Precocious central puberty

E4_PRECOXCENTPUB

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E22.80, E22.88
  • Hospital discharge: ICD-9 259
  • Cause of death: ICD-10 E22.80, E22.88
  • Cause of death: ICD-9 259

2 out of 7 registries used, show all original rules.

240

4. Check minimum number of events

None

240

5. Include endpoints

None

240

6. Filter based on genotype QC (FinnGen only)

219

Control definitions (FinnGen only)

Control exclude
E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF6

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2852 1930 912
Only index persons 2430 1642 788
Unadjusted period prevalence (%)
Whole population 0.05 0.06 0.03
Only index persons 0.05 0.06 0.03
Median age at first event (years)
Whole population 9.59 8.54 11.31
Only index persons 9.31 8.52 10.97

-FinnGen-

Key figures

All Female Male
Number of individuals 219 151 68
Unadjusted period prevalence (%) 0.05 0.05 0.03
Median age at first event (years) 10.34 8.94 13.45

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
240
Matched controls
2400
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L02AE02
ATC
leuprorelin; implant, parenteral
79.0
117.3
64
11
E22.80
ICD-10 Finland
Central precocious puberty
+∞
111.3
98
*
2594A
ICD-9 Finland
Other endocrine disorders, Dwarfism, not elsewhere classified
+∞
50.9
47
*
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
18.5
50.7
43
28
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
38.6
36
*
H01AC01
ATC
somatropin; parenteral
+∞
36.4
34
*
E30.1
ICD-10 Finland
Precocious puberty
+∞
36.4
34
*
Z51.80
ICD-10 Finland
Manipulation of puberty development with hormone therapy
+∞
32.0
30
*
H02AB09
ATC
hydrocortisone; systemic
11.2
25.2
28
28
2591A
ICD-9 Finland
Other endocrine disorders, Precocious sexual development and puberty, not elsewhere classified
+∞
22.2
21
*
E22.88
ICD-10 Finland
Other hyperfunction of pituitary gland
+∞
21.2
20
*
2590A
ICD-9 Finland
Other endocrine disorders, Delay in sexual development and puberty, not elsewhere classified
+∞
20.1
19
*
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
+∞
17.9
17
*
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
16.9
16
*
L02AE04
ATC
triptorelin; parenteral
+∞
14.7
14
*
E34.39
ICD-10 Finland
Short stature, not elsewhere classified
159.3
14.6
15
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.6
14.0
36
88
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
79.8
13.7
15
*
2599X
ICD-9 Finland
Other endocrine disorders, Unspecified endocrine disorder
+∞
13.7
13
*
E22.1
ICD-10 Finland
Hyperprolactinaemia
+∞
12.6
12
*
7834C
ICD-9 Finland
Symptoms concerning nutrition, metabolism and development, Lack of expected normal physiological development[HÄIRIINTYNYT PITUUSKASVU]
+∞
12.6
12
*
2592A
ICD-9 Finland
Other endocrine disorders, Carcinoid syndrome
+∞
12.6
12
*
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
125.8
11.5
12
*
102
Kela drug reimbursment
Diabetes insipidus
+∞
10.5
10
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.6
10.3
85
423
H47.2
ICD-10 Finland
Optic atrophy
41.9
10.1
12
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.7
10.0
34
102
E34.35
ICD-10 Finland
Abnormal growth retardation
57.4
9.7
11
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.6
9.6
71
334
301
Kela drug reimbursment
Growth hormone
+∞
9.4
9
*
186
Kela drug reimbursment
Growth retardation associated with renal failure (growth hormone)
+∞
9.4
9
*
2598X
ICD-9 Finland
Other endocrine disorders, Other specified endocrine disorders
+∞
9.4
9
*
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
5.3
9.3
19
38
E34.31
ICD-10 Finland
Short stature, prenatal disorder
93.2
8.5
9
*
F83
ICD-10 Finland
Mixed specific developmental disorders
10.6
8.2
15
15
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
8.1
81
434
F82
ICD-10 Finland
Specific developmental disorder of motor function
9.3
7.7
15
17
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
14.0
7.5
12
9
E30.9
ICD-10 Finland
Disorder of puberty, unspecified
+∞
7.3
7
*
E30.8
ICD-10 Finland
Other disorders of puberty
+∞
7.3
7
*
E22.8
ICD-10 Finland
Other hyperfunction of pituitary gland
+∞
7.3
7
*
E34.30
ICD-10 Finland
Short stature NOS
+∞
7.3
7
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
7.0
7.3
17
26
L04AA01
ATC
[U] ciclosporin
20.8
7.2
10
5
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
4.4
7.1
18
43
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.4
7.1
26
82
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
41.2
6.8
8
*
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
23.3
6.7
9
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.0
6.7
19
50
G03DB01
ATC
dydrogesterone; oral
3.1
6.5
29
103
G81.1
ICD-10 Finland
Spastic hemiplegia
71.7
6.5
7
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
6.4
47
218
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
6.3
42
185
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.3
6.3
53
260
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
6.3
47
219
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
+∞
6.3
6
*
E34.45
ICD-10 Finland
Abnormal growth increase
+∞
6.3
6
*
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
+∞
6.3
6
*
P85
ICPC
Mental retardation
27.5
6.3
8
*
G91.1
ICD-10 Finland
Obstructive hydrocephalus
27.5
6.3
8
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.5
6.2
22
68
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.7
6.0
35
144

