No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
200 |
4. Check minimum number of eventsNone |
200 |
5. Include endpointsNone |
200 |
6. Filter based on genotype QC (FinnGen only) |
200 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
- Parent code in ICD-10
- E22
- Name in latin
- Hyperprolactinaemia
Similar endpoints
↥List of similar endpoints to
Hyperprolactinaemia, drug-induced
based on the number of shared cases.
Similar with more cases:
- Hyperprolactinaemia
- Hyperfunction of pituitary gland
- Exclusions for E4_PCOS_BROAD
- Disorders of other endocrine glands
- Exclusions for E4_PCOS_CONSORTIUM
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (not available in FinRegistry).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 200 | 173 | 27 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.01 |
| Median age at first event (years) | 38.59 | 36.44 | 52.33 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 187
- Matched controls
- 1870
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E22.1
ICD-10 Finland
Hyperprolactinaemia
+∞
257.0
187
8
G02CB01
ATC
bromocriptine; systemic
249.2
144.3
135
19
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
183.4
53.0
53
*
G02CB03
ATC
cabergoline; oral (prolactine inhibitors)
617.2
49.8
47
*
N04BC06
ATC
cabergoline; oral (dopamine agonists)
371.7
31.9
31
*
G02CB04
ATC
quinagolide; oral
371.7
31.9
31
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
91.4
22.2
24
*
XLA10
NOMESCO Finland
NA
7.2
19.6
51
92
2273A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Pituitary gland and craniopharyngeal duct (pouch)
+∞
14.8
14
*
G03DB01
ATC
dydrogesterone; oral
3.8
13.2
65
228
2531A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Other and unspecified anterior pituitary hyperfunction[HYPERPROLACTINAEMIA]
+∞
11.6
11
*
E23.00
ICD-10 Finland
Panhypopituitarism
105.1
9.5
10
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
38.7
9.1
11
*
H02AB09
ATC
hydrocortisone; systemic
8.9
8.8
18
22
N91.1
ICD-10 Finland
Secondary amenorrhoea
19.4
7.7
11
6
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
+∞
7.3
7
*
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
+∞
7.3
7
*
N05AA01
ATC
chlorpromazine; systemic, rectal
9.9
6.9
13
14
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
4.0
6.7
26
72
N05AX08
ATC
risperidone; systemic
4.6
6.6
22
53
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.2
6.3
82
482
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
+∞
6.3
6
*
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
8.1
6.2
13
17
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
51
294
1.99
4.02
3.0
2.6
2.5
2.4
mmol/l
0.61
43
265
8
12
6.89
3.71
3.9
16.8
819.4
1142.3
nmol/l
—
8
12
8
12
6.89
3.71
8.1
18.1
1723.3
2136.5
nmol/l
—
8
12
86
628
