No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
239 |
4. Check minimum number of eventsNone |
239 |
5. Include endpointsNone |
239 |
6. Filter based on genotype QC (FinnGen only) |
239 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF6
Similar endpoints
↥List of similar endpoints to
Precocious central puberty
based on the number of shared cases.
Similar with more cases:
- Hyperfunction of pituitary gland
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2852 | 1930 | 912 |
| Only index persons | 2430 | 1642 | 788 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.03 |
| Only index persons | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 9.59 | 8.54 | 11.31 |
| Only index persons | 9.31 | 8.52 | 10.97 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 239 | 165 | 74 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | 10.10 | 8.90 | 12.76 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 223
- Matched controls
- 2228
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E22.80
ICD-10 Finland
Central precocious puberty
+∞
102.1
90
*
L02AE02
ATC
leuprorelin; implant, parenteral
62.3
52.4
60
13
2594A
ICD-9 Finland
Other endocrine disorders, Dwarfism, not elsewhere classified
+∞
46.5
43
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
36.5
34
*
H01AC01
ATC
somatropin; parenteral
+∞
33.1
31
*
E30.1
ICD-10 Finland
Precocious puberty
+∞
32.0
30
*
Z51.80
ICD-10 Finland
Manipulation of puberty development with hormone therapy
+∞
32.0
30
*
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
21.5
27.8
41
23
2591A
ICD-9 Finland
Other endocrine disorders, Precocious sexual development and puberty, not elsewhere classified
+∞
20.1
19
*
2590A
ICD-9 Finland
Other endocrine disorders, Delay in sexual development and puberty, not elsewhere classified
+∞
20.1
19
*
E22.88
ICD-10 Finland
Other hyperfunction of pituitary gland
+∞
20.1
19
*
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
+∞
15.8
15
*
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
15.8
15
*
L02AE04
ATC
triptorelin; parenteral
+∞
14.7
14
*
E34.39
ICD-10 Finland
Short stature, not elsewhere classified
160.0
14.6
15
*
H02AB09
ATC
hydrocortisone; systemic
11.1
12.8
24
24
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
74.2
12.7
14
*
2592A
ICD-9 Finland
Other endocrine disorders, Carcinoid syndrome
+∞
12.6
12
*
2599X
ICD-9 Finland
Other endocrine disorders, Unspecified endocrine disorder
+∞
12.6
12
*
E22.1
ICD-10 Finland
Hyperprolactinaemia
+∞
11.6
11
*
102
Kela drug reimbursment
Diabetes insipidus
+∞
10.5
10
*
E34.35
ICD-10 Finland
Abnormal growth retardation
+∞
10.5
10
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.7
10.3
35
84
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
57.5
9.7
11
*
E34.31
ICD-10 Finland
Short stature, prenatal disorder