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
52
99
6.43
27.48
3.6
1.4
6.47
7.76
u/l
0.45
47
77
46
110
4.94
18.61
3.6
1.4
9.40
13.30
iu/l
0.62
39
83
105
607
2.30
8.89
9.6
6.4
1.21
1.22
mmol/l
0.20
94
568
111
690
2.13
7.54
11.1
6.5
1.21
1.22
mmol/l
0.36
98
606
87
497
2.18
7.30
5.2
6.9
1.06
1.13
inr
0.76
29
171
17
26
6.95
7.25
2.8
1.5
—
—
—
0
0
59
287
2.40
7.24
5.6
3.7
—
—
—
0
0
35
149
2.58
5.64
7.7
8.7
25.18
24.96
mmol/l
0.16
35
149
65
362
2.09
5.63
5.2
3.2
7.38
7.40
ph
0.87
12
64
210
1767
2.51
5.47
17.6
8.7
3.90
3.89
mmol/l
0.06
203
1697
210
1767
2.51
5.47
17.8
8.7
139.57
139.45
mmol/l
0.27
203
1708
38
178
2.35
4.99
2.5
2.0
—
—
—
0
0
130
948
1.81
4.84
6.4
4.2
6.15
6.29
mmol/l
0.37
121
834
104
724
1.77
4.42
7.0
4.9
9.62
10.24
umol/l
0.37
98
670
7
6
11.96
4.30
2.0
1.0
—
—
—
0
0
7
7
10.25
4.03
5.7
1.0
2.87
2.04
nmol/l
—
7
7
33
160
2.23
4.00
9.6
8.8
—
—
—
0
0
36
181
2.16
3.99
5.5
6.5
5.86
5.68
kpa
0.73
36
176
70
446
1.80
3.94
3.0
2.3
2.37
2.35
mmol/l
0.52
63
404
141
1094
1.70
3.89
12.5
7.9
4.44
3.86
e9/l
1.99
127
962
51
296
1.92
3.84
3.9
2.8
—
—
—
0
0
70
452
1.77
3.75
2.6
2.3
48.44
58.05
u/l
2.02
63
419
28
136
2.20
3.38
15.9
7.3
8.15
6.17
mmol/l
1.03
28
131
80
552
1.67
3.33
7.2
4.7
36.32
37.85
g/l
1.78
71
521
147
1182
1.63
3.30
8.5
5.4
81.90
78.53
u/l
0.33
138
1118
70
474
1.67
3.10
4.6
2.8
40.87
52.35
e6/l
0.19
55
359
65
433
1.69
3.06
4.6
2.9
0.49
0.25
e6/l
0.42
51
322
51
320
1.75
2.96
4.4
2.3
9.04
8.26
e6/l
0.15
46
286
11
32
3.55
2.94
4.8
2.3
24.45
23.87
mmol/l
0.18
11
32
35
198
1.90
2.83
2.2
1.5
—
—
—
0
0
26
132
2.09
2.83
6.2
6.9
23.96
23.35
mmol/l
0.60
26
132
18
78
2.41
2.82
1.7
1.5
—
—
—
0
0
122
961
1.55
2.82
10.4
6.0
0.60
0.54
e9/l
2.11
108
855
122
962
1.55
2.80
10.4
6.0
0.03
0.04
e9/l
0.58
108
854
24
119
2.13
2.77
3.9
4.7
1.56
1.06
%
—
9
33
5
6
8.48
2.76
3.8
1.7
29.64
11.22
umol/l
—
5
6
127
1016
1.53
2.69
10.3
5.8
2.07
2.01
e9/l
0.34
115
926
64
439
1.62
2.66
4.6
2.8
—
—
—
0
0
10
30
3.43
2.63
10.4
1.7
—
—
—
0
0
9
25
3.70
2.60
7.8
2.4
10.23
9.30
kpa