1.65
2.96
2.3
1.9
89.4
99.0
pmol/l
0.98
39
306
102
787
1.60
2.75
3.3
2.7
90.2
89.0
ug/l
0.03
97
735
7
15
4.79
2.62
4.9
2.5
5.7
2.7
nmol/l
—
7
15
15
62
2.53
2.61
4.1
1.6
—
—
—
0
0
27
145
2.00
2.57
1.3
1.3
18.1
29.3
iu/l
1.72
22
127
41
255
1.76
2.50
3.1
2.4
0.5
1.1
e6/l
1.25
24
135
152
1316
1.65
2.35
4.2
4.0
12.9
10.6
mm/h
1.25
146
1222
9
29
3.20
2.25
1.3
1.5
—
—
—
0
0
40
256
1.70
2.21
1.7
1.7
1152.5
1212.6
nmol/l
0.16
32
196
27
155
1.86
2.13
2.0
1.8
—
—
—
0
0
27
158
1.82
2.01
2.1
1.9
—
—
—
0
0
111
914
1.48
2.00
5.8
3.7
6.5
6.5
mmol/l
0.20
103
858
52
368
1.56
1.92
1.7
1.5
18.5
21.3
nmol/l
0.84
46
311
36
233
1.66
1.91
3.3
2.6
5.5
3.1
e6/l
0.40
20
113
35
225
1.67
1.90
2.0
1.7
—
—
—
0
0
21
117
1.89
1.82
2.5
3.5
2.6
2.1
mmol/l
0.29
16
96
98
798
1.45
1.81
8.6
5.8
1.2
1.2
mmol/l
0.25
89
681
100
818
1.44
1.80
4.1
3.3
0.0
0.0
estimate
0.00
18
152
100
820
1.44
1.77
5.7
4.6
0.1
0.0
estimate
0.79
19
157
15
75
2.08
1.74
1.2
1.5
—
—
—
0
0
100
824
1.43
1.70
4.2
3.4
0.0
0.0
estimate
0.00
17
151
17
93
1.90
1.57
1.3
1.5
—
—
—
0
0
39
271
1.55
1.56
4.2
3.2
38.0
140.3
ng/l
1.40
26
187
70
550
1.42
1.52
3.3
2.8
—
—
—
0
0
116
996
1.39
1.49
14.2
9.4
4.0
3.8
e9/l
0.36
101
869
31
207
1.59
1.46
2.0
1.8
29.0
29.4
s
0.19
31
198
89
741
1.36
1.34
3.2
2.3
77.3
77.3
nmol/l
0.01
84
677
18
107
1.75
1.31
1.2
1.5
—
—
—
0
0
5
18
2.82
1.29
1.6
1.3
—
—
—
0
0
5
18
2.82
1.29
1.6
1.3
—
—
—
0
0
14
77
1.88
1.29
1.7
1.7
—
—
—
0
0
7
145
0.46
1.26
1.4
2.7
19.7
54.8
u/ml
—
7
138
5
19
2.67
1.22
1.6
1.3
—
—
—
0
0
5
19
2.67
1.22
1.6
1.3
—
—
—
0
0
5
19
2.67
1.22
1.6
1.3
—
—
—
0
0
8
38
2.15
1.20
6.5
4.6
28.6
198.2
mg/l
—
8
32
5
20
2.54
1.16
1.4
1.5
3.8
2.8
u/ml
—
5
20
50
388
1.38
1.14
3.6
2.6
803.1
665.0
ng/l
0.17
45
319
53
419
1.36
1.08
3.3
2.7
0.2
0.5
e6/l
0.62
38
306
183
1745
1.57
0.99
5.0
4.3
4.8
4.9
mmol/l
0.62
177
1644
0
31
0.00
0.97
0.0
3.2
—
64.4
—
0
31
9
51
1.80
0.96
1.0
1.3
—
42.1
—
0
7
6
27
2.26
0.94
1.3
1.3
—
—
—
0
0
29
385
0.71
0.91
2.4
2.0
—
—
—
0
0
6
30
2.03
0.87
1.0
1.3
—
—
—
0
0
6
30
2.03
0.87
1.0
1.3
—
—
—
0
0
75
641
1.27
0.87
4.3
3.3
—
—
—
0
0
26
190
1.42
0.84
2.9
2.3
22.1
23.8
%
0.24
19
159
14
211
0.64
0.84
16.9
5.6
—
—
—
0
0
18
122
1.52
0.83
10.2
6.5
1.1
1.3
mmol/l
0.56
18
117
184
1767
1.52
0.82
5.6
4.8
2.9
2.9
mmol/l
0.02
177
1651
177
1689
1.42
0.81
4.9
4.3
5.8
5.8
mmol/l
0.02
171
1574
6
33
1.84
0.79
1.3
1.7
—
—
—
0
0
0
25
0.00
0.79
0.0
1.7
—
—
—
0
0
181
1737
1.44
0.76
4.7
4.3
1.5
1.6
mmol/l
1.98
173
1628
181
1737
1.44
0.76
15.0
11.5
22.3
19.7
mg/l
0.38
136
1325
143
1331
1.26
0.74
8.1
7.0
76.9
76.9
u/l
0.00
136
1261
7
38
1.87
0.74
7.1
4.6
27.7
26.5
mg/l
—
7
32
173
1656
1.33
0.66
6.8
4.9
1.8
2.6
mu/l
0.54
165
1534
59
506
1.24
0.65
1.7
1.7
1.6
1.4
mmol/l
0.67
52
440
49
415
1.24
0.60
2.3
2.4
318.6
7690.8
umol/l
2.51
38
364
51
435
1.23
0.59
4.5
3.5
0.0
0.0