+∞
9.4
9
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.2
8.4
32
86
186
Kela drug reimbursment
Growth retardation associated with renal failure (growth hormone)
+∞
8.4
8
*
2598X
ICD-9 Finland
Other endocrine disorders, Other specified endocrine disorders
+∞
8.4
8
*
7834C
ICD-9 Finland
Symptoms concerning nutrition, metabolism and development, Lack of expected normal physiological development[HÄIRIINTYNYT PITUUSKASVU]
34.7
8.1
10
*
F82
ICD-10 Finland
Specific developmental disorder of motor function
11.4
7.9
14
13
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
7.1
7.8
18
27
H03AA01
ATC
levothyroxine sodium; systemic
3.0
7.7
46
175
WX408
NOMESCO Finland
General anesthesy, balanced
2.5
7.6
67
322
H47.2
ICD-10 Finland
Optic atrophy
26.0
7.6
10
*
E34.30
ICD-10 Finland
Short stature NOS
+∞
7.3
7
*
E22.8
ICD-10 Finland
Other hyperfunction of pituitary gland
+∞
7.3
7
*
G81.1
ICD-10 Finland
Spastic hemiplegia
+∞
7.3
7
*
E30.9
ICD-10 Finland
Disorder of puberty, unspecified
+∞
7.3
7
*
301
Kela drug reimbursment
Growth hormone
+∞
7.3
7
*
E30.8
ICD-10 Finland
Other disorders of puberty
+∞
7.3
7
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
8.4
7.2
15
19
L04AA01
ATC
[U] ciclosporin; systemic
31.1
7.2
9
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.1
6.9
39
144
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.8
6.9
22
50
602
Kela drug reimbursment
Children's severe malnutrition
23.3
6.7
9
*
E34.45
ICD-10 Finland
Abnormal growth increase
+∞
6.3
6
*
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
+∞
6.3
6
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
6.1
42
176
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
51
101
6.15
25.82
3.6
1.4
6.5
7.8
u/l
0.45
46
78
46
111
4.89
18.41
3.6
1.4
9.4
13.3
iu/l
0.62
39
83
104
606
2.27
8.58
9.7
6.6
1.2
1.2
mmol/l
0.17
92
564
110
689
2.11
7.27
11.2
6.7
1.2
1.2
mmol/l
0.33
96
601
209
1762
2.48
5.36
17.6
8.9
3.9
3.9
mmol/l
0.06
202
1691
209
1762
2.48
5.36
17.9
8.9
139.6
139.5
mmol/l
0.28
202
1702
5
0
+∞
5.22
2.0
0.0
—
—
—
0
0
34
149
2.49
5.16
7.8
9.1
25.2
25.0
mmol/l
0.20
34
149
129
946
1.79
4.66
6.4
4.3
6.1
6.3
mmol/l
0.36
120
832
104
722
1.78
4.48
7.0
5.1
9.6
10.2
umol/l
0.35
98
669
80
517
1.82
4.36
5.2
3.1
—
—
—
0
0
36
180
2.18
4.05
5.5
7.3
5.9
5.7
kpa
0.78
36
175
7
7
10.25
4.03
5.7
1.0
2.9
2.0
nmol/l
—
7
7
70
445
1.81
3.98
3.0
2.4
2.4
2.4
mmol/l
0.55
63
400
38
198
2.09
3.85
2.1
1.7
—
—
—
0
0
140
1087
1.70
3.84
12.6
8.1
4.5
3.9
e9/l
2.08
126
955
183
1533
1.83
3.80
11.9
7.1
105.2
100.0
ml/min/173m2
2.24
140
1152
70
453
1.77
3.72
2.6
2.3
48.4
56.8
u/l
1.71
63
420
6
6
10.21
3.51
1.3
1.5
—
—
—
0
0
10
27
3.82
3.39
1.3
1.3
—
—
—
0
0
147
1180
1.64
3.35
8.5
5.4
81.9
78.0
u/l
0.40
138
1114
80
552
1.68
3.33
7.2
4.8
36.3
37.8
g/l
1.76
71
519
99
724
1.63
3.27
3.6
2.4
70.5
71.4
nmol/l
0.12
92
666
28
138
2.17
3.27
1.9
1.6
—
—
—
0
0
35
191
1.98
3.14
2.8
3.4
588.0
904.2
ng/l
0.51
29
150
8
16
5.13
3.07
2.1
1.6
—
—
—
0
0
65
433
1.69
3.06
4.6
2.9
0.5
0.3
e6/l
0.42
51
321
27
136
2.11
2.99
16.5
7.9
8.3
6.3
mmol/l
0.97
27
131
5
5
10.17
2.99
2.4
2.8
—
—
—
0
0
23
109
2.23
2.96
3.1
2.6
—
—
—
0
0
27
138
2.08
2.89
2.0
1.6
—
—
—
0
0
18
82
2.29
2.54
1.8
1.4
—
—
—
0
0
39
238
1.76
2.49
2.8
2.8
7.9
3.7
e6/l
0.90
23
122
8
22
3.72
2.38
1.6
1.7
—
—
—
0
0
10
35
2.94
2.33
1.9
1.6
—
—
—
0
0
40
252
1.71
2.29
2.6
2.7
1.3
0.8
e6/l
0.55
23
136
171
1491
1.52
2.20
5.6
3.8
14.4
14.4
pmol/l
0.01
160
1365
60
424
1.55
2.18
3.8
2.4
11.8
31.1
ng/l
1.35
35
178
9
30
3.08
2.17
2.0
1.6
—
—
—
0
0
7
20
3.57
2.07
1.0
1.3
—
—
—
0
0
10
38
2.70
2.03
2.5
1.6
—
—
—
0
0
5
12
4.23
1.83
2.4
1.2
1.9
1.6
mmol/l
—
5
12
209
1931
1.66
1.82
12.1
7.4
28.1
26.9
u/l
0.33
204
1864
54
391
1.49
1.74
4.7
2.3
—
—
—
0
0
76
592
1.42
1.67
4.4
2.9
54.3
30.2
u/l
0.74
71
552
102
837
1.38
1.65
5.5
3.9
—
—
—
0
0
12
57
2.16
1.58
2.1
2.2
0.3
0.1
e6/l
0.56
12
52
171
1533
1.41
1.57
3.6
2.9
5.6
5.6
mmol/l
0.04
158
1404
51
376
1.45
1.50
1.9
1.5
1.6
1.3
mmol/l
1.18
46
328
7
155
0.44
1.48
1.7
1.7
—
—
—
0
0
5
16
3.17
1.44
2.0
1.2
—
—
—
0
0
5
16
3.17
1.44
3.2
2.9
—
—
—
0
0
15
82
1.88
1.39
2.6
1.6
—
—
—
0
0
16
90
1.83
1.37
1.5
1.4
—
—
—
0
0
23
145
1.65
1.35
10.8
4.6
1.1
1.3
mmol/l
0.09
18
104
8
34
2.40
1.30
1.1
1.2
—
—
—
0
0
8
34
2.40
1.30
1.1
1.2
—
—
—
0
0
23
147
1.62
1.28
11.2
4.6
5.1
5.0
kpa
0.44
23
139
13
70
1.91
1.26
1.5
1.6
—
—
—
0
0
166
1505
1.34
1.26
3.4
2.8
1.3
1.2
mmol/l
2.01
159
1417
187
1727
1.38
1.25
5.9
4.3
1.7
1.7
mu/l
0.71
178
1618
148
1327
1.30
1.18
4.8
3.7
37.7
37.5
mmol/mol
0.07
143
1249
5
20
2.53
1.15
1.8
1.5
—
—
—
0
0
5
20
2.53
1.15
5.2
3.0
—
—
—
0
0
11
58
1.94
1.14
1.5
1.8
—
—
—
0
0
55
432
1.35
1.13
1.5
1.4
—
—
—
0
0
7
31
2.30
1.11
1.3
1.4
—
—
—
0
0
5
21
2.41
1.09
11.4
20.8
1964.4
1326.2
nmol/l
—
5
21
5
21
2.41
1.09
7.4
14.2
1092.8
767.7
nmol/l
—
5
21
5
21
2.41
1.09
2.0
1.2
—
—
—
0
0
140
1257
1.27
1.05
4.4
3.0
35.5
32.6
u/l
0.28
129
1207
142
1280
1.27
1.02
5.0
3.5
9.4
7.8
mm/h
1.10
132
1196
39
296
1.38
0.99
1.2
1.3
60.5
19.8
iu/ml
0.45
13
84
11
63
1.78
0.91
15.5
10.6
0.7
0.7
%
0.02
11
63
6
30
2.03
0.87
1.7
1.4
—
—
—
0
0
170
1581
1.26
0.86
3.7
3.0
1.4
1.5
mmol/l
0.44
164
1489
204
1942
1.34
0.85
17.1
10.5
39.7
40.4
%
0.72
161
1658
171
1593
1.26
0.84
3.8
3.2
2.8
2.8
mmol/l
0.12
164
1494
12
73
1.68
0.83
2.3
5.6
3.1
3.2
g/l
0.19
12
68
13
81
1.64
0.83
29.7
12.4
1.2
1.0
mg/l
0.39
13
75
60
500
1.27
0.81
1.7
1.5
98.7
98.0
pmol/l
0.04
29
256
19
131
1.49
0.81
4.8
4.6
—
—
—
0
0
64
751
0.80
0.80
2.3
1.9
—
—
—
0
0
170
1589
1.24
0.78
3.8
3.1
4.6
4.6
mmol/l
0.05
164
1503
18
124
1.49
0.77
3.4
3.1
26.2
32.0
%
1.32
12
88
7
38
1.87
0.74
1.7
1.6
—
—
—
0
0
5
25
2.02
0.73
1.0
1.0
—
—
—
0
0
26
197
1.36
0.69
1.1
1.3
147.5
175.1
iu/ml
—
7
79
99
885
1.20
0.69
4.4
3.0
0.0
0.0
estimate
0.00
20
181
7
43
1.65
0.67
1.3
1.1
—
—
—
0
0
15
103
1.49
0.66
12.7
4.7
10.1
9.8
kpa
0.21
15
98
56
476
1.23
0.64
4.7
3.2
0.0
0.0
estimate
0.80
18
186
100
900
1.19
0.64
4.5
3.1
0.0
0.0
estimate
0.00
20
179
202
1939
1.27
0.64
17.2
9.0
22.5
20.5
mg/l
0.36
168
1412
10
63
1.61
0.63
16.8
10.6
1.0
1.3
%
—
10
63
8
50
1.62
0.62
1.0
1.1
—
—
—
0
0
47
394
1.24
0.61
1.7
2.3
4.5
1.1
mg/l
0.55
30
277
31
248
1.29
0.59
2.0
2.3
6482.2
4493.4
u/l
—
8
107
18
132
1.39
0.59
1.1
1.4
217.6
281.9
miu/ml
—
9
66
8
54
1.50
0.58
1.8
1.9
—
—
—
0
0
6
36
1.68
0.57
1.0
1.3
—
—
—
0
0
17
227
0.73
0.56
1.2
1.4
—
—
—
0
0
24
187
1.32
0.55
2.5
1.9
—
—
—
0
0
28
346
0.78
0.54
1.4
1.5
—
—
—
0
0
50
439
1.18
0.42
3.0
2.2
2.7
2.6
mg/l
0.13
43
379
96
886
1.14
0.42
6.6
4.3
0.0
0.0
estimate
0.00
18
187
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.2
—
106.1
—
0
17
0
17
0.00
0.41
0.0
2.9
—
—
—
0
0
10
137
0.72
0.40
1.1
1.5
—
—
—
0
0
76
695
1.14
0.38
4.9
3.0
—
—
—
0
0
13
168
0.76
0.37
1.3
1.3
—
—
—
0
0
9
71
1.28
0.36
1.4
1.7
—
—
—
0
0
71
651
1.13
0.34
1.5
1.5
0.6
2.2
u/ml
1.36
13
154
14
173
0.80
0.29
1.4
1.6
—
—
—
0
0
16
194
0.81
0.29
1.4
1.5
—
—
—
0
0
11
85
1.31
0.28
1.5
1.3
—
—
—
0
0
11
87
1.28
0.24
1.4
1.2
—
—
—
0
0
106
1009
1.09
0.24
4.5
2.8
93.0
64.8
ug/l
0.80
96
943
27
237
1.16
0.24
2.7
2.4
2063.1
528.3
ng/l
0.58
14
106
33
295
1.14
0.24
1.2
1.2
3.0
7.7
u/ml
0.96
12
132
5
39
1.29
0.23
2.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
4.1
—
128.7
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
1.3
—
0
9
6
52
1.16
0.19
2.7
1.8
—
—
—
0
0
6
52
1.16
0.19
1.3
1.1
—
—
—
0
0
7
63
1.11
0.17
1.4
2.1
—
—
—
0
0
9
83
1.09
0.15
1.1
1.5
—
—
—
0
0
21
232
0.90
0.14
1.2
1.5
—
—
—
0
0
62
645
0.95
0.10
2.3
2.2
—
—
—
0
0
5
47
1.07
0.09
1.4
1.1
—
—
—
0
0
5
47
1.07
0.09
1.4
1.1
—
—
—
0
0
6
54
1.11
0.09
2.3
2.0
—
—
—
0
0
9
104
0.86
0.06
1.3
1.4
—
—
—
0
0
39
378
1.04
0.04
1.8
1.9
—
—
—
0
0
44
452
0.97
0.04
2.6
2.0
—
—
—
0
0
10
92
1.09
0.03
1.5
1.7
—
—
—
0
0
185
1858
0.98
0.01
4.7
4.0
—
—
—
0
0
71
702
1.02
0.01
2.6
2.4
—
—
—
0
0
17
176
0.96
0.00
1.3
1.4
—
—
—
0
0
17
176
0.96
0.00
1.3
1.4
—
—
—
0
0
19
184
1.04
0.00
1.1
1.1
—
—
—
0
0
13
128
1.02
0.00
2.1
2.0
—
—
—
0
0
17
175
0.97
0.00
1.2
1.4
—
—
—
0
0
17
175
0.97
0.00
1.2
1.4
—
—
—
0
0
10
105
0.95
0.00
1.1
1.2
0.2
2.6
u/ml
—
5
54
6
69
0.87
0.00
1.5
1.3
—
—
—
0
0
5
51
0.98
0.00
1.0
1.2
—
13.7
—
0
7
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
301.9
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_PRECOXCENTPUB and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_PRECOXCENTPUB.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_PRECOXCENTPUB – Precocious central puberty
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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