—
9
25
9
25
3.70
2.60
7.8
2.4
5.11
5.14
kpa
—
9
25
13
50
2.69
2.57
13.2
11.1
24.08
23.57
mmol/l
0.21
13
50
6
11
5.56
2.56
3.8
5.1
2.85
2.14
mmol/l
—
6
11
25
131
2.01
2.52
9.2
8.3
106.16
105.24
mmol/l
0.31
25
131
39
240
1.75
2.42
2.8
2.8
7.93
3.67
e6/l
0.93
23
123
172
1495
1.53
2.29
5.6
3.8
14.38
14.39
pmol/l
0.02
161
1369
6
13
4.70
2.28
2.7
1.2
—
—
—
0
0
60
423
1.56
2.20
3.8
2.5
11.83
30.85
ng/l
1.34
35
180
122
997
1.45
2.17
11.7
6.2
0.16
0.19
e9/l
1.48
110
892
26
146
1.88
2.17
1.4
1.4
—
—
—
0
0
114
921
1.45
2.15
10.7
6.3
—
—
—
0
0
21
111
1.98
2.08
4.2
4.8
0.14
0.21
%
—
7
24
18
90
2.08
2.06
6.0
3.6
69.52
68.05
e9/l
0.05
12
63
22
119
1.93
2.05
9.5
5.2
—
—
—
0
0
10
38
2.70
2.03
3.9
3.1
—
—
—
0
0
219
2037
1.86
2.00
14.1
8.2
—
—
—
0
0
67
495
1.49
1.97
3.1
2.3
—
—
—
0
0
5
11
4.62
1.95
3.0
1.4
—
—
nmol/l
—
0
0
69
517
1.47
1.88
4.6
2.1
—
—
—
0
0
65
483
1.47
1.85
10.8
7.0
—
—
—
0
0
5
12
4.23
1.83
2.4
1.3
1.92
1.56
mmol/l
—
5
12
9
35
2.63
1.82
4.7
2.7
—
—
—
0
0
7
162
0.42
1.74
1.0
1.4
—
—
—
0
0
209
1935
1.62
1.73
12.1
7.3
28.05
26.90
u/l
0.34
204
1869
5
13
3.90
1.72
1.0
1.6
2.88
4.80
mmol/24h
—
5
13
76
590
1.42
1.70
5.5
3.4
69.08
65.03
e6/l
0.05
57
379
24
146
1.72
1.58
10.8
4.7
7.40
7.43
ph
—
5
10
19
108
1.82
1.56
2.8
4.6
0.60
1.08
%
—
5
26
8
33
2.47
1.55
3.9
3.8
3.44
4.14
e9/l
—
8
33
8
33
2.47
1.55
4.0
4.1
51.63
55.73
%
—
8
33
24
147
1.70
1.54
10.8
4.7
5.11
4.96
kpa
0.49
24
140
171
1535
1.40
1.54
3.6
2.9
5.57
5.56
mmol/l
0.04
158
1406
11
51
2.21
1.53
1.3
1.1
—
—
—
0
0
37
254
1.54
1.52
4.0
3.8
1546.38
331.84
mg/l
0.36
26
178
51
377
1.45
1.48
1.9
1.5
1.57
1.31
mmol/l
1.23
46
329
11
52
2.17
1.47
9.3
4.2
—
—
—
0
0
57
432
1.42
1.45
4.7
3.6
8.91
8.43
mmol/l
0.20
48
384
5
16
3.17
1.44
8.2
3.8
—
—
—
0
0
6
22
2.77
1.44
1.2
1.3
—
—
—
0
0
6
22
2.77
1.44
8.3
1.9
—
—
—
0
0
38
266
1.51
1.44
4.3
4.5
3.12
16.82
mg/mmol
2.49
25
182
107
901
1.34
1.42
14.3
8.0
0.05
0.00
e9/l
0.49
87
735
115
979
1.34
1.41
3.1
2.6
—
—
—
0
0
12
60
2.05
1.40
2.1
2.2
0.31
0.09
e6/l
0.56
12
55
11
54
2.09
1.35
21.6
8.2
—
—
—
0
0
188
1731
1.40
1.32
5.9
4.3
1.66
1.74
mu/l
0.70
179
1622
8
160
0.48
1.30
1.3
1.2
—
144.00
—
0
5
5
18
2.81
1.29
2.2
3.6
11.20
16.50
%
—
5
18
166
1505
1.33
1.25
3.4
2.8
1.33
1.18
mmol/l
2.02
159
1417
10
49
2.09
1.24
5.4
1.2
—
—
—
0
0
5
19
2.66
1.22
5.2
3.3
76.80
67.68
%
—
5
19
5
19
2.66
1.22
5.2
3.3
6.00
10.16
%
—
5
19
23
152
1.57
1.14
1.4
1.2
—
—
—
0
0
148
1330
1.29
1.14
4.7
3.7
37.67
37.46
mmol/mol
0.07
143
1252
5
21
2.41
1.09
7.4
14.2
1092.80
767.71
nmol/l
—
5
21
5
21
2.41
1.09
11.4
20.8
1955.40
1355.00
nmol/l
—
5
21
28
196
1.49
1.08
1.1
1.3
—
—
—
0
0
140
1257
1.27
1.05
4.4
3.0
35.50
32.56
u/l
0.29
129
1207
36
267
1.41
1.04
1.4
1.5
231.11
498.04
titre
—
9
51
48
374
1.35
1.04
1.5
1.6
—
—
—
0
0
5
22
2.30
1.04
3.8
1.8
—
—
—
0
0
31
224
1.44
1.03
1.6
1.6
—
—
—
0
0
0
29
0.00
0.98
0.0
1.1
—
—
—
0
0
0
30
0.00
0.98
0.0
1.0
—
1.38
—
0
12
19
278
0.66
0.97
1.1
1.3
—
—
—
0
0
142
1285
1.26
0.96
5.0
3.5
9.40
7.73
mm/h
1.15
132
1201
39
298
1.37
0.96
1.2
1.3
60.45
19.67
iu/ml
0.45
13
85
11
62
1.81
0.96
15.5
10.6
0.68
0.70
%
0.04
11
62
16
102
1.61
0.93
12.1
4.7
10.08
9.78
kpa
0.29
16
97
36
465
0.73
0.93
1.8
1.6
—
—
—
0
0
229
2219
1.70
0.92
23.2
13.6
272.98
261.58
e9/l
1.77
222
2168
11
63
1.78
0.91
3.5
2.5
—
—
—
0
0
16
103
1.59
0.90
1.0
1.1
—
—
—
0
0
229
2222
1.67
0.87
23.4
13.5
4.57
4.59
e12/l
0.13
222
2165
170
1583
1.25
0.83
3.7
3.0
1.42
1.45
mmol/l
0.42
164
1494
13
81
1.64
0.83
29.7
11.0
1.16
1.05
mg/l
0.39
13
75
171
1595
1.25
0.82
3.8
3.2
2.79
2.81
mmol/l
0.11
164
1500
229
2225
1.64
0.82
23.5
13.6
7.25
6.75
e9/l
2.74
222
2164
60
501
1.26
0.80
1.7
1.5
98.74
98.03
pmol/l
0.04
29
256
85
742
1.23
0.76
4.2
2.9
5.55
5.91
ph
—
10
72
170
1591
1.23
0.75
3.8
3.1
4.62
4.62
mmol/l
0.03
164
1508
33
257
1.33
0.74
1.3
1.2
—
—
—
0
0
7
39
1.82
0.73
1.0
2.3
—
—
—
0
0
228
2219
1.55
0.72
23.9
13.6
40.06
40.46
%
0.51
217
2121
7
40
1.77
0.72
2.0
1.9
—
—
—
0
0
140
1289
1.21
0.72
5.8
3.7
—
—
—
0
0
26
196
1.37
0.71
1.1
1.3
147.50
166.32
iu/ml
—
7
78
5
27
1.87
0.69
1.2
1.2
—
—
—
0
0
14
94
1.52
0.68
5.9
3.0
—
—
—
0
0
203
1945
1.28
0.68
17.1
9.0
22.61
20.48
mg/l
0.39
169
1413
23
172
1.37
0.66
2.1
1.4
—
—
—
0
0
47
390
1.26
0.66
1.7
2.3
4.55
1.05
mg/l
0.55
30
275
20
146
1.40
0.66
1.4
1.2
—
—
—
0
0
10
62
1.64
0.66
16.8
10.6
1.00
1.27
%
—
10
62
56
478
1.22
0.62
4.7
3.2
0.00
0.01
estimate
0.80
18
186
14
197
0.69
0.62
2.0
1.3
—
—
—
0
0
5
30
1.68
0.62
1.4
1.4
—
—
—
0
0
31
247
1.29
0.60
2.0
2.3
6482.21
4493.39
u/l
—
8
107
0
22
0.00
0.59
0.0
1.0
—
—
—
0
0
18
132
1.39
0.59
1.1
1.4
217.56
281.43
miu/ml
—
9
67
41
340
1.25
0.59
2.5
2.6
85.73
71.44
ug/g
0.23
32
259
99
896
1.18
0.58
4.6
3.0
0.00
0.00
estimate
-0.00
21
189
100
906
1.18
0.58
4.5
3.1
0.00
0.00
estimate
-0.00
20
178
6
35
1.73
0.58
5.2
1.8
136.00
134.20
g/l
—
6
25
16
216
0.72
0.56
4.7
1.7
—
—
—
0
0
8
55
1.47
0.56
1.1
1.2
—
—
—
0
0
18
238
0.74
0.56
4.4
1.6
—
—
—
0
0
18
237
0.74
0.55
4.4
1.6
—
—
—
0
0
18
237
0.74
0.55
4.4
1.6
—
—
—
0
0
9
60
1.52
0.55
1.4
1.4
—
—
—
0
0
15
108
1.41
0.54
1.3
1.2
—
—
—
0
0
14
100
1.42
0.53
6.0
4.5
—
—
—
0
0
18
235
0.75
0.52
4.4
1.7
—
—
—
0
0
7
45
1.57
0.49
2.4
3.1
—
—
—
0
0
10
68
1.49
0.47
1.1
1.6
—
—
—
0
0
61
539
1.18
0.47
4.4
2.6
—
—
—
0
0
46
397
1.20
0.46
3.9
3.1
—
—
—
0
0
7
49
1.44
0.46
1.1
1.1
—
—
—
0
0
20
249
0.79
0.42
1.7
2.0
—
—
—
0
0
50
439
1.18
0.42
3.0
2.2
2.72
2.63
mg/l
0.13
43
379
0
16
0.00
0.41
0.0
1.0
—
4.06
—
0
11
0
16
0.00
0.41
0.0
2.2
—
41.17
—
0
6
0
17
0.00
0.41
0.0
1.1
—
2.04
—
0
17
21
169
1.27
0.40
4.8
3.3
—
—
—
0
0
48
422
1.17
0.40
4.6
2.8
1.01
1.02
kg/l
—
9
57
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
5
37
1.36
0.37
1.0
2.0
—
—
—
0
0
96
892
1.13
0.37
6.6
4.3
0.00
0.00
estimate
-0.00
18
186
15
117
1.30
0.36
1.4
1.2
—
32.81
—
0
7
65
591
1.14
0.35
1.7
1.4
1.71
1.98
g/l
1.28
34
352
6
43
1.41
0.35
2.3
6.8
—
—
—
0
0
28
238
1.20
0.34
2.7
2.5
1984.60
526.46
ng/l
0.60
15
107
13
100
1.32
0.34
1.8
1.4
—
—
—
0
0
71
659
1.11
0.27
1.5
1.5
0.62
2.23
u/ml
1.35
13
155
20
169
1.20
0.27
1.2
1.4
—
—
—
0
0
5
71
0.70
0.26
1.6
1.7
—
—
—
0
0
11
138
0.79
0.26
1.1
1.1
—
—
—
0
0
9
74
1.22
0.25
2.0
1.5
1.21
1.21
g/l
—
9
69
54
585
0.90
0.24
2.1
1.8
—
—
—
0
0
6
84
0.71
0.24
1.0
1.1
—
—
—
0
0
106
1011
1.09
0.23
4.5
2.7
93.01
63.07
ug/l
0.88
96
945
0
11
0.00
0.21
0.0
3.4
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
73.18
—
0
11
0
10
0.00
0.21
0.0
7.8
—
—
—
0
0
0
10
0.00
0.21
0.0
3.9
—
—
—
0
0
16
187
0.85
0.21
2.3
1.6
—
—
—
0
0
33
299
1.12
0.20
1.2
1.2
3.00
7.75
u/ml
0.96
12
132
6
51
1.18
0.19
1.5
1.2
—
—
—
0
0
15
174
0.85
0.18
3.0
2.1
—
—
—
0
0
7
63
1.11
0.17
1.9
1.6
—
—
—
0
0
15
135
1.12
0.10
1.1
1.1
—
—
—
0
0
6
58
1.04
0.08
3.0
6.1
0.83
0.67
%
—
6
58
61
591
1.04
0.07
2.4
1.7
—
—
—
0
0
75
732
1.04
0.06
1.5
1.8
—
—
—
0
0
185
1835
1.04
0.05
19.0
11.4
332.97
334.37
g/l
1.06
185
1820
64
655
0.97
0.05
1.8
1.7
—
—
—
0
0
15
141
1.07
0.03
1.3
1.4
—
—
—
0
0
67
659
1.02
0.03
2.4
2.0
—
—
—
0
0
15
142
1.06
0.02
1.3
1.4
—
—
—
0
0
10
99
1.01
0.00
3.8
2.3
—
—
—
0
0
11
107
1.03
0.00
3.1
1.9
—
—
—
0
0
15
145
1.04
0.00
1.3
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
27.96
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
0.00
1.4
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
170.40
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
5.70
—
0
8
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0
6
59
1.02
-0.00
1.3
1.5
—
60.00
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
59
1.02
-0.00
1.5
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
5
50
1.00
-0.00
1.0
1.2
—
4.02
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
8
80
1.00
-0.00
1.1
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
8.0
—
—
—
0
0
82
820
1.00
-0.00
2.6
2.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint E4_PRECOXCENTPUB and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_PRECOXCENTPUB.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: E4_PRECOXCENTPUB – Precocious central puberty

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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