estimate
0.00
19
154
20
150
1.37
0.58
5.4
4.3
18.3
21.1
%
—
6
68
174
1676
1.29
0.55
4.3
3.8
1.3
1.3
mmol/l
0.74
166
1563
166
1593
1.25
0.52
6.0
5.1
40.0
39.0
mmol/mol
0.68
159
1499
189
1844
1.45
0.52
18.8
13.5
71.6
70.3
umol/l
0.29
189
1844
6
40
1.52
0.52
1.2
1.1
—
—
—
0
0
14
189
0.72
0.51
1.4
1.7
—
—
—
0
0
128
1202
1.18
0.50
2.7
2.9
44.1
40.3
u/l
0.24
121
1138
44
377
1.21
0.49
2.4
1.6
1.1
0.8
mg/l
0.56
34
302
7
47
1.51
0.48
1.0
1.0
—
3.2
—
0
8
51
575
0.85
0.43
5.6
3.1
25.1
22.1
ng/l
0.13
28
349
8
58
1.39
0.42
1.3
1.1
—
—
—
0
0
47
412
1.18
0.42
1.3
1.3
0.9
2.1
u/ml
—
9
132
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
5
35
1.44
0.39
2.0
1.4
—
—
—
0
0
6
45
1.34
0.34
2.5
2.1
184.0
178.4
%
—
6
45
7
56
1.26
0.29
1.4
1.5
—
—
—
0
0
170
1658
1.17
0.29
13.4
10.9
81.8
84.3
ml/min/173m2
1.06
145
1369
8
63
1.28
0.28
1.4
1.8
—
—
—
0
0
28
244
1.17
0.27
4.5
2.5
0.8
0.8
mmol/l
0.09
28
232
71
760
0.90
0.27
4.1
3.7
—
—
—
0
0
47
427
1.13
0.27
1.5
1.4
—
—
—
0
0
194
1916
1.42
0.24
26.0
17.9
134.3
134.4
g/l
0.05
194
1892
5
37
1.36
0.23
2.0
1.4
—
—
—
0
0
121
1165
1.10
0.23
3.1
3.2
—
—
—
0
0
5
39
1.29
0.23
1.2
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
5
43
1.17
0.21
1.2
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
85.6
—
0
8
0
13
0.00
0.21
0.0
1.3
—
25.3
—
0
8
13
108
1.22
0.20
1.4
1.3
—
—
—
0
0
6
50
1.21
0.20
1.0
1.2
—
—
—
0
0
6
50
1.21
0.20
2.0
1.5
18.8
33.1
u/l
—
6
43
20
175
1.16
0.19
2.1
1.6
—
—
—
0
0
7
58
1.21
0.18
1.3
1.1
—
—
—
0
0
13
110
1.19
0.17
2.2
2.9
0.4
0.7
ug/l
—
8
71
18
159
1.15
0.15
2.2
1.6
—
—
—
0
0
9
79
1.15
0.15
1.1
1.4
—
—
—
0
0
33
357
0.91
0.15
1.4
1.3
1.4
8.5
u/ml
2.39
16
147
12
139
0.85
0.14
2.8
3.1
—
—
—
0
0
10
84
1.20
0.14
1.3
1.4
—
—
—
0
0
92
891
1.06
0.12
6.6
5.8
11.9
10.1
umol/l
0.53
85
845
15
166
0.90
0.10
1.1
1.2
122.7
194.8
iu/ml
—
5
74
10
87
1.16
0.09
14.6
6.0
26.7
25.6
mmol/l
—
10
87
6
56
1.07
0.08
1.5
1.5
—
—
—
0
0
7
65
1.08
0.08
1.4
1.6
—
—
—
0
0
9
102
0.88
0.06
1.4
1.5
—
—
—
0
0
38
367
1.04
0.05
1.4
1.3
12.0
29.5
iu/ml
2.15
12
123
36
351
1.03
0.02
1.4
1.4
—
—
—
0
0
158
1586
0.98
0.00
21.5
13.0
39.8
39.8
%
0.04
130
1231
17
168
1.01
0.00
10.9
14.1
1.3
1.3
inr
—
6
31
0
7
0.00
0.00
0.0
3.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
22.3
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
3.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
9
95
0.94
0.00
1.0
1.0
—
—
—
0
0
7
74
0.94
0.00
2.6
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
9.1
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
207.5
—
0
8
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded (not available in FinRegistry).
Relationships between endpoints
↥Index endpoint: E4_HYPERPRO_ADVERSE – Hyperprolactinaemia, drug-induced
GWS hits: -
This endpoint is excluded (not available in FinRegistry).