No definition available.
Central nervous system disorder causing precocious puberty
E4_CENTRAL_NERVOUS_SYSTEM_DISORDER_CAUSING_PRECOCIOUS_PUBERTY
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
100 |
4. Check minimum number of eventsNone |
100 |
5. Include endpointsNone |
100 |
6. Filter based on genotype QC (FinnGen only) |
82 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Similar endpoints
↥List of similar endpoints to
Central nervous system disorder causing precocious puberty
based on the number of shared cases.
Similar with more cases:
- Precocious central puberty
- Disorders of puberty, all
- Hyperfunction of pituitary gland
- Exclusions for E4_PCOS_BROAD
- Disorders of other endocrine glands
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 82 | 72 | 10 |
| Unadjusted period prevalence (%) | 0.02 | 0.03 | 0.00 |
| Median age at first event (years) | 9.08 | 8.79 | 11.15 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 100
- Matched controls
- 1000
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E22.80
ICD-10 Finland
Central precocious puberty
+∞
138.5
98
*
L02AE02
ATC
leuprorelin; implant, parenteral
243.8
63.9
60
6
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
11.9
31.4
41
55
Z51.80
ICD-10 Finland
Manipulation of puberty development with hormone therapy
211.2
30.5
30
*
E30.1
ICD-10 Finland
Precocious puberty
49.0
26.2
31
9
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
6.2
12.5
25
51
101
Kela drug reimbursment
Anterior pituitary hypofunction
19.6
12.2
18
11
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
5.5
11.9
28
66
ZXE10
NOMESCO Finland
More than one and less than three hours
4.3
11.5
47
172
H01AC01
ATC
somatropin; parenteral
10.9
10.1
19
21
E23.00
ICD-10 Finland
Panhypopituitarism
110.0
9.6
10
*
H47.2
ICD-10 Finland
Optic atrophy
110.0
9.6
10
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
5.7
9.5
20
42
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.8
9.0
37
133
L02AE04
ATC
triptorelin; parenteral
+∞
8.4
8
*
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
14.7
8.1
13
10
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
5.1
8.1
19
44
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
4.7
7.9
21
54
H03AA01
ATC
levothyroxine sodium; systemic
4.3
7.9
24
69
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
20.3
7.8
11
6
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
+∞
7.4
7
*
ZXA00
NOMESCO Finland
Right side
4.2
7.4
23
67
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
10.0
7.3
14
16
F82
ICD-10 Finland
Specific developmental disorder of motor function
9.4
7.1
14
17
WX408
NOMESCO Finland
General anesthesy, balanced
3.3
7.1
36
146
E30.9
ICD-10 Finland
Disorder of puberty, unspecified
74.4
6.5
7
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.9
6.3
43
204
H02AB09
ATC
hydrocortisone; systemic
6.4
6.3
16
29
102
Kela drug reimbursment
Diabetes insipidus
+∞
6.3
6
*
E34.39
ICD-10 Finland
Short stature, not elsewhere classified
11.1
6.2
11
11
F83
ICD-10 Finland
Mixed specific developmental disorders
8.1
6.2
13
18
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
11
11
11.06
6.21
1.9
1.5
4.89
5.36
nmol/l
0.06
11
11
87
663
3.40
4.43
5.7
3.7
14.11
14.25
pmol/l
0.19
82
589
25
107
2.78
4.26
8.8
11.6
25.32
25.14
mmol/l
0.09
25
107
8
10
8.57
4.14
2.8
2.0
132.25
124.20
ng/l
—
8
10
23
104
2.57
3.49
6.8
10.1
24.30
23.56
mmol/l
1.10
23
104
37
208
2.24
3.47
5.3
3.5
0.48
0.16
e6/l
0.51
27
164
39
238
2.05
2.89
5.5
4.0
—
—
—
0
0
30
173
2.05
2.55
6.0
2.7
—
—
—
0
0
70
546
1.94
2.36
9.3
6.0
115.38
112.63
ml/min/173m2
0.52
49
380
64
489
1.86
2.26
15.6
8.8
4.29
3.76
e9/l
0.89
56
429
6
14
4.48
2.18
2.8
1.1
91.83
184.50
pmol/l
—
6
14
16
76
2.32
2.16
13.1
12.3
0.89
0.79
mmol/l
0.47
16
70
22
121
2.05
2.10
2.5
3.4
0.95
0.56
e6/l
0.34
11
68
6
15
4.18
2.07
4.8
4.3
44.83
52.00
%
—
6
15
5
11
4.72
1.96
3.6
6.2
