnGen only) |
200 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
- Parent code in ICD-10
- E22
- Name in latin
- Hyperprolactinaemia
Similar endpoints
↥List of similar endpoints to
Hyperprolactinaemia, drug-induced
based on the number of shared cases.
Similar with more cases:
- Hyperprolactinaemia
- Hyperfunction of pituitary gland
- Exclusions for E4_PCOS_BROAD
- Disorders of other endocrine glands
- Exclusions for E4_PCOS_CONSORTIUM
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (not available in FinRegistry).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 200 | 173 | 27 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.01 |
| Median age at first event (years) | 38.59 | 36.44 | 52.33 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 187
- Matched controls
- 1870
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E22.1
ICD-10 Finland
Hyperprolactinaemia
+∞
257.0
187
8
G02CB01
ATC
bromocriptine; systemic
249.2
144.3
135
19
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
183.4
53.0
53
*
G02CB03
ATC
cabergoline; oral (prolactine inhibitors)
617.2
49.8
47
*
G02CB04
ATC
quinagolide; oral
371.7
31.9
31
*
N04BC06
ATC
cabergoline; oral (dopamine agonists)
371.7
31.9
31
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
91.4
22.2
24
*
XLA10
NOMESCO Finland
NA
7.2
19.6
51
92
2273A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Pituitary gland and craniopharyngeal duct (pouch)
+∞
14.8
14
*
G03DB01
ATC
dydrogesterone; oral
3.8
13.2
65
228
2531A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Other and unspecified anterior pituitary hyperfunction[HYPERPROLACTINAEMIA]
+∞
11.6
11
*
E23.00
ICD-10 Finland
Panhypopituitarism
105.1
9.5
10
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
38.7
9.1
11
*
H02AB09
ATC
hydrocortisone; systemic
8.9
8.8
18
22
N91.1
ICD-10 Finland
Secondary amenorrhoea
19.4
7.7
11
6
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
+∞
7.3
7
*
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
+∞
7.3
7
*
N05AA01
ATC
chlorpromazine; systemic, rectal
9.9
6.9
13
14
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
4.0
6.7
26
72
N05AX08
ATC
risperidone; systemic
4.6
6.6
22
53
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.2
6.3
82
482
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
+∞
6.3
6
*
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
8.1
6.2
13
17
Mortality – FinRegistry
↥This endpoint is excluded (not available in FinRegistry).
Relationships between endpoints
↥Index endpoint: E4_HYPERPRO_ADVERSE – Hyperprolactinaemia, drug-induced
GWS hits: -
This endpoint is excluded (not available in FinRegistry).