0.84
1.71
ug/l
—
5
11
53
395
1.73
1.92
7.2
5.6
5.86
6.12
mmol/l
0.53
48
337
9
34
2.81
1.92
1.8
1.4
—
—
—
0
0
23
133
1.95
1.91
2.1
1.5
1.59
1.17
mmol/l
1.59
23
118
48
349
1.72
1.90
5.5
2.8
—
—
—
0
0
5
14
3.70
1.63
5.2
3.5
6.00
7.93
%
—
5
14
5
14
3.70
1.63
5.2
3.4
—
—
—
0
0
26
167
1.75
1.55
3.3
4.6
0.98
1.07
inr
—
10
58
5
15
3.45
1.54
1.4
1.1
—
—
—
0
0
5
15
3.45
1.54
1.2
1.3
—
—
—
0
0
5
15
3.45
1.54
1.2
1.3
—
—
—
0
0
20
119
1.85
1.52
2.7
3.7
11.50
3.41
e6/l
—
10
66
24
153
1.75
1.46
2.0
3.5
8.24
1.46
mg/l
0.52
15
100
31
219
1.60
1.29
4.9
3.8
67.16
29.79
u/l
0.47
31
208
8
36
2.33
1.27
1.6
1.4
—
—
—
0
0
8
37
2.26
1.24
1.5
1.4
—
—
—
0
0
18
111
1.76
1.22
1.6
2.3
7.40
15.61
ng/l
—
8
30
5
20
2.58
1.16
24.4
12.1
23.40
23.43
mmol/l
—
5
20
60
502
1.49
1.11
3.9
2.5
1.36
1.12
mmol/l
1.90
60
480
5
21
2.45
1.10
25.2
11.3
0.96
0.91
%
—
5
21
5
21
2.45
1.10
25.2
11.3
0.56
0.59
%
—
5
21
9
45
2.10
1.08
15.8
11.5
106.67
105.29
mmol/l
—
9
45
88
804
1.79
1.07
15.2
9.4
20.97
21.77
mg/l
0.07
76
563
47
378
1.46
1.04
5.6
4.8
0.00
0.00
estimate
—
8
80
47
379
1.45
1.03
4.1
3.3
0.00
0.00
estimate
—
9
80
7
35
2.07
1.02
2.9
2.1
—
—
—
0
0
62
529
1.45
0.99
4.2
2.4
1.35
1.47
mmol/l
1.61
62
500
12
70
1.81
0.97
2.2
1.3
375.10
557.82
u/ml
0.17
12
64
15
94
1.70
0.97
11.1
7.8
4.84
4.98
kpa
0.39
15
89
15
94
1.70
0.97
11.1
7.8
0.31
1.57
mmol/l
—
10
65
10
55
1.91
0.96
1.4
1.9
—
—
—
0
0
47
384
1.42
0.94
4.1
3.4
0.00
0.00
estimate
—
9
80
62
533
1.43
0.92
4.3
2.5
2.76
2.70
mmol/l
0.24
62
501
10
56
1.87
0.91
1.3
1.8
—
—
—
0
0
62
536
1.41
0.88
4.3
2.6
4.48
4.45
mmol/l
0.07
62
508
13
81
1.70
0.86
12.5
6.9
10.42
10.11
kpa
0.30
13
75
9
55
1.70
0.76
2.9
6.7
103.33
96.02
%
—
9
55
17
118
1.53
0.75
1.6
1.7
—
—
—
0
0
5
25
2.05
0.74
1.4
1.3
—
—
—
0
0
5
28
1.83
0.67
1.2
1.4
25.00
21.54
u/ml
—
5
28
6
103
0.56
0.66
1.0
1.6
—
—
—
0
0
12
81
1.55
0.60
1.5
1.9
—
—
—
0
0
5
86
0.56
0.59
1.0
1.5
—
—
—
0
0
6
37
1.66
0.56
4.5
2.2
—
—
—
0
0
11
76
1.50
0.50
1.2
1.5
551.09
98529839.65
pmol/l
0.49
11
68
11
76
1.50
0.50
4.2
2.7
31.83
25.08
%
0.31
11
70
33
277
1.29
0.50
4.0
3.2
—
—
—
0
0
6
94
0.62
0.44
1.2
1.3
—
—
—
0
0
13
96
1.41
0.44
4.3
4.9
297.23
290.12
umol/l
0.14
13
91
14
106
1.37
0.42
1.2
1.3
22.35
19.06
nmol/l
0.42
14
94
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
11
84
1.35
0.31
1.4
1.4
—
—
—
0
0
11
84
1.35
0.31
1.3
1.4
—
—
—
0
0
11
84
1.35
0.31
1.3
1.4
—
—
—
0
0
11
84
1.35
0.31
1.4
1.4
—
—
—
0
0
18
149
1.25
0.30
2.3
2.5
10336.14
3518.65
u/l
—
5
60
24
206
1.22
0.30
4.9
3.4
0.00
0.00
estimate
—
8
79
21
178
1.23
0.29
1.4
1.4
107.31
91.60
pmol/l
—
10
89
38
342
1.18
0.29
2.4
2.5
—
—
—
0
0
5
71
0.69
0.27
1.4
1.2
—
—
—
0
0
12
96
1.28
0.26
3.5
2.6
17.56
14.88
umol/l
0.31
12
88
40
365
1.16
0.25
2.9
2.8
—
—
—
0
0
16
188
0.82
0.24
1.3
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
11
90
1.25
0.20
3.9
2.5
2.57
2.59
g/l
0.02
11
81
10
121
0.81
0.19
1.1
1.4
—
—
—
0
0
21
187
1.16
0.17
1.1
1.4
—
—
—
0
0
11
95
1.18
0.12
1.5
1.5
—
—
—
0
0
41
431
0.92
0.12
2.4
2.0
—
—
—
0
0
10
115
0.86
0.11
1.2
1.1
—
—
—
0
0
10
87
1.17
0.10
1.6
2.2
409.40
786.41
ng/l
—
5
27
5
47
1.07
0.09
1.6
1.8
—
—
—
0
0
5
48
1.04
0.09
1.2
1.4
—
—
—
0
0
7
64
1.10
0.08
1.4
1.5
—
—
—
0
0
85
862
0.91
0.07
4.7
4.3
—
—
—
0
0
38
368
1.05
0.05
1.6
1.7
0.57
2.19
u/ml
—
7
74
28
269
1.06
0.04
2.7
2.2
—
—
—
0
0
23
229
1.01
0.00
1.8
2.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
99.00
—
0
9
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
6.22
—
0
5
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
7.8
—
1.26
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
1373.80
—
0
5
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
7.5
—
286.83
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: E4_CENTRAL_NERVOUS_SYSTEM_DISORDER_CAUSING_PRECOCIOUS_PUBERTY – Central nervous system disorder causing precocious puberty